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The map label for this gene is gltP [H]

Identifier: 209694816

GI number: 209694816

Start: 1390096

End: 1391400

Strand: Reverse

Name: gltP [H]

Synonym: VSAL_I1281

Alternate gene names: 209694816

Gene position: 1391400-1390096 (Counterclockwise)

Preceding gene: 209694821

Following gene: 209694811

Centisome position: 41.84

GC content: 42.84

Gene sequence:

>1305_bases
ATGACGAATGACAACAAAAAAATTAAAAGCTCTTTAACTGCTCGCATCATTACCGGCATGGTTGCTGGTATTTTATGTGG
ATTTTTGATCCGTACTTTTTTAGGCGACAATAGTTTTATTAACGAGTACCTAGTCAATGGTTTGTTTGATGTTGGCGGAA
AAATTTTCATTGCCAGCTTAAAAATGCTCGTAATTCCCCTTGTCTTTGTTTCCCTTGTTTGCGGTACAAGTTCTTTAAAA
GACATGACAACATTAGGTCGATTAGGCGGTAAGACTCTCGCTTTCTATATCGGAACCACTGCGTTAGCCATCTCTTTAGC
GCTCATCATGGGTATCTTCTTACACCCAGGAGCAGGTGCCGATCTAACCTCTGCGGCTTCTTTTAGCACAGCAGAAGCGC
CTTCATTAGGCCAAGTTATTGTTGGCATGTTCCCAAGCAACCCGATGGCAGCAATGTCTCAAGGTAATACATTGCAAGTT
ATCGTATTTGCGGTGCTATTTGGTATAGCCATCAGCCTTGCTGGAGAAGCAGGGCAACGTGTTTCTGATTTCTTTAGCGA
CGTAAATGAAGTAATCATGAAGCTGGTTACGCTGCTAATGAAAGTAGCGCCTTACGGTATTTTCTTCTTAATGGCGAAAC
TGTTTACTGGTTTAGGTTTAGATTCAATCGCAAACCTAGCGGCATACTTCTTAGTTCTTGTTGCGGCACTGCTTATTCAT
GCCTTTGTCACTTACAGTATTCTTCTTAAAGTTCTTTCAGGCCTAAGCCCTATCGTATTTTGGAAGAAGATGAAAGATGC
CATCATGTTTGCCTTTTCTACCGCCTCTTCTAATGCCACTATTCCAGTGACCATGGAAACGGCAACACATCGATTAGGTG
TCAGTAATAAAGTCGCTTCATTTACCATTCCTCTTGGTGCCACCATTAATATGGATGGTACGGCCATCATGCAAGGGGTC
GCAACGGCCTTTATTGCTCAAGCATTTGGCGTAGATCTAAGCATTGGGGATTACATGACAGTGATCCTAACAGCAACGCT
TGCATCTGTAGGTACCGCTGGTGTCCCTGGCGTTGGTTTGATCATGTTAGCGATGGTATTAAACCAAGTAGGCTTACCTT
TAGAAGGTATTGCACTCATCATGGGTGTTGACCGCTTACTTGACATGATCCGTACGGCGGTAAATATTACCGGTGACAGT
GTGGTGACTTGTATTGTGGCTAAATCAGAAAATGAGTTAGACATTGATGCCTTTAATGATCCAAAAGCTGGTGAAGCGGA
ACTCGCACTAAAAAGAAGTGCTTAA

Upstream 100 bases:

>100_bases
AATGGACAAATTATAAATGTAACGAACAAGTTTCATTTTAGATCTGCTAACCTGCTCGCACTTTGAAAGTTGTACAAAGT
AATTTAATGGAGATTAGTTC

Downstream 100 bases:

>100_bases
TTAAATACGTATCTCTCGCTTAACCATAAAGGCCTCAACATCATGTTAAGGCCTTTATTTTTCAACTCATTTATTTATGC
TTAAGCAAACGGATCTACGT

Product: sodium/dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTNDNKKIKSSLTARIITGMVAGILCGFLIRTFLGDNSFINEYLVNGLFDVGGKIFIASLKMLVIPLVFVSLVCGTSSLK
DMTTLGRLGGKTLAFYIGTTALAISLALIMGIFLHPGAGADLTSAASFSTAEAPSLGQVIVGMFPSNPMAAMSQGNTLQV
IVFAVLFGIAISLAGEAGQRVSDFFSDVNEVIMKLVTLLMKVAPYGIFFLMAKLFTGLGLDSIANLAAYFLVLVAALLIH
AFVTYSILLKVLSGLSPIVFWKKMKDAIMFAFSTASSNATIPVTMETATHRLGVSNKVASFTIPLGATINMDGTAIMQGV
ATAFIAQAFGVDLSIGDYMTVILTATLASVGTAGVPGVGLIMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDS
VVTCIVAKSENELDIDAFNDPKAGEAELALKRSA

Sequences:

>Translated_434_residues
MTNDNKKIKSSLTARIITGMVAGILCGFLIRTFLGDNSFINEYLVNGLFDVGGKIFIASLKMLVIPLVFVSLVCGTSSLK
DMTTLGRLGGKTLAFYIGTTALAISLALIMGIFLHPGAGADLTSAASFSTAEAPSLGQVIVGMFPSNPMAAMSQGNTLQV
IVFAVLFGIAISLAGEAGQRVSDFFSDVNEVIMKLVTLLMKVAPYGIFFLMAKLFTGLGLDSIANLAAYFLVLVAALLIH
AFVTYSILLKVLSGLSPIVFWKKMKDAIMFAFSTASSNATIPVTMETATHRLGVSNKVASFTIPLGATINMDGTAIMQGV
ATAFIAQAFGVDLSIGDYMTVILTATLASVGTAGVPGVGLIMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDS
VVTCIVAKSENELDIDAFNDPKAGEAELALKRSA
>Mature_433_residues
TNDNKKIKSSLTARIITGMVAGILCGFLIRTFLGDNSFINEYLVNGLFDVGGKIFIASLKMLVIPLVFVSLVCGTSSLKD
MTTLGRLGGKTLAFYIGTTALAISLALIMGIFLHPGAGADLTSAASFSTAEAPSLGQVIVGMFPSNPMAAMSQGNTLQVI
VFAVLFGIAISLAGEAGQRVSDFFSDVNEVIMKLVTLLMKVAPYGIFFLMAKLFTGLGLDSIANLAAYFLVLVAALLIHA
FVTYSILLKVLSGLSPIVFWKKMKDAIMFAFSTASSNATIPVTMETATHRLGVSNKVASFTIPLGATINMDGTAIMQGVA
TAFIAQAFGVDLSIGDYMTVILTATLASVGTAGVPGVGLIMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDSV
VTCIVAKSENELDIDAFNDPKAGEAELALKRSA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=456, Percent_Identity=32.4561403508772, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI40254478, Length=456, Percent_Identity=34.6491228070175, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI66773030, Length=453, Percent_Identity=32.2295805739514, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI194239697, Length=463, Percent_Identity=29.8056155507559, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI21314632, Length=420, Percent_Identity=31.6666666666667, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4827012, Length=289, Percent_Identity=37.7162629757785, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI5032093, Length=374, Percent_Identity=34.4919786096257, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI223468566, Length=258, Percent_Identity=36.4341085271318, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=36.9477911646586, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI262359914, Length=382, Percent_Identity=29.5811518324607, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI301601644, Length=172, Percent_Identity=39.5348837209302, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1790514, Length=421, Percent_Identity=35.8669833729216, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1789947, Length=385, Percent_Identity=31.9480519480519, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788024, Length=453, Percent_Identity=28.476821192053, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789473, Length=275, Percent_Identity=28.7272727272727, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=475, Percent_Identity=34.1052631578947, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71983106, Length=462, Percent_Identity=34.1991341991342, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI193206505, Length=439, Percent_Identity=35.0797266514806, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71996953, Length=451, Percent_Identity=33.0376940133038, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17537407, Length=429, Percent_Identity=33.7995337995338, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI193206654, Length=431, Percent_Identity=31.554524361949, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17541374, Length=455, Percent_Identity=31.2087912087912, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24583025, Length=464, Percent_Identity=30.6034482758621, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137668, Length=464, Percent_Identity=30.6034482758621, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24583023, Length=464, Percent_Identity=30.6034482758621, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI281360481, Length=459, Percent_Identity=29.4117647058824, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI281360483, Length=459, Percent_Identity=29.4117647058824, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17137666, Length=459, Percent_Identity=29.4117647058824, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45427; Mature: 45295

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDNKKIKSSLTARIITGMVAGILCGFLIRTFLGDNSFINEYLVNGLFDVGGKIFIASL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHH
KMLVIPLVFVSLVCGTSSLKDMTTLGRLGGKTLAFYIGTTALAISLALIMGIFLHPGAGA
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
DLTSAASFSTAEAPSLGQVIVGMFPSNPMAAMSQGNTLQVIVFAVLFGIAISLAGEAGQR
CCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHH
VSDFFSDVNEVIMKLVTLLMKVAPYGIFFLMAKLFTGLGLDSIANLAAYFLVLVAALLIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AFVTYSILLKVLSGLSPIVFWKKMKDAIMFAFSTASSNATIPVTMETATHRLGVSNKVAS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEHHHHHHCCCCCCCEE
FTIPLGATINMDGTAIMQGVATAFIAQAFGVDLSIGDYMTVILTATLASVGTAGVPGVGL
EEECCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
IMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDSVVTCIVAKSENELDIDAFND
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
PKAGEAELALKRSA
CCCCCHHHHEECCC
>Mature Secondary Structure 
TNDNKKIKSSLTARIITGMVAGILCGFLIRTFLGDNSFINEYLVNGLFDVGGKIFIASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHH
KMLVIPLVFVSLVCGTSSLKDMTTLGRLGGKTLAFYIGTTALAISLALIMGIFLHPGAGA
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
DLTSAASFSTAEAPSLGQVIVGMFPSNPMAAMSQGNTLQVIVFAVLFGIAISLAGEAGQR
CCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHH
VSDFFSDVNEVIMKLVTLLMKVAPYGIFFLMAKLFTGLGLDSIANLAAYFLVLVAALLIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AFVTYSILLKVLSGLSPIVFWKKMKDAIMFAFSTASSNATIPVTMETATHRLGVSNKVAS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEHHHHHHCCCCCCCEE
FTIPLGATINMDGTAIMQGVATAFIAQAFGVDLSIGDYMTVILTATLASVGTAGVPGVGL
EEECCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
IMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDSVVTCIVAKSENELDIDAFND
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
PKAGEAELALKRSA
CCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]