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The map label for this gene is parE [H]

Identifier: 203283965

GI number: 203283965

Start: 45118

End: 46914

Strand: Reverse

Name: parE [H]

Synonym: BDU_41

Alternate gene names: 203283965

Gene position: 46914-45118 (Counterclockwise)

Preceding gene: 203283966

Following gene: 203283964

Centisome position: 5.04

GC content: 28.49

Gene sequence:

>1797_bases
ATGAAAAAAAATTTTTATGATGAGAGTAAAATTGTTACCTTATCTTCTCTTGAACATATTAGATTACGATCTGGAATGTA
TATTGGAAGACTAGGAGATGGTTCTAATATTGATGATGGTATTTATATTTTAATTAAAGAAATCGTTGATAATTCAATTG
ATGAATTTATTATGGGTTATGGCAAAGAAATTGTTATAAAAAGAGAGGATAATGTCATTACTGTAAGAGATTATGGTCGT
GGAATTCCTCTTGGAAAGGTTGTTGAGAGTGTCTCTGTTATTAATACTGGTGCTAAGTATAATGACGATGTTTTTCAATT
TTCTGTAGGGCTTAATGGAGTTGGGACTAAAGCTGTTAATGCTTTAAGTTCAAAATTTTTAATAAGGTCGATAAGAGAAG
GTAATTTCTTTGAAGCTGTTTTTTCAAAAGGAAATTTAATTAATACTACAGAAGGTAAATCTGATGAACAAAATGGCACT
TACATTGAGTTTTTAGCAGATACAGAAATTTTTGGGAAATATAAGTATAGTGAGGATTTTTTACAAAGAAGATTTTTTCA
TTATGCTTGCTTAAATAAAGGTTTAGAAATTAATTATAATGATCAAATTTTTCGGTCTGATAATGGGCTTCTTGATTTTA
TAAGAGCCGAGATTAAGTATGAAGATTTACTTTATGATTTTGTTTATTATTCTAGTAAAACTTTAGAGTTTGCATTTTCT
CATACAAATAATTATGGTGAGACATATTTTTCATTTGTAAATGGACAATATACTAGTGATGGAGGTACTCATCAAACAGG
TTTTAGAGAAGGTTTTGCGAGAGCCATTAATGATTTTTTAAAAAAAACATATTCGTCTACTGATATTAGAGAAGGACTTG
TGGCAACTCTTTCAATTAAAATAAAGGATCCAATATTTGAAAGTCAGACTAAAAATAAGCTTGGTAATGTTGAAACTAGA
GGTAACATTGCTAAGGAAGTGCAAAGGCTAATTTTAGAGATTTTATATAAAGATAAAACACTTGCAAAAACGATAGAGAG
TAAAGTTATTGATAATGAACGTCTTAGAAAGGAATTAAGCAGTGTACGGAAAGAGGCAAAAGAGAGAGCAAAAAAAATAT
CTTTTAAAATTCCTAAACTTAAAGATTGTAAATTTCATTTTAATGAAAAAAGTGTACATTCTGATGCAACCATGATTTTT
TTAACAGAAGGAGATTCTGCAACAGGATCAATGGTGTCTTGTAGAGATGTATATACACAGGCTATATTTTCTCTTCGTGG
TAAACCCCAAAATATGTTTGAAAAAAATAGATCTGAAATTTATAAAAATGAAGAACTCTATAATATGATGGTAGCTCTTG
GTATTGAAGAATCAATTGAAAATTTAAGATATAATAAAGTAGTAATTGCTACAGATGCAGATTTTGATGGATTTCATATT
AGGAATTTGCTTTTAACATTTTTCTTAACTTATTTTGAAGATTTGGTTTTAAATGGGCATATGCATATTTTAGAGACACC
ACTTTTTAGAGTAAGAAATAAGAGTGCTACTATTTATTGTTATTCTGAGGAAGATAAACAGAAAGCGCTTCTTAAACTTA
AAAATCCTGAAGTTACAAGATTTAAAGGACTTGGAGAAATTTCGCCAAATGAATTTAAGGGTTTTATTGATGTTGCTAAT
ATTAAACTTACAAAGGTAGATCTTGTCAATATTAAAGAAATAAAAGAGCAATTGGGATTTTATATGGGGCCAAATACTCC
TGAGAGACGAAACTTTATTATGGAGAATTTAATTTAA

Upstream 100 bases:

>100_bases
CAGATGATGAGAAGGAGCAGCTTCATGTTATTGTGAGAGATAAAATAGTTAAAAAATTAGAAAAAATGAAAATTCAGTAT
AATTGTTGATAGGAATTTAA

Downstream 100 bases:

>100_bases
TGAACATTAAAACATTACTTAGAGATAATTTTTTACAGTATTCATCTTATGTTATTAAAGATCGTGCAATTGCTAGTGTT
ATTGATGGATTTAAACCGGT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MKKNFYDESKIVTLSSLEHIRLRSGMYIGRLGDGSNIDDGIYILIKEIVDNSIDEFIMGYGKEIVIKREDNVITVRDYGR
GIPLGKVVESVSVINTGAKYNDDVFQFSVGLNGVGTKAVNALSSKFLIRSIREGNFFEAVFSKGNLINTTEGKSDEQNGT
YIEFLADTEIFGKYKYSEDFLQRRFFHYACLNKGLEINYNDQIFRSDNGLLDFIRAEIKYEDLLYDFVYYSSKTLEFAFS
HTNNYGETYFSFVNGQYTSDGGTHQTGFREGFARAINDFLKKTYSSTDIREGLVATLSIKIKDPIFESQTKNKLGNVETR
GNIAKEVQRLILEILYKDKTLAKTIESKVIDNERLRKELSSVRKEAKERAKKISFKIPKLKDCKFHFNEKSVHSDATMIF
LTEGDSATGSMVSCRDVYTQAIFSLRGKPQNMFEKNRSEIYKNEELYNMMVALGIEESIENLRYNKVVIATDADFDGFHI
RNLLLTFFLTYFEDLVLNGHMHILETPLFRVRNKSATIYCYSEEDKQKALLKLKNPEVTRFKGLGEISPNEFKGFIDVAN
IKLTKVDLVNIKEIKEQLGFYMGPNTPERRNFIMENLI

Sequences:

>Translated_598_residues
MKKNFYDESKIVTLSSLEHIRLRSGMYIGRLGDGSNIDDGIYILIKEIVDNSIDEFIMGYGKEIVIKREDNVITVRDYGR
GIPLGKVVESVSVINTGAKYNDDVFQFSVGLNGVGTKAVNALSSKFLIRSIREGNFFEAVFSKGNLINTTEGKSDEQNGT
YIEFLADTEIFGKYKYSEDFLQRRFFHYACLNKGLEINYNDQIFRSDNGLLDFIRAEIKYEDLLYDFVYYSSKTLEFAFS
HTNNYGETYFSFVNGQYTSDGGTHQTGFREGFARAINDFLKKTYSSTDIREGLVATLSIKIKDPIFESQTKNKLGNVETR
GNIAKEVQRLILEILYKDKTLAKTIESKVIDNERLRKELSSVRKEAKERAKKISFKIPKLKDCKFHFNEKSVHSDATMIF
LTEGDSATGSMVSCRDVYTQAIFSLRGKPQNMFEKNRSEIYKNEELYNMMVALGIEESIENLRYNKVVIATDADFDGFHI
RNLLLTFFLTYFEDLVLNGHMHILETPLFRVRNKSATIYCYSEEDKQKALLKLKNPEVTRFKGLGEISPNEFKGFIDVAN
IKLTKVDLVNIKEIKEQLGFYMGPNTPERRNFIMENLI
>Mature_598_residues
MKKNFYDESKIVTLSSLEHIRLRSGMYIGRLGDGSNIDDGIYILIKEIVDNSIDEFIMGYGKEIVIKREDNVITVRDYGR
GIPLGKVVESVSVINTGAKYNDDVFQFSVGLNGVGTKAVNALSSKFLIRSIREGNFFEAVFSKGNLINTTEGKSDEQNGT
YIEFLADTEIFGKYKYSEDFLQRRFFHYACLNKGLEINYNDQIFRSDNGLLDFIRAEIKYEDLLYDFVYYSSKTLEFAFS
HTNNYGETYFSFVNGQYTSDGGTHQTGFREGFARAINDFLKKTYSSTDIREGLVATLSIKIKDPIFESQTKNKLGNVETR
GNIAKEVQRLILEILYKDKTLAKTIESKVIDNERLRKELSSVRKEAKERAKKISFKIPKLKDCKFHFNEKSVHSDATMIF
LTEGDSATGSMVSCRDVYTQAIFSLRGKPQNMFEKNRSEIYKNEELYNMMVALGIEESIENLRYNKVVIATDADFDGFHI
RNLLLTFFLTYFEDLVLNGHMHILETPLFRVRNKSATIYCYSEEDKQKALLKLKNPEVTRFKGLGEISPNEFKGFIDVAN
IKLTKVDLVNIKEIKEQLGFYMGPNTPERRNFIMENLI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=609, Percent_Identity=26.2725779967159, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI19913406, Length=616, Percent_Identity=25.3246753246753, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI48994957, Length=563, Percent_Identity=32.3268206039076, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1789408, Length=587, Percent_Identity=29.9829642248722, Blast_Score=246, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17535065, Length=621, Percent_Identity=25.2818035426731, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI212645845, Length=537, Percent_Identity=26.6294227188082, Blast_Score=107, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324241, Length=591, Percent_Identity=24.8730964467005, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136538, Length=572, Percent_Identity=27.4475524475524, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 68712; Mature: 68712

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNFYDESKIVTLSSLEHIRLRSGMYIGRLGDGSNIDDGIYILIKEIVDNSIDEFIMGY
CCCCCCCCCCEEEECCHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHCC
GKEIVIKREDNVITVRDYGRGIPLGKVVESVSVINTGAKYNDDVFQFSVGLNGVGTKAVN
CCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHH
ALSSKFLIRSIREGNFFEAVFSKGNLINTTEGKSDEQNGTYIEFLADTEIFGKYKYSEDF
HHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCCCCCCCCCEEEEEECCHHHCCCCCCHHH
LQRRFFHYACLNKGLEINYNDQIFRSDNGLLDFIRAEIKYEDLLYDFVYYSSKTLEFAFS
HHHHHHHHHHHCCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
HTNNYGETYFSFVNGQYTSDGGTHQTGFREGFARAINDFLKKTYSSTDIREGLVATLSIK
CCCCCCHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEE
IKDPIFESQTKNKLGNVETRGNIAKEVQRLILEILYKDKTLAKTIESKVIDNERLRKELS
EECCCHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHH
SVRKEAKERAKKISFKIPKLKDCKFHFNEKSVHSDATMIFLTEGDSATGSMVSCRDVYTQ
HHHHHHHHHHHHCEECCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
AIFSLRGKPQNMFEKNRSEIYKNEELYNMMVALGIEESIENLRYNKVVIATDADFDGFHI
HHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCCCHHH
RNLLLTFFLTYFEDLVLNGHMHILETPLFRVRNKSATIYCYSEEDKQKALLKLKNPEVTR
HHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHEECCCCCCC
FKGLGEISPNEFKGFIDVANIKLTKVDLVNIKEIKEQLGFYMGPNTPERRNFIMENLI
CCCCCCCCHHHHCCEEEEEEEEEEEEEECCHHHHHHHCCEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKKNFYDESKIVTLSSLEHIRLRSGMYIGRLGDGSNIDDGIYILIKEIVDNSIDEFIMGY
CCCCCCCCCCEEEECCHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHCC
GKEIVIKREDNVITVRDYGRGIPLGKVVESVSVINTGAKYNDDVFQFSVGLNGVGTKAVN
CCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHH
ALSSKFLIRSIREGNFFEAVFSKGNLINTTEGKSDEQNGTYIEFLADTEIFGKYKYSEDF
HHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCCCCCCCCCEEEEEECCHHHCCCCCCHHH
LQRRFFHYACLNKGLEINYNDQIFRSDNGLLDFIRAEIKYEDLLYDFVYYSSKTLEFAFS
HHHHHHHHHHHCCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
HTNNYGETYFSFVNGQYTSDGGTHQTGFREGFARAINDFLKKTYSSTDIREGLVATLSIK
CCCCCCHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEE
IKDPIFESQTKNKLGNVETRGNIAKEVQRLILEILYKDKTLAKTIESKVIDNERLRKELS
EECCCHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHH
SVRKEAKERAKKISFKIPKLKDCKFHFNEKSVHSDATMIFLTEGDSATGSMVSCRDVYTQ
HHHHHHHHHHHHCEECCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
AIFSLRGKPQNMFEKNRSEIYKNEELYNMMVALGIEESIENLRYNKVVIATDADFDGFHI
HHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCCCHHH
RNLLLTFFLTYFEDLVLNGHMHILETPLFRVRNKSATIYCYSEEDKQKALLKLKNPEVTR
HHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHEECCCCCCC
FKGLGEISPNEFKGFIDVANIKLTKVDLVNIKEIKEQLGFYMGPNTPERRNFIMENLI
CCCCCCCCHHHHCCEEEEEEEEEEEEEECCHHHHHHHCCEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685; 7812434 [H]