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The map label for this gene is dapA2 [H]

Identifier: 209694473

GI number: 209694473

Start: 1000299

End: 1001192

Strand: Direct

Name: dapA2 [H]

Synonym: VSAL_I0899

Alternate gene names: 209694473

Gene position: 1000299-1001192 (Clockwise)

Preceding gene: 209694471

Following gene: 209694474

Centisome position: 30.08

GC content: 40.49

Gene sequence:

>894_bases
ATGAAAAAGTTAACAGGTTTAATTGCAGCTCCACATACTCCATTCGATAGTTCAAGTAACGTTAATTTTGAAGAGATTGA
TAAAATTGCCAAGCATTTAATTAATGATGGCGTAAAAGGTATTTATGTCTGTGGCACAACAGGTGAAGGCATTCATTGCA
GCGTAGAAGAACGTAAAGCAATTGCTGAACGCTGGGTAAGTGCTTGTAATCATAAACTCGACATCATTGTTCACACTGGT
GCGCTTAGCATTGTAGATACATTAGAACTAACTCGTCATGCCGATACGCTTGATATTTTAGCGACCTCAGCCATTGGTCC
TTGTTTCTTTAAACCAGGTAGCGTGTCTGACCTAGTGGAATACTGTGCAACTATCGCGGCAGCAGCTCCATCTAAAGGTT
TCTATTACTATCATTCGGGAATGTCTGGCGTAAACTTGAATATGGAAGAATTTTTAATCCAAGCCGATAAACGCATTCCT
AACTTATCTGGTTTAAAATTTAACAGCGGTGATTTATACGAATACCAACGTTGTCTTCGTGCTTGTGATGGTAAATTTGA
TGTACCGTTTGGTGTTGATGAGTTCCTACCCGGCGCATTAGCCGTTGGTGCAAAAAGTGCAGTAGGCAGTACTTATAACT
ACGCAGCACCTCACTTTAATTCTATTATTGAGGCTTTCAATAAGGGTGACCACGACGCTGTATTTAATAAAATGACCAAC
GTTATTGAATTAATCCGAGTGCTGGTTGAGTTTGGTGGTGTGGCCGCAGGAAAAATCGCGATGGAACTTCACGACATTAA
TGCTGGTGATCCTCGTTTACCACTAATGCCGCTAAGCGCAGAGCAAAAGTTAACGGTCGTTGAAAAAATGAGAGCCGCAA
ATTTTCTTAAATAA

Upstream 100 bases:

>100_bases
CATATTGCAAAATGAAACTTTACTCCATAGTATTAGTTTAACTCCAAAGTATTTAAATTAATGAAGAATGACTTCAAAAA
GATAATCTAATGAGGATGAC

Downstream 100 bases:

>100_bases
AGAATAACTTAGTTAACCACACGCCTTAATTTAGCTCCTAAGCTGAAAAACGTTTCCCCTTACGTTTTTCAGCTTTTTTT
AATCTATGTTTTCCTTATTT

Product: dihydropicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKKLTGLIAAPHTPFDSSSNVNFEEIDKIAKHLINDGVKGIYVCGTTGEGIHCSVEERKAIAERWVSACNHKLDIIVHTG
ALSIVDTLELTRHADTLDILATSAIGPCFFKPGSVSDLVEYCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKRIP
NLSGLKFNSGDLYEYQRCLRACDGKFDVPFGVDEFLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNKGDHDAVFNKMTN
VIELIRVLVEFGGVAAGKIAMELHDINAGDPRLPLMPLSAEQKLTVVEKMRAANFLK

Sequences:

>Translated_297_residues
MKKLTGLIAAPHTPFDSSSNVNFEEIDKIAKHLINDGVKGIYVCGTTGEGIHCSVEERKAIAERWVSACNHKLDIIVHTG
ALSIVDTLELTRHADTLDILATSAIGPCFFKPGSVSDLVEYCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKRIP
NLSGLKFNSGDLYEYQRCLRACDGKFDVPFGVDEFLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNKGDHDAVFNKMTN
VIELIRVLVEFGGVAAGKIAMELHDINAGDPRLPLMPLSAEQKLTVVEKMRAANFLK
>Mature_297_residues
MKKLTGLIAAPHTPFDSSSNVNFEEIDKIAKHLINDGVKGIYVCGTTGEGIHCSVEERKAIAERWVSACNHKLDIIVHTG
ALSIVDTLELTRHADTLDILATSAIGPCFFKPGSVSDLVEYCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKRIP
NLSGLKFNSGDLYEYQRCLRACDGKFDVPFGVDEFLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNKGDHDAVFNKMTN
VIELIRVLVEFGGVAAGKIAMELHDINAGDPRLPLMPLSAEQKLTVVEKMRAANFLK

Specific function: Important in N-acetylneuraminate lyase reaction [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=39.8671096345515, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1789620, Length=264, Percent_Identity=28.4090909090909, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082415, Length=233, Percent_Identity=24.8927038626609, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786463, Length=230, Percent_Identity=24.7826086956522, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32201; Mature: 32201

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00665 DHDPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTGLIAAPHTPFDSSSNVNFEEIDKIAKHLINDGVKGIYVCGTTGEGIHCSVEERKA
CCCHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECHHHHHH
IAERWVSACNHKLDIIVHTGALSIVDTLELTRHADTLDILATSAIGPCFFKPGSVSDLVE
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHH
YCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKRIPNLSGLKFNSGDLYEYQRCLR
HHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHH
ACDGKFDVPFGVDEFLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNKGDHDAVFNKMTN
HCCCCCCCCCCHHHHCCCHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VIELIRVLVEFGGVAAGKIAMELHDINAGDPRLPLMPLSAEQKLTVVEKMRAANFLK
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLTGLIAAPHTPFDSSSNVNFEEIDKIAKHLINDGVKGIYVCGTTGEGIHCSVEERKA
CCCHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECHHHHHH
IAERWVSACNHKLDIIVHTGALSIVDTLELTRHADTLDILATSAIGPCFFKPGSVSDLVE
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHH
YCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKRIPNLSGLKFNSGDLYEYQRCLR
HHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHH
ACDGKFDVPFGVDEFLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNKGDHDAVFNKMTN
HCCCCCCCCCCHHHHCCCHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VIELIRVLVEFGGVAAGKIAMELHDINAGDPRLPLMPLSAEQKLTVVEKMRAANFLK
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]