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The map label for this gene is uvrD [H]

Identifier: 209693834

GI number: 209693834

Start: 264252

End: 266456

Strand: Direct

Name: uvrD [H]

Synonym: VSAL_I0222

Alternate gene names: 209693834

Gene position: 264252-266456 (Clockwise)

Preceding gene: 209693833

Following gene: 209693836

Centisome position: 7.95

GC content: 42.99

Gene sequence:

>2205_bases
ATGGACGTTTCTTTTCTTCTTGATGGTCTTAATGACAAACAGCGCGAAGCCGTAGCCGCTCCGTTAGAAAACATGCTTGT
ACTTGCGGGTGCCGGTAGTGGTAAAACTCGAGTACTTGTTCATCGTATCGCATGGTTAATGCAAATCGAGCAAGCGTCGC
CCTTCTCAATTATGTCGGTGACATTTACCAATAAAGCCGCCGCTGAAATGCGTGGTCGTATTGAAGAATTAATGCATGGC
AGCGCAGGGGGAATGTGGAACGGTACTTTTCATGGTATTTGTCACCGTATTCTTCGTGCTCATTATCTTGATGCGAAACT
GCCTGAAGGTTTTCAGATCATCGACTCTGATGATCAACAACGCTTATTAAAGCGTTTGATTAAAGCGCAGAACTTGGATG
ATAAAAACTGGCCTGCACGTCAAGCTGCATGGTTCATCAATGGGAAAAAAGATGAAGGTTTACGCCCGCATCAAATTAAC
TCATTTAATGATCCTATCGCTGAAACATGGTTAAAAGTGTATCGCGCTTATCAAGAAGCTTGTGATCGTTCAGGCTTGGT
CGATTTTGCTGAAATTCTTCTTCGTGCTCATGAACTATTGCGTGATCATCAGTATATCTGCGAACACTACCAAGCTCGCT
TTAAGCACATTCTTGTCGACGAATTCCAAGATACGAACAACATTCAATATGCATGGCTACGTATGATGGCAGGCTCGGAT
TGTAAGGTCATGATCGTTGGGGATGATGATCAATCAATCTATGGTTGGCGTGGTGCTCAAATTGAAAATATTCAACGATT
CTTAAATGAATTTGTTGGTGCTAAAACCATCCTTTTAGAGCAAAACTACCGTTCAACAGCCAATATATTGAATGCTGCCA
ATGAATTGATCAGTAACAATACCGAGCGAATGGGCAAAGAGCTGTGGACTGAAGACGCTGATGGCGAGTTGATTTCAATC
TATTCAGCTTACAATGAAATGGACGAAGCTCGTTTTGCGGTTGGAAAAATTAAAGAATGGCGCGATAACGGGGGAGCATT
AGAAGATACCGCTTTCTTATATCGTAATAATGCTCAATCTCGAGTTCTTGAAGAAGCCTTAATACAAGCAGGTTTACCTT
ATCGTATTTATGGTGGGATGCGATTCTTTGAACGTCAAGAAATCAAAGATGCACTGTCCTACTTACGTTTAATGAATAAT
CGTAATGATGATGCTGCGTTTGAACGTGTCGTAAATACGCCAACACGAGGCCTAGGTGACAAAACTCTGGAAACTGTGCG
TTTGGCAGCGCGTGAACGTGGTGCAACCATGTGGCAAGCAAGTATTGCCTTAATCGAAGAACAAGTATTACCTGGGCGTG
CGGCGGGAGCGTTAGGTCGTTTCGTTGAGCTAATTAATGCGCTAGAAGATGATACACGTGATTGCCGTCTGCATGAACAA
ACTGACCAAGTGATTAAAAGCTCGGGTTTGTTTACTATGTACGAACAAGAAAAAGGCGAAAAATCGAAAGCGCGTATTGA
AAACTTGGAAGAATTAGTGACCGCAACGCGTCAATTTGATAAACCTGAAGAAGCAGAAGAAATGACGGATTTAACCGCAT
TCTTGACGCATGCCGCATTAGAAGCGGGTGATGGTCAGGCGGATGAATTTGAAGATGCGGTGCAATTAATGACGTTGCAC
AGTGCAAAAGGGTTAGAGTTTCCTTTGGTCTTTATGGTGGGTGTTGAAGAGGGTATGTTCCCAAGTCAAATGTCAGCAGA
AGAAGCAGGGCGTTTAGAAGAAGAACGTCGTCTTTGTTATGTTGGTATGACTCGTGCGATGGAGAAGCTCTATATTCTTT
ACGCAGAAACTCGTCGAGTGTATGGGCAAGAGAAATTTCATAAGCCATCACGCTTTATTAAAGAAATCTCGGCAAAGTTT
GTTGAAGAAGTTCGCATGAAAGCAAAAGTCAGCCGAACCAGTTTATATGGTAGCTATGGCTCTCAAAGTGAGTCATCCCA
AGAGCGTTTTGGTCAAACGGCAATGAGTAATAGCTTTAATGAAACGGGCTACAATTTAGGGCAGCGAGTGAAGCATCCTA
AATTTGGTGAAGGAACGATCATCAATTTTGAAGGTGCTGGCCCACAAGGGCGTGTTCAGGTTGCTTTTAATGGTGAAGGG
ATCAAATGGCTTGTAACGCAATACGCGAAATTAGAGTCGGTGTAA

Upstream 100 bases:

>100_bases
ACTTTCCTGATTATGGGTGTGCTGTAAAAAGACACCGTTTGGGTCTCACTTCATTTCAGTATATACTCCACTCACATGTA
TAAATAACCAGTGTGATGTG

Downstream 100 bases:

>100_bases
TTTAATTGATATTTTTAACAATAAAAAGAGTCTATATAATATAGGCTCTTTTTTTATGTTCTATATTACCTTGACGTTTA
GTCTAACAATGGGCTTAAAA

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 734; Mature: 734

Protein sequence:

>734_residues
MDVSFLLDGLNDKQREAVAAPLENMLVLAGAGSGKTRVLVHRIAWLMQIEQASPFSIMSVTFTNKAAAEMRGRIEELMHG
SAGGMWNGTFHGICHRILRAHYLDAKLPEGFQIIDSDDQQRLLKRLIKAQNLDDKNWPARQAAWFINGKKDEGLRPHQIN
SFNDPIAETWLKVYRAYQEACDRSGLVDFAEILLRAHELLRDHQYICEHYQARFKHILVDEFQDTNNIQYAWLRMMAGSD
CKVMIVGDDDQSIYGWRGAQIENIQRFLNEFVGAKTILLEQNYRSTANILNAANELISNNTERMGKELWTEDADGELISI
YSAYNEMDEARFAVGKIKEWRDNGGALEDTAFLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYLRLMNN
RNDDAAFERVVNTPTRGLGDKTLETVRLAARERGATMWQASIALIEEQVLPGRAAGALGRFVELINALEDDTRDCRLHEQ
TDQVIKSSGLFTMYEQEKGEKSKARIENLEELVTATRQFDKPEEAEEMTDLTAFLTHAALEAGDGQADEFEDAVQLMTLH
SAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMEKLYILYAETRRVYGQEKFHKPSRFIKEISAKF
VEEVRMKAKVSRTSLYGSYGSQSESSQERFGQTAMSNSFNETGYNLGQRVKHPKFGEGTIINFEGAGPQGRVQVAFNGEG
IKWLVTQYAKLESV

Sequences:

>Translated_734_residues
MDVSFLLDGLNDKQREAVAAPLENMLVLAGAGSGKTRVLVHRIAWLMQIEQASPFSIMSVTFTNKAAAEMRGRIEELMHG
SAGGMWNGTFHGICHRILRAHYLDAKLPEGFQIIDSDDQQRLLKRLIKAQNLDDKNWPARQAAWFINGKKDEGLRPHQIN
SFNDPIAETWLKVYRAYQEACDRSGLVDFAEILLRAHELLRDHQYICEHYQARFKHILVDEFQDTNNIQYAWLRMMAGSD
CKVMIVGDDDQSIYGWRGAQIENIQRFLNEFVGAKTILLEQNYRSTANILNAANELISNNTERMGKELWTEDADGELISI
YSAYNEMDEARFAVGKIKEWRDNGGALEDTAFLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYLRLMNN
RNDDAAFERVVNTPTRGLGDKTLETVRLAARERGATMWQASIALIEEQVLPGRAAGALGRFVELINALEDDTRDCRLHEQ
TDQVIKSSGLFTMYEQEKGEKSKARIENLEELVTATRQFDKPEEAEEMTDLTAFLTHAALEAGDGQADEFEDAVQLMTLH
SAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMEKLYILYAETRRVYGQEKFHKPSRFIKEISAKF
VEEVRMKAKVSRTSLYGSYGSQSESSQERFGQTAMSNSFNETGYNLGQRVKHPKFGEGTIINFEGAGPQGRVQVAFNGEG
IKWLVTQYAKLESV
>Mature_734_residues
MDVSFLLDGLNDKQREAVAAPLENMLVLAGAGSGKTRVLVHRIAWLMQIEQASPFSIMSVTFTNKAAAEMRGRIEELMHG
SAGGMWNGTFHGICHRILRAHYLDAKLPEGFQIIDSDDQQRLLKRLIKAQNLDDKNWPARQAAWFINGKKDEGLRPHQIN
SFNDPIAETWLKVYRAYQEACDRSGLVDFAEILLRAHELLRDHQYICEHYQARFKHILVDEFQDTNNIQYAWLRMMAGSD
CKVMIVGDDDQSIYGWRGAQIENIQRFLNEFVGAKTILLEQNYRSTANILNAANELISNNTERMGKELWTEDADGELISI
YSAYNEMDEARFAVGKIKEWRDNGGALEDTAFLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYLRLMNN
RNDDAAFERVVNTPTRGLGDKTLETVRLAARERGATMWQASIALIEEQVLPGRAAGALGRFVELINALEDDTRDCRLHEQ
TDQVIKSSGLFTMYEQEKGEKSKARIENLEELVTATRQFDKPEEAEEMTDLTAFLTHAALEAGDGQADEFEDAVQLMTLH
SAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMEKLYILYAETRRVYGQEKFHKPSRFIKEISAKF
VEEVRMKAKVSRTSLYGSYGSQSESSQERFGQTAMSNSFNETGYNLGQRVKHPKFGEGTIINFEGAGPQGRVQVAFNGEG
IKWLVTQYAKLESV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=734, Percent_Identity=70.1634877384196, Blast_Score=1073, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=636, Percent_Identity=38.3647798742138, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=27.9411764705882, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=760, Percent_Identity=27.1052631578947, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324477, Length=694, Percent_Identity=22.7665706051873, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83404; Mature: 83404

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSFLLDGLNDKQREAVAAPLENMLVLAGAGSGKTRVLVHRIAWLMQIEQASPFSIMSV
CCHHHHHCCCCHHHHHHHHCCHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
TFTNKAAAEMRGRIEELMHGSAGGMWNGTFHGICHRILRAHYLDAKLPEGFQIIDSDDQQ
EECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHH
RLLKRLIKAQNLDDKNWPARQAAWFINGKKDEGLRPHQINSFNDPIAETWLKVYRAYQEA
HHHHHHHHHCCCCCCCCCCHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CDRSGLVDFAEILLRAHELLRDHQYICEHYQARFKHILVDEFQDTNNIQYAWLRMMAGSD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
CKVMIVGDDDQSIYGWRGAQIENIQRFLNEFVGAKTILLEQNYRSTANILNAANELISNN
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCC
TERMGKELWTEDADGELISIYSAYNEMDEARFAVGKIKEWRDNGGALEDTAFLYRNNAQS
HHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHH
RVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYLRLMNNRNDDAAFERVVNTPTRGLGD
HHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
KTLETVRLAARERGATMWQASIALIEEQVLPGRAAGALGRFVELINALEDDTRDCRLHEQ
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCHHHHH
TDQVIKSSGLFTMYEQEKGEKSKARIENLEELVTATRQFDKPEEAEEMTDLTAFLTHAAL
HHHHHHHCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EAGDGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCY
HCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCHHHHHHHHH
VGMTRAMEKLYILYAETRRVYGQEKFHKPSRFIKEISAKFVEEVRMKAKVSRTSLYGSYG
HHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SQSESSQERFGQTAMSNSFNETGYNLGQRVKHPKFGEGTIINFEGAGPQGRVQVAFNGEG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEEECCCC
IKWLVTQYAKLESV
HHHHHHHHHHHCCC
>Mature Secondary Structure
MDVSFLLDGLNDKQREAVAAPLENMLVLAGAGSGKTRVLVHRIAWLMQIEQASPFSIMSV
CCHHHHHCCCCHHHHHHHHCCHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
TFTNKAAAEMRGRIEELMHGSAGGMWNGTFHGICHRILRAHYLDAKLPEGFQIIDSDDQQ
EECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHH
RLLKRLIKAQNLDDKNWPARQAAWFINGKKDEGLRPHQINSFNDPIAETWLKVYRAYQEA
HHHHHHHHHCCCCCCCCCCHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CDRSGLVDFAEILLRAHELLRDHQYICEHYQARFKHILVDEFQDTNNIQYAWLRMMAGSD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
CKVMIVGDDDQSIYGWRGAQIENIQRFLNEFVGAKTILLEQNYRSTANILNAANELISNN
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCC
TERMGKELWTEDADGELISIYSAYNEMDEARFAVGKIKEWRDNGGALEDTAFLYRNNAQS
HHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHH
RVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYLRLMNNRNDDAAFERVVNTPTRGLGD
HHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
KTLETVRLAARERGATMWQASIALIEEQVLPGRAAGALGRFVELINALEDDTRDCRLHEQ
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCHHHHH
TDQVIKSSGLFTMYEQEKGEKSKARIENLEELVTATRQFDKPEEAEEMTDLTAFLTHAAL
HHHHHHHCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EAGDGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCY
HCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCHHHHHHHHH
VGMTRAMEKLYILYAETRRVYGQEKFHKPSRFIKEISAKFVEEVRMKAKVSRTSLYGSYG
HHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SQSESSQERFGQTAMSNSFNETGYNLGQRVKHPKFGEGTIINFEGAGPQGRVQVAFNGEG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEEECCCC
IKWLVTQYAKLESV
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]