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The map label for this gene is sfcA

Identifier: 209694811

GI number: 209694811

Start: 1382175

End: 1383863

Strand: Reverse

Name: sfcA

Synonym: VSAL_I1274

Alternate gene names: 209694811

Gene position: 1383863-1382175 (Counterclockwise)

Preceding gene: 209694816

Following gene: 209694810

Centisome position: 41.62

GC content: 41.98

Gene sequence:

>1689_bases
ATGAATAATCACATACGTCCCCTATATATCCCTTATGCTGGCCCAGCACTTCTAAGTACTCCTCTGCTAAACAAAGGCAG
CGCATTCAGCACTACTGAGCGTAAATATTTTAACTTAGAAGGCTTACTTCCTGAAGCCATTGAAAGTATCGAAGAACAAA
CTGGTCGTGCATACAAGCAATACCAAAGCTTTGAAAATGATATGGATAAACATATCTATCTTCGTAATATTCAAGACACG
AATGAAACTTTGTTTTACCGTTTAGTTCAAAATCACATCAGCGAAATGATGCCCATTATTTACACCCCTACGGTTGGCGC
TGCTTGTGAAAACTTCTCTAATATTTATCGTCGTGGTCGTGGATTATTCATCTCTTATGAAAACAAAAACCGCATTGATG
ATCTACTAAACAACGCCGCAAACCAAAACGTAAAAGTTATCGTGGTGACTGATGGCGAACGTATTCTTGGTCTAGGCGAT
CAGGGGATCGGCGGCATGGGTATCCCAATTGGTAAATTAGCACTGTATACCGCTTGTGGTGGTATCAGCCCTGCTCATAC
TCTACCAATCGTTCTTGATGTGGGCACAAATAACCCTCAACGTCTTGCCGATCCAATGTACATGGGCTGGCGTCATCCTC
GTGTTACTGGTAACGAATATAAAGATTTTGTTGAAGAGTTCATTCAAGCTGTTCAACGTCGCTGGCCTCAAGCTCTCGTT
CAATTTGAAGATTTCGCTCAGAAAAATGCGATGCCTTTACTTGAACGTTACAAAAATCGCATTTGTTGCTTTAATGATGA
TATTCAAGGTACCGCTGCGGTTACTGTTGGGTCTTTACTTGCGGCATGTAAAGCAGCAGGAAGTTCATTAGCTCAGCAAC
GAGTTACTTTCCTTGGTGCAGGCTCAGCGGGTTGTGGTATTGCAGAGGCGATCATTGCTCAAATGGTATCTGAAGGTATT
TCTGATGCTCAAGCTCGTTCACAAGTGTACATGGTTGACCGTTGGGGCTTATTGCAAGAAGGCATGCCTAACCTGCTTGA
TTTCCAACAACGCTTAGTTCAAAAAGCAGAAAATACAAAAGAGTGGGTTTCTGAAGAACCAAATTACTCTCTTTTTGATG
TCATGCATAATGCAAAACCAACCGTTCTTATTGGCGTATCTGGTGCTCCTGGCTTATTTAGCAAAGAAGTTATCCAAGAA
ATGCACAAGCATTGTGAGCGCCCAATTGTATTCCCATTATCGAATCCAACAAGTCGTGTAGAAGCAACACCAAACGACAT
TATTCGTTGGACAGACGGACAAGCATTAGTGGCAACAGGTAGCCCATTTGATCCAGTAACACACAATGGTCAAACCTACC
CAATCGCACAATGTAACAACAGTTTCATCTTCCCAGGTATTGGTCTCGGCGTATTGGCAATTAAAGCGACTCGTGTCTCT
GATGAAATGCTAAGAGAATCAAGCCGTGCATTATCAGAATGCTCACCACTTGCCATAAATGGCTCAGGTGCGCTTCTTCC
ACCATTGGAAGAAATTCATACTGTATCGAAGAAAATTGCTTTTGCCGTGGCTAAAAAAGCCATTGAACAAGGTTATGCCT
TAGAGATTACAGATGAAGCATTAATGCAGAAAATTGAACAATATTTCTGGAAACCAGTATACCGTCGCTACAAACGTACT
GCTTTTTAA

Upstream 100 bases:

>100_bases
AACATGACTCCTTTCGCACTTTATTCGCATTCACGCTTTGATATTTCAGTAAAGTAGGAATAGGATCGGTGGTTCATTCT
TGATTTGAAGAAGCATAACA

Downstream 100 bases:

>100_bases
TTAAAAATTTCCATCGATATCAAAACCAGAGAAAATTTCTCTGGTTTTTTTTCAACTATCTGTTTCTATTAGCGCTAGAA
TACCCACTACATTACTATTT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNNHIRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQSFENDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGNEYKDFVEEFIQAVQRRWPQALV
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLAQQRVTFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKEWVSEEPNYSLFDVMHNAKPTVLIGVSGAPGLFSKEVIQE
MHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVTHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVS
DEMLRESSRALSECSPLAINGSGALLPPLEEIHTVSKKIAFAVAKKAIEQGYALEITDEALMQKIEQYFWKPVYRRYKRT
AF

Sequences:

>Translated_562_residues
MNNHIRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQSFENDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGNEYKDFVEEFIQAVQRRWPQALV
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLAQQRVTFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKEWVSEEPNYSLFDVMHNAKPTVLIGVSGAPGLFSKEVIQE
MHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVTHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVS
DEMLRESSRALSECSPLAINGSGALLPPLEEIHTVSKKIAFAVAKKAIEQGYALEITDEALMQKIEQYFWKPVYRRYKRT
AF
>Mature_562_residues
MNNHIRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQSFENDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGNEYKDFVEEFIQAVQRRWPQALV
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLAQQRVTFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKEWVSEEPNYSLFDVMHNAKPTVLIGVSGAPGLFSKEVIQE
MHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVTHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVS
DEMLRESSRALSECSPLAINGSGALLPPLEEIHTVSKKIAFAVAKKAIEQGYALEITDEALMQKIEQYFWKPVYRRYKRT
AF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family

Homologues:

Organism=Homo sapiens, GI4505143, Length=522, Percent_Identity=43.6781609195402, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI62420882, Length=530, Percent_Identity=41.8867924528302, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI62420880, Length=530, Percent_Identity=41.8867924528302, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI239049447, Length=530, Percent_Identity=41.8867924528302, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI4505145, Length=553, Percent_Identity=40.3254972875226, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI270265879, Length=464, Percent_Identity=43.3189655172414, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI87081919, Length=557, Percent_Identity=67.8635547576302, Blast_Score=789, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=516, Percent_Identity=43.4108527131783, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6322823, Length=559, Percent_Identity=42.9338103756708, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI281362674, Length=519, Percent_Identity=43.3526011560694, Blast_Score=434, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362672, Length=519, Percent_Identity=43.3526011560694, Blast_Score=434, Evalue=1e-121,
Organism=Drosophila melanogaster, GI21356279, Length=519, Percent_Identity=43.3526011560694, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24646388, Length=513, Percent_Identity=41.130604288499, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24646386, Length=513, Percent_Identity=41.130604288499, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI78707242, Length=537, Percent_Identity=39.1061452513966, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707238, Length=537, Percent_Identity=39.1061452513966, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=37.9174852652259, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707240, Length=515, Percent_Identity=39.2233009708738, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363505, Length=508, Percent_Identity=37.7952755905512, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707236, Length=508, Percent_Identity=37.7952755905512, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363503, Length=506, Percent_Identity=37.5494071146245, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19922384, Length=545, Percent_Identity=28.9908256880734, Blast_Score=256, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAO1_ALISL (B6EK11)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262739.1
- GeneID:   6986955
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1274
- HOGENOM:   HBG289821
- OMA:   IQDNNET
- ProtClustDB:   PRK13529
- HAMAP:   MF_01619
- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000106
- PRINTS:   PR00072
- SMART:   SM00919

Pfam domain/function: PF00390 malic; PF03949 Malic_M

EC number: =1.1.1.38

Molecular weight: Translated: 62468; Mature: 62468

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: ACT_SITE 101-101 ACT_SITE 172-172 BINDING 154-154 BINDING 267-267 BINDING 415-415

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHIRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQ
CCCCCCEEEECCCCHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHH
YQSFENDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGR
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCC
GLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACG
CEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHC
GISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGNEYKDFVEEFIQAVQRRWPQALV
CCCCCCCEEEEEECCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLAQQRVTFLGA
HHHHHHHHCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
GSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTK
CCCCCHHHHHHHHHHHHHCCCHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHCHH
EWVSEEPNYSLFDVMHNAKPTVLIGVSGAPGLFSKEVIQEMHKHCERPIVFPLSNPTSRV
HHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
EATPNDIIRWTDGQALVATGSPFDPVTHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVS
CCCCCCCEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCCHHHHEEEHHHHH
DEMLRESSRALSECSPLAINGSGALLPPLEEIHTVSKKIAFAVAKKAIEQGYALEITDEA
HHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHH
LMQKIEQYFWKPVYRRYKRTAF
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNHIRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQ
CCCCCCEEEECCCCHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHH
YQSFENDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGR
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCC
GLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACG
CEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHC
GISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGNEYKDFVEEFIQAVQRRWPQALV
CCCCCCCEEEEEECCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLAQQRVTFLGA
HHHHHHHHCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
GSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTK
CCCCCHHHHHHHHHHHHHCCCHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHCHH
EWVSEEPNYSLFDVMHNAKPTVLIGVSGAPGLFSKEVIQEMHKHCERPIVFPLSNPTSRV
HHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
EATPNDIIRWTDGQALVATGSPFDPVTHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVS
CCCCCCCEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCCHHHHEEEHHHHH
DEMLRESSRALSECSPLAINGSGALLPPLEEIHTVSKKIAFAVAKKAIEQGYALEITDEA
HHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHH
LMQKIEQYFWKPVYRRYKRTAF
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA