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The map label for this gene is sdaA [H]

Identifier: 209694872

GI number: 209694872

Start: 1457621

End: 1458982

Strand: Reverse

Name: sdaA [H]

Synonym: VSAL_I1343

Alternate gene names: 209694872

Gene position: 1458982-1457621 (Counterclockwise)

Preceding gene: 209694873

Following gene: 209694871

Centisome position: 43.88

GC content: 42.88

Gene sequence:

>1362_bases
ATGATTAGTGTTTTTGATATCTACAAAATTGGAGTTGGTCCATCTAGCTCCCACACTGTTGGTCCAATGAAAGCGGGTAA
AGAGTTTATCGACGATTTACGTGGCATGGGCAAACTGCGTGATATCACTAAAATCACTGTTGATGTTTACGGTTCGTTAT
CACTGACAGGGAAAGGTCACCATACTGATATAGCTATTATTATGGGTCTGGCAGGCAACACGCCAGAACACGTAGATATT
GACTCAATTCCAGGCTTTATTGCTCGCGTTGAAGAAACAGAACGCCTACCCGTTGGCATGCATTGCCATACGGTAGAGTT
TCCTAAAGATGGTGGGATGAATTTCCACAAAACCAATCTTGAATTGCATGAAAATGGTATGCAGATCCATGCGTGGATAG
ATGGTGAAGTCGTTTACTCTAAAACATATTACTCTATCGGTGGTGGTTTTATTGTTGATGAAGAACACTTTGGTAAAGAA
GTAGAATCATCAATCAAGGTACCTTATGCCTTTAATAGTGCAGAAGAGCTCGTTAATCTATGTAAAGAACATGGCTTATC
TATTAGTGCCTTAGTAATGAAGAACGAACACGCGATTCTTGCAGAAGATGAAGTTCGTACTTATTTCGCAAAAATTTGGA
AAACCATGCGTGATTGCATGGAAAAAGGCATGAATACCGAAGGGCTTCTTCCTGGACCTCTACGTGTTCCTCGTCGTGCT
GCGGCACTTCGTCAACAGTTGCTTACATCAGAAAAAACATCAACTGATCCTATGGAAGTTCTGGATTGGGTGAATATGTT
TGCATTCGCTGTTAATGAAGAGAACGCTGCTGGTGGACGTGTTGTTACAGCACCAACAAACGGCGCATGTGGCATCATCC
CTGCTGTATTAGCGTATTACGACAAGTTTATACAAACAGTAACAGAGAAAGATTACATTCGTTATTTCGCAGCATCTGGT
GCGATCGGCGGTCTATACAAACAAAATGCATCTATCTCTGGTGCTGAAGTGGGTTGTCAGGGTGAAGTCGGTGTTGCTTG
TTCAATGGCTGCTGCTGGTCTTGCTGAATTAATGGGTGGAAGCCCTGAGCAGGTCTGTATGGCGGCTGAAATTGGTATGG
AGCATAACCTTGGGTTAACGTGTGATCCTGTTGCAGGACAAGTACAAGTCCCTTGTATTGAACGTAATGGTATTGCTTCT
GTAAAAGCAATCAACTCAACTCGTATGGCACTTCGTCGTTCGTCGGATCCTCGTGTTTCTTTAGACAAAGTTATTGAAAC
AATGCTTGAAACAGGCAAGGACATGAACGCGAAATACCGAGAGACATCTCAAGGTGGCCTAGCGATTAAAGTTATCTGCT
AG

Upstream 100 bases:

>100_bases
TAATCGTCATTCTATATGTTGATATAGACATCGATTATTCGAAGTAATAATAATGATAATAAAAGCCCCCTATTAATGGG
GGCTTATTCGAGGTAACAAC

Downstream 100 bases:

>100_bases
ATCACTCATTGATACATTCAGGGACGTTAATTCGTCCCTTTTTTTTATTTTTATTCATTCATACAACTAATTCCTTTCAA
TTGAACTATACTAATCATAC

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRGMGKLRDITKITVDVYGSLSLTGKGHHTDIAIIMGLAGNTPEHVDI
DSIPGFIARVEETERLPVGMHCHTVEFPKDGGMNFHKTNLELHENGMQIHAWIDGEVVYSKTYYSIGGGFIVDEEHFGKE
VESSIKVPYAFNSAEELVNLCKEHGLSISALVMKNEHAILAEDEVRTYFAKIWKTMRDCMEKGMNTEGLLPGPLRVPRRA
AALRQQLLTSEKTSTDPMEVLDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIQTVTEKDYIRYFAASG
AIGGLYKQNASISGAEVGCQGEVGVACSMAAAGLAELMGGSPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAS
VKAINSTRMALRRSSDPRVSLDKVIETMLETGKDMNAKYRETSQGGLAIKVIC

Sequences:

>Translated_453_residues
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRGMGKLRDITKITVDVYGSLSLTGKGHHTDIAIIMGLAGNTPEHVDI
DSIPGFIARVEETERLPVGMHCHTVEFPKDGGMNFHKTNLELHENGMQIHAWIDGEVVYSKTYYSIGGGFIVDEEHFGKE
VESSIKVPYAFNSAEELVNLCKEHGLSISALVMKNEHAILAEDEVRTYFAKIWKTMRDCMEKGMNTEGLLPGPLRVPRRA
AALRQQLLTSEKTSTDPMEVLDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIQTVTEKDYIRYFAASG
AIGGLYKQNASISGAEVGCQGEVGVACSMAAAGLAELMGGSPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAS
VKAINSTRMALRRSSDPRVSLDKVIETMLETGKDMNAKYRETSQGGLAIKVIC
>Mature_453_residues
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRGMGKLRDITKITVDVYGSLSLTGKGHHTDIAIIMGLAGNTPEHVDI
DSIPGFIARVEETERLPVGMHCHTVEFPKDGGMNFHKTNLELHENGMQIHAWIDGEVVYSKTYYSIGGGFIVDEEHFGKE
VESSIKVPYAFNSAEELVNLCKEHGLSISALVMKNEHAILAEDEVRTYFAKIWKTMRDCMEKGMNTEGLLPGPLRVPRRA
AALRQQLLTSEKTSTDPMEVLDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIQTVTEKDYIRYFAASG
AIGGLYKQNASISGAEVGCQGEVGVACSMAAAGLAELMGGSPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAS
VKAINSTRMALRRSSDPRVSLDKVIETMLETGKDMNAKYRETSQGGLAIKVIC

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=453, Percent_Identity=74.8344370860927, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=452, Percent_Identity=70.5752212389381, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=453, Percent_Identity=68.4326710816777, Blast_Score=644, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49047; Mature: 49047

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRGMGKLRDITKITVDVYGSLSLTGKGH
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEEEEEEEEEECCCCC
HTDIAIIMGLAGNTPEHVDIDSIPGFIARVEETERLPVGMHCHTVEFPKDGGMNFHKTNL
CCEEEEEEEECCCCCCCCCHHCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCC
ELHENGMQIHAWIDGEVVYSKTYYSIGGGFIVDEEHFGKEVESSIKVPYAFNSAEELVNL
EEECCCEEEEEEECCEEEEEEEEEECCCCEEECHHHHCHHHHHCCCCCEEECCHHHHHHH
CKEHGLSISALVMKNEHAILAEDEVRTYFAKIWKTMRDCMEKGMNTEGLLPGPLRVPRRA
HHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
AALRQQLLTSEKTSTDPMEVLDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIQTVTEKDYIRYFAASGAIGGLYKQNASISGAEVGCQGEVGVACSMAAAGLAELMGG
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIASVKAINSTRMALRRSSDPRVS
CHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCCCCC
LDKVIETMLETGKDMNAKYRETSQGGLAIKVIC
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRGMGKLRDITKITVDVYGSLSLTGKGH
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEEEEEEEEEECCCCC
HTDIAIIMGLAGNTPEHVDIDSIPGFIARVEETERLPVGMHCHTVEFPKDGGMNFHKTNL
CCEEEEEEEECCCCCCCCCHHCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCC
ELHENGMQIHAWIDGEVVYSKTYYSIGGGFIVDEEHFGKEVESSIKVPYAFNSAEELVNL
EEECCCEEEEEEECCEEEEEEEEEECCCCEEECHHHHCHHHHHCCCCCEEECCHHHHHHH
CKEHGLSISALVMKNEHAILAEDEVRTYFAKIWKTMRDCMEKGMNTEGLLPGPLRVPRRA
HHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
AALRQQLLTSEKTSTDPMEVLDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIQTVTEKDYIRYFAASGAIGGLYKQNASISGAEVGCQGEVGVACSMAAAGLAELMGG
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIASVKAINSTRMALRRSSDPRVS
CHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCCCCC
LDKVIETMLETGKDMNAKYRETSQGGLAIKVIC
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]