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The map label for this gene is phoQ [H]

Identifier: 209695437

GI number: 209695437

Start: 2120425

End: 2121759

Strand: Reverse

Name: phoQ [H]

Synonym: VSAL_I1978

Alternate gene names: 209695437

Gene position: 2121759-2120425 (Counterclockwise)

Preceding gene: 209695438

Following gene: 209695436

Centisome position: 63.81

GC content: 36.25

Gene sequence:

>1335_bases
ATGCCGAATAACAAAAGTAATTTCAAGCATTTAAGTTTAAAAAATCGCTTATTGTTAACGACTACCTTATGGTTAAGCCT
GATGCTTGTCAGTGCTGGATTATTGATCCCTTATTTAATAAATGACTACTTAACCACAGATATAAAAAAGACACTCAGTC
ATTCAATGGATGAAATCATTGCGAATTTAGAAGTCGACAATAACGGAAAATTAGTTCAGTCCGGTCAATTATCTGATCCT
CGATTTAAGCGTCCCTACAGTGGACTCTATTGGTATGCCGAAAGTAAAAAGCAAACCTTACGATCTCGCTCTTTATGGGA
CAGTTCCTTACAAGAAAAAAAACACCATTACCTTGGGCCTAATAATGAAGAACTGATCACGATTAAAAAATCGATTTCTT
TGTTTGATGTAAAAGGCCCGGTCTCCATCATTGTTGGTATTGATAAAGCCCCACTATCTTCAACCATTGAGCAGGTAATG
CAACGAATATGGCTATTATTAAGCCTCTTATTTATTGGCGTATTTACCTTAATCAGTTTTCAGGTTAAATGGTCTTTAAA
GCCTTTATCTAAGCTGCAAACCGAGTTGCAAAAACTTCGTGATGGAGAACAAAACGCTTTAAAGCAATATTACCCTAACG
AGATCCAACCACTCGTGACTGATCTCAATGCACTCGTCTTCCACTATCAAGAATTATTAGATCGTGCTCGTCATCATGCA
GGAAATCTTTCTCATGCTTTAAAAACACCACTGTCCATTCTAAAAAATGAAACAGAAACACTGCCAGAAGAAAAAAAGAA
ACACTTTGAGCCCGCGTTATATGACTTACAACATCATATTGATTACCACTTAAATCAAGCACGTATGGCTGGCTCAAAAC
ACATTTTATCAGCCAATAGCTCTCCCTCTAAGCGTATAGATAGCATGTCTATTGCCTTTGATAAACTGTACAGCCAACAC
TCTATTCTCGTTATTAACGAAATAGACTACGATCTTTTAGTCAATATTGAACAAACGGATTTAGATGAAATTTTAGGAAA
CCTACTTGAAAACGGGTACAAATGGGCGACATCGATTATCCGTATCACGGCTAATATTGTGGACGATTTTGTTGAAATAA
ATATTGAAGATGATGGTCTTGGTATTCCCGAAAATAAATTCAAAGAAGTACTTAAAAGGGGCATACGATTAGATGAATCG
GTAAAAGGGACAGGACTCGGTCTTAATATCGTACAAGAAGTCATTCATAGTTATCGCGGAAAACTCAACATTTCGAGATC
ACATTTAGGCGGTGCTAAAATTACGGTTTACCTTCCATTATTTAAACAAAATTAA

Upstream 100 bases:

>100_bases
GATCGCGATTCAAATACTATTGAAGTGTTTATTGGGCGAATTCGAAGAAAGTTATCGCCTTCCGTAATAAAAACAGTGCG
TGGACTTGGGTACCAACTTA

Downstream 100 bases:

>100_bases
TATATCGAGTATCAACCCATTACCAAAATTAAAACTCTGGTCTGTATTTTGCTTTACAAAAGTATAATGTCAATTTATCT
AATACGTTACTAACAAATAA

Product: signal transduction protein, histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPNNKSNFKHLSLKNRLLLTTTLWLSLMLVSAGLLIPYLINDYLTTDIKKTLSHSMDEIIANLEVDNNGKLVQSGQLSDP
RFKRPYSGLYWYAESKKQTLRSRSLWDSSLQEKKHHYLGPNNEELITIKKSISLFDVKGPVSIIVGIDKAPLSSTIEQVM
QRIWLLLSLLFIGVFTLISFQVKWSLKPLSKLQTELQKLRDGEQNALKQYYPNEIQPLVTDLNALVFHYQELLDRARHHA
GNLSHALKTPLSILKNETETLPEEKKKHFEPALYDLQHHIDYHLNQARMAGSKHILSANSSPSKRIDSMSIAFDKLYSQH
SILVINEIDYDLLVNIEQTDLDEILGNLLENGYKWATSIIRITANIVDDFVEINIEDDGLGIPENKFKEVLKRGIRLDES
VKGTGLGLNIVQEVIHSYRGKLNISRSHLGGAKITVYLPLFKQN

Sequences:

>Translated_444_residues
MPNNKSNFKHLSLKNRLLLTTTLWLSLMLVSAGLLIPYLINDYLTTDIKKTLSHSMDEIIANLEVDNNGKLVQSGQLSDP
RFKRPYSGLYWYAESKKQTLRSRSLWDSSLQEKKHHYLGPNNEELITIKKSISLFDVKGPVSIIVGIDKAPLSSTIEQVM
QRIWLLLSLLFIGVFTLISFQVKWSLKPLSKLQTELQKLRDGEQNALKQYYPNEIQPLVTDLNALVFHYQELLDRARHHA
GNLSHALKTPLSILKNETETLPEEKKKHFEPALYDLQHHIDYHLNQARMAGSKHILSANSSPSKRIDSMSIAFDKLYSQH
SILVINEIDYDLLVNIEQTDLDEILGNLLENGYKWATSIIRITANIVDDFVEINIEDDGLGIPENKFKEVLKRGIRLDES
VKGTGLGLNIVQEVIHSYRGKLNISRSHLGGAKITVYLPLFKQN
>Mature_443_residues
PNNKSNFKHLSLKNRLLLTTTLWLSLMLVSAGLLIPYLINDYLTTDIKKTLSHSMDEIIANLEVDNNGKLVQSGQLSDPR
FKRPYSGLYWYAESKKQTLRSRSLWDSSLQEKKHHYLGPNNEELITIKKSISLFDVKGPVSIIVGIDKAPLSSTIEQVMQ
RIWLLLSLLFIGVFTLISFQVKWSLKPLSKLQTELQKLRDGEQNALKQYYPNEIQPLVTDLNALVFHYQELLDRARHHAG
NLSHALKTPLSILKNETETLPEEKKKHFEPALYDLQHHIDYHLNQARMAGSKHILSANSSPSKRIDSMSIAFDKLYSQHS
ILVINEIDYDLLVNIEQTDLDEILGNLLENGYKWATSIIRITANIVDDFVEINIEDDGLGIPENKFKEVLKRGIRLDESV
KGTGLGLNIVQEVIHSYRGKLNISRSHLGGAKITVYLPLFKQN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=341, Percent_Identity=28.7390029325513, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1790551, Length=287, Percent_Identity=27.5261324041812, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=348, Percent_Identity=22.4137931034483, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=24.5421245421245, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=23.6734693877551, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786783, Length=304, Percent_Identity=20.0657894736842, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787894, Length=297, Percent_Identity=23.2323232323232, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=22, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50655; Mature: 50524

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNNKSNFKHLSLKNRLLLTTTLWLSLMLVSAGLLIPYLINDYLTTDIKKTLSHSMDEII
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLEVDNNGKLVQSGQLSDPRFKRPYSGLYWYAESKKQTLRSRSLWDSSLQEKKHHYLGP
HHCEECCCCCEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
NNEELITIKKSISLFDVKGPVSIIVGIDKAPLSSTIEQVMQRIWLLLSLLFIGVFTLISF
CCCEEEEEEECCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVKWSLKPLSKLQTELQKLRDGEQNALKQYYPNEIQPLVTDLNALVFHYQELLDRARHHA
HHEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GNLSHALKTPLSILKNETETLPEEKKKHFEPALYDLQHHIDYHLNQARMAGSKHILSANS
CCHHHHHHHHHHHHHCCHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SPSKRIDSMSIAFDKLYSQHSILVINEIDYDLLVNIEQTDLDEILGNLLENGYKWATSII
CCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
RITANIVDDFVEINIEDDGLGIPENKFKEVLKRGIRLDESVKGTGLGLNIVQEVIHSYRG
HHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
KLNISRSHLGGAKITVYLPLFKQN
CEEEEHHCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
PNNKSNFKHLSLKNRLLLTTTLWLSLMLVSAGLLIPYLINDYLTTDIKKTLSHSMDEII
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLEVDNNGKLVQSGQLSDPRFKRPYSGLYWYAESKKQTLRSRSLWDSSLQEKKHHYLGP
HHCEECCCCCEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
NNEELITIKKSISLFDVKGPVSIIVGIDKAPLSSTIEQVMQRIWLLLSLLFIGVFTLISF
CCCEEEEEEECCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVKWSLKPLSKLQTELQKLRDGEQNALKQYYPNEIQPLVTDLNALVFHYQELLDRARHHA
HHEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GNLSHALKTPLSILKNETETLPEEKKKHFEPALYDLQHHIDYHLNQARMAGSKHILSANS
CCHHHHHHHHHHHHHCCHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SPSKRIDSMSIAFDKLYSQHSILVINEIDYDLLVNIEQTDLDEILGNLLENGYKWATSII
CCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
RITANIVDDFVEINIEDDGLGIPENKFKEVLKRGIRLDESVKGTGLGLNIVQEVIHSYRG
HHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
KLNISRSHLGGAKITVYLPLFKQN
CEEEEHHCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA