Click here to switch to the map view.

The map label for this gene is pepQ [H]

Identifier: 203283993

GI number: 203283993

Start: 72182

End: 73960

Strand: Reverse

Name: pepQ [H]

Synonym: BDU_71

Alternate gene names: 203283993

Gene position: 73960-72182 (Counterclockwise)

Preceding gene: 203284007

Following gene: 203283992

Centisome position: 7.94

GC content: 28.27

Gene sequence:

>1779_bases
ATGGAGGTTAATACAAGAATATTATCTTTAAGAAAATTGATGATAAAAAATAAGATAGATGCATATTTAATAGCAAGTCA
TGATCCGCATATGAGTGAATATTCTCATGCTAGATTTAATATTCGTGAATTTGTTACAGGTTTTACAGGAAGTGCTGGAA
CAGTAATTATTACAGAAACGGAATCAGTTCTTTTTACTGATGGTAGATATTTTTTACAAGCGACAAATGAACTTGAAGGA
ACTGAGTTTAAATTAATAAAACTTGGGGTTAAGGGGCATCCAGATATTTTTAGCTATGTTAATATGAAGCTTAAAGGATT
ACGGATTGGAGTTTATGCTGAGGATATTAGTATAAAATTTTATGATGATTTGGTTAAAAATTGTAAATTTACAGATATTG
AGATTTTACATGAAGATTTAATTTCTAAAATTTGGCAGGATAGGCCTTATTTTACAGGTAATAAAATATTTGAACTTAAG
GAAGCTCAAAAAAATGACAAAAGAATAAATAAAATCAATAAAGTTAATGCAAAATTAGAAGAAAATACAATTGATTTTTA
TGTTATAAGTTCTTTGGATGAAATAGCATGGCTTTTAAATTTAAGAGGATTTGATATTGAATCATCAGCTTTGTTTTATG
CTTTTTTGTTTATAGCTAGAAGTGAGAGATATAAGAATGTTCTTTTCGTTAATGTCGATAAACTTGATTTTGATTTAATA
GAGAGACTTGAAGTTGAAGGAATTGAGGTCGAAGATTATGGCAATTTTTATTCATTTTTAGAAGAGATTAATCATGAGGG
CAAATTTTTGATACCAGTTAATAGTAATGTTAAAATATTGGAATCTATTGGTAGATCAAATGCAGTGCTTGGACTTAGTA
TTGTTAATGAACTGAAGGCAATAAAATCTGATTATGAGATTAGTAAGATAAGAGACGCGCATATTATTGATGCTGTAAGT
TTGGTTAAATTTTTGTATAAATTTAAAAATTTAACCAAAGATGAACTTGCTGATTTGGATGAGGTTGATGTTTCAAATAT
GCTTTTAAGCTTTAGGACATTAAGAGATGAATTTTTTAGTTCTAGTTTTGATTCGATCATTGGTTTTAAAGAAAATTCAG
CATTGCCTCATTATAGACCAAAAAAAGGATTTAAAAAACTTAATCAGGATGGATTGCTTTTAATAGATTCTGGAGGTTCT
TATCTTGAACTTGGTACTACAGATGTTACGAGGACAGTTTTAATTGGAACAGCATCTCATAAAGAGAGAGAAGACTATAC
TTTAGTTCTTAAATCTTTTATTGCTCTTGCTTCTTTAAAATTTCCTTTTGGAATGTTAGGTGCATCTCTTGATGGTATTG
CCAGATTTCCTTTGCTTAAGCATGGCTTAAATTTTGCTCATGGAACGGGGCATGGAGTGGGATTTTTTCTTAATGTTCAT
GAATTTCCTGTTTCTATTAGTCCTTTATCCACTTATTCTTTTAAAGGTTCTGAAATTATTTCAATTGAACCTGGGATATA
TAGAACTTCTGAATATGGTATTAGAATTGAAAATTTAGTTTTTGTAAAGCAAAGTTATTCAAATGAATTTGGAATTTTTT
TGGAATTTGAAAATTTAACTCTTGTACCTTTTGAAAAAGAATTGATAGTTGTTGAAATGCTGTCAAAAGATGAATTAGAC
TATGTTAATAGTTATCATGAATTTGTATATTTTGCTTTAAAAGAATATCTTAGTGGTGATGAACTTAAGTTTTTAGAGAT
GTTAACTAGTAAGATATGA

Upstream 100 bases:

>100_bases
GTTACATTTAATTATATCAGATAAGAAGTTTTTTTAAAATTGAATTATTTGTTATAATTAAATAAAAAGTTACTTTTTAA
ATCCTAAGGAGCTTGCTTAT

Downstream 100 bases:

>100_bases
AATTTGTAAATTTATTGGCAATATTTATTTTTATTGTTTTTAATTCTGTATATTTGTTTTCAAATTCATTTAATGTTGTT
TTTCATGATTCTTATGAGGA

Product: peptidase, putative

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MEVNTRILSLRKLMIKNKIDAYLIASHDPHMSEYSHARFNIREFVTGFTGSAGTVIITETESVLFTDGRYFLQATNELEG
TEFKLIKLGVKGHPDIFSYVNMKLKGLRIGVYAEDISIKFYDDLVKNCKFTDIEILHEDLISKIWQDRPYFTGNKIFELK
EAQKNDKRINKINKVNAKLEENTIDFYVISSLDEIAWLLNLRGFDIESSALFYAFLFIARSERYKNVLFVNVDKLDFDLI
ERLEVEGIEVEDYGNFYSFLEEINHEGKFLIPVNSNVKILESIGRSNAVLGLSIVNELKAIKSDYEISKIRDAHIIDAVS
LVKFLYKFKNLTKDELADLDEVDVSNMLLSFRTLRDEFFSSSFDSIIGFKENSALPHYRPKKGFKKLNQDGLLLIDSGGS
YLELGTTDVTRTVLIGTASHKEREDYTLVLKSFIALASLKFPFGMLGASLDGIARFPLLKHGLNFAHGTGHGVGFFLNVH
EFPVSISPLSTYSFKGSEIISIEPGIYRTSEYGIRIENLVFVKQSYSNEFGIFLEFENLTLVPFEKELIVVEMLSKDELD
YVNSYHEFVYFALKEYLSGDELKFLEMLTSKI

Sequences:

>Translated_592_residues
MEVNTRILSLRKLMIKNKIDAYLIASHDPHMSEYSHARFNIREFVTGFTGSAGTVIITETESVLFTDGRYFLQATNELEG
TEFKLIKLGVKGHPDIFSYVNMKLKGLRIGVYAEDISIKFYDDLVKNCKFTDIEILHEDLISKIWQDRPYFTGNKIFELK
EAQKNDKRINKINKVNAKLEENTIDFYVISSLDEIAWLLNLRGFDIESSALFYAFLFIARSERYKNVLFVNVDKLDFDLI
ERLEVEGIEVEDYGNFYSFLEEINHEGKFLIPVNSNVKILESIGRSNAVLGLSIVNELKAIKSDYEISKIRDAHIIDAVS
LVKFLYKFKNLTKDELADLDEVDVSNMLLSFRTLRDEFFSSSFDSIIGFKENSALPHYRPKKGFKKLNQDGLLLIDSGGS
YLELGTTDVTRTVLIGTASHKEREDYTLVLKSFIALASLKFPFGMLGASLDGIARFPLLKHGLNFAHGTGHGVGFFLNVH
EFPVSISPLSTYSFKGSEIISIEPGIYRTSEYGIRIENLVFVKQSYSNEFGIFLEFENLTLVPFEKELIVVEMLSKDELD
YVNSYHEFVYFALKEYLSGDELKFLEMLTSKI
>Mature_592_residues
MEVNTRILSLRKLMIKNKIDAYLIASHDPHMSEYSHARFNIREFVTGFTGSAGTVIITETESVLFTDGRYFLQATNELEG
TEFKLIKLGVKGHPDIFSYVNMKLKGLRIGVYAEDISIKFYDDLVKNCKFTDIEILHEDLISKIWQDRPYFTGNKIFELK
EAQKNDKRINKINKVNAKLEENTIDFYVISSLDEIAWLLNLRGFDIESSALFYAFLFIARSERYKNVLFVNVDKLDFDLI
ERLEVEGIEVEDYGNFYSFLEEINHEGKFLIPVNSNVKILESIGRSNAVLGLSIVNELKAIKSDYEISKIRDAHIIDAVS
LVKFLYKFKNLTKDELADLDEVDVSNMLLSFRTLRDEFFSSSFDSIIGFKENSALPHYRPKKGFKKLNQDGLLLIDSGGS
YLELGTTDVTRTVLIGTASHKEREDYTLVLKSFIALASLKFPFGMLGASLDGIARFPLLKHGLNFAHGTGHGVGFFLNVH
EFPVSISPLSTYSFKGSEIISIEPGIYRTSEYGIRIENLVFVKQSYSNEFGIFLEFENLTLVPFEKELIVVEMLSKDELD
YVNSYHEFVYFALKEYLSGDELKFLEMLTSKI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=586, Percent_Identity=34.8122866894198, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI264681565, Length=585, Percent_Identity=33.3333333333333, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI93141226, Length=606, Percent_Identity=32.5082508250825, Blast_Score=273, Evalue=4e-73,
Organism=Escherichia coli, GI1788728, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=609, Percent_Identity=35.1395730706076, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25149105, Length=599, Percent_Identity=28.0467445742905, Blast_Score=206, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6322999, Length=661, Percent_Identity=32.67776096823, Blast_Score=293, Evalue=6e-80,
Organism=Drosophila melanogaster, GI17137632, Length=608, Percent_Identity=34.8684210526316, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI161078230, Length=605, Percent_Identity=27.4380165289256, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21357287, Length=605, Percent_Identity=27.4380165289256, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67756; Mature: 67756

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVNTRILSLRKLMIKNKIDAYLIASHDPHMSEYSHARFNIREFVTGFTGSAGTVIITET
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCHHHHHCCCCCCCCEEEEEEC
ESVLFTDGRYFLQATNELEGTEFKLIKLGVKGHPDIFSYVNMKLKGLRIGVYAEDISIKF
CEEEEECCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHCEEEEEEEEEEEEECEEEEE
YDDLVKNCKFTDIEILHEDLISKIWQDRPYFTGNKIFELKEAQKNDKRINKINKVNAKLE
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEE
ENTIDFYVISSLDEIAWLLNLRGFDIESSALFYAFLFIARSERYKNVLFVNVDKLDFDLI
CCCEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
ERLEVEGIEVEDYGNFYSFLEEINHEGKFLIPVNSNVKILESIGRSNAVLGLSIVNELKA
HHHCCCCEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCCCEEHHHHHHHHHH
IKSDYEISKIRDAHIIDAVSLVKFLYKFKNLTKDELADLDEVDVSNMLLSFRTLRDEFFS
HHCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHC
SSFDSIIGFKENSALPHYRPKKGFKKLNQDGLLLIDSGGSYLELGTTDVTRTVLIGTASH
CCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCC
KEREDYTLVLKSFIALASLKFPFGMLGASLDGIARFPLLKHGLNFAHGTGHGVGFFLNVH
CCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
EFPVSISPLSTYSFKGSEIISIEPGIYRTSEYGIRIENLVFVKQSYSNEFGIFLEFENLT
ECCEEECCCCEEECCCCEEEEECCCEEECCCCCEEEEEEEEEEECCCCCCEEEEEECCEE
LVPFEKELIVVEMLSKDELDYVNSYHEFVYFALKEYLSGDELKFLEMLTSKI
EEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEVNTRILSLRKLMIKNKIDAYLIASHDPHMSEYSHARFNIREFVTGFTGSAGTVIITET
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCHHHHHCCCCCCCCEEEEEEC
ESVLFTDGRYFLQATNELEGTEFKLIKLGVKGHPDIFSYVNMKLKGLRIGVYAEDISIKF
CEEEEECCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHCEEEEEEEEEEEEECEEEEE
YDDLVKNCKFTDIEILHEDLISKIWQDRPYFTGNKIFELKEAQKNDKRINKINKVNAKLE
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEE
ENTIDFYVISSLDEIAWLLNLRGFDIESSALFYAFLFIARSERYKNVLFVNVDKLDFDLI
CCCEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
ERLEVEGIEVEDYGNFYSFLEEINHEGKFLIPVNSNVKILESIGRSNAVLGLSIVNELKA
HHHCCCCEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCCCEEHHHHHHHHHH
IKSDYEISKIRDAHIIDAVSLVKFLYKFKNLTKDELADLDEVDVSNMLLSFRTLRDEFFS
HHCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHC
SSFDSIIGFKENSALPHYRPKKGFKKLNQDGLLLIDSGGSYLELGTTDVTRTVLIGTASH
CCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCC
KEREDYTLVLKSFIALASLKFPFGMLGASLDGIARFPLLKHGLNFAHGTGHGVGFFLNVH
CCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
EFPVSISPLSTYSFKGSEIISIEPGIYRTSEYGIRIENLVFVKQSYSNEFGIFLEFENLT
ECCEEECCCCEEECCCCEEEEECCCEEECCCCCEEEEEEEEEEECCCCCCEEEEEECCEE
LVPFEKELIVVEMLSKDELDYVNSYHEFVYFALKEYLSGDELKFLEMLTSKI
EEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]