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The map label for this gene is ppiB [H]

Identifier: 209695402

GI number: 209695402

Start: 2074118

End: 2074615

Strand: Reverse

Name: ppiB [H]

Synonym: VSAL_I1939

Alternate gene names: 209695402

Gene position: 2074615-2074118 (Counterclockwise)

Preceding gene: 209695412

Following gene: 209695401

Centisome position: 62.39

GC content: 39.76

Gene sequence:

>498_bases
ATGATCATCCTTCACACTTCTTTTGGTGACATTACAGTTAAACTTCATGAAGACAAAGCACCAGTAACTTGTGCTAACTT
CCTACAATACTGTCAAGATGGTTTCTACGACAACACACTTTTCCACCGTGTAATTGATGGCTTTATGGTTCAAGGCGGCG
GCATGACTGCGGGTCTTGAAGAAAAAACAAGCCGTGCAACAATCAAAAATGAAGCAAACAATGGCCTAAACAATAAAGTA
GGTACATTAGCGATGGCTCGTACTATGGAACCGCATTCTGCAAGTTCTCAGTTCTTCATCAACGTTAATGACAACAAATT
CTTAGACTTTAAATCAGAGTCTGTAGATGGTTGGGGTTACTGTGTATTTGCTGAAGTTGTTGACGGCATGGACGTAGTAA
ACAAAATCAAAGGTGTTGCAACTGGTAACTACGGTTACGTACACCAAGATGTACCTGTTGAAGAAGTATTCATCACTGGT
ACAACAATTACAGAATAA

Upstream 100 bases:

>100_bases
AACCTATAATAAGTAATGATAGCAAGAAAATTCCCTGTAGATCCGACTTAATCTTAGGTAAAATAAAATTCTATTTAAAT
ACAATTACAAAGGTAATTCC

Downstream 100 bases:

>100_bases
TTGTTCTTTTTATGCCAGCGTTAATCGCTGGCATTTTATCTACTACAATGTGACTTATGACTATCCTATTTATCTCCGAT
CTGCACCTCTGCCCTACTCG

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MIILHTSFGDITVKLHEDKAPVTCANFLQYCQDGFYDNTLFHRVIDGFMVQGGGMTAGLEEKTSRATIKNEANNGLNNKV
GTLAMARTMEPHSASSQFFINVNDNKFLDFKSESVDGWGYCVFAEVVDGMDVVNKIKGVATGNYGYVHQDVPVEEVFITG
TTITE

Sequences:

>Translated_165_residues
MIILHTSFGDITVKLHEDKAPVTCANFLQYCQDGFYDNTLFHRVIDGFMVQGGGMTAGLEEKTSRATIKNEANNGLNNKV
GTLAMARTMEPHSASSQFFINVNDNKFLDFKSESVDGWGYCVFAEVVDGMDVVNKIKGVATGNYGYVHQDVPVEEVFITG
TTITE
>Mature_165_residues
MIILHTSFGDITVKLHEDKAPVTCANFLQYCQDGFYDNTLFHRVIDGFMVQGGGMTAGLEEKTSRATIKNEANNGLNNKV
GTLAMARTMEPHSASSQFFINVNDNKFLDFKSESVDGWGYCVFAEVVDGMDVVNKIKGVATGNYGYVHQDVPVEEVFITG
TTITE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=35.1515151515151, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=35.1515151515151, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=35.5828220858896, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI7706339, Length=160, Percent_Identity=33.75, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=32.1212121212121, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI64276486, Length=104, Percent_Identity=41.3461538461538, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI24308049, Length=164, Percent_Identity=34.7560975609756, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI20911035, Length=180, Percent_Identity=29.4444444444444, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1786736, Length=165, Percent_Identity=64.8484848484848, Blast_Score=230, Evalue=5e-62,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=50.6172839506173, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71980594, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=160, Percent_Identity=33.75, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=144, Percent_Identity=36.8055555555556, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=160, Percent_Identity=32.5, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=164, Percent_Identity=33.5365853658537, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=164, Percent_Identity=33.5365853658537, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=167, Percent_Identity=32.9341317365269, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=167, Percent_Identity=31.7365269461078, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=35.2517985611511, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=157, Percent_Identity=36.9426751592357, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=157, Percent_Identity=32.484076433121, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=160, Percent_Identity=35, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=30.3030303030303, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355677, Length=166, Percent_Identity=26.5060240963855, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=36.2962962962963, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652460, Length=172, Percent_Identity=29.6511627906977, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357249, Length=102, Percent_Identity=36.2745098039216, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18160; Mature: 18160

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILHTSFGDITVKLHEDKAPVTCANFLQYCQDGFYDNTLFHRVIDGFMVQGGGMTAGLE
CEEEEECCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCC
EKTSRATIKNEANNGLNNKVGTLAMARTMEPHSASSQFFINVNDNKFLDFKSESVDGWGY
CCCCHHEECCCCCCCCCCCHHHEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
CVFAEVVDGMDVVNKIKGVATGNYGYVHQDVPVEEVFITGTTITE
EEHHHHHCCHHHHHHHCCEECCCCCEEECCCCHHHEEEECEEECC
>Mature Secondary Structure
MIILHTSFGDITVKLHEDKAPVTCANFLQYCQDGFYDNTLFHRVIDGFMVQGGGMTAGLE
CEEEEECCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCC
EKTSRATIKNEANNGLNNKVGTLAMARTMEPHSASSQFFINVNDNKFLDFKSESVDGWGY
CCCCHHEECCCCCCCCCCCHHHEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
CVFAEVVDGMDVVNKIKGVATGNYGYVHQDVPVEEVFITGTTITE
EEHHHHHCCHHHHHHHCCEECCCCCEEECCCCHHHEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]