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The map label for this gene is hisG

Identifier: 209694683

GI number: 209694683

Start: 1236478

End: 1237374

Strand: Direct

Name: hisG

Synonym: VSAL_I1133

Alternate gene names: 209694683

Gene position: 1236478-1237374 (Clockwise)

Preceding gene: 209694682

Following gene: 209694684

Centisome position: 37.19

GC content: 41.58

Gene sequence:

>897_bases
ATGTCAGCACAACGTTTACGCATCGCAATTCAAAAGAAAGGACGTTTGTCTAAAGAGTGCCAAGAGCTGTTTAAGCGCTG
TGGTATGAAATTTAATATATCAGGTGAGCGTTTAGTGGTTCATTCTGAAAATATGCCGATTGATTTATTGTTGGTTCGTG
ATGATGATATTCCAAGTCTTATCATGGATGGCGTTGTTGACTTAGGTGTTATTGGCGAAAACGAATTAGAAGAAGTTCGT
TTAGAGCGTAAAGCATTAGGCGAGCCTTCAGCATTTACCACATTGCGTCGCTTAGATTTTGGTGGTTGTCGTCTGTCTAT
CGCGATTGATAAAGATGCTGTTTATAACGGACCACAAGACCTTGCTGGTAAACGTATCGCAACGACTTACTCACAATTGC
TTAAAAGCTTTATGGATGAGAAAAATATCCCGTTCTCAACTTGTATTTTAAATGGTTCAGTTGAAGTTGCTCCACGTGCC
GGTCTGTCTGATGCGATTGCTGATTTAGTTTCAACAGGCGCAACTCTTGAGGCTAATGGCCTAAAAGAAGCTGAAGTAAT
TTTCCGCTCTAAAGCGACGTTAATTCAACGTGAAGGTGAATTCGATGCTGATAAAGCGGCCTTGATTGATAAATTACTGA
CTCGTATGCAAGGCTGTATCCAAGCGAAAGAATCTAAGTACATCATGCTACACGCGCCAACCGATAAATTAGAAGCGATT
AAATCACTACTACCGGGTGCGGAAGATCCAACGGTGCTTCCTCTATCAAGTGACGGTGCGAAAGTGGCAGTTCACCTAGT
GAGTACTGAAAATCTATTCTGGGAAACGATGGAACAACTAAAAGCATTGGGTGCGAGCTCTATTCTTGTTCTTCCAATTG
AGAAGATGATGGAGTAA

Upstream 100 bases:

>100_bases
AAGGTAAAACTTCTGAGGGTTTTTTCGTTTTATGACTAAATAATTGAGCAATTGATAGTTAACAACAAATTTAGAATTAC
ATTTTTACAAGGAAGAGATT

Downstream 100 bases:

>100_bases
CCATTATGAAAACCCTAGTTTGGCAATCACTCAGTAATTCACAACAAGACACCGTCTTACAGCGTCCTGCTATTACCGAA
GGCGCAAATATTACCGCTGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSAQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSLIMDGVVDLGVIGENELEEVR
LERKALGEPSAFTTLRRLDFGGCRLSIAIDKDAVYNGPQDLAGKRIATTYSQLLKSFMDEKNIPFSTCILNGSVEVAPRA
GLSDAIADLVSTGATLEANGLKEAEVIFRSKATLIQREGEFDADKAALIDKLLTRMQGCIQAKESKYIMLHAPTDKLEAI
KSLLPGAEDPTVLPLSSDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME

Sequences:

>Translated_298_residues
MSAQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSLIMDGVVDLGVIGENELEEVR
LERKALGEPSAFTTLRRLDFGGCRLSIAIDKDAVYNGPQDLAGKRIATTYSQLLKSFMDEKNIPFSTCILNGSVEVAPRA
GLSDAIADLVSTGATLEANGLKEAEVIFRSKATLIQREGEFDADKAALIDKLLTRMQGCIQAKESKYIMLHAPTDKLEAI
KSLLPGAEDPTVLPLSSDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME
>Mature_297_residues
SAQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSLIMDGVVDLGVIGENELEEVRL
ERKALGEPSAFTTLRRLDFGGCRLSIAIDKDAVYNGPQDLAGKRIATTYSQLLKSFMDEKNIPFSTCILNGSVEVAPRAG
LSDAIADLVSTGATLEANGLKEAEVIFRSKATLIQREGEFDADKAALIDKLLTRMQGCIQAKESKYIMLHAPTDKLEAIK
SLLPGAEDPTVLPLSSDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=68.3673469387755, Blast_Score=420, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320896, Length=295, Percent_Identity=28.4745762711864, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ALISL (B6EJ87)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262611.1
- GeneID:   6986863
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1133
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32675; Mature: 32544

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSL
CCCCCEEEEEHHCCCHHHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEEEEECCCCHHH
IMDGVVDLGVIGENELEEVRLERKALGEPSAFTTLRRLDFGGCRLSIAIDKDAVYNGPQD
HHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
LAGKRIATTYSQLLKSFMDEKNIPFSTCILNGSVEVAPRAGLSDAIADLVSTGATLEANG
HCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEAEVIFRSKATLIQREGEFDADKAALIDKLLTRMQGCIQAKESKYIMLHAPTDKLEAI
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
KSLLPGAEDPTVLPLSSDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME
HHHCCCCCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
SAQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSL
CCCCEEEEEHHCCCHHHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEEEEECCCCHHH
IMDGVVDLGVIGENELEEVRLERKALGEPSAFTTLRRLDFGGCRLSIAIDKDAVYNGPQD
HHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
LAGKRIATTYSQLLKSFMDEKNIPFSTCILNGSVEVAPRAGLSDAIADLVSTGATLEANG
HCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEAEVIFRSKATLIQREGEFDADKAALIDKLLTRMQGCIQAKESKYIMLHAPTDKLEAI
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
KSLLPGAEDPTVLPLSSDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME
HHHCCCCCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA