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The map label for this gene is manA [H]

Identifier: 209695114

GI number: 209695114

Start: 1720037

End: 1721143

Strand: Reverse

Name: manA [H]

Synonym: VSAL_I1613

Alternate gene names: 209695114

Gene position: 1721143-1720037 (Counterclockwise)

Preceding gene: 209695115

Following gene: 209695112

Centisome position: 51.76

GC content: 39.21

Gene sequence:

>1107_bases
ATGAATACTGTATATAACGTTGAAGCAGGGCAGCGCCATTATCAATGGGGATCCCACTTACTTTATGGTTTGTTTGGGCT
TCCAATTAAAGATGATAAACCGCTGGCTGAGTTGTGGTTGGGAGGGCATCCATCGTTGCCTTCTAAAGTTCAACTTGATG
ATAGATCTTGGCAAACACTGGATAAGTTTCTTGAACAAAAGCCGCTTAGATTTTTGTTTAAAGTATTGAGTGCATCGCAA
CCTTTATCGCTTCAAGTACATCCAAATAATGTTCAAGCCAAAGCCGGTTTTGAGCGTGAAAATGCACAACATATTCCTTT
AGGTGCACCACACCGAAATTATAAAGACGCTTATGCTAAACCAGAAATGGTCATGGCGCTGTCACCTTTTAAAATAATGG
TGGGGTTTAGGCCGTTAGAAGAGATCATTGATAACCTTAACTTAATTCAATCAGATGCATTAAAGACTATCTTACACAGT
GAAATATTTAATCATCAGACGTTATTATTATCCTTGTTGCAACTAACACAAAAAGATAAACAGCAGATTATTGCACAAGC
ATTATCTATTGCTATTACTTGTAATGAACCAATGTGGCAGCAATTGGTTGAGCTTGGACATTACTACCCATGCGATATTG
GAATATTAGCGCCGCTTTATATGAATTGTTTAACGTTAGAGCCGGGTGAGGCGATGTATTTACCTACGGGAACGATTCAT
GCGTACACAAAGGGGACGTGTATTGAGTTAATGGGGTGTTCAGATAATGTATTAAGAGCAGGGCTTACCCCAAAGTATAT
TGATACGGATGAGCTAATGGCTTGTACTCAATTTGTTCCGTTTACCCCTGAAAAGTTAGTGCCAATGCTTGTTAAGTCAG
AACGAATATTGCAACCAACAGAGACTGATTTCGGGCTAGCGTTATGCCAAGTCACTGAGCATGAACAATCTTTAACGGTG
ACGTCTCGTTCAATATTATTGGTTGCCAAAGGAAAGGTTCAATTTAATGATACGGTGTTGTTAGCTGGGCAATCATTATT
CATTGAATCAGGTGCTTATCAGGTATCTGGTGATGGATTATTAGTTCGGGCTTTTGAATCTAAATAG

Upstream 100 bases:

>100_bases
TTGCAGGAAAAGGTTTTGTGAGACTTAACCTAGGCTGTCCGCGCATAAAAGTGGAAAAAGGCTTATCTGCGCTCATTTCT
GCAATTAAAGAGCAATCTTA

Downstream 100 bases:

>100_bases
AAAAAAAGAGCCGATAATGTTATCGGCTCTTTTATAACTATCAGACAATTATGAGAAATACTGAGAGTAGTTGATACCGA
TTATTTGATTACATCAGGAT

Product: mannose-6-phosphate isomerase (phosphomannose isomerase)

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNTVYNVEAGQRHYQWGSHLLYGLFGLPIKDDKPLAELWLGGHPSLPSKVQLDDRSWQTLDKFLEQKPLRFLFKVLSASQ
PLSLQVHPNNVQAKAGFERENAQHIPLGAPHRNYKDAYAKPEMVMALSPFKIMVGFRPLEEIIDNLNLIQSDALKTILHS
EIFNHQTLLLSLLQLTQKDKQQIIAQALSIAITCNEPMWQQLVELGHYYPCDIGILAPLYMNCLTLEPGEAMYLPTGTIH
AYTKGTCIELMGCSDNVLRAGLTPKYIDTDELMACTQFVPFTPEKLVPMLVKSERILQPTETDFGLALCQVTEHEQSLTV
TSRSILLVAKGKVQFNDTVLLAGQSLFIESGAYQVSGDGLLVRAFESK

Sequences:

>Translated_368_residues
MNTVYNVEAGQRHYQWGSHLLYGLFGLPIKDDKPLAELWLGGHPSLPSKVQLDDRSWQTLDKFLEQKPLRFLFKVLSASQ
PLSLQVHPNNVQAKAGFERENAQHIPLGAPHRNYKDAYAKPEMVMALSPFKIMVGFRPLEEIIDNLNLIQSDALKTILHS
EIFNHQTLLLSLLQLTQKDKQQIIAQALSIAITCNEPMWQQLVELGHYYPCDIGILAPLYMNCLTLEPGEAMYLPTGTIH
AYTKGTCIELMGCSDNVLRAGLTPKYIDTDELMACTQFVPFTPEKLVPMLVKSERILQPTETDFGLALCQVTEHEQSLTV
TSRSILLVAKGKVQFNDTVLLAGQSLFIESGAYQVSGDGLLVRAFESK
>Mature_368_residues
MNTVYNVEAGQRHYQWGSHLLYGLFGLPIKDDKPLAELWLGGHPSLPSKVQLDDRSWQTLDKFLEQKPLRFLFKVLSASQ
PLSLQVHPNNVQAKAGFERENAQHIPLGAPHRNYKDAYAKPEMVMALSPFKIMVGFRPLEEIIDNLNLIQSDALKTILHS
EIFNHQTLLLSLLQLTQKDKQQIIAQALSIAITCNEPMWQQLVELGHYYPCDIGILAPLYMNCLTLEPGEAMYLPTGTIH
AYTKGTCIELMGCSDNVLRAGLTPKYIDTDELMACTQFVPFTPEKLVPMLVKSERILQPTETDFGLALCQVTEHEQSLTV
TSRSILLVAKGKVQFNDTVLLAGQSLFIESGAYQVSGDGLLVRAFESK

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=384, Percent_Identity=33.59375, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787899, Length=382, Percent_Identity=36.3874345549738, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71997620, Length=288, Percent_Identity=34.7222222222222, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17557650, Length=384, Percent_Identity=29.1666666666667, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320839, Length=411, Percent_Identity=28.2238442822384, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21356061, Length=348, Percent_Identity=32.183908045977, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 41224; Mature: 41224

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVYNVEAGQRHYQWGSHLLYGLFGLPIKDDKPLAELWLGGHPSLPSKVQLDDRSWQTL
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEECCCHHHHH
DKFLEQKPLRFLFKVLSASQPLSLQVHPNNVQAKAGFERENAQHIPLGAPHRNYKDAYAK
HHHHHHCHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCHHCCC
PEMVMALSPFKIMVGFRPLEEIIDNLNLIQSDALKTILHSEIFNHQTLLLSLLQLTQKDK
CCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
QQIIAQALSIAITCNEPMWQQLVELGHYYPCDIGILAPLYMNCLTLEPGEAMYLPTGTIH
HHHHHHHHEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCEEEECCCCEE
AYTKGTCIELMGCSDNVLRAGLTPKYIDTDELMACTQFVPFTPEKLVPMLVKSERILQPT
EECCCCEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC
ETDFGLALCQVTEHEQSLTVTSRSILLVAKGKVQFNDTVLLAGQSLFIESGAYQVSGDGL
CCCCCEEEEEECCCCCEEEEEECEEEEEEECCEEECCEEEEECCEEEEECCCEEEECCCE
LVRAFESK
EEEEECCC
>Mature Secondary Structure
MNTVYNVEAGQRHYQWGSHLLYGLFGLPIKDDKPLAELWLGGHPSLPSKVQLDDRSWQTL
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEECCCHHHHH
DKFLEQKPLRFLFKVLSASQPLSLQVHPNNVQAKAGFERENAQHIPLGAPHRNYKDAYAK
HHHHHHCHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCHHCCC
PEMVMALSPFKIMVGFRPLEEIIDNLNLIQSDALKTILHSEIFNHQTLLLSLLQLTQKDK
CCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
QQIIAQALSIAITCNEPMWQQLVELGHYYPCDIGILAPLYMNCLTLEPGEAMYLPTGTIH
HHHHHHHHEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCEEEECCCCEE
AYTKGTCIELMGCSDNVLRAGLTPKYIDTDELMACTQFVPFTPEKLVPMLVKSERILQPT
EECCCCEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC
ETDFGLALCQVTEHEQSLTVTSRSILLVAKGKVQFNDTVLLAGQSLFIESGAYQVSGDGL
CCCCCEEEEEECCCCCEEEEEECEEEEEEECCEEECCEEEEECCEEEEECCCEEEECCCE
LVRAFESK
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]