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The map label for this gene is moeA [H]

Identifier: 209695395

GI number: 209695395

Start: 2066319

End: 2067563

Strand: Reverse

Name: moeA [H]

Synonym: VSAL_I1932

Alternate gene names: 209695395

Gene position: 2067563-2066319 (Counterclockwise)

Preceding gene: 209695397

Following gene: 209695394

Centisome position: 62.18

GC content: 42.09

Gene sequence:

>1245_bases
ATGGATTGCTGCGCAACTCAAGGTCTCATCCCCGTAGAAACGGCATTGGATACCCTTTTATCTCAAGTTACCCCTATTTC
ATTAGCAAAAACATTGCCTCTCTCTGATGCCATTGGTTTTGTTTTGGCTGAAGATATTTGCTCCCCAATTAACGTTCCTC
CTTTTGCAAACTCAGCAATGGATGGTTATGCAGTTCGTCTGTCTGATTTAGCACTCTCTCTGACATTACCAGTTACAGGT
AAGTCTTTTGCTGGCATTCCTTTTGAAGGAGAATGGCAAGAACAAAGCACAATTAGAATCATGACTGGAGCGAAGATCCC
TGTTGGTTGTGATGCCGTTATTATGCAAGAACTCACCTCGGATTCTGATGGTAACATTACGTTTGATGTCACTCTTTCTG
ATATAAAACCTCAAACCAATATTCGTCCGATTGGTGATGATGTTTCACAAGGACAAACCGTCTTAGAGAAAGGTCACCGC
TTAACACCAAGAGACATTCCATTAATTGCTTCACTTGGTATTAATGATATTCCCGTCGTTCATAAACCTAAAGTTGCCTT
TTTCTCAACGGGTGACGAACTGACACCATTAGGTCAACCACTAGAAGATGGTCAGATCTATGACAGTAATCGCTACGGTA
TTAAAGTATTAATCGAGAGATTTGGTTGTGAAGCCATTGACCTTGGTATTATTCCAGATTGCCCACAAACGCTAAGAGAC
GTCTTTCTTAAAGCTGATAAAGAAGCGGATGTGGTGGTGACATCAGGTGGTGTGAGCGTTGGTGAAGCCGATTACACAAA
AGACATCTTAGATGAATTAGGCCAAATTGGCTTTTGGAAATTAGCCATAAAACCGGGTAAACCTTTTGCCTTTGGTCAGC
TGCCTGATTCTTATTTCTGTGGTTTACCGGGAAACCCCGTTTCTGCGATGTTAACAATGTATGTATTGGTTCAGCCGATG
CTAGCGAAACTTGCAGGTCACTCTAAATGGGAAGCTCCTAAAGCGATCCCAGCAGTGGCAACGACGGTCTTTAAAAAACG
TCCTGGTCGTACTGATTATCAACGCGGTATTTACTCCATTAATGATAAAGGTCAATTTGAAGTGGCCACTACGGGCAATC
AAGGTTCAGGAGCATTTAGCTCAATGAGTATTGCTAATTGTTTTGTTGTTCTGGAACGAGAGCGTGATCGTGTTAGTGTT
GGCGAAACCGTTAATATCGAACTATTTAACGCCTCTCTTTATTAG

Upstream 100 bases:

>100_bases
GTAAAATAAATACACCCTGATTTTCATGGGTCTATTAGATGTTCAGCACCAAAATATGGTAATGTTCTTCCTTATTACTA
CTAGTTCAGAGAATATCATG

Downstream 100 bases:

>100_bases
AAGTGATCCCAATGTCTGAATTATCTGATCAAGAGATGCTGCGCTATAATCGTCAAATCATTTTGAGAAATTTTGATTTT
GAAGGCCAAGAGAAACTCAA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDCCATQGLIPVETALDTLLSQVTPISLAKTLPLSDAIGFVLAEDICSPINVPPFANSAMDGYAVRLSDLALSLTLPVTG
KSFAGIPFEGEWQEQSTIRIMTGAKIPVGCDAVIMQELTSDSDGNITFDVTLSDIKPQTNIRPIGDDVSQGQTVLEKGHR
LTPRDIPLIASLGINDIPVVHKPKVAFFSTGDELTPLGQPLEDGQIYDSNRYGIKVLIERFGCEAIDLGIIPDCPQTLRD
VFLKADKEADVVVTSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPDSYFCGLPGNPVSAMLTMYVLVQPM
LAKLAGHSKWEAPKAIPAVATTVFKKRPGRTDYQRGIYSINDKGQFEVATTGNQGSGAFSSMSIANCFVVLERERDRVSV
GETVNIELFNASLY

Sequences:

>Translated_414_residues
MDCCATQGLIPVETALDTLLSQVTPISLAKTLPLSDAIGFVLAEDICSPINVPPFANSAMDGYAVRLSDLALSLTLPVTG
KSFAGIPFEGEWQEQSTIRIMTGAKIPVGCDAVIMQELTSDSDGNITFDVTLSDIKPQTNIRPIGDDVSQGQTVLEKGHR
LTPRDIPLIASLGINDIPVVHKPKVAFFSTGDELTPLGQPLEDGQIYDSNRYGIKVLIERFGCEAIDLGIIPDCPQTLRD
VFLKADKEADVVVTSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPDSYFCGLPGNPVSAMLTMYVLVQPM
LAKLAGHSKWEAPKAIPAVATTVFKKRPGRTDYQRGIYSINDKGQFEVATTGNQGSGAFSSMSIANCFVVLERERDRVSV
GETVNIELFNASLY
>Mature_414_residues
MDCCATQGLIPVETALDTLLSQVTPISLAKTLPLSDAIGFVLAEDICSPINVPPFANSAMDGYAVRLSDLALSLTLPVTG
KSFAGIPFEGEWQEQSTIRIMTGAKIPVGCDAVIMQELTSDSDGNITFDVTLSDIKPQTNIRPIGDDVSQGQTVLEKGHR
LTPRDIPLIASLGINDIPVVHKPKVAFFSTGDELTPLGQPLEDGQIYDSNRYGIKVLIERFGCEAIDLGIIPDCPQTLRD
VFLKADKEADVVVTSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPDSYFCGLPGNPVSAMLTMYVLVQPM
LAKLAGHSKWEAPKAIPAVATTVFKKRPGRTDYQRGIYSINDKGQFEVATTGNQGSGAFSSMSIANCFVVLERERDRVSV
GETVNIELFNASLY

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=413, Percent_Identity=35.5932203389831, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=36.4556962025316, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1787049, Length=406, Percent_Identity=56.8965517241379, Blast_Score=458, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI25147659, Length=310, Percent_Identity=32.258064516129, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=332, Percent_Identity=25.3012048192771, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136978, Length=363, Percent_Identity=31.6804407713499, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24638841, Length=363, Percent_Identity=31.6804407713499, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44551; Mature: 44551

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCCATQGLIPVETALDTLLSQVTPISLAKTLPLSDAIGFVLAEDICSPINVPPFANSAM
CCCCCCCCCEEHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
DGYAVRLSDLALSLTLPVTGKSFAGIPFEGEWQEQSTIRIMTGAKIPVGCDAVIMQELTS
CCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCC
DSDGNITFDVTLSDIKPQTNIRPIGDDVSQGQTVLEKGHRLTPRDIPLIASLGINDIPVV
CCCCCEEEEEEEECCCCCCCCCCCCCCHHCCHHHHHCCCCCCCCCCCEEEECCCCCCCCE
HKPKVAFFSTGDELTPLGQPLEDGQIYDSNRYGIKVLIERFGCEAIDLGIIPDCPQTLRD
ECCCEEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHHHH
VFLKADKEADVVVTSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPDSYFC
HHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCEEC
GLPGNPVSAMLTMYVLVQPMLAKLAGHSKWEAPKAIPAVATTVFKKRPGRTDYQRGIYSI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCEEE
NDKGQFEVATTGNQGSGAFSSMSIANCFVVLERERDRVSVGETVNIELFNASLY
CCCCCEEEEECCCCCCCCCHHHHHEEEEEEEECCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MDCCATQGLIPVETALDTLLSQVTPISLAKTLPLSDAIGFVLAEDICSPINVPPFANSAM
CCCCCCCCCEEHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
DGYAVRLSDLALSLTLPVTGKSFAGIPFEGEWQEQSTIRIMTGAKIPVGCDAVIMQELTS
CCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCC
DSDGNITFDVTLSDIKPQTNIRPIGDDVSQGQTVLEKGHRLTPRDIPLIASLGINDIPVV
CCCCCEEEEEEEECCCCCCCCCCCCCCHHCCHHHHHCCCCCCCCCCCEEEECCCCCCCCE
HKPKVAFFSTGDELTPLGQPLEDGQIYDSNRYGIKVLIERFGCEAIDLGIIPDCPQTLRD
ECCCEEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHHHH
VFLKADKEADVVVTSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPDSYFC
HHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCEEC
GLPGNPVSAMLTMYVLVQPMLAKLAGHSKWEAPKAIPAVATTVFKKRPGRTDYQRGIYSI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCEEE
NDKGQFEVATTGNQGSGAFSSMSIANCFVVLERERDRVSVGETVNIELFNASLY
CCCCCEEEEECCCCCCCCCHHHHHEEEEEEEECCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]