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The map label for this gene is moeB [H]

Identifier: 209695394

GI number: 209695394

Start: 2065558

End: 2066307

Strand: Reverse

Name: moeB [H]

Synonym: VSAL_I1931

Alternate gene names: 209695394

Gene position: 2066307-2065558 (Counterclockwise)

Preceding gene: 209695395

Following gene: 209695390

Centisome position: 62.14

GC content: 40.4

Gene sequence:

>750_bases
ATGTCTGAATTATCTGATCAAGAGATGCTGCGCTATAATCGTCAAATCATTTTGAGAAATTTTGATTTTGAAGGCCAAGA
GAAACTCAAAGACAGCACCATTCTCATTATTGGTGCTGGCGGGTTAGGTTGTGCTTCAACCCAGTATTTAGCGGCTGCCG
GATTAGGGTCAATGACACTAGTTGATGATGACGTTGTCGAACTCTCAAACTTACAACGTCAAATTTTGCATTGCGACGAT
ACCATTGGTGAAAAGAAAGTCATTTCAGCGAAAAATGCCTTAAACCGTATTAATCCTAATTGTCATATTACCCCTATTGA
TAAGCGTTTATCTGATGATGAGTTACGTGTTCTTATTTCATCTCATGATTTAGTGTTAGATGGCACCGATAACGTAGAAA
CCAGAAATCAGTTAAACCGACTATGCTTTGAATCTAAAACACCGTTAATCTCAGGTGCGGCAATTCGTATGGAAGGCCAA
GTGAGCGTTTATACTTATCAAGACAACGAGCCTTGTTATCAATGCTTAAGTAGCTTATTTGGTGAGCAGGCGCTTACTTG
TGTTGAAGCCGGCGTAATGTCTCCTGTTGTTGGCATTATTGGTGTAACACAAGCTCTTGAGGCCATCAAGGTATTAACTA
ATTACGGACACCCCTTAATCGGGAAACTTCTGATCTTAGATGCCCTTTCAATGAACTGGCGTGAGATGAAATTAGCAAAA
ACACCCCACTGTTCTGTATGCGGTAAATAG

Upstream 100 bases:

>100_bases
ATTGTTTTGTTGTTCTGGAACGAGAGCGTGATCGTGTTAGTGTTGGCGAAACCGTTAATATCGAACTATTTAACGCCTCT
CTTTATTAGAAGTGATCCCA

Downstream 100 bases:

>100_bases
CACGCTCCACAATATCAAGATCAATAAAAAGGCGCTAACCCATTTGGATTAACGCCTTTTTTCATTTCGACTTAAAACAA
AGACCCTACAATTTAAAATA

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSELSDQEMLRYNRQIILRNFDFEGQEKLKDSTILIIGAGGLGCASTQYLAAAGLGSMTLVDDDVVELSNLQRQILHCDD
TIGEKKVISAKNALNRINPNCHITPIDKRLSDDELRVLISSHDLVLDGTDNVETRNQLNRLCFESKTPLISGAAIRMEGQ
VSVYTYQDNEPCYQCLSSLFGEQALTCVEAGVMSPVVGIIGVTQALEAIKVLTNYGHPLIGKLLILDALSMNWREMKLAK
TPHCSVCGK

Sequences:

>Translated_249_residues
MSELSDQEMLRYNRQIILRNFDFEGQEKLKDSTILIIGAGGLGCASTQYLAAAGLGSMTLVDDDVVELSNLQRQILHCDD
TIGEKKVISAKNALNRINPNCHITPIDKRLSDDELRVLISSHDLVLDGTDNVETRNQLNRLCFESKTPLISGAAIRMEGQ
VSVYTYQDNEPCYQCLSSLFGEQALTCVEAGVMSPVVGIIGVTQALEAIKVLTNYGHPLIGKLLILDALSMNWREMKLAK
TPHCSVCGK
>Mature_248_residues
SELSDQEMLRYNRQIILRNFDFEGQEKLKDSTILIIGAGGLGCASTQYLAAAGLGSMTLVDDDVVELSNLQRQILHCDDT
IGEKKVISAKNALNRINPNCHITPIDKRLSDDELRVLISSHDLVLDGTDNVETRNQLNRLCFESKTPLISGAAIRMEGQV
SVYTYQDNEPCYQCLSSLFGEQALTCVEAGVMSPVVGIIGVTQALEAIKVLTNYGHPLIGKLLILDALSMNWREMKLAKT
PHCSVCGK

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=251, Percent_Identity=40.6374501992032, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI4885649, Length=158, Percent_Identity=29.746835443038, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI23510338, Length=166, Percent_Identity=29.5180722891566, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI23510340, Length=166, Percent_Identity=29.5180722891566, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI38045944, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI38045942, Length=162, Percent_Identity=29.0123456790123, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI150417996, Length=150, Percent_Identity=27.3333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=65.863453815261, Blast_Score=356, Evalue=1e-100,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=42.4489795918367, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI1789177, Length=124, Percent_Identity=31.4516129032258, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17540406, Length=251, Percent_Identity=37.4501992031873, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI193203301, Length=154, Percent_Identity=32.4675324675325, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71984476, Length=173, Percent_Identity=26.0115606936416, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=253, Percent_Identity=32.4110671936759, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322639, Length=164, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582879, Length=249, Percent_Identity=45.3815261044177, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24660640, Length=151, Percent_Identity=33.112582781457, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573937, Length=161, Percent_Identity=32.2981366459627, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI20129973, Length=163, Percent_Identity=32.5153374233129, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27372; Mature: 27241

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSDQEMLRYNRQIILRNFDFEGQEKLKDSTILIIGAGGLGCASTQYLAAAGLGSMTL
CCCCCHHHHHHHCCEEEEEECCCCCHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEE
VDDDVVELSNLQRQILHCDDTIGEKKVISAKNALNRINPNCHITPIDKRLSDDELRVLIS
ECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEE
SHDLVLDGTDNVETRNQLNRLCFESKTPLISGAAIRMEGQVSVYTYQDNEPCYQCLSSLF
CCCEEEECCCCCHHHHHHHHHHHHCCCCEEECEEEEEECEEEEEEECCCCHHHHHHHHHH
GEQALTCVEAGVMSPVVGIIGVTQALEAIKVLTNYGHPLIGKLLILDALSMNWREMKLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCC
TPHCSVCGK
CCCCCCCCC
>Mature Secondary Structure 
SELSDQEMLRYNRQIILRNFDFEGQEKLKDSTILIIGAGGLGCASTQYLAAAGLGSMTL
CCCCHHHHHHHCCEEEEEECCCCCHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEE
VDDDVVELSNLQRQILHCDDTIGEKKVISAKNALNRINPNCHITPIDKRLSDDELRVLIS
ECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEE
SHDLVLDGTDNVETRNQLNRLCFESKTPLISGAAIRMEGQVSVYTYQDNEPCYQCLSSLF
CCCEEEECCCCCHHHHHHHHHHHHCCCCEEECEEEEEECEEEEEEECCCCHHHHHHHHHH
GEQALTCVEAGVMSPVVGIIGVTQALEAIKVLTNYGHPLIGKLLILDALSMNWREMKLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCC
TPHCSVCGK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]