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The map label for this gene is prlC [H]

Identifier: 209693745

GI number: 209693745

Start: 156846

End: 158888

Strand: Direct

Name: prlC [H]

Synonym: VSAL_I0122

Alternate gene names: 209693745

Gene position: 156846-158888 (Clockwise)

Preceding gene: 209693742

Following gene: 209693748

Centisome position: 4.72

GC content: 43.42

Gene sequence:

>2043_bases
ATGTCTAATCCGTTACTTACCTTTACTGACTTGCCTCTTTTTTCTCAAATTAAGCCAGAACACATTCAACCTGCAGTAGA
ACAAGCGATTGCAGATTGCCGAGCTAAAATAGAAGACGTATTGGCGTCTGATGCCGTACCAAGTTGGAACAGCATTATTG
TTCCCCTTGCTGAAACGGATGATCGTCTAAGCCGCATTTGGTCACCAGTGAGTCATTTGAATTCAGTGCAAAACAGTGAA
GCCCTGCGTGAAGCGTATGAAGCGTGCTTACCTATCCTTTCCGAGTACGGAACTTGGGTTGGGCAGAACAAAGCGCTCTA
TCACGCCTATAAAGAAATCAAAGCGAGTGCCGATTTTTCTGCACTTTCTCAAGCTCAACAAAAAACCATTATTGATGAAT
TGCGTGATTTTGAATTATCAGGCATTGGTTTACCCGCTGATCAACAAAAGCGTTACGGTGATATCAGTAAGCGCACGTCA
GAATTAAGCTCAAATTTCAGCAACAATGTGCTTGATGCAACCATGGGTTGGTCAAAGCATATTACGGATGAAGCCGAATT
ATCAGGGTTACCTGAATCGGCGATGTCAGCGGCGAAAGCGGCGGCAGAAGCAAAAGAATTAGACGGTTGGTTACTGACAT
TAGAGATGCCATCGTACATTCCAGTCATGACGTACAGTGACAATAAACCACTGCGCCGTGAAATTTACGAAGCGTTTGTG
ACTCGTGCATCGGATCGTGGTCCAAATGCCGGTAAGTGGGATAACACCGATCTTATTTCAGAAGAGCTTAATCTTCGTCA
TGAAGTCTCGCGCCTATTGGGTTTCTCTTCGTACAGTGAAAAATCGTTAGCAACAAAAATGGCCGAGAGCCCAACGCAAG
TCCTTGGTTTTTTAAATGACTTAGCAGCGAAGGCTAAACCACAAGGTGAGCGCGAAGTTGCAGAGCTAAAAGCGTTTGTA
AAAGAAGAGTTTGATATTGATGAGTTGGATCTATGGGATGTGACTTATTACTCTGAAAAATTAAAGCAAAAGCTATATCA
GATTTCAGATGAAGAATTACGTCCTTACTTCCCTGAATCAAAAGCCGTCTCTGGCCTATTTGAAGTGCTAAACCGTGTGT
TTGGTATGACAGTGGTAGAGCGTGAAGGCGTTGATGTATGGCACGAATCAGTGCGTTTCTTTGATATCTTCGATTCAACC
AACACCTTACGTGGCAGCTTCTATTTAGATTTATACGCGCGTGAACACAAACGTGGTGGTGCATGGATGGATGAATGTCG
TGTTCGTCGTTTAACTGAAAATGGTGAACTGCAAACGCCTGTCGCGTATTTAACGTGTAACTTCAGTAAGCCTGTTGGTG
GTAAGCCTGCATTATTTACTCATGATGAAGTAGTGACGTTATTTCACGAATTTGGTCATGGTATCCACCACATGCTAACG
CAAATTGATGTAGCGTCAGTGTCGGGTATTAATGGTGTGCCTTGGGATGCGGTTGAGCTACCAAGTCAATTCTTAGAAAA
CTGGTGTTATGAAGAAGAAGCACTCGCGTTTATTTCTGGTCACTATGAAACGGGTGAGCCATTACCAAAAGAAATGTTAG
ATAAAATGCTGGCGGCGAAAAACTTCCAATCAGCGATGTTTATTTTGCGTCAGTTAGAATTCGGGATGTTCGATTTCACA
CTGCACACAAATTACGATCCAGATCTAGGTGCAAAAGTATTAGAAACCCTAGCAGAAGTAAAAGCAAAGGTAGCGGTATT
ACCTAGTGTCGAGTGGAACCGTTTTTCTCACAGCTTTAGTCATATTTTCGCGGGTGGTTACGGTGCGGGTTATTACAGCT
ATCTATGGGCAGAAGTATTATCAGCCGATGCGTTCTCGCGTTTTGAAGAAGAAGGAATTTTCAACACGGAAACAGGCCAA
AGCTTCTTGAATAATATTCTTGAAATGGGCGGCAGTGAAGAACCTATGGAATTGTTTAAACGCTTCCGTGGTCGTGAACC
ACAAGTGGATGCCATGTTACGTCATGCGGGCATTGGTGCGTAA

Upstream 100 bases:

>100_bases
ATGTGCACACTCTTGCATCACCCATTGAAATTTAATCCATTAAGCACCATCTTAAGTAGATAGCGACATCAAATCGAATA
AGAAATAAAAAGGAATGAAT

Downstream 100 bases:

>100_bases
TAAACTAAGCAAGTAAGTGCCATAAATAAAACGCCTCAATCATTATATTGAGGCGTTTTTTGTTTTAAAGCGTTTATTTC
TTATAGGGCTTAGTCACGAC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MSNPLLTFTDLPLFSQIKPEHIQPAVEQAIADCRAKIEDVLASDAVPSWNSIIVPLAETDDRLSRIWSPVSHLNSVQNSE
ALREAYEACLPILSEYGTWVGQNKALYHAYKEIKASADFSALSQAQQKTIIDELRDFELSGIGLPADQQKRYGDISKRTS
ELSSNFSNNVLDATMGWSKHITDEAELSGLPESAMSAAKAAAEAKELDGWLLTLEMPSYIPVMTYSDNKPLRREIYEAFV
TRASDRGPNAGKWDNTDLISEELNLRHEVSRLLGFSSYSEKSLATKMAESPTQVLGFLNDLAAKAKPQGEREVAELKAFV
KEEFDIDELDLWDVTYYSEKLKQKLYQISDEELRPYFPESKAVSGLFEVLNRVFGMTVVEREGVDVWHESVRFFDIFDST
NTLRGSFYLDLYAREHKRGGAWMDECRVRRLTENGELQTPVAYLTCNFSKPVGGKPALFTHDEVVTLFHEFGHGIHHMLT
QIDVASVSGINGVPWDAVELPSQFLENWCYEEEALAFISGHYETGEPLPKEMLDKMLAAKNFQSAMFILRQLEFGMFDFT
LHTNYDPDLGAKVLETLAEVKAKVAVLPSVEWNRFSHSFSHIFAGGYGAGYYSYLWAEVLSADAFSRFEEEGIFNTETGQ
SFLNNILEMGGSEEPMELFKRFRGREPQVDAMLRHAGIGA

Sequences:

>Translated_680_residues
MSNPLLTFTDLPLFSQIKPEHIQPAVEQAIADCRAKIEDVLASDAVPSWNSIIVPLAETDDRLSRIWSPVSHLNSVQNSE
ALREAYEACLPILSEYGTWVGQNKALYHAYKEIKASADFSALSQAQQKTIIDELRDFELSGIGLPADQQKRYGDISKRTS
ELSSNFSNNVLDATMGWSKHITDEAELSGLPESAMSAAKAAAEAKELDGWLLTLEMPSYIPVMTYSDNKPLRREIYEAFV
TRASDRGPNAGKWDNTDLISEELNLRHEVSRLLGFSSYSEKSLATKMAESPTQVLGFLNDLAAKAKPQGEREVAELKAFV
KEEFDIDELDLWDVTYYSEKLKQKLYQISDEELRPYFPESKAVSGLFEVLNRVFGMTVVEREGVDVWHESVRFFDIFDST
NTLRGSFYLDLYAREHKRGGAWMDECRVRRLTENGELQTPVAYLTCNFSKPVGGKPALFTHDEVVTLFHEFGHGIHHMLT
QIDVASVSGINGVPWDAVELPSQFLENWCYEEEALAFISGHYETGEPLPKEMLDKMLAAKNFQSAMFILRQLEFGMFDFT
LHTNYDPDLGAKVLETLAEVKAKVAVLPSVEWNRFSHSFSHIFAGGYGAGYYSYLWAEVLSADAFSRFEEEGIFNTETGQ
SFLNNILEMGGSEEPMELFKRFRGREPQVDAMLRHAGIGA
>Mature_679_residues
SNPLLTFTDLPLFSQIKPEHIQPAVEQAIADCRAKIEDVLASDAVPSWNSIIVPLAETDDRLSRIWSPVSHLNSVQNSEA
LREAYEACLPILSEYGTWVGQNKALYHAYKEIKASADFSALSQAQQKTIIDELRDFELSGIGLPADQQKRYGDISKRTSE
LSSNFSNNVLDATMGWSKHITDEAELSGLPESAMSAAKAAAEAKELDGWLLTLEMPSYIPVMTYSDNKPLRREIYEAFVT
RASDRGPNAGKWDNTDLISEELNLRHEVSRLLGFSSYSEKSLATKMAESPTQVLGFLNDLAAKAKPQGEREVAELKAFVK
EEFDIDELDLWDVTYYSEKLKQKLYQISDEELRPYFPESKAVSGLFEVLNRVFGMTVVEREGVDVWHESVRFFDIFDSTN
TLRGSFYLDLYAREHKRGGAWMDECRVRRLTENGELQTPVAYLTCNFSKPVGGKPALFTHDEVVTLFHEFGHGIHHMLTQ
IDVASVSGINGVPWDAVELPSQFLENWCYEEEALAFISGHYETGEPLPKEMLDKMLAAKNFQSAMFILRQLEFGMFDFTL
HTNYDPDLGAKVLETLAEVKAKVAVLPSVEWNRFSHSFSHIFAGGYGAGYYSYLWAEVLSADAFSRFEEEGIFNTETGQS
FLNNILEMGGSEEPMELFKRFRGREPQVDAMLRHAGIGA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=549, Percent_Identity=35.1548269581056, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI14149738, Length=676, Percent_Identity=31.2130177514793, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI156105687, Length=660, Percent_Identity=26.8181818181818, Blast_Score=209, Evalue=1e-53,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=69.1740412979351, Blast_Score=992, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=686, Percent_Identity=29.7376093294461, Blast_Score=300, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71999758, Length=595, Percent_Identity=26.0504201680672, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI32565901, Length=595, Percent_Identity=23.0252100840336, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319793, Length=664, Percent_Identity=28.4638554216867, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6322715, Length=712, Percent_Identity=23.7359550561798, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356111, Length=589, Percent_Identity=28.0135823429542, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI20129717, Length=593, Percent_Identity=23.7774030354132, Blast_Score=168, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76622; Mature: 76491

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLTFTDLPLFSQIKPEHIQPAVEQAIADCRAKIEDVLASDAVPSWNSIIVPLAETD
CCCCCEEEECCCHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCH
DRLSRIWSPVSHLNSVQNSEALREAYEACLPILSEYGTWVGQNKALYHAYKEIKASADFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHH
ALSQAQQKTIIDELRDFELSGIGLPADQQKRYGDISKRTSELSSNFSNNVLDATMGWSKH
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHCCCHHH
ITDEAELSGLPESAMSAAKAAAEAKELDGWLLTLEMPSYIPVMTYSDNKPLRREIYEAFV
CCCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHH
TRASDRGPNAGKWDNTDLISEELNLRHEVSRLLGFSSYSEKSLATKMAESPTQVLGFLND
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
LAAKAKPQGEREVAELKAFVKEEFDIDELDLWDVTYYSEKLKQKLYQISDEELRPYFPES
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCH
KAVSGLFEVLNRVFGMTVVEREGVDVWHESVRFFDIFDSTNTLRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCEECCCHHHHHHCCCEEEEECCCCCCCCEEEEEEEHHHHCCCC
AWMDECRVRRLTENGELQTPVAYLTCNFSKPVGGKPALFTHDEVVTLFHEFGHGIHHMLT
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEECCHHHHHHHHHHCHHHHHHHH
QIDVASVSGINGVPWDAVELPSQFLENWCYEEEALAFISGHYETGEPLPKEMLDKMLAAK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NFQSAMFILRQLEFGMFDFTLHTNYDPDLGAKVLETLAEVKAKVAVLPSVEWNRFSHSFS
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HIFAGGYGAGYYSYLWAEVLSADAFSRFEEEGIFNTETGQSFLNNILEMGGSEEPMELFK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQVDAMLRHAGIGA
HHCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLTFTDLPLFSQIKPEHIQPAVEQAIADCRAKIEDVLASDAVPSWNSIIVPLAETD
CCCCEEEECCCHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCH
DRLSRIWSPVSHLNSVQNSEALREAYEACLPILSEYGTWVGQNKALYHAYKEIKASADFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHH
ALSQAQQKTIIDELRDFELSGIGLPADQQKRYGDISKRTSELSSNFSNNVLDATMGWSKH
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHCCCHHH
ITDEAELSGLPESAMSAAKAAAEAKELDGWLLTLEMPSYIPVMTYSDNKPLRREIYEAFV
CCCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHH
TRASDRGPNAGKWDNTDLISEELNLRHEVSRLLGFSSYSEKSLATKMAESPTQVLGFLND
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
LAAKAKPQGEREVAELKAFVKEEFDIDELDLWDVTYYSEKLKQKLYQISDEELRPYFPES
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCH
KAVSGLFEVLNRVFGMTVVEREGVDVWHESVRFFDIFDSTNTLRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCEECCCHHHHHHCCCEEEEECCCCCCCCEEEEEEEHHHHCCCC
AWMDECRVRRLTENGELQTPVAYLTCNFSKPVGGKPALFTHDEVVTLFHEFGHGIHHMLT
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEECCHHHHHHHHHHCHHHHHHHH
QIDVASVSGINGVPWDAVELPSQFLENWCYEEEALAFISGHYETGEPLPKEMLDKMLAAK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NFQSAMFILRQLEFGMFDFTLHTNYDPDLGAKVLETLAEVKAKVAVLPSVEWNRFSHSFS
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HIFAGGYGAGYYSYLWAEVLSADAFSRFEEEGIFNTETGQSFLNNILEMGGSEEPMELFK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQVDAMLRHAGIGA
HHCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]