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The map label for this gene is lon-1

Identifier: 203284173

GI number: 203284173

Start: 274749

End: 277199

Strand: Reverse

Name: lon-1

Synonym: BDU_255

Alternate gene names: 203284173

Gene position: 277199-274749 (Counterclockwise)

Preceding gene: 203284178

Following gene: 203284166

Centisome position: 29.75

GC content: 30.31

Gene sequence:

>2451_bases
ATGAAATCTAGGGAGATTGAATACTTTATGGAAGAAATAAAAGATACTGTTTCTAAGGAAAAGAAGCGTTCAAAGAACTC
TGGAGGCATTTTGCCACATTTTGATAAACCCGTAAGAGTACCTTTAATTGCTGTTCCATCACATCCTGTATTTCCAAGTA
TGTTTATTCCAATTGTTATAGTTTCTGATATTGATATGAAGGCTGTTGATTATGTTATTAAAGGTAATGGAATTATTTCT
TTATTTGTTTTGCGTGATAAATTTTTAGAAAAATCAGGGAATAATAAGGATGGTAAATTAACTATTAATTATCAGAAGGA
TATTTATTCTGTTGGTGTTACTGCTAAAATAGTAAAAAAGATTAATCTTCCTGATGGTGGATATAATATTTTTGTTTCCA
CTATTGATAGAGTTAAATTTGTTAAAGTTGTTCTTAATGAGGATTTTCCAATAATTGAAGTTGATTATTTAAAGCAAATT
CCAATTAAAAAGTATGATGTTAATTTAAAAGCAATTTATAGTAGTATTTTACTTAAAACTAAAGAAATATTCTCACATAG
GAAAATGCCCGAATTTCAGTTAAATATGGTGAATATTGAAGATAAGGGTAGATTATGTGATGTTGTTGCAGGAATGATAG
CGTCTTCAAAGGAATCTCATCAAGAGGTGCTTGAAACATTAAGTGTTAAGGATAGGCTTAAAAAGGTTTTAGAATTGCTT
TATGAAGAATTAAACCTGATTGAGATTCAAAATAAAATTGCTAAAGGTATTCAAGAAAAATTAGAAAAACAGCAAAAAGA
GTTCTTTTTAAAGGAACAACTTAAAGCTATTAAGACTGAGCTTGGTGTTGGAGATGAGAAGAATAGTGAATTTTTAAAAA
TGAAATCTAAAATAGATGCTTTAGCTTTAAAAGGAGAAGCTTTAGATGCGGTTGGAAGGGAGCTTGAGAAGTTTTCATTT
CTTGAGAGACATTCGTCTGAGTATATTGTAGTTAGGAATTATCTTGAACTTATTACAAATCTTCCTTGGGAAGATACCAA
GGTTGATTTTGATAAATTTAATTTACAAAGAGCAGAAAAAATTTTAGATAAAACTCATTATGGCATGAGGGAGGTTAAAG
ATAGAATTCTTGAATATATTTCTGTCCTTAAATTAAGAAAATCTCAAAAAGGGGCTATTATGCTTTTAGTTGGTCCACCT
GGGGTTGGTAAAACCTCGATAGGAGCAGCTATTGCTGAAGTTCTTAATACGAAATTTTTTAGATTTTCTGTAGGTGGTAT
AAGAGATGAATCAGAAATTAAAGGACATAGAAGAACTTATGTAGGAGCATTACCTGGAAAAATTATTCAAGGACTCAGAA
TTACAAAAACAAATTCTCCTGTTTTTTTAATAGATGAAATTGATAAGGTATCGTCTTCTCATTATGGAGATCCGTTTTCA
GTTCTTCTTGAGGTTTTAGATCCCGAACAAAATGTTAATTTTAGAGATCATTATCTTGATTTGCCTTTTGATATTTCTAA
TGTATTTTTTATTTTAACGGCCAATTCTCTTGAAACAATACCTACACCTTTATTAAATAGGATGGAGGTAATTCAACTCT
CAGGATATGTTGATGATGAAAAAATAGAGATAGCAAGAAAATATTTGATACCAAAGGTCTTAAAGGAAAATGGTGTTGAT
AAAGATTCCTTAAAATTTCAAAGTTCATCTCTTGTTCAGATAGCTAGAGAATATGCTAGAGATAATGGACTGAGAAATTT
TGAGAAATATTTAAAACAAATTGTTCGAAAAATTGCAAGAAAGCTTGTTGAAGATCAATCTGTCAAAGCATATCAGATTT
CTAAGGAAAATTTGGAAGAGTATATTGGCATTCCTGTATTTAGAAAAGAAAAATTTTTAGATAAAGCTATGTCTCCAGGT
ATGGTAATGGGTCTTGCATGGACCAATTATGGTGGGTCAACTTTGATTATTGAGACTGTAAAGACTGAATCTAAATCTCC
TGGTATTAAGTTGACAGGTAGGCTTGGAGATGTTATGAAAGAATCTGCAAATATTGCGTTTACTTATGTCAATAGTATTA
GTAATGAACTTAAAGTGCATAAGTCCTTTTTTGAAAAATACATGATACATTTGCATATTCCAGAAGGTGCTACTCCAAAA
GATGGGCCTTCTGCTGGAATTACTATTGCTAGTGCTTTTATATCTCTGGCTCTTAATAAGACTGTAAGACCCAATTTGGC
TATGACAGGAGAGTTATCATTAACAGGTAATGTAATGGCTATTGGCGGATTGAAAGCCAAAATAATTGCTGCTAAGAGAA
ATGGTGTTGAGCACATTATTATTCCTAAAGCAAATAAAGTAGATCTTGATGATATTCCTATTAATATTAAAAATGGTATA
AATTTTCATCTTGTAGATAGTATGAAAGAAGTAATTAAATTGTTATTTTGA

Upstream 100 bases:

>100_bases
GTTATTATAGCATTGATTTTGTTAAACAGCATTATACATTATTGTATAATAAAAAAATTCATTATTAAATGAATTCTCAT
AAAAATTTTCTTTTGTTATA

Downstream 100 bases:

>100_bases
TTTTATAAAGTTTTAAGTTTAATTTGTGTTTTAATGTTTTTGAGATATATTATTTGTAATCTTTACACTTTTGTTGTACT
TACTGTTTTAACAGTTGGTT

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MKSREIEYFMEEIKDTVSKEKKRSKNSGGILPHFDKPVRVPLIAVPSHPVFPSMFIPIVIVSDIDMKAVDYVIKGNGIIS
LFVLRDKFLEKSGNNKDGKLTINYQKDIYSVGVTAKIVKKINLPDGGYNIFVSTIDRVKFVKVVLNEDFPIIEVDYLKQI
PIKKYDVNLKAIYSSILLKTKEIFSHRKMPEFQLNMVNIEDKGRLCDVVAGMIASSKESHQEVLETLSVKDRLKKVLELL
YEELNLIEIQNKIAKGIQEKLEKQQKEFFLKEQLKAIKTELGVGDEKNSEFLKMKSKIDALALKGEALDAVGRELEKFSF
LERHSSEYIVVRNYLELITNLPWEDTKVDFDKFNLQRAEKILDKTHYGMREVKDRILEYISVLKLRKSQKGAIMLLVGPP
GVGKTSIGAAIAEVLNTKFFRFSVGGIRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEIDKVSSSHYGDPFS
VLLEVLDPEQNVNFRDHYLDLPFDISNVFFILTANSLETIPTPLLNRMEVIQLSGYVDDEKIEIARKYLIPKVLKENGVD
KDSLKFQSSSLVQIAREYARDNGLRNFEKYLKQIVRKIARKLVEDQSVKAYQISKENLEEYIGIPVFRKEKFLDKAMSPG
MVMGLAWTNYGGSTLIIETVKTESKSPGIKLTGRLGDVMKESANIAFTYVNSISNELKVHKSFFEKYMIHLHIPEGATPK
DGPSAGITIASAFISLALNKTVRPNLAMTGELSLTGNVMAIGGLKAKIIAAKRNGVEHIIIPKANKVDLDDIPINIKNGI
NFHLVDSMKEVIKLLF

Sequences:

>Translated_816_residues
MKSREIEYFMEEIKDTVSKEKKRSKNSGGILPHFDKPVRVPLIAVPSHPVFPSMFIPIVIVSDIDMKAVDYVIKGNGIIS
LFVLRDKFLEKSGNNKDGKLTINYQKDIYSVGVTAKIVKKINLPDGGYNIFVSTIDRVKFVKVVLNEDFPIIEVDYLKQI
PIKKYDVNLKAIYSSILLKTKEIFSHRKMPEFQLNMVNIEDKGRLCDVVAGMIASSKESHQEVLETLSVKDRLKKVLELL
YEELNLIEIQNKIAKGIQEKLEKQQKEFFLKEQLKAIKTELGVGDEKNSEFLKMKSKIDALALKGEALDAVGRELEKFSF
LERHSSEYIVVRNYLELITNLPWEDTKVDFDKFNLQRAEKILDKTHYGMREVKDRILEYISVLKLRKSQKGAIMLLVGPP
GVGKTSIGAAIAEVLNTKFFRFSVGGIRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEIDKVSSSHYGDPFS
VLLEVLDPEQNVNFRDHYLDLPFDISNVFFILTANSLETIPTPLLNRMEVIQLSGYVDDEKIEIARKYLIPKVLKENGVD
KDSLKFQSSSLVQIAREYARDNGLRNFEKYLKQIVRKIARKLVEDQSVKAYQISKENLEEYIGIPVFRKEKFLDKAMSPG
MVMGLAWTNYGGSTLIIETVKTESKSPGIKLTGRLGDVMKESANIAFTYVNSISNELKVHKSFFEKYMIHLHIPEGATPK
DGPSAGITIASAFISLALNKTVRPNLAMTGELSLTGNVMAIGGLKAKIIAAKRNGVEHIIIPKANKVDLDDIPINIKNGI
NFHLVDSMKEVIKLLF
>Mature_816_residues
MKSREIEYFMEEIKDTVSKEKKRSKNSGGILPHFDKPVRVPLIAVPSHPVFPSMFIPIVIVSDIDMKAVDYVIKGNGIIS
LFVLRDKFLEKSGNNKDGKLTINYQKDIYSVGVTAKIVKKINLPDGGYNIFVSTIDRVKFVKVVLNEDFPIIEVDYLKQI
PIKKYDVNLKAIYSSILLKTKEIFSHRKMPEFQLNMVNIEDKGRLCDVVAGMIASSKESHQEVLETLSVKDRLKKVLELL
YEELNLIEIQNKIAKGIQEKLEKQQKEFFLKEQLKAIKTELGVGDEKNSEFLKMKSKIDALALKGEALDAVGRELEKFSF
LERHSSEYIVVRNYLELITNLPWEDTKVDFDKFNLQRAEKILDKTHYGMREVKDRILEYISVLKLRKSQKGAIMLLVGPP
GVGKTSIGAAIAEVLNTKFFRFSVGGIRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEIDKVSSSHYGDPFS
VLLEVLDPEQNVNFRDHYLDLPFDISNVFFILTANSLETIPTPLLNRMEVIQLSGYVDDEKIEIARKYLIPKVLKENGVD
KDSLKFQSSSLVQIAREYARDNGLRNFEKYLKQIVRKIARKLVEDQSVKAYQISKENLEEYIGIPVFRKEKFLDKAMSPG
MVMGLAWTNYGGSTLIIETVKTESKSPGIKLTGRLGDVMKESANIAFTYVNSISNELKVHKSFFEKYMIHLHIPEGATPK
DGPSAGITIASAFISLALNKTVRPNLAMTGELSLTGNVMAIGGLKAKIIAAKRNGVEHIIIPKANKVDLDDIPINIKNGI
NFHLVDSMKEVIKLLF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=693, Percent_Identity=43.001443001443, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI31377667, Length=840, Percent_Identity=32.5, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1786643, Length=787, Percent_Identity=38.6277001270648, Blast_Score=571, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17505831, Length=655, Percent_Identity=42.9007633587786, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=40, Blast_Score=409, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=750, Percent_Identity=41.6, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24666867, Length=684, Percent_Identity=43.7134502923977, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221513036, Length=684, Percent_Identity=43.7134502923977, Blast_Score=563, Evalue=1e-160,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_BORDL (B5RL78)

Other databases:

- EMBL:   CP000976
- RefSeq:   YP_002221913.1
- MEROPS:   S16.002
- EnsemblBacteria:   EBBORT00000001615
- GeneID:   6918339
- GenomeReviews:   CP000976_GR
- KEGG:   bdu:BDU_255
- GeneTree:   EBGT00050000007303
- HOGENOM:   HBG566281
- OMA:   VRNYLEL
- ProtClustDB:   CLSK544900
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 92253; Mature: 92253

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 724-724 ACT_SITE 767-767

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSREIEYFMEEIKDTVSKEKKRSKNSGGILPHFDKPVRVPLIAVPSHPVFPSMFIPIVI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHEEEEE
VSDIDMKAVDYVIKGNGIISLFVLRDKFLEKSGNNKDGKLTINYQKDIYSVGVTAKIVKK
EECCCHHHEEEEEECCCEEEEEEHHHHHHHHCCCCCCCEEEEEECCCHHHHCHHHHHHHH
INLPDGGYNIFVSTIDRVKFVKVVLNEDFPIIEVDYLKQIPIKKYDVNLKAIYSSILLKT
CCCCCCCCEEEEEHHHHHHHHHHEECCCCCEEEEHHHHCCCCCCCCCHHHHHHHHHHHHH
KEIFSHRKMPEFQLNMVNIEDKGRLCDVVAGMIASSKESHQEVLETLSVKDRLKKVLELL
HHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YEELNLIEIQNKIAKGIQEKLEKQQKEFFLKEQLKAIKTELGVGDEKNSEFLKMKSKIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LALKGEALDAVGRELEKFSFLERHSSEYIVVRNYLELITNLPWEDTKVDFDKFNLQRAEK
HHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ILDKTHYGMREVKDRILEYISVLKLRKSQKGAIMLLVGPPGVGKTSIGAAIAEVLNTKFF
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEE
RFSVGGIRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEIDKVSSSHYGDPFS
EEECCCCCCHHHHCCCHHEEEECCCHHHHCCEEEEECCCCEEEEECHHHHCCCCCCCHHH
VLLEVLDPEQNVNFRDHYLDLPFDISNVFFILTANSLETIPTPLLNRMEVIQLSGYVDDE
HHHHHHCCCCCCCCCHHEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHEEEECCCCCHH
KIEIARKYLIPKVLKENGVDKDSLKFQSSSLVQIAREYARDNGLRNFEKYLKQIVRKIAR
HHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KLVEDQSVKAYQISKENLEEYIGIPVFRKEKFLDKAMSPGMVMGLAWTNYGGSTLIIETV
HHHCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEE
KTESKSPGIKLTGRLGDVMKESANIAFTYVNSISNELKVHKSFFEKYMIHLHIPEGATPK
ECCCCCCCEEEECHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
DGPSAGITIASAFISLALNKTVRPNLAMTGELSLTGNVMAIGGLKAKIIAAKRNGVEHII
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEECCCEEEEEEEECCCCCEEE
IPKANKVDLDDIPINIKNGINFHLVDSMKEVIKLLF
ECCCCCCCCCCCCEEECCCCCEEEHHHHHHHHHHHC
>Mature Secondary Structure
MKSREIEYFMEEIKDTVSKEKKRSKNSGGILPHFDKPVRVPLIAVPSHPVFPSMFIPIVI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHEEEEE
VSDIDMKAVDYVIKGNGIISLFVLRDKFLEKSGNNKDGKLTINYQKDIYSVGVTAKIVKK
EECCCHHHEEEEEECCCEEEEEEHHHHHHHHCCCCCCCEEEEEECCCHHHHCHHHHHHHH
INLPDGGYNIFVSTIDRVKFVKVVLNEDFPIIEVDYLKQIPIKKYDVNLKAIYSSILLKT
CCCCCCCCEEEEEHHHHHHHHHHEECCCCCEEEEHHHHCCCCCCCCCHHHHHHHHHHHHH
KEIFSHRKMPEFQLNMVNIEDKGRLCDVVAGMIASSKESHQEVLETLSVKDRLKKVLELL
HHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YEELNLIEIQNKIAKGIQEKLEKQQKEFFLKEQLKAIKTELGVGDEKNSEFLKMKSKIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LALKGEALDAVGRELEKFSFLERHSSEYIVVRNYLELITNLPWEDTKVDFDKFNLQRAEK
HHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ILDKTHYGMREVKDRILEYISVLKLRKSQKGAIMLLVGPPGVGKTSIGAAIAEVLNTKFF
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEE
RFSVGGIRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEIDKVSSSHYGDPFS
EEECCCCCCHHHHCCCHHEEEECCCHHHHCCEEEEECCCCEEEEECHHHHCCCCCCCHHH
VLLEVLDPEQNVNFRDHYLDLPFDISNVFFILTANSLETIPTPLLNRMEVIQLSGYVDDE
HHHHHHCCCCCCCCCHHEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHEEEECCCCCHH
KIEIARKYLIPKVLKENGVDKDSLKFQSSSLVQIAREYARDNGLRNFEKYLKQIVRKIAR
HHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KLVEDQSVKAYQISKENLEEYIGIPVFRKEKFLDKAMSPGMVMGLAWTNYGGSTLIIETV
HHHCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEE
KTESKSPGIKLTGRLGDVMKESANIAFTYVNSISNELKVHKSFFEKYMIHLHIPEGATPK
ECCCCCCCEEEECHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
DGPSAGITIASAFISLALNKTVRPNLAMTGELSLTGNVMAIGGLKAKIIAAKRNGVEHII
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEECCCEEEEEEEECCCCCEEE
IPKANKVDLDDIPINIKNGINFHLVDSMKEVIKLLF
ECCCCCCCCCCCCEEECCCCCEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA