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The map label for this gene is phuW [H]

Identifier: 209695230

GI number: 209695230

Start: 1864187

End: 1865509

Strand: Reverse

Name: phuW [H]

Synonym: VSAL_I1750

Alternate gene names: 209695230

Gene position: 1865509-1864187 (Counterclockwise)

Preceding gene: 209695236

Following gene: 209695229

Centisome position: 56.1

GC content: 38.7

Gene sequence:

>1323_bases
TTGGGTGAGTCTACACCTGAGCCTTTACTTTACGCATTCCAACGTAAATCATCAGCGCATGCAGGTGGAGAAAATACGCC
AATTTCAAGTGATTTATATGAAGAAAAAGCGAAGGAAGTTCTCTCAAATACGGAAGGATTAGCCGCAACGAGATGTTTAT
ATATTCATATTCCTTTTTGCCGAGTTCGTTGTACTTATTGTAATTTTTTCCAACACGCCTCAAGTAAATCATTAGTGGAG
AGTTATTTTGATGCCTTAATGATTGAAATTAAATGGAAAGCCCAACAGGCTTGGACGCAAGCTGCTCCTTTTCATGCCGT
CTATGTTGGGGGGGGAACCCCAACAGATTTGTCTGCCCAACAAATTGAATTATTAGGAAAGGCGGTTCGTACTTATTTCC
CACTAACCACGGATTGTGAAATTACTTTAGAAGGGCGTATTAATCGATTTGATGAAGAGATGTTTGAGCGCTCTCTTGAA
GGTGGTTTTAATCGATTTTCTTTTGGTGTTCAAAGTTTTAATACTCAAGTAAGAAGATCAGCCAAAAGGCTTGATGATAA
AGAATATGTATTACGCCGAATTCAAGAATTAAGTAATAGTAATCAAGCGCCTATCGTACTTGATTTATTATATGGGCTTC
CTTTTCAAACAAGTGATATTTGGCAACAAGACTTAAATGATTTTCTTGAAACAGGGGCTCATGGTGTCGACTTATATCAA
TTAATTGAGATGGGTGGGACACCAATGAAGGGAATGATCGAACAAGGGAAATTGCCACAACCTGCGAGCACAGAAGAAAA
AGCGTATATGTATAAATATGGTGTTGAATTTATGAGTAAACACCATTTAAACCGACTGAGTGTTAATCATTGGGCGAGCA
ATAATAGAGAGCGAAGTATCTATAACAGCCTAGCTAAAACAACGGCAGAAGTTCTTCCTATTGGGTGTGGCGCAGGGGGG
AATGTTGGCGGGATCGGAATGATGCAACATCGAACATTAAATGCTTATATTGATGCTATTCAACAAAATACACTTCCAAT
CGCCATGATGACTCGTTCGTCTGAGAATTCAGCATTAAATGCGATGATTAAAGCGGGTTTTGATCATGGCGTTTTATCTC
GTCATACCTTACTGCAATACAACAATAAAGATGTCTTTGGTTTTCTTATGCCATTATTTATGCATTGGGAAAATAACGGC
TTGGTTATTGTTGAAAACGATTATTTAAGTCTAACGTTAGCAGGACAGTTTTGGTCAGTAACGTTGGCACAAAGTGTTAT
TACCGCACTTCAACATGCTCAACGACACATTCAAGCCGCTTAA

Upstream 100 bases:

>100_bases
ATTCATTCCAGAGACGAAGCTCTTAGTAGTTAAGGGGCTGAGAAATTAGAATGAAAGCATTAAAAATCAAATAGATATAT
CAAGTTTAGATACTTTAATA

Downstream 100 bases:

>100_bases
AATAAAGAAAGAGAGATATTGTGAAAACAGAAATACTAGCGCTATTTGAAAATGATCCATCTTTATTACCTAGTGAGATG
GCAAAACAACTCTCAACAGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MGESTPEPLLYAFQRKSSAHAGGENTPISSDLYEEKAKEVLSNTEGLAATRCLYIHIPFCRVRCTYCNFFQHASSKSLVE
SYFDALMIEIKWKAQQAWTQAAPFHAVYVGGGTPTDLSAQQIELLGKAVRTYFPLTTDCEITLEGRINRFDEEMFERSLE
GGFNRFSFGVQSFNTQVRRSAKRLDDKEYVLRRIQELSNSNQAPIVLDLLYGLPFQTSDIWQQDLNDFLETGAHGVDLYQ
LIEMGGTPMKGMIEQGKLPQPASTEEKAYMYKYGVEFMSKHHLNRLSVNHWASNNRERSIYNSLAKTTAEVLPIGCGAGG
NVGGIGMMQHRTLNAYIDAIQQNTLPIAMMTRSSENSALNAMIKAGFDHGVLSRHTLLQYNNKDVFGFLMPLFMHWENNG
LVIVENDYLSLTLAGQFWSVTLAQSVITALQHAQRHIQAA

Sequences:

>Translated_440_residues
MGESTPEPLLYAFQRKSSAHAGGENTPISSDLYEEKAKEVLSNTEGLAATRCLYIHIPFCRVRCTYCNFFQHASSKSLVE
SYFDALMIEIKWKAQQAWTQAAPFHAVYVGGGTPTDLSAQQIELLGKAVRTYFPLTTDCEITLEGRINRFDEEMFERSLE
GGFNRFSFGVQSFNTQVRRSAKRLDDKEYVLRRIQELSNSNQAPIVLDLLYGLPFQTSDIWQQDLNDFLETGAHGVDLYQ
LIEMGGTPMKGMIEQGKLPQPASTEEKAYMYKYGVEFMSKHHLNRLSVNHWASNNRERSIYNSLAKTTAEVLPIGCGAGG
NVGGIGMMQHRTLNAYIDAIQQNTLPIAMMTRSSENSALNAMIKAGFDHGVLSRHTLLQYNNKDVFGFLMPLFMHWENNG
LVIVENDYLSLTLAGQFWSVTLAQSVITALQHAQRHIQAA
>Mature_439_residues
GESTPEPLLYAFQRKSSAHAGGENTPISSDLYEEKAKEVLSNTEGLAATRCLYIHIPFCRVRCTYCNFFQHASSKSLVES
YFDALMIEIKWKAQQAWTQAAPFHAVYVGGGTPTDLSAQQIELLGKAVRTYFPLTTDCEITLEGRINRFDEEMFERSLEG
GFNRFSFGVQSFNTQVRRSAKRLDDKEYVLRRIQELSNSNQAPIVLDLLYGLPFQTSDIWQQDLNDFLETGAHGVDLYQL
IEMGGTPMKGMIEQGKLPQPASTEEKAYMYKYGVEFMSKHHLNRLSVNHWASNNRERSIYNSLAKTTAEVLPIGCGAGGN
VGGIGMMQHRTLNAYIDAIQQNTLPIAMMTRSSENSALNAMIKAGFDHGVLSRHTLLQYNNKDVFGFLMPLFMHWENNGL
VIVENDYLSLTLAGQFWSVTLAQSVITALQHAQRHIQAA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=291, Percent_Identity=27.4914089347079, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082341, Length=406, Percent_Identity=24.6305418719212, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1789325, Length=190, Percent_Identity=31.5789473684211, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49455; Mature: 49324

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGESTPEPLLYAFQRKSSAHAGGENTPISSDLYEEKAKEVLSNTEGLAATRCLYIHIPFC
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEEEEECHH
RVRCTYCNFFQHASSKSLVESYFDALMIEIKWKAQQAWTQAAPFHAVYVGGGTPTDLSAQ
HHHHHHHHHHHHCCHHHHHHHHHHHEEEEEEECHHHHHHHCCCCEEEEECCCCCCCCCHH
QIELLGKAVRTYFPLTTDCEITLEGRINRFDEEMFERSLEGGFNRFSFGVQSFNTQVRRS
HHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKRLDDKEYVLRRIQELSNSNQAPIVLDLLYGLPFQTSDIWQQDLNDFLETGAHGVDLYQ
HHHCCCHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LIEMGGTPMKGMIEQGKLPQPASTEEKAYMYKYGVEFMSKHHLNRLSVNHWASNNRERSI
HHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHH
YNSLAKTTAEVLPIGCGAGGNVGGIGMMQHRTLNAYIDAIQQNTLPIAMMTRSSENSALN
HHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
AMIKAGFDHGVLSRHTLLQYNNKDVFGFLMPLFMHWENNGLVIVENDYLSLTLAGQFWSV
HHHHCCCCCCHHHHHHHEEECCCCHHHHHHHHHHEECCCCEEEEECCEEEEEECCCHHHH
TLAQSVITALQHAQRHIQAA
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GESTPEPLLYAFQRKSSAHAGGENTPISSDLYEEKAKEVLSNTEGLAATRCLYIHIPFC
CCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEEEEECHH
RVRCTYCNFFQHASSKSLVESYFDALMIEIKWKAQQAWTQAAPFHAVYVGGGTPTDLSAQ
HHHHHHHHHHHHCCHHHHHHHHHHHEEEEEEECHHHHHHHCCCCEEEEECCCCCCCCCHH
QIELLGKAVRTYFPLTTDCEITLEGRINRFDEEMFERSLEGGFNRFSFGVQSFNTQVRRS
HHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKRLDDKEYVLRRIQELSNSNQAPIVLDLLYGLPFQTSDIWQQDLNDFLETGAHGVDLYQ
HHHCCCHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LIEMGGTPMKGMIEQGKLPQPASTEEKAYMYKYGVEFMSKHHLNRLSVNHWASNNRERSI
HHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHH
YNSLAKTTAEVLPIGCGAGGNVGGIGMMQHRTLNAYIDAIQQNTLPIAMMTRSSENSALN
HHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
AMIKAGFDHGVLSRHTLLQYNNKDVFGFLMPLFMHWENNGLVIVENDYLSLTLAGQFWSV
HHHHCCCCCCHHHHHHHEEECCCCHHHHHHHHHHEECCCCEEEEECCEEEEEECCCHHHH
TLAQSVITALQHAQRHIQAA
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]