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The map label for this gene is cysM [C]

Identifier: 209695425

GI number: 209695425

Start: 2109374

End: 2110438

Strand: Reverse

Name: cysM [C]

Synonym: VSAL_I1966

Alternate gene names: 209695425

Gene position: 2110438-2109374 (Counterclockwise)

Preceding gene: 209695427

Following gene: 209695424

Centisome position: 63.47

GC content: 42.35

Gene sequence:

>1065_bases
ATGTGTACAGATCATAACTGGATTAATAACGCTATTCGTAAAATTGAAGCGGACTACCAACGCTCTGCAGATACCCATCT
CATTAAGCTTGATTTGCCAATGCTTAATGGTATTTATGTTTACCTAAAGGATGAAAGTACGCATCCAACAGGGTCACTTA
AGCATCGCTTAGCCCGATCTCTTTTCCTTTATGCCATCTCAAATGGATGGATTGGCCCTAACACCCCGATTATTGAATCC
TCATCAGGCAGTACTGCGGTATCTGAAGCCTATTTCGCACGTCTTTTAGGTCTTCCTTTTATTGCTGTCGTGCCTCGCTG
TACCGCGAGTAAAAAAATAGAAATGATTCAGTTCTATGGCGGTAAAACGCATTTTGTCGAACGTTCTGATGAAATTTATG
CAGAATCTCGCCGTTTAGCGCAAGAGTTAGATGGTCATTATATGGATCAATTTACTTACGCAGAGCGAGCAACGGATTGG
CGTGGCAACAATAACATCGCTGACAGTATATTCAGTCAAATGAAATTAGAAGATCACCCTGAACCAACATGGATCGTAAT
GAATCCAGGGACTGGCGGAACGTCAGCAACCATTGGTCGCTTCATTCGATATCAAAAATACCACACGAAATTGTGTGTGG
TTGATCCTGAAAATTCGGTATTCCATGATTTCTATAAAACAGGCAATAAAGACCTAACATTAGAATGTGGAAGTAAAATT
GAAGGAATTGGGCGTCCGCGAGTGGAACCTAGCTTTATTCCGGGCGTCATTGATGAAATGCGCACCATTCCTGACGCAGC
AAGTGTTGCAACAGCACGTTGGCTAGAAGGCATTCTAGGCAGAAAAGCAGGGGCTTCAACAGGAACCAATTTACATGGCG
CATTACAATTGGCTTGTGAAATGGAGCAACGTGGTGAAAAAGGATCTATTGTGACTTTATTGTGTGACAGTGGTGACCGT
TATTTGGATACATACTATAACGATGAATGGGTAGCTAAACATATTGGCGACCTAACACCTCATCTCTCTCAGTTAAAAAA
CTTCGAACGCACAGGTCAGCTGTAA

Upstream 100 bases:

>100_bases
TTATTTCTCTTTAACTGCTAATATACAGTAAATATAGCAAAGTTTTTCTCAAGTAACAGAGGTAAATTATTCACATCGCC
CATATTTAAGGAAAAGAATT

Downstream 100 bases:

>100_bases
CCCTACGAGTAAACCCCATAATCAAAGCCATCATTAACGTGATGGCTTTTTTATCTATTCTTCCTTACTATGCTCACTAA
TTACAAAACTTGGAGTTAAT

Product: pyridoxal-phosphate dependent enzyme

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLNGIYVYLKDESTHPTGSLKHRLARSLFLYAISNGWIGPNTPIIES
SSGSTAVSEAYFARLLGLPFIAVVPRCTASKKIEMIQFYGGKTHFVERSDEIYAESRRLAQELDGHYMDQFTYAERATDW
RGNNNIADSIFSQMKLEDHPEPTWIVMNPGTGGTSATIGRFIRYQKYHTKLCVVDPENSVFHDFYKTGNKDLTLECGSKI
EGIGRPRVEPSFIPGVIDEMRTIPDAASVATARWLEGILGRKAGASTGTNLHGALQLACEMEQRGEKGSIVTLLCDSGDR
YLDTYYNDEWVAKHIGDLTPHLSQLKNFERTGQL

Sequences:

>Translated_354_residues
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLNGIYVYLKDESTHPTGSLKHRLARSLFLYAISNGWIGPNTPIIES
SSGSTAVSEAYFARLLGLPFIAVVPRCTASKKIEMIQFYGGKTHFVERSDEIYAESRRLAQELDGHYMDQFTYAERATDW
RGNNNIADSIFSQMKLEDHPEPTWIVMNPGTGGTSATIGRFIRYQKYHTKLCVVDPENSVFHDFYKTGNKDLTLECGSKI
EGIGRPRVEPSFIPGVIDEMRTIPDAASVATARWLEGILGRKAGASTGTNLHGALQLACEMEQRGEKGSIVTLLCDSGDR
YLDTYYNDEWVAKHIGDLTPHLSQLKNFERTGQL
>Mature_354_residues
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLNGIYVYLKDESTHPTGSLKHRLARSLFLYAISNGWIGPNTPIIES
SSGSTAVSEAYFARLLGLPFIAVVPRCTASKKIEMIQFYGGKTHFVERSDEIYAESRRLAQELDGHYMDQFTYAERATDW
RGNNNIADSIFSQMKLEDHPEPTWIVMNPGTGGTSATIGRFIRYQKYHTKLCVVDPENSVFHDFYKTGNKDLTLECGSKI
EGIGRPRVEPSFIPGVIDEMRTIPDAASVATARWLEGILGRKAGASTGTNLHGALQLACEMEQRGEKGSIVTLLCDSGDR
YLDTYYNDEWVAKHIGDLTPHLSQLKNFERTGQL

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=297, Percent_Identity=27.9461279461279, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI295821200, Length=297, Percent_Identity=27.9461279461279, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4557415, Length=297, Percent_Identity=27.9461279461279, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI2367138, Length=328, Percent_Identity=27.7439024390244, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=356, Percent_Identity=30.8988764044944, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17539800, Length=359, Percent_Identity=32.3119777158774, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539640, Length=362, Percent_Identity=30.6629834254144, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=24.3243243243243, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=26.6457680250784, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=26.6457680250784, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39732; Mature: 39732

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLNGIYVYLKDESTHPTGSLKHRLARS
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
LFLYAISNGWIGPNTPIIESSSGSTAVSEAYFARLLGLPFIAVVPRCTASKKIEMIQFYG
HHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEC
GKTHFVERSDEIYAESRRLAQELDGHYMDQFTYAERATDWRGNNNIADSIFSQMKLEDHP
CEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
EPTWIVMNPGTGGTSATIGRFIRYQKYHTKLCVVDPENSVFHDFYKTGNKDLTLECGSKI
CCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCC
EGIGRPRVEPSFIPGVIDEMRTIPDAASVATARWLEGILGRKAGASTGTNLHGALQLACE
CCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MEQRGEKGSIVTLLCDSGDRYLDTYYNDEWVAKHIGDLTPHLSQLKNFERTGQL
HHHCCCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLNGIYVYLKDESTHPTGSLKHRLARS
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
LFLYAISNGWIGPNTPIIESSSGSTAVSEAYFARLLGLPFIAVVPRCTASKKIEMIQFYG
HHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEC
GKTHFVERSDEIYAESRRLAQELDGHYMDQFTYAERATDWRGNNNIADSIFSQMKLEDHP
CEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
EPTWIVMNPGTGGTSATIGRFIRYQKYHTKLCVVDPENSVFHDFYKTGNKDLTLECGSKI
CCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCC
EGIGRPRVEPSFIPGVIDEMRTIPDAASVATARWLEGILGRKAGASTGTNLHGALQLACE
CCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MEQRGEKGSIVTLLCDSGDRYLDTYYNDEWVAKHIGDLTPHLSQLKNFERTGQL
HHHCCCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]