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The map label for this gene is malY [H]

Identifier: 209695115

GI number: 209695115

Start: 1721143

End: 1722312

Strand: Reverse

Name: malY [H]

Synonym: VSAL_I1614

Alternate gene names: 209695115

Gene position: 1722312-1721143 (Counterclockwise)

Preceding gene: 209695116

Following gene: 209695114

Centisome position: 51.8

GC content: 39.66

Gene sequence:

>1170_bases
ATGTTTACTTTCTCTGAGCAAATCAATCGTAAAGGCAGTTACTGCACTCAATGGGATTACGTTGCTGACCGATTCGGTGA
AGCGGACCTTCTGCCATTTACCATATCGGATATGGATTTTTCAGCACCACCTGTGGTTATGAACGCACTGAAATCACGAA
TGGAACATCCTGTATTTGGTTATAGCCGTTGGGATCACAGTGATTTCAAAGGGGCGATTACACATTGGTTTAAACGTCGA
TTTAATGCTGAATTTGATGGGAAGGACCTGGTTTACGGACCTTCTGTTATTTACATTATTTCGCAATTAATCCGTCAATG
GAGTAGTGCCAGTGAAGGGGTTATTATTCATACACCGGCTTATGATGCCTTTGACAAAATGATTTTAGGATTAGAACGAA
CCATTATTCCAAATCAATTATCGCCTTCTTCAGAAGGGTATCAAATTGATTGGAATGTATTTGAAGCTCAATTATCTGAT
CCTAATAACACGGTTTTATTGCTGTGCAGCCCTCATAATCCAACAGGCAAAGTCTGGAGTGCTGATGAGTTGAAACGCAT
GGCGGTTCTTTGTGAAAAATACCATGTGGCAGTGATCAGTGATGAGATCCACATGGACATCTGTTTTAAACCTCATACGC
CTTGGCAAGGATTTGGAATGGGGACTCGTTGGGCCTTAGTCAGTTCTGCATCAAAGTCATTTAATATTCCTGCGCTTAAT
GGGGCTTATGCCTTTATTGCTGATGATGTTGCAAGAGAACATTATTTATTTAACCTTAAACAAGTGGATGGGCTTTCTTC
ACCTTCTATTCTTGGTGTTATTGCTCTTATGGCGGCTTATCAAGAAGGTGGACCGTGGCTTGATGAATTAAAGTCATACT
TATATGAAAATCATCGTTACGTTCAAGAGACATTAGAGAAAGAGCTACCAAGTATTGGTTATCAAATTCCCGATTCTACT
TATCTTGCATGGATTGATCTTTCTTCTTTTTCGTTAGATATGGATGCATTAAATCAATGCTTAATTAAAAATCATAAAGT
TGCCATCATGCAAGGCAGTACTTACGGGGTTGCAGGAAAAGGTTTTGTGAGACTTAACCTAGGCTGTCCGCGCATAAAAG
TGGAAAAAGGCTTATCTGCGCTCATTTCTGCAATTAAAGAGCAATCTTAA

Upstream 100 bases:

>100_bases
AATGTCAGCAACAGCTTAATTTTTATAGGTGGAGGTTCTCTCCACCTTTTTCACACTCTTTGTTTTTTAGTTCACATAAA
TATGAGCTTTTGGAGTCGCT

Downstream 100 bases:

>100_bases
TGAATACTGTATATAACGTTGAAGCAGGGCAGCGCCATTATCAATGGGGATCCCACTTACTTTATGGTTTGTTTGGGCTT
CCAATTAAAGATGATAAACC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MFTFSEQINRKGSYCTQWDYVADRFGEADLLPFTISDMDFSAPPVVMNALKSRMEHPVFGYSRWDHSDFKGAITHWFKRR
FNAEFDGKDLVYGPSVIYIISQLIRQWSSASEGVIIHTPAYDAFDKMILGLERTIIPNQLSPSSEGYQIDWNVFEAQLSD
PNNTVLLLCSPHNPTGKVWSADELKRMAVLCEKYHVAVISDEIHMDICFKPHTPWQGFGMGTRWALVSSASKSFNIPALN
GAYAFIADDVAREHYLFNLKQVDGLSSPSILGVIALMAAYQEGGPWLDELKSYLYENHRYVQETLEKELPSIGYQIPDST
YLAWIDLSSFSLDMDALNQCLIKNHKVAIMQGSTYGVAGKGFVRLNLGCPRIKVEKGLSALISAIKEQS

Sequences:

>Translated_389_residues
MFTFSEQINRKGSYCTQWDYVADRFGEADLLPFTISDMDFSAPPVVMNALKSRMEHPVFGYSRWDHSDFKGAITHWFKRR
FNAEFDGKDLVYGPSVIYIISQLIRQWSSASEGVIIHTPAYDAFDKMILGLERTIIPNQLSPSSEGYQIDWNVFEAQLSD
PNNTVLLLCSPHNPTGKVWSADELKRMAVLCEKYHVAVISDEIHMDICFKPHTPWQGFGMGTRWALVSSASKSFNIPALN
GAYAFIADDVAREHYLFNLKQVDGLSSPSILGVIALMAAYQEGGPWLDELKSYLYENHRYVQETLEKELPSIGYQIPDST
YLAWIDLSSFSLDMDALNQCLIKNHKVAIMQGSTYGVAGKGFVRLNLGCPRIKVEKGLSALISAIKEQS
>Mature_389_residues
MFTFSEQINRKGSYCTQWDYVADRFGEADLLPFTISDMDFSAPPVVMNALKSRMEHPVFGYSRWDHSDFKGAITHWFKRR
FNAEFDGKDLVYGPSVIYIISQLIRQWSSASEGVIIHTPAYDAFDKMILGLERTIIPNQLSPSSEGYQIDWNVFEAQLSD
PNNTVLLLCSPHNPTGKVWSADELKRMAVLCEKYHVAVISDEIHMDICFKPHTPWQGFGMGTRWALVSSASKSFNIPALN
GAYAFIADDVAREHYLFNLKQVDGLSSPSILGVIALMAAYQEGGPWLDELKSYLYENHRYVQETLEKELPSIGYQIPDST
YLAWIDLSSFSLDMDALNQCLIKNHKVAIMQGSTYGVAGKGFVRLNLGCPRIKVEKGLSALISAIKEQS

Specific function: Acts as a beta-cystathionase and as a repressor of the maltose regulon [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=55.4123711340206, Blast_Score=456, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43841; Mature: 43841

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTFSEQINRKGSYCTQWDYVADRFGEADLLPFTISDMDFSAPPVVMNALKSRMEHPVFG
CCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCC
YSRWDHSDFKGAITHWFKRRFNAEFDGKDLVYGPSVIYIISQLIRQWSSASEGVIIHTPA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEEEECCC
YDAFDKMILGLERTIIPNQLSPSSEGYQIDWNVFEAQLSDPNNTVLLLCSPHNPTGKVWS
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCC
ADELKRMAVLCEKYHVAVISDEIHMDICFKPHTPWQGFGMGTRWALVSSASKSFNIPALN
HHHHHHHHHHHHHHEEEEEECCEEEEEEECCCCCCCCCCCCCHHHEEECCCCCCCCCCCC
GAYAFIADDVAREHYLFNLKQVDGLSSPSILGVIALMAAYQEGGPWLDELKSYLYENHRY
CCEEEHHHHHHHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VQETLEKELPSIGYQIPDSTYLAWIDLSSFSLDMDALNQCLIKNHKVAIMQGSTYGVAGK
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCC
GFVRLNLGCPRIKVEKGLSALISAIKEQS
CEEEEECCCCEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFTFSEQINRKGSYCTQWDYVADRFGEADLLPFTISDMDFSAPPVVMNALKSRMEHPVFG
CCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCC
YSRWDHSDFKGAITHWFKRRFNAEFDGKDLVYGPSVIYIISQLIRQWSSASEGVIIHTPA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEEEECCC
YDAFDKMILGLERTIIPNQLSPSSEGYQIDWNVFEAQLSDPNNTVLLLCSPHNPTGKVWS
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCC
ADELKRMAVLCEKYHVAVISDEIHMDICFKPHTPWQGFGMGTRWALVSSASKSFNIPALN
HHHHHHHHHHHHHHEEEEEECCEEEEEEECCCCCCCCCCCCCHHHEEECCCCCCCCCCCC
GAYAFIADDVAREHYLFNLKQVDGLSSPSILGVIALMAAYQEGGPWLDELKSYLYENHRY
CCEEEHHHHHHHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VQETLEKELPSIGYQIPDSTYLAWIDLSSFSLDMDALNQCLIKNHKVAIMQGSTYGVAGK
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCC
GFVRLNLGCPRIKVEKGLSALISAIKEQS
CEEEEECCCCEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 7665481; 10698925 [H]