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The map label for this gene is uvrC

Identifier: 209695581

GI number: 209695581

Start: 2294845

End: 2296671

Strand: Reverse

Name: uvrC

Synonym: VSAL_I2140

Alternate gene names: 209695581

Gene position: 2296671-2294845 (Counterclockwise)

Preceding gene: 209695582

Following gene: 209695580

Centisome position: 69.07

GC content: 38.86

Gene sequence:

>1827_bases
GTGCCTCCTTTTGATTCAAAAGCTTTTCTACTATCAGTTACCCATCAGCCCGGCGTTTATCGAATGTATAACGCCGAAGC
TGAGGTTATTTACGTCGGTAAAGCAAAGGATTTAAAAAAGCGATTATCGAGCTATTTTCGCAGTAATATCCCTTCAGAAA
AAACCAAAGCCTTGGTCACTCATATTGCACAAATTGATGTTACGGTCACTCATACAGAAACTGAAGCATTAATTCTTGAG
CATAATTATATTAAGCAATATTTACCTAAATATAATGTGCTGCTGCGTGATGATAAATCTTATCCTTACATTTTTATTTC
GAATCATAAGCATCCAAGGATCTCCATTCATCGTGGTACGAAACGAAAAAAAGGAGAATATTTTGGACCTTATCCTGATT
CAGGAGCGGTTAGAGATTCCCTTCATCTAATTCAAAAACTATTCCCTATTCGTCAATGTGAAGATTCAGTGTATGCAAAT
CGTCATAGACCTTGTTTAATGCATCAAATTGGTCGCTGTTTAGCACCATGCGTAAAAGGCATTATTAGTGATGAAGATTA
TGCCGAGCAAACTGAATTTATTCGATTGTTTTTGCAAGGGAAAGATCGACAAGTTATTCAATCTCTAGTTGAACAAATGG
AAGGGGCGAGTCAGGCTCTTAATTTTGAAAAAGCAGCGACAATTCGTGATCAAATTCAATCAATGAGACGCGTACAAGAA
CAACAATATGTTTCGGATGAAAGTAGTGACGATCTTGATGTATTAGGTTTTACAATTGAAAATGGACTCGCTTGTATTCA
CTTGTTAATGATTCGGCATGGAAAGATTTTAGGCAGCCGTAGCTTTTTTCCTAAAATTCCAGCTAAAACTGAGAAAGAGG
AAGTGTTTTCTAGTTTTCTCACTCAATATTATTTAAACCATAGTCAAGGGCGCACTATTCCCAATCGAGTGATTACCAGT
TTTGAATTTGAGAGTGAAGGGCTAGAGCAGGCATTAACGGAGCTGTCTGGCCGTAAAGTGTTATTTCAATTAAACCCTAA
AGGAATGAAAGGTCGCTATTTAAAACTCGCGGATACGAATGCATTGTCGGCCTTAACGAGTAAGGCTAACCATAAGCTTA
CGGTTTATCAGCGATTTAAACAGTTAGAAGAAGCGCTTTCTTTAGCATCTATCCAACGTATGGAATGTTTTGATATCAGT
CATACGATGGGAGAGAAAACCGTTGCGTCATGCGTTGTATTTAATCAAGAAGGGCCAGTAAAATCGGAATATCGTCGATA
CAATATTACCGGTATTACTGGAGGGGATGATTACGCCGCGATGGCTCAAGTTTTAGAGCGTCGTTATAGTAAGCAATTGG
ATATTGATAAAATCCCTGATATTGTGTTTATTGACGGAGGAAAAGGGCAATTGAACAGAGCTTACGACGTTATTCGTCAG
CATTGGGGAGATTGGCCTAAAAGACCGTTATTACTTGGGATTGCAAAAGGAGTGACAAGAAAGCATGGGCTAGAGACTCT
GGTGAAAATTACAGGAGAAGAGTTTTCGATGCCAAGTGATTCGCCTGCATTGCATTTAATACAACATATTCGTGATGAGA
GTCATAATCATGCGATTAGCGGGCACCGTGCTCAGCGCGCTAAAGTAAGAAAAACCAGTACATTGCAACACATTGAAGGT
GTCGGTCCTAAGCGGAGACAAGCATTATTACAATATTTAGGTGGTCTACAAGAATTAAAAAAGGCAAGTGTTGAAGAAAT
AAGCAAAGTGCCAGGTATTAGCCGCTCTTTAGCAGAAAAAATACAGGATGCGTTGAAACAAGGGTAA

Upstream 100 bases:

>100_bases
GTTATCGTTATCGATTATTCAGTAAATTAGACATTAGTGGAGATGTTGAATTAACGCATTTAGCTATTCGTCATGGCATA
TTAGATGCTGAGACGCTGTA

Downstream 100 bases:

>100_bases
AAAAAGCGCACCATAGACCCGCGTACCAAAACTAAAGAATTATTATGCGATTAACGATACCAAATATACTCACGTTTATC
CGACTTGCACTTATTCCAGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPPFDSKAFLLSVTHQPGVYRMYNAEAEVIYVGKAKDLKKRLSSYFRSNIPSEKTKALVTHIAQIDVTVTHTETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFISNHKHPRISIHRGTKRKKGEYFGPYPDSGAVRDSLHLIQKLFPIRQCEDSVYAN
RHRPCLMHQIGRCLAPCVKGIISDEDYAEQTEFIRLFLQGKDRQVIQSLVEQMEGASQALNFEKAATIRDQIQSMRRVQE
QQYVSDESSDDLDVLGFTIENGLACIHLLMIRHGKILGSRSFFPKIPAKTEKEEVFSSFLTQYYLNHSQGRTIPNRVITS
FEFESEGLEQALTELSGRKVLFQLNPKGMKGRYLKLADTNALSALTSKANHKLTVYQRFKQLEEALSLASIQRMECFDIS
HTMGEKTVASCVVFNQEGPVKSEYRRYNITGITGGDDYAAMAQVLERRYSKQLDIDKIPDIVFIDGGKGQLNRAYDVIRQ
HWGDWPKRPLLLGIAKGVTRKHGLETLVKITGEEFSMPSDSPALHLIQHIRDESHNHAISGHRAQRAKVRKTSTLQHIEG
VGPKRRQALLQYLGGLQELKKASVEEISKVPGISRSLAEKIQDALKQG

Sequences:

>Translated_608_residues
MPPFDSKAFLLSVTHQPGVYRMYNAEAEVIYVGKAKDLKKRLSSYFRSNIPSEKTKALVTHIAQIDVTVTHTETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFISNHKHPRISIHRGTKRKKGEYFGPYPDSGAVRDSLHLIQKLFPIRQCEDSVYAN
RHRPCLMHQIGRCLAPCVKGIISDEDYAEQTEFIRLFLQGKDRQVIQSLVEQMEGASQALNFEKAATIRDQIQSMRRVQE
QQYVSDESSDDLDVLGFTIENGLACIHLLMIRHGKILGSRSFFPKIPAKTEKEEVFSSFLTQYYLNHSQGRTIPNRVITS
FEFESEGLEQALTELSGRKVLFQLNPKGMKGRYLKLADTNALSALTSKANHKLTVYQRFKQLEEALSLASIQRMECFDIS
HTMGEKTVASCVVFNQEGPVKSEYRRYNITGITGGDDYAAMAQVLERRYSKQLDIDKIPDIVFIDGGKGQLNRAYDVIRQ
HWGDWPKRPLLLGIAKGVTRKHGLETLVKITGEEFSMPSDSPALHLIQHIRDESHNHAISGHRAQRAKVRKTSTLQHIEG
VGPKRRQALLQYLGGLQELKKASVEEISKVPGISRSLAEKIQDALKQG
>Mature_607_residues
PPFDSKAFLLSVTHQPGVYRMYNAEAEVIYVGKAKDLKKRLSSYFRSNIPSEKTKALVTHIAQIDVTVTHTETEALILEH
NYIKQYLPKYNVLLRDDKSYPYIFISNHKHPRISIHRGTKRKKGEYFGPYPDSGAVRDSLHLIQKLFPIRQCEDSVYANR
HRPCLMHQIGRCLAPCVKGIISDEDYAEQTEFIRLFLQGKDRQVIQSLVEQMEGASQALNFEKAATIRDQIQSMRRVQEQ
QYVSDESSDDLDVLGFTIENGLACIHLLMIRHGKILGSRSFFPKIPAKTEKEEVFSSFLTQYYLNHSQGRTIPNRVITSF
EFESEGLEQALTELSGRKVLFQLNPKGMKGRYLKLADTNALSALTSKANHKLTVYQRFKQLEEALSLASIQRMECFDISH
TMGEKTVASCVVFNQEGPVKSEYRRYNITGITGGDDYAAMAQVLERRYSKQLDIDKIPDIVFIDGGKGQLNRAYDVIRQH
WGDWPKRPLLLGIAKGVTRKHGLETLVKITGEEFSMPSDSPALHLIQHIRDESHNHAISGHRAQRAKVRKTSTLQHIEGV
GPKRRQALLQYLGGLQELKKASVEEISKVPGISRSLAEKIQDALKQG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=606, Percent_Identity=64.1914191419142, Blast_Score=814, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ALISL (B6EI86)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263510.1
- GeneID:   6988968
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2140
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69140; Mature: 69009

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPFDSKAFLLSVTHQPGVYRMYNAEAEVIYVGKAKDLKKRLSSYFRSNIPSEKTKALVT
CCCCCCCEEEEEEECCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHH
HIAQIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISNHKHPRISIHRGT
HHHHEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCEEEEECCC
KRKKGEYFGPYPDSGAVRDSLHLIQKLFPIRQCEDSVYANRHRPCLMHQIGRCLAPCVKG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IISDEDYAEQTEFIRLFLQGKDRQVIQSLVEQMEGASQALNFEKAATIRDQIQSMRRVQE
HCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHH
QQYVSDESSDDLDVLGFTIENGLACIHLLMIRHGKILGSRSFFPKIPAKTEKEEVFSSFL
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
TQYYLNHSQGRTIPNRVITSFEFESEGLEQALTELSGRKVLFQLNPKGMKGRYLKLADTN
HHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCH
ALSALTSKANHKLTVYQRFKQLEEALSLASIQRMECFDISHTMGEKTVASCVVFNQEGPV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCC
KSEYRRYNITGITGGDDYAAMAQVLERRYSKQLDIDKIPDIVFIDGGKGQLNRAYDVIRQ
HHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
HWGDWPKRPLLLGIAKGVTRKHGLETLVKITGEEFSMPSDSPALHLIQHIRDESHNHAIS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHCCCCCCCCC
GHRAQRAKVRKTSTLQHIEGVGPKRRQALLQYLGGLQELKKASVEEISKVPGISRSLAEK
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IQDALKQG
HHHHHHCC
>Mature Secondary Structure 
PPFDSKAFLLSVTHQPGVYRMYNAEAEVIYVGKAKDLKKRLSSYFRSNIPSEKTKALVT
CCCCCCEEEEEEECCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHH
HIAQIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISNHKHPRISIHRGT
HHHHEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCEEEEECCC
KRKKGEYFGPYPDSGAVRDSLHLIQKLFPIRQCEDSVYANRHRPCLMHQIGRCLAPCVKG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IISDEDYAEQTEFIRLFLQGKDRQVIQSLVEQMEGASQALNFEKAATIRDQIQSMRRVQE
HCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHH
QQYVSDESSDDLDVLGFTIENGLACIHLLMIRHGKILGSRSFFPKIPAKTEKEEVFSSFL
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
TQYYLNHSQGRTIPNRVITSFEFESEGLEQALTELSGRKVLFQLNPKGMKGRYLKLADTN
HHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCH
ALSALTSKANHKLTVYQRFKQLEEALSLASIQRMECFDISHTMGEKTVASCVVFNQEGPV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCC
KSEYRRYNITGITGGDDYAAMAQVLERRYSKQLDIDKIPDIVFIDGGKGQLNRAYDVIRQ
HHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
HWGDWPKRPLLLGIAKGVTRKHGLETLVKITGEEFSMPSDSPALHLIQHIRDESHNHAIS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHCCCCCCCCC
GHRAQRAKVRKTSTLQHIEGVGPKRRQALLQYLGGLQELKKASVEEISKVPGISRSLAEK
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IQDALKQG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA