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The map label for this gene is serS

Identifier: 203284145

GI number: 203284145

Start: 241080

End: 242354

Strand: Reverse

Name: serS

Synonym: BDU_226

Alternate gene names: 203284145

Gene position: 242354-241080 (Counterclockwise)

Preceding gene: 203284148

Following gene: 203284143

Centisome position: 26.01

GC content: 32.08

Gene sequence:

>1275_bases
ATGCTTGATCTGAAGTTTATAAGAGATAATTTAGAACTTGTTCGGGAAAATATTAAAAATAGAGGATTAAAATTAGAACT
TGATTTGTTAATTTCATTTGATGATGAACGTAGAAAACTTATTACAAAGATAGGTGAATTGAATGCTTTAAGGAATGAAA
ATGCTAATGCCATGAAAGACAATATTGATGATTCTAGTAGGCATTATTTAATAGAAAAGGGCAAAGCTTTAAAAGCTGAA
ATTATGGATTTAGAAGAAAGGTTGGGTTATTTAACATCTAGACTTTTAGTTGAACATAAACGAATTCCAAATATTTCTGC
TCCTGATGTCCCTGTTGGTGTTAGTGAGGATGAAAATGTTGTATTAAAAGTATCAGGAAATATTCCAAAATTCGATTTTA
AGCCAAAAGATCATTTAGAGATAGGTATACATTTAGATCTTTTTGATTTTGAAAAGGCACGTGAGGTTAGTGGAAATAAA
TTTTATTATCTTAAAAATGAAGCTGTTTTTTTGGAACTTGCAATGATTAATTTTGCCTTTAGTAAACTTAAAGCAAAGGG
ATTTGATTTGTTTATTACACCTGATGTTGCAAGGGAATTTATAGTTGATGGGATTGGATTTAATCCACGTGGTGCTGAGA
GTAATATTTATAAAATTGAGGATACTGATAAATATCTTGTTGGTACGGCTGAGATTACCCTTGGTGGATATTATTATAAT
ACTATATTGGATCTCAAATCACCATTAAAAATGGCAGGACTCTCACATTGTTTTCGCAAGGAGGCTGGGGCAGCTGGACA
ATTTTCTAAAGGACTCTATAGAGTTCATCAATTTAGTAAAGTTGAGATGTTTTGTTTTTGTAGAAGTGAGGATTCTGATC
GTATTCACAATGAGTTTTTGGAATTAGAAGAAGAAATTTTTACAGAACTTGAAATTCCATATAGAGTTTTAAATGTTTGT
TCTTCTGATCTTGGTGCTCCAGCTTATAAGAAGTATGATATTGAAGCTTGGATGCCAGGTAGAGGAGAGAATGGCGATTA
TGGAGAGGTGACTTCAACTTCAAATTGTACAGATTATCAGTCAAGGCGCCTTAAGATTAGGTATAAAGAGGATGGGCAGA
ATAAATTTGTACATATGATAAATGGAACAGCAATAGCCTCCACTAGAACTCTTATTGCTATACTTGAAAATTTTCAAGAT
GCAAAAGGAGGGGTTCGTATACCTAAGAGTTTGGTTAAGTATACAGGTTTTGATTATATATCTCCTAAGAATTAG

Upstream 100 bases:

>100_bases
CAAGTATTATATAATACTTATTATACTAATTAGTATAATTTATTTTTCATTATTTTATTTTAATTATCTTTAATTAATTT
ATTATATTGGGAGTTCGTTA

Downstream 100 bases:

>100_bases
AGCTTAGGGTGTCTTCTTTTAGATGTTCAATTGCATTTAAGAGAATTTCATGGTTTTTCAGATTTTGATTAAAAGGTGCG
GTTAAGGCTTGTCTAAATTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDLKFIRDNLELVRENIKNRGLKLELDLLISFDDERRKLITKIGELNALRNENANAMKDNIDDSSRHYLIEKGKALKAE
IMDLEERLGYLTSRLLVEHKRIPNISAPDVPVGVSEDENVVLKVSGNIPKFDFKPKDHLEIGIHLDLFDFEKAREVSGNK
FYYLKNEAVFLELAMINFAFSKLKAKGFDLFITPDVAREFIVDGIGFNPRGAESNIYKIEDTDKYLVGTAEITLGGYYYN
TILDLKSPLKMAGLSHCFRKEAGAAGQFSKGLYRVHQFSKVEMFCFCRSEDSDRIHNEFLELEEEIFTELEIPYRVLNVC
SSDLGAPAYKKYDIEAWMPGRGENGDYGEVTSTSNCTDYQSRRLKIRYKEDGQNKFVHMINGTAIASTRTLIAILENFQD
AKGGVRIPKSLVKYTGFDYISPKN

Sequences:

>Translated_424_residues
MLDLKFIRDNLELVRENIKNRGLKLELDLLISFDDERRKLITKIGELNALRNENANAMKDNIDDSSRHYLIEKGKALKAE
IMDLEERLGYLTSRLLVEHKRIPNISAPDVPVGVSEDENVVLKVSGNIPKFDFKPKDHLEIGIHLDLFDFEKAREVSGNK
FYYLKNEAVFLELAMINFAFSKLKAKGFDLFITPDVAREFIVDGIGFNPRGAESNIYKIEDTDKYLVGTAEITLGGYYYN
TILDLKSPLKMAGLSHCFRKEAGAAGQFSKGLYRVHQFSKVEMFCFCRSEDSDRIHNEFLELEEEIFTELEIPYRVLNVC
SSDLGAPAYKKYDIEAWMPGRGENGDYGEVTSTSNCTDYQSRRLKIRYKEDGQNKFVHMINGTAIASTRTLIAILENFQD
AKGGVRIPKSLVKYTGFDYISPKN
>Mature_424_residues
MLDLKFIRDNLELVRENIKNRGLKLELDLLISFDDERRKLITKIGELNALRNENANAMKDNIDDSSRHYLIEKGKALKAE
IMDLEERLGYLTSRLLVEHKRIPNISAPDVPVGVSEDENVVLKVSGNIPKFDFKPKDHLEIGIHLDLFDFEKAREVSGNK
FYYLKNEAVFLELAMINFAFSKLKAKGFDLFITPDVAREFIVDGIGFNPRGAESNIYKIEDTDKYLVGTAEITLGGYYYN
TILDLKSPLKMAGLSHCFRKEAGAAGQFSKGLYRVHQFSKVEMFCFCRSEDSDRIHNEFLELEEEIFTELEIPYRVLNVC
SSDLGAPAYKKYDIEAWMPGRGENGDYGEVTSTSNCTDYQSRRLKIRYKEDGQNKFVHMINGTAIASTRTLIAILENFQD
AKGGVRIPKSLVKYTGFDYISPKN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=412, Percent_Identity=40.0485436893204, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI225579074, Length=338, Percent_Identity=43.1952662721894, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI16306548, Length=337, Percent_Identity=37.0919881305638, Blast_Score=205, Evalue=6e-53,
Organism=Escherichia coli, GI1787120, Length=438, Percent_Identity=32.8767123287671, Blast_Score=217, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17539260, Length=470, Percent_Identity=31.4893617021277, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=419, Percent_Identity=33.4128878281623, Blast_Score=184, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321799, Length=355, Percent_Identity=40, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=32.8089887640449, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17737985, Length=321, Percent_Identity=38.9408099688474, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24581334, Length=469, Percent_Identity=32.409381663113, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24649556, Length=408, Percent_Identity=22.7941176470588, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BORDL (B5RL50)

Other databases:

- EMBL:   CP000976
- RefSeq:   YP_002221885.1
- EnsemblBacteria:   EBBORT00000000986
- GeneID:   6918310
- GenomeReviews:   CP000976_GR
- KEGG:   bdu:BDU_226
- GeneTree:   EBGT00050000007332
- HOGENOM:   HBG629391
- OMA:   PKFDFKP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48405; Mature: 48405

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 275-275 BINDING 282-282 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKFIRDNLELVRENIKNRGLKLELDLLISFDDERRKLITKIGELNALRNENANAMKD
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHC
NIDDSSRHYLIEKGKALKAEIMDLEERLGYLTSRLLVEHKRIPNISAPDVPVGVSEDENV
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
VLKVSGNIPKFDFKPKDHLEIGIHLDLFDFEKAREVSGNKFYYLKNEAVFLELAMINFAF
EEEEECCCCCCCCCCCCCEEEEEEEEEECCHHHHHCCCCEEEEEECCEEEEEHHHHHHHH
SKLKAKGFDLFITPDVAREFIVDGIGFNPRGAESNIYKIEDTDKYLVGTAEITLGGYYYN
HHHHCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEEEEEECCEEEE
TILDLKSPLKMAGLSHCFRKEAGAAGQFSKGLYRVHQFSKVEMFCFCRSEDSDRIHNEFL
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHH
ELEEEIFTELEIPYRVLNVCSSDLGAPAYKKYDIEAWMPGRGENGDYGEVTSTSNCTDYQ
HHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
SRRLKIRYKEDGQNKFVHMINGTAIASTRTLIAILENFQDAKGGVRIPKSLVKYTGFDYI
CCEEEEEEEECCCCEEEEEECCCEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
SPKN
CCCC
>Mature Secondary Structure
MLDLKFIRDNLELVRENIKNRGLKLELDLLISFDDERRKLITKIGELNALRNENANAMKD
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHC
NIDDSSRHYLIEKGKALKAEIMDLEERLGYLTSRLLVEHKRIPNISAPDVPVGVSEDENV
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
VLKVSGNIPKFDFKPKDHLEIGIHLDLFDFEKAREVSGNKFYYLKNEAVFLELAMINFAF
EEEEECCCCCCCCCCCCCEEEEEEEEEECCHHHHHCCCCEEEEEECCEEEEEHHHHHHHH
SKLKAKGFDLFITPDVAREFIVDGIGFNPRGAESNIYKIEDTDKYLVGTAEITLGGYYYN
HHHHCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEEEEEECCEEEE
TILDLKSPLKMAGLSHCFRKEAGAAGQFSKGLYRVHQFSKVEMFCFCRSEDSDRIHNEFL
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHH
ELEEEIFTELEIPYRVLNVCSSDLGAPAYKKYDIEAWMPGRGENGDYGEVTSTSNCTDYQ
HHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
SRRLKIRYKEDGQNKFVHMINGTAIASTRTLIAILENFQDAKGGVRIPKSLVKYTGFDYI
CCEEEEEEEECCCCEEEEEECCCEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
SPKN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA