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The map label for this gene is hisD [H]

Identifier: 209694684

GI number: 209694684

Start: 1237380

End: 1238675

Strand: Direct

Name: hisD [H]

Synonym: VSAL_I1134

Alternate gene names: 209694684

Gene position: 1237380-1238675 (Clockwise)

Preceding gene: 209694683

Following gene: 209694685

Centisome position: 37.21

GC content: 42.21

Gene sequence:

>1296_bases
ATGAAAACCCTAGTTTGGCAATCACTCAGTAATTCACAACAAGACACCGTCTTACAGCGTCCTGCTATTACCGAAGGCGC
AAATATTACCGCTGCGGTAACTAGCGTGATTAATACCGTTAAACAAGATGGCGATGCTGGCGTGTTAGCGTTGACTGAAA
AGTTTGATAAGGTGAAACCTGAATCCATTCGTGTATCTAAATCAGAGATTGATGCGGCAAGTGAACGTTTATCTGAAAAG
ATGAAAGCGGCACTGCAACAAGCTTATAGCAATATTTCTAAGTTTCATAAAGCACAAAAGCCTCAGCCAATCAAAGTTGA
AACTCAACCTGGTGTCGTATGTGAACAAATCACGATGCCAGTGAATAAAGTCGGCTTGTATATTCCGGGTGGCAGTGCAC
CATTGCCTTCAACAGTATTAATGTTAGGCATTCCTGCACAGATTGCGGGCTGTCATAAAGTGGTACTTTGTTCGCCACCG
CCGATTGCTGATGAGATCTTATACGTTGCAAAACTATGTAAAGTCGATGAGGTGTATAACATTGGTGGCGCACAAGCGAT
TGCTGCTATGGCGTATGGTACTGAATCTGTTTCTAAAGTAGATAAGATCTTTGGCCCAGGTAACGCATACGTCACTGAAG
CAAAACGCCAAGTTTCTAATGACTTTCGTGGTGCTGCTATTGATATGCCTGCGGGACCTTCTGAAGTCTTGGTTATTGCG
GATGAAACGGCTGATCCTGATTTTATTGCGGCAGATCTTCTTAGCCAAGCTGAACATGGTCCTGATTCACAAGTTATCTT
AGTCACGCCTTCGCCAATCATCGCTGATCAAGTTGCTGATGCCATCGAGAAGCAATTAAAAGAACTGACTCGTGCGGATA
TCGCTCGTCAAGCGCTAGGTTCTAGTTTGTTGATTATTGCTAAATCATTGACGCAATGTGTTTCAATCTCAAACTTTTAT
GGTCCTGAGCACTTGATTGTTCAAACTAAAAACCCACGTGAATTATTACCATTGCTAGATAATGCAGGTTCTATTTTCTT
GGGTGAGTATTCTCCAGAATCAGCAGGGGATTATGCATCGGGTACAAACCATGTTTTACCAACTTATGGTTATACAAGAA
CGCACTCAAGCTTAGGTTTAGCTGATTTTTCTAAACGCATGACAGTACAAGAGTTAACTGCTGATGGTTTAAAAGGGTTA
GCGCCAACGGTTGTCACAATGGCTGATGCTGAAGGGCTAGATGCACATAAACGTGCCGTGACTATTCGAATTGAAAAATT
AGCTAAATTGAATTAA

Upstream 100 bases:

>100_bases
GTACTGAAAATCTATTCTGGGAAACGATGGAACAACTAAAAGCATTGGGTGCGAGCTCTATTCTTGTTCTTCCAATTGAG
AAGATGATGGAGTAACCATT

Downstream 100 bases:

>100_bases
TAGAGACCATAGATATGGAAAAATTAGCTCGTAAACAAGTTCAAGCCTTGACGCCGTATCTATCGGCTCGTCGTATTGGT
GGCAGTGGTGATGTTTGGCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKTLVWQSLSNSQQDTVLQRPAITEGANITAAVTSVINTVKQDGDAGVLALTEKFDKVKPESIRVSKSEIDAASERLSEK
MKAALQQAYSNISKFHKAQKPQPIKVETQPGVVCEQITMPVNKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPP
PIADEILYVAKLCKVDEVYNIGGAQAIAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADPDFIAADLLSQAEHGPDSQVILVTPSPIIADQVADAIEKQLKELTRADIARQALGSSLLIIAKSLTQCVSISNFY
GPEHLIVQTKNPRELLPLLDNAGSIFLGEYSPESAGDYASGTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTADGLKGL
APTVVTMADAEGLDAHKRAVTIRIEKLAKLN

Sequences:

>Translated_431_residues
MKTLVWQSLSNSQQDTVLQRPAITEGANITAAVTSVINTVKQDGDAGVLALTEKFDKVKPESIRVSKSEIDAASERLSEK
MKAALQQAYSNISKFHKAQKPQPIKVETQPGVVCEQITMPVNKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPP
PIADEILYVAKLCKVDEVYNIGGAQAIAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADPDFIAADLLSQAEHGPDSQVILVTPSPIIADQVADAIEKQLKELTRADIARQALGSSLLIIAKSLTQCVSISNFY
GPEHLIVQTKNPRELLPLLDNAGSIFLGEYSPESAGDYASGTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTADGLKGL
APTVVTMADAEGLDAHKRAVTIRIEKLAKLN
>Mature_431_residues
MKTLVWQSLSNSQQDTVLQRPAITEGANITAAVTSVINTVKQDGDAGVLALTEKFDKVKPESIRVSKSEIDAASERLSEK
MKAALQQAYSNISKFHKAQKPQPIKVETQPGVVCEQITMPVNKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPP
PIADEILYVAKLCKVDEVYNIGGAQAIAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADPDFIAADLLSQAEHGPDSQVILVTPSPIIADQVADAIEKQLKELTRADIARQALGSSLLIIAKSLTQCVSISNFY
GPEHLIVQTKNPRELLPLLDNAGSIFLGEYSPESAGDYASGTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTADGLKGL
APTVVTMADAEGLDAHKRAVTIRIEKLAKLN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=65.6398104265403, Blast_Score=569, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=49.2857142857143, Blast_Score=398, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45898; Mature: 45898

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLVWQSLSNSQQDTVLQRPAITEGANITAAVTSVINTVKQDGDAGVLALTEKFDKVKP
CCCEEHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCC
ESIRVSKSEIDAASERLSEKMKAALQQAYSNISKFHKAQKPQPIKVETQPGVVCEQITMP
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCC
VNKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKVDEVYN
HHHEEEEECCCCCCCCCEEEEEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
IGGAQAIAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADPDFIAADLLSQAEHGPDSQVILVTPSPIIADQVADAIEKQLKELTRADIARQALG
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SSLLIIAKSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGEYSPESAGDYAS
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTADGLKGLAPTVVTMADAEGLDAHKRAV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHEE
TIRIEKLAKLN
EEEEHHHHCCC
>Mature Secondary Structure
MKTLVWQSLSNSQQDTVLQRPAITEGANITAAVTSVINTVKQDGDAGVLALTEKFDKVKP
CCCEEHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCC
ESIRVSKSEIDAASERLSEKMKAALQQAYSNISKFHKAQKPQPIKVETQPGVVCEQITMP
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCC
VNKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKVDEVYN
HHHEEEEECCCCCCCCCEEEEEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
IGGAQAIAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADPDFIAADLLSQAEHGPDSQVILVTPSPIIADQVADAIEKQLKELTRADIARQALG
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SSLLIIAKSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGEYSPESAGDYAS
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTADGLKGLAPTVVTMADAEGLDAHKRAV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHEE
TIRIEKLAKLN
EEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA