Click here to switch to the map view.

The map label for this gene is lpxH

Identifier: 209695401

GI number: 209695401

Start: 2073336

End: 2074061

Strand: Reverse

Name: lpxH

Synonym: VSAL_I1938

Alternate gene names: 209695401

Gene position: 2074061-2073336 (Counterclockwise)

Preceding gene: 209695402

Following gene: 209695400

Centisome position: 62.37

GC content: 36.09

Gene sequence:

>726_bases
ATGACTATCCTATTTATCTCCGATCTGCACCTCTGCCCTACTCGCCCTGAAATCACAACCTGCTTTCTTGATTTTATGGA
GAATGAAGCCGTACACGCTAAAGAGCTGTATGTCTTAGGTGATCTCTTCGAATTTTGGATTGGTGATGATGATAACTCTT
CATTTAGTTCATTAATTAAAAATGCCTTTACGACATTAACCAACCAAGGTGTCCATTGTTTTTTCATCCAAGGAAATCGT
GACTTTTTATTAAATAAACGATTCTGTAAAGAAACGGGCATCACCTTACTTGCCGATCATACCGTAATTGATGTTGATGG
AAAAAAAGTGCTGATCATGCATGGTGACACGCTTTGCATTGACGACGTTAAATATCAAGAATTCAGAGCAAAAGTTCATC
AACCGTGGCTACAGTGGATTTTCAATCGTATCCCGTTATTTATTCGCCAGCATATTGTCAAAAATGTACAAGATAAAATA
AAAGAAAAAAAACAGCATAAAACATTATCAATAATGGATGTCACCCAAAGTGAAGTCGAAAGAGTCATGCATGAAGAAGG
CGTCAACCTATTAATTCATGGTCATACTCATCGTCCAGACACTCATTCTTTCACAGTAAATGATAATCAAATGACAAGAA
TTGTGCTTGGCGATTGGTACACGCAAGGCTCAATACTTACCTATAAAGACAATACATTTACACTTTTAAATAAAAGCTTT
AAATAA

Upstream 100 bases:

>100_bases
CTGTTGAAGAAGTATTCATCACTGGTACAACAATTACAGAATAATTGTTCTTTTTATGCCAGCGTTAATCGCTGGCATTT
TATCTACTACAATGTGACTT

Downstream 100 bases:

>100_bases
CTCACAGTTATAAGCGTTCATTTGGTGCTTAATCATTATTGAGACATGGTTTTTTTGTGTAAATACGATTATCATTAAAA
CTCATTGATCCAGTATGCTG

Product: UDP-2,3-diacylglucosamine hydrolase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTILFISDLHLCPTRPEITTCFLDFMENEAVHAKELYVLGDLFEFWIGDDDNSSFSSLIKNAFTTLTNQGVHCFFIQGNR
DFLLNKRFCKETGITLLADHTVIDVDGKKVLIMHGDTLCIDDVKYQEFRAKVHQPWLQWIFNRIPLFIRQHIVKNVQDKI
KEKKQHKTLSIMDVTQSEVERVMHEEGVNLLIHGHTHRPDTHSFTVNDNQMTRIVLGDWYTQGSILTYKDNTFTLLNKSF
K

Sequences:

>Translated_241_residues
MTILFISDLHLCPTRPEITTCFLDFMENEAVHAKELYVLGDLFEFWIGDDDNSSFSSLIKNAFTTLTNQGVHCFFIQGNR
DFLLNKRFCKETGITLLADHTVIDVDGKKVLIMHGDTLCIDDVKYQEFRAKVHQPWLQWIFNRIPLFIRQHIVKNVQDKI
KEKKQHKTLSIMDVTQSEVERVMHEEGVNLLIHGHTHRPDTHSFTVNDNQMTRIVLGDWYTQGSILTYKDNTFTLLNKSF
K
>Mature_240_residues
TILFISDLHLCPTRPEITTCFLDFMENEAVHAKELYVLGDLFEFWIGDDDNSSFSSLIKNAFTTLTNQGVHCFFIQGNRD
FLLNKRFCKETGITLLADHTVIDVDGKKVLIMHGDTLCIDDVKYQEFRAKVHQPWLQWIFNRIPLFIRQHIVKNVQDKIK
EKKQHKTLSIMDVTQSEVERVMHEEGVNLLIHGHTHRPDTHSFTVNDNQMTRIVLGDWYTQGSILTYKDNTFTLLNKSFK

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=49.1666666666667, Blast_Score=258, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_ALISL (B6EH41)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263330.1
- GeneID:   6987468
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1938
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 28132; Mature: 28000

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILFISDLHLCPTRPEITTCFLDFMENEAVHAKELYVLGDLFEFWIGDDDNSSFSSLIK
CEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NAFTTLTNQGVHCFFIQGNRDFLLNKRFCKETGITLLADHTVIDVDGKKVLIMHGDTLCI
HHHHHHHCCCEEEEEEECCCCEEECHHHHHHCCCEEEECCEEEEECCCEEEEEECCEEEE
DDVKYQEFRAKVHQPWLQWIFNRIPLFIRQHIVKNVQDKIKEKKQHKTLSIMDVTQSEVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHH
RVMHEEGVNLLIHGHTHRPDTHSFTVNDNQMTRIVLGDWYTQGSILTYKDNTFTLLNKSF
HHHHHCCCEEEEECCCCCCCCCEEEECCCCEEEEEEEEEECCCEEEEEECCEEEEECCCC
K
C
>Mature Secondary Structure 
TILFISDLHLCPTRPEITTCFLDFMENEAVHAKELYVLGDLFEFWIGDDDNSSFSSLIK
EEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NAFTTLTNQGVHCFFIQGNRDFLLNKRFCKETGITLLADHTVIDVDGKKVLIMHGDTLCI
HHHHHHHCCCEEEEEEECCCCEEECHHHHHHCCCEEEECCEEEEECCCEEEEEECCEEEE
DDVKYQEFRAKVHQPWLQWIFNRIPLFIRQHIVKNVQDKIKEKKQHKTLSIMDVTQSEVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHH
RVMHEEGVNLLIHGHTHRPDTHSFTVNDNQMTRIVLGDWYTQGSILTYKDNTFTLLNKSF
HHHHHCCCEEEEECCCCCCCCCEEEECCCCEEEEEEEEEECCCEEEEEECCEEEEECCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA