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The map label for this gene is lysA [H]

Identifier: 209693748

GI number: 209693748

Start: 161114

End: 162367

Strand: Direct

Name: lysA [H]

Synonym: VSAL_I0125

Alternate gene names: 209693748

Gene position: 161114-162367 (Clockwise)

Preceding gene: 209693745

Following gene: 209693749

Centisome position: 4.85

GC content: 42.82

Gene sequence:

>1254_bases
TTGGATTATTTCAATTATAAGGACGATGGACAGCTTTGGGCTGAAGAACGACCAATTACACAATTGGCTGAGCAATATGG
TACGCCATTGTATGTGTATTCTCGTGCGACATTAGAGCGTCATTGGAATGCATTTGATAGCTCGGTCGGTGAGCAACCTC
ATCTTGTGTGCTATGCCGTTAAAGCAAACTCAAACATTGGTGTATTGAATGCGCTTGCCTGTCTAGGTTCAGGTTTTGAT
ATCGTTTCTCAAGGTGAACTTGAGCGTGTGGTTGCTGCTGGTGGTGATCCTACGAAAGTCGTGTTTTCTGGTGTTGGTAA
AACAGCAAAAGAAATGCGCCGCGCATTAGAATTAAACATTAAATGTTTCAACGTAGAATCGGAACCAGAGCTTGAGCGCT
TAAATGCGGTCGCTGAAGAGATGGGTGTGATTGCGCCAATTTCATTGCGAATTAATCCTGATGTTGATGCAAAAACACAC
CCGTATATTTCTACTGGTTTGCGTGACAATAAATTTGGTATCGCGTTTGATCGCGCACCAGAAGTGTACAAATTTGCACA
AACGTTACCGAACTTAAATATCCAAGGCATTGATTGCCATATCGGTTCTCAATTAACGGACATTACGCCATTCATTGATG
CAACGGATCGCTTGTTAGCGTTGATTGATGACTTAAAAGCACAAGGTGTGAATATTCGCCACCTTGATGTTGGTGGTGGT
TTAGGCGTGGTTTATCGTGATGAATTACCGCCTCAACCGTCAGAATACGCTACGGCATTATTAAGTCGCTTAACGGGTCG
TGAGGACTTAGAGCTTATTTTTGAGCCGGGTCGTGCGATTGCAGCAAATGCGGGGATATTAGTGACTAAAGTTGAGTTCC
TAAAACATACGGAACACAAAAACTTTGCGATCATTGATGCCGCAATGAATGATTTAATGCGTCCAGCACTGTATCAAGCA
TGGCAAGACATTGTGCCTGTTGTTCCGCGTGAAGGCGAAGCTCAAAGTTATGACTTAGTTGGCCCTATTTGTGAAACGGG
TGATTTCTTGGGTAAAGATCGTGATTTAGTTCTTGAAGCGAATGATTTATTGGCTGTTCGTTCATCAGGTGCGTATGGCT
TTGTTATGTCATCAAACTACAATACACGTACTCGTGCGGCAGAAATAATGGTCGATGGCGATCAAGTACATCTTGTTCGT
AAGCGAGAAGAATTAAGCTCTTTATGGGAGCTGGAATCTATTTTACCAAACTAA

Upstream 100 bases:

>100_bases
ACCAAAAACAGAAGCCGCAGAATAGTGTATTTGTAATAAATGTATTCATGCACTGAAATCTATTAATAGAATAACTGAAA
ACTAGACAAGGAAGATGACA

Downstream 100 bases:

>100_bases
CTTAGAATAAAGAGCAAGAGGCTTAGGCTGCTTGCTCTTTTGGTATTCAACCTAGAAGATAAAATAAAAAGAAGAACAAC
TATGCACTTTCATTTTTCTA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDYFNYKDDGQLWAEERPITQLAEQYGTPLYVYSRATLERHWNAFDSSVGEQPHLVCYAVKANSNIGVLNALACLGSGFD
IVSQGELERVVAAGGDPTKVVFSGVGKTAKEMRRALELNIKCFNVESEPELERLNAVAEEMGVIAPISLRINPDVDAKTH
PYISTGLRDNKFGIAFDRAPEVYKFAQTLPNLNIQGIDCHIGSQLTDITPFIDATDRLLALIDDLKAQGVNIRHLDVGGG
LGVVYRDELPPQPSEYATALLSRLTGREDLELIFEPGRAIAANAGILVTKVEFLKHTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVVPREGEAQSYDLVGPICETGDFLGKDRDLVLEANDLLAVRSSGAYGFVMSSNYNTRTRAAEIMVDGDQVHLVR
KREELSSLWELESILPN

Sequences:

>Translated_417_residues
MDYFNYKDDGQLWAEERPITQLAEQYGTPLYVYSRATLERHWNAFDSSVGEQPHLVCYAVKANSNIGVLNALACLGSGFD
IVSQGELERVVAAGGDPTKVVFSGVGKTAKEMRRALELNIKCFNVESEPELERLNAVAEEMGVIAPISLRINPDVDAKTH
PYISTGLRDNKFGIAFDRAPEVYKFAQTLPNLNIQGIDCHIGSQLTDITPFIDATDRLLALIDDLKAQGVNIRHLDVGGG
LGVVYRDELPPQPSEYATALLSRLTGREDLELIFEPGRAIAANAGILVTKVEFLKHTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVVPREGEAQSYDLVGPICETGDFLGKDRDLVLEANDLLAVRSSGAYGFVMSSNYNTRTRAAEIMVDGDQVHLVR
KREELSSLWELESILPN
>Mature_417_residues
MDYFNYKDDGQLWAEERPITQLAEQYGTPLYVYSRATLERHWNAFDSSVGEQPHLVCYAVKANSNIGVLNALACLGSGFD
IVSQGELERVVAAGGDPTKVVFSGVGKTAKEMRRALELNIKCFNVESEPELERLNAVAEEMGVIAPISLRINPDVDAKTH
PYISTGLRDNKFGIAFDRAPEVYKFAQTLPNLNIQGIDCHIGSQLTDITPFIDATDRLLALIDDLKAQGVNIRHLDVGGG
LGVVYRDELPPQPSEYATALLSRLTGREDLELIFEPGRAIAANAGILVTKVEFLKHTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVVPREGEAQSYDLVGPICETGDFLGKDRDLVLEANDLLAVRSSGAYGFVMSSNYNTRTRAAEIMVDGDQVHLVR
KREELSSLWELESILPN

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=349, Percent_Identity=24.0687679083095, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789203, Length=430, Percent_Identity=29.3023255813954, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789307, Length=296, Percent_Identity=25, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=235, Percent_Identity=26.3829787234043, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=383, Percent_Identity=24.5430809399478, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24586474, Length=397, Percent_Identity=25.4408060453401, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24586472, Length=335, Percent_Identity=25.0746268656716, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46081; Mature: 46081

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFNYKDDGQLWAEERPITQLAEQYGTPLYVYSRATLERHWNAFDSSVGEQPHLVCYAV
CCCCCCCCCCCEECCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEE
KANSNIGVLNALACLGSGFDIVSQGELERVVAAGGDPTKVVFSGVGKTAKEMRRALELNI
ECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHHEECCCHHHHHHHHHHEECE
KCFNVESEPELERLNAVAEEMGVIAPISLRINPDVDAKTHPYISTGLRDNKFGIAFDRAP
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCEEEECCCC
EVYKFAQTLPNLNIQGIDCHIGSQLTDITPFIDATDRLLALIDDLKAQGVNIRHLDVGGG
HHHHHHHHCCCCCEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGVVYRDELPPQPSEYATALLSRLTGREDLELIFEPGRAIAANAGILVTKVEFLKHTEHK
EEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCEEEEEEHHHHHCCCC
NFAIIDAAMNDLMRPALYQAWQDIVPVVPREGEAQSYDLVGPICETGDFLGKDRDLVLEA
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHCCCCCCEEEEC
NDLLAVRSSGAYGFVMSSNYNTRTRAAEIMVDGDQVHLVRKREELSSLWELESILPN
CCEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYFNYKDDGQLWAEERPITQLAEQYGTPLYVYSRATLERHWNAFDSSVGEQPHLVCYAV
CCCCCCCCCCCEECCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEE
KANSNIGVLNALACLGSGFDIVSQGELERVVAAGGDPTKVVFSGVGKTAKEMRRALELNI
ECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHHEECCCHHHHHHHHHHEECE
KCFNVESEPELERLNAVAEEMGVIAPISLRINPDVDAKTHPYISTGLRDNKFGIAFDRAP
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCEEEECCCC
EVYKFAQTLPNLNIQGIDCHIGSQLTDITPFIDATDRLLALIDDLKAQGVNIRHLDVGGG
HHHHHHHHCCCCCEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGVVYRDELPPQPSEYATALLSRLTGREDLELIFEPGRAIAANAGILVTKVEFLKHTEHK
EEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCEEEEEEHHHHHCCCC
NFAIIDAAMNDLMRPALYQAWQDIVPVVPREGEAQSYDLVGPICETGDFLGKDRDLVLEA
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHCCCCCCEEEEC
NDLLAVRSSGAYGFVMSSNYNTRTRAAEIMVDGDQVHLVRKREELSSLWELESILPN
CCEEEEECCCCEEEEEECCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]