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The map label for this gene is htrA [H]

Identifier: 203284029

GI number: 203284029

Start: 112531

End: 113988

Strand: Reverse

Name: htrA [H]

Synonym: BDU_107

Alternate gene names: 203284029

Gene position: 113988-112531 (Counterclockwise)

Preceding gene: 203284030

Following gene: 203284028

Centisome position: 12.23

GC content: 32.03

Gene sequence:

>1458_bases
ATGGAGGTGTATAAAATGAATAAAAATTTTATTTCTGTGTTTTTTGCTAGTTTTTTAGCTTTAGCTGTTGGATTTTTTGT
TGGAATAGGTTATTTGAAGTCTGAAAAAAATACTATTGTTTTTGCACAGGAGAAAGGAGATGCTGTACACTCTCTTCAAG
ATTCTTTTAGAGAAGTATCTAAAAAAATTTTACCATCAACTGTGGAAATTTATGCTACTGGAACAATTAAAACACGCGAT
CCTATGCAATTCTTTTTCTTTGATATCCCAGGTCTTAATCTTGAAAAAAAAGCACAATGGGGTGGTTCTGGCGTTATTAT
TGGAAAAGATTCTAAGAAAACAAATTTGTTTTATGTTCTGACAAATAGTCATATTCTAGAAAATGCTAGTGAGTTTGAAG
TTGGAACTTATAATAATAAAAGTTATAAAGCTCAGTTAGTGGGTAAGGACGATAAAAAAGATATTGCATTGGTTAGTTTT
GAGGCTGATGATGTTGCAGATATTGGGGTAGCTGAACTTGGTGATAGCGATAGACTTGAAGTGGGAGATTGGGTTATAGC
TGTTGGAAGTCCTTATCACTTTAGTTTTTCAGTTACAGCAGGTATTATTAGTGGTCTTCATCGTTCTTTTAATCCTAATT
TAAAAGCTAGAAATTTATTTATTCAAACAGATGCGGCTATTAATCGTGGTAATTCTGGAGGACCTCTTGTTAATACTAAA
GGAGAAGTTATTGGTATCAATTCGTGGATTTCATCTCCTTCTGGAGGAAATATTGGACTTGGTTTTGCTATTCCTATTAA
TAATGCTAAGAGTGTTTTTGATGCATTAATGAGTGGACAAAAAAGTGAATCAGCTTGGATGGGCGTTGCATTTCATCGTT
TGAGGTCTAAAGATGTAGAATTTCTTAAAAGTTTAGGTTATGAAGATGAGTCTGTTTCATTAGCAATTGTTGCAGGTGTT
TATGATGGTTCTCCAGCTTTGAAAGCAGGATTTAGAGCTGGTGATGTGATTAGCAAGATAGATGGTGTTGCAATGAATCT
TTTCTTTGATGTTAAGCAATACATTAATGATTTTTATGCTAAGGAAAAAATTAAAGTTGAGGTTTTAAGAGGACAAGAGA
CGAAAACTTTTGAGGTAGAACTTGGTGTTATGCCTACTAATATCGATAAGGAAAAGGGCAATACTTTAGATTTAAAATTG
ATGCCAGGCTTTACTGTTTATCCTTTAACTAAAGAGGTTAGGGTGCAACTTGGTTTGAGAAATTGGATTAATGGAGTTGT
TGTTGATAGTATTGATTCAACTTTGGGTAATAATCCTCAAATTGCAACAGGAGATATTATTATGATTGTTAATTCAAAAA
ATGTTAAAACTTTAATAGATTTTTATGATGCTATTAAGCATGGAAAAAATAATTATAGTATTTTAAGAAATGGACAAACT
TTAAAAGTGTCTATTTGA

Upstream 100 bases:

>100_bases
CATTTTGAACATACTGTTGCTGTTATTGATGGTTTGCCTTTAATTTTAAGTAAAGTTTGATAATACTTAAGTAAATATTT
AAAAGATTTGGTTTTATATT

Downstream 100 bases:

>100_bases
TAATACATTTTATTTTTTGTATAAGGCTTAAAGATGTTAATTCTTTAAGCCTTTAGGCATTAAATTTGGTAATTCTATTT
TGTATTATTAATTTTTTTAC

Product: periplasmic serine protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MEVYKMNKNFISVFFASFLALAVGFFVGIGYLKSEKNTIVFAQEKGDAVHSLQDSFREVSKKILPSTVEIYATGTIKTRD
PMQFFFFDIPGLNLEKKAQWGGSGVIIGKDSKKTNLFYVLTNSHILENASEFEVGTYNNKSYKAQLVGKDDKKDIALVSF
EADDVADIGVAELGDSDRLEVGDWVIAVGSPYHFSFSVTAGIISGLHRSFNPNLKARNLFIQTDAAINRGNSGGPLVNTK
GEVIGINSWISSPSGGNIGLGFAIPINNAKSVFDALMSGQKSESAWMGVAFHRLRSKDVEFLKSLGYEDESVSLAIVAGV
YDGSPALKAGFRAGDVISKIDGVAMNLFFDVKQYINDFYAKEKIKVEVLRGQETKTFEVELGVMPTNIDKEKGNTLDLKL
MPGFTVYPLTKEVRVQLGLRNWINGVVVDSIDSTLGNNPQIATGDIIMIVNSKNVKTLIDFYDAIKHGKNNYSILRNGQT
LKVSI

Sequences:

>Translated_485_residues
MEVYKMNKNFISVFFASFLALAVGFFVGIGYLKSEKNTIVFAQEKGDAVHSLQDSFREVSKKILPSTVEIYATGTIKTRD
PMQFFFFDIPGLNLEKKAQWGGSGVIIGKDSKKTNLFYVLTNSHILENASEFEVGTYNNKSYKAQLVGKDDKKDIALVSF
EADDVADIGVAELGDSDRLEVGDWVIAVGSPYHFSFSVTAGIISGLHRSFNPNLKARNLFIQTDAAINRGNSGGPLVNTK
GEVIGINSWISSPSGGNIGLGFAIPINNAKSVFDALMSGQKSESAWMGVAFHRLRSKDVEFLKSLGYEDESVSLAIVAGV
YDGSPALKAGFRAGDVISKIDGVAMNLFFDVKQYINDFYAKEKIKVEVLRGQETKTFEVELGVMPTNIDKEKGNTLDLKL
MPGFTVYPLTKEVRVQLGLRNWINGVVVDSIDSTLGNNPQIATGDIIMIVNSKNVKTLIDFYDAIKHGKNNYSILRNGQT
LKVSI
>Mature_485_residues
MEVYKMNKNFISVFFASFLALAVGFFVGIGYLKSEKNTIVFAQEKGDAVHSLQDSFREVSKKILPSTVEIYATGTIKTRD
PMQFFFFDIPGLNLEKKAQWGGSGVIIGKDSKKTNLFYVLTNSHILENASEFEVGTYNNKSYKAQLVGKDDKKDIALVSF
EADDVADIGVAELGDSDRLEVGDWVIAVGSPYHFSFSVTAGIISGLHRSFNPNLKARNLFIQTDAAINRGNSGGPLVNTK
GEVIGINSWISSPSGGNIGLGFAIPINNAKSVFDALMSGQKSESAWMGVAFHRLRSKDVEFLKSLGYEDESVSLAIVAGV
YDGSPALKAGFRAGDVISKIDGVAMNLFFDVKQYINDFYAKEKIKVEVLRGQETKTFEVELGVMPTNIDKEKGNTLDLKL
MPGFTVYPLTKEVRVQLGLRNWINGVVVDSIDSTLGNNPQIATGDIIMIVNSKNVKTLIDFYDAIKHGKNNYSILRNGQT
LKVSI

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=297, Percent_Identity=32.996632996633, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI24308541, Length=299, Percent_Identity=32.1070234113712, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI22129776, Length=272, Percent_Identity=30.8823529411765, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI7019477, Length=297, Percent_Identity=29.96632996633, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786356, Length=370, Percent_Identity=34.0540540540541, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1789629, Length=336, Percent_Identity=35.7142857142857, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1789630, Length=382, Percent_Identity=26.7015706806283, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=32.8671328671329, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53150; Mature: 53150

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVYKMNKNFISVFFASFLALAVGFFVGIGYLKSEKNTIVFAQEKGDAVHSLQDSFREVS
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHH
KKILPSTVEIYATGTIKTRDPMQFFFFDIPGLNLEKKAQWGGSGVIIGKDSKKTNLFYVL
HHHCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCHHCCCCCCEEEEECCCCCCEEEEEE
TNSHILENASEFEVGTYNNKSYKAQLVGKDDKKDIALVSFEADDVADIGVAELGDSDRLE
ECCHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHCCCCCCEE
VGDWVIAVGSPYHFSFSVTAGIISGLHRSFNPNLKARNLFIQTDAAINRGNSGGPLVNTK
ECCEEEEECCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEEEECHHHCCCCCCCCEEECC
GEVIGINSWISSPSGGNIGLGFAIPINNAKSVFDALMSGQKSESAWMGVAFHRLRSKDVE
CCEEEEEHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
FLKSLGYEDESVSLAIVAGVYDGSPALKAGFRAGDVISKIDGVAMNLFFDVKQYINDFYA
HHHHCCCCCCCEEEEEEEEEECCCHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHC
KEKIKVEVLRGQETKTFEVELGVMPTNIDKEKGNTLDLKLMPGFTVYPLTKEVRVQLGLR
CCEEEEEEEECCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCEEEECCCHHHHEEECHH
NWINGVVVDSIDSTLGNNPQIATGDIIMIVNSKNVKTLIDFYDAIKHGKNNYSILRNGQT
HHCCCEEEECHHHHCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCE
LKVSI
EEEEC
>Mature Secondary Structure
MEVYKMNKNFISVFFASFLALAVGFFVGIGYLKSEKNTIVFAQEKGDAVHSLQDSFREVS
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHH
KKILPSTVEIYATGTIKTRDPMQFFFFDIPGLNLEKKAQWGGSGVIIGKDSKKTNLFYVL
HHHCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCHHCCCCCCEEEEECCCCCCEEEEEE
TNSHILENASEFEVGTYNNKSYKAQLVGKDDKKDIALVSFEADDVADIGVAELGDSDRLE
ECCHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHCCCCCCEE
VGDWVIAVGSPYHFSFSVTAGIISGLHRSFNPNLKARNLFIQTDAAINRGNSGGPLVNTK
ECCEEEEECCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEEEECHHHCCCCCCCCEEECC
GEVIGINSWISSPSGGNIGLGFAIPINNAKSVFDALMSGQKSESAWMGVAFHRLRSKDVE
CCEEEEEHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
FLKSLGYEDESVSLAIVAGVYDGSPALKAGFRAGDVISKIDGVAMNLFFDVKQYINDFYA
HHHHCCCCCCCEEEEEEEEEECCCHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHC
KEKIKVEVLRGQETKTFEVELGVMPTNIDKEKGNTLDLKLMPGFTVYPLTKEVRVQLGLR
CCEEEEEEEECCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCEEEECCCHHHHEEECHH
NWINGVVVDSIDSTLGNNPQIATGDIIMIVNSKNVKTLIDFYDAIKHGKNNYSILRNGQT
HHCCCEEEECHHHHCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCE
LKVSI
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]