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The map label for this gene is tesB [H]

Identifier: 209695427

GI number: 209695427

Start: 2111094

End: 2111957

Strand: Reverse

Name: tesB [H]

Synonym: VSAL_I1968

Alternate gene names: 209695427

Gene position: 2111957-2111094 (Counterclockwise)

Preceding gene: 209695429

Following gene: 209695425

Centisome position: 63.51

GC content: 42.82

Gene sequence:

>864_bases
ATGAACAAACCACTTAATGAATTATTAACCCTGTTGCAATTAGAGCAACTCGAACAAGGGCTATTTAGAGGACAAAGCGA
GAACCTAGGCTTACCTCAAGTATATGGTGGTCAAGTCGTTGGACAGGCTTTATCGGCCGCTCGCTATACCGTTGATAACG
CCAGAACAGTGCATTCTTTTCACAGCTATTTCCTTTATCCTGGCGATCCTGAAAAAGCCATCATCTACGATGTAGAAAAC
CTACGAGATGGCAGAAGTTTCAGCACTCGTCGAGTGAAAGCCATTCAAAATGGTCGCCCTATTTTCTATTTAACGGCGTC
TTATCATGGTGATGAACCTGGATTTGAGCATCAATCAAAAATGCCAGAAATTGCGGGCCCTGAAAACTTCGCCTCTGAAA
CTCAACTTGCAGAAGCAATTAAGCACGTACTTCCACCTCAAATACAAAAAATATTCTGCAGCGAAAAACCGATCGAAGTT
CGCCCAGTAAATATCATTAATCCATTAGCCCCTAAAAAAGCAGCGCCAACACAACATTTATGGATCAAAGCCAATGGTGA
TTTACCTGATATCCAGTTGATCCATCAATATATATTGGCTTATGCGTCTGATTGGGGATTCTTAACGACGGCACTTCACC
CGCACGAAGTCAGCTTGCTCACTCCCAATTTTCAAGTGGCAACCATTGATCATTCAATGTGGTTCCACCGCCCATTCAAA
ATGGATGAATGGTTGCTTTACTCAATTGAAAGCACCAACGCCAGCGGTTCTCGTGGCTTAGTTCGTGGCGAGATATTCAA
CCAAAAAGGCGAACTTGTGGCATCTGCAATGCAAGAAGGCTTAATGAGAATGAAAAACAAATAA

Upstream 100 bases:

>100_bases
ATAGATCTTCCTCCTATTAACACCCTATTTAACTTATTGAACTCAAACTGAATCTATTTCACAATAGAGCGATAACGTTA
GAATTTAAAAGGCATTCTTG

Downstream 100 bases:

>100_bases
GTACTTAATCTGTTTAAAAACGCGTAAGGCGCATCAATTGCTCTTGCGCATTTTTGATCTCACTTTTATTACAGAGGTAA
TTCCGTTGTGTATTTCAATG

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNKPLNELLTLLQLEQLEQGLFRGQSENLGLPQVYGGQVVGQALSAARYTVDNARTVHSFHSYFLYPGDPEKAIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSKMPEIAGPENFASETQLAEAIKHVLPPQIQKIFCSEKPIEV
RPVNIINPLAPKKAAPTQHLWIKANGDLPDIQLIHQYILAYASDWGFLTTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
MDEWLLYSIESTNASGSRGLVRGEIFNQKGELVASAMQEGLMRMKNK

Sequences:

>Translated_287_residues
MNKPLNELLTLLQLEQLEQGLFRGQSENLGLPQVYGGQVVGQALSAARYTVDNARTVHSFHSYFLYPGDPEKAIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSKMPEIAGPENFASETQLAEAIKHVLPPQIQKIFCSEKPIEV
RPVNIINPLAPKKAAPTQHLWIKANGDLPDIQLIHQYILAYASDWGFLTTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
MDEWLLYSIESTNASGSRGLVRGEIFNQKGELVASAMQEGLMRMKNK
>Mature_287_residues
MNKPLNELLTLLQLEQLEQGLFRGQSENLGLPQVYGGQVVGQALSAARYTVDNARTVHSFHSYFLYPGDPEKAIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSKMPEIAGPENFASETQLAEAIKHVLPPQIQKIFCSEKPIEV
RPVNIINPLAPKKAAPTQHLWIKANGDLPDIQLIHQYILAYASDWGFLTTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
MDEWLLYSIESTNASGSRGLVRGEIFNQKGELVASAMQEGLMRMKNK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=287, Percent_Identity=40.7665505226481, Blast_Score=211, Evalue=7e-55,
Organism=Escherichia coli, GI1786657, Length=272, Percent_Identity=61.0294117647059, Blast_Score=356, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=38.2252559726962, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17558508, Length=306, Percent_Identity=38.2352941176471, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17531889, Length=271, Percent_Identity=35.7933579335793, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=271, Percent_Identity=35.7933579335793, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=271, Percent_Identity=35.7933579335793, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71982224, Length=272, Percent_Identity=27.5735294117647, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI212645202, Length=265, Percent_Identity=30.9433962264151, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322480, Length=306, Percent_Identity=25.1633986928105, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32393; Mature: 32393

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPLNELLTLLQLEQLEQGLFRGQSENLGLPQVYGGQVVGQALSAARYTVDNARTVHSF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
HSYFLYPGDPEKAIIYDVENLRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSK
HHEEEECCCCCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHC
MPEIAGPENFASETQLAEAIKHVLPPQIQKIFCSEKPIEVRPVNIINPLAPKKAAPTQHL
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEE
WIKANGDLPDIQLIHQYILAYASDWGFLTTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEEEECHHHCCCCCC
MDEWLLYSIESTNASGSRGLVRGEIFNQKGELVASAMQEGLMRMKNK
CCCEEEEEEECCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKPLNELLTLLQLEQLEQGLFRGQSENLGLPQVYGGQVVGQALSAARYTVDNARTVHSF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
HSYFLYPGDPEKAIIYDVENLRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSK
HHEEEECCCCCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHC
MPEIAGPENFASETQLAEAIKHVLPPQIQKIFCSEKPIEVRPVNIINPLAPKKAAPTQHL
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEE
WIKANGDLPDIQLIHQYILAYASDWGFLTTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEEEECHHHCCCCCC
MDEWLLYSIESTNASGSRGLVRGEIFNQKGELVASAMQEGLMRMKNK
CCCEEEEEEECCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]