Click here to switch to the map view.

The map label for this gene is thiL [H]

Identifier: 209694496

GI number: 209694496

Start: 1024736

End: 1025728

Strand: Direct

Name: thiL [H]

Synonym: VSAL_I0927

Alternate gene names: 209694496

Gene position: 1024736-1025728 (Clockwise)

Preceding gene: 209694495

Following gene: 209694497

Centisome position: 30.82

GC content: 37.46

Gene sequence:

>993_bases
ATGACCAGTGAATTTAATTTAATTGAACGGTTCTTTGTTGAAGGGAACTTATCAAGAAAAGACGTAGAACTTGGTATTGG
AGATGATTGCGCTTTAGTGTCAGTACCAGAAAATCACCATGTAGCCATTACGACAGATACTTTAGCTGCAGGAACTCATT
TTCTTTTAACTGCTGACCCTGTCAATGTTGGTTACAAAGCGCTTGCTTCAAATTTAAGTGACTTAGCTGCGATGGGAGCA
AAACCTACATGGGTGTCTTTGGCATTAACATTACCAGAGCCAAATGAAGAATGGCTTAAAGGGTTCTGTGAAGGTTTTTT
TTGTTTAGCGAAATTGCATAACGTGCAACTTATCGGTGGAGATACAACAAAAGGGCCATTAAGTATTACAATTACAGTTC
AAGGTATTGTTCCAAAGGGGGAAGCGATGACTCGTAAAGGTGCACTCTGCGGTGATGATATTTATGTGACAGGAACATTA
GGTGATAGCGCTGCAGGTCTTGAGGTTATCCTTGAACAGACAAATGATATTGAATTACCCTTAGCAAAAGAGCTTGAACA
TCGACATTATTATTCATCACCACGAATCGAATTAGCGCAAGAAATACGTCATTTATGCCATTCGGCACTGGATATTTCTG
ATGGTGTAATTTCTGATTTAGGCCATATACTGAAACAATCAAACGTGAATGCATTATTAGAAGTCACTCTTTTGCCTATC
TCTAATGAGCTAAAATCTTATCATCATGGTGATGATGAGAAGTGTCAAAAAATGGCATTAATAAGTGGAGAAGAATATGA
ACTTTGCTTTACTGCACCAAGAGAGAATCGCGAAGCAATAAAAAAAATAACGACTCTTTTAAATCAAAACGTTAGTATAA
TTGGTGAAATAACACAGGGTCCATTTACTAATTTACAGAGTGGCGTACAATTAGTGAAAGAAGGCAAGCAATTAGATTGG
AGTCTATACGGTTACGATCATTTCAGGAGTTAA

Upstream 100 bases:

>100_bases
GTAAAAAGTAAGTTGGAATTAGCATACTAATTAATACTAAAGGTCAGCTAATTGCTGGCCTTTTTTATATCTTAAATACA
AGATAAGAATACTTAATAAT

Downstream 100 bases:

>100_bases
GCATGACAAATCCATTAGCACTTATTAGTTTAAAAAATCCGTGGCATTTATTAGCGACAGGCTTTGGCAGTGGTTTGGCT
CCTATTATTCCGGGAACGAT

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTSEFNLIERFFVEGNLSRKDVELGIGDDCALVSVPENHHVAITTDTLAAGTHFLLTADPVNVGYKALASNLSDLAAMGA
KPTWVSLALTLPEPNEEWLKGFCEGFFCLAKLHNVQLIGGDTTKGPLSITITVQGIVPKGEAMTRKGALCGDDIYVTGTL
GDSAAGLEVILEQTNDIELPLAKELEHRHYYSSPRIELAQEIRHLCHSALDISDGVISDLGHILKQSNVNALLEVTLLPI
SNELKSYHHGDDEKCQKMALISGEEYELCFTAPRENREAIKKITTLLNQNVSIIGEITQGPFTNLQSGVQLVKEGKQLDW
SLYGYDHFRS

Sequences:

>Translated_330_residues
MTSEFNLIERFFVEGNLSRKDVELGIGDDCALVSVPENHHVAITTDTLAAGTHFLLTADPVNVGYKALASNLSDLAAMGA
KPTWVSLALTLPEPNEEWLKGFCEGFFCLAKLHNVQLIGGDTTKGPLSITITVQGIVPKGEAMTRKGALCGDDIYVTGTL
GDSAAGLEVILEQTNDIELPLAKELEHRHYYSSPRIELAQEIRHLCHSALDISDGVISDLGHILKQSNVNALLEVTLLPI
SNELKSYHHGDDEKCQKMALISGEEYELCFTAPRENREAIKKITTLLNQNVSIIGEITQGPFTNLQSGVQLVKEGKQLDW
SLYGYDHFRS
>Mature_329_residues
TSEFNLIERFFVEGNLSRKDVELGIGDDCALVSVPENHHVAITTDTLAAGTHFLLTADPVNVGYKALASNLSDLAAMGAK
PTWVSLALTLPEPNEEWLKGFCEGFFCLAKLHNVQLIGGDTTKGPLSITITVQGIVPKGEAMTRKGALCGDDIYVTGTLG
DSAAGLEVILEQTNDIELPLAKELEHRHYYSSPRIELAQEIRHLCHSALDISDGVISDLGHILKQSNVNALLEVTLLPIS
NELKSYHHGDDEKCQKMALISGEEYELCFTAPRENREAIKKITTLLNQNVSIIGEITQGPFTNLQSGVQLVKEGKQLDWS
LYGYDHFRS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=327, Percent_Identity=49.8470948012232, Blast_Score=306, Evalue=9e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 36142; Mature: 36011

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEFNLIERFFVEGNLSRKDVELGIGDDCALVSVPENHHVAITTDTLAAGTHFLLTADP
CCCCHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCEEEEEECHHCCCCEEEEEECC
VNVGYKALASNLSDLAAMGAKPTWVSLALTLPEPNEEWLKGFCEGFFCLAKLHNVQLIGG
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECC
DTTKGPLSITITVQGIVPKGEAMTRKGALCGDDIYVTGTLGDSAAGLEVILEQTNDIELP
CCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHEEECCCCCCCC
LAKELEHRHYYSSPRIELAQEIRHLCHSALDISDGVISDLGHILKQSNVNALLEVTLLPI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEECC
SNELKSYHHGDDEKCQKMALISGEEYELCFTAPRENREAIKKITTLLNQNVSIIGEITQG
CHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCC
PFTNLQSGVQLVKEGKQLDWSLYGYDHFRS
CCHHHHHHHHHHHCCCCCEEEEECCHHCCC
>Mature Secondary Structure 
TSEFNLIERFFVEGNLSRKDVELGIGDDCALVSVPENHHVAITTDTLAAGTHFLLTADP
CCCHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCEEEEEECHHCCCCEEEEEECC
VNVGYKALASNLSDLAAMGAKPTWVSLALTLPEPNEEWLKGFCEGFFCLAKLHNVQLIGG
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECC
DTTKGPLSITITVQGIVPKGEAMTRKGALCGDDIYVTGTLGDSAAGLEVILEQTNDIELP
CCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCEEEEEECCCCCCCHHHEEECCCCCCCC
LAKELEHRHYYSSPRIELAQEIRHLCHSALDISDGVISDLGHILKQSNVNALLEVTLLPI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEECC
SNELKSYHHGDDEKCQKMALISGEEYELCFTAPRENREAIKKITTLLNQNVSIIGEITQG
CHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCC
PFTNLQSGVQLVKEGKQLDWSLYGYDHFRS
CCHHHHHHHHHHHCCCCCEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]