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The map label for this gene is atpB

Identifier: 197120292

GI number: 197120292

Start: 4468885

End: 4469574

Strand: Direct

Name: atpB

Synonym: Gbem_3931

Alternate gene names: 197120292

Gene position: 4468885-4469574 (Clockwise)

Preceding gene: 197120291

Following gene: 197120293

Centisome position: 96.83

GC content: 59.71

Gene sequence:

>690_bases
ATGGTTCATCCGTATCTATTCCTCAATTTTTTCCGCGAGTTGCTTCATCCCCTCGGTTTCTCCGAGGCTGGAGCCGACGC
CGTCGTTTATACCTGGCTGATCATGATCGGCTTGGTGGTCCTCTCCATCGCAGCCACCAAGCGGCTGCAGGCCGTTCCGT
CCGGTCTCCAGAACTTCATGGAAGTCATCGTCGGGGGCATTGAGAACATGCTGGTGGAAACCATGGGCGAGCACGGCAAG
CCGTTCTTCCCGCTGGTCGCAACCCTGGCGCTCTTCATCCTGGTGTCGAACCTGATCGGCCTGGTCCCCGGCTTCTTCCC
GCCGACCGCCAACATCAACACCACTGCTGCCTGCGCGGTCGTCGTGTTCGTCACCACCCACATCGTCGGTGTCAAGCACC
ACGGCGCCGGCTACATCAAGCATTTCCTGGGCCCCATCGCCTGGCTCGCGCCGATGATGTTCTTCATCGAGGTGATCGGT
CACCTGAGCCGCGTGATCTCCCTGACGCTGCGTCTCTTCGGTAACATGAACGGCCACGAGCTGGTCCTGATCATCTTCTT
CGGCCTGGCTCCGTTCATAGTGCCCCTGCCGATGATGCTAATGGGCGTCCTGGTCTCCTTCATCCAGGCCTTCGTGTTCA
TGCTGCTGGCGATGATCTACATCCAGGGCTCGCTGGAGCACGCGCACTAA

Upstream 100 bases:

>100_bases
GGGTCGACATCTTCGGCCTGCTGATCGGACTGTCAGTCCTGGTCCTGAACATAACGGTATTTTCAATATATTTGTCCACC
CGTAAAGGAGGCTAGCAGCA

Downstream 100 bases:

>100_bases
GAGGCAGATAAAGATAAAGATTGAGATTAAGAACACCCTCGATCTTTGTCCGGTTTCCTCAATCTTAGTCTTAATCTCAA
TCTGATTTTTAATTCCTATA

Product: ATP synthase F0 subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MVHPYLFLNFFRELLHPLGFSEAGADAVVYTWLIMIGLVVLSIAATKRLQAVPSGLQNFMEVIVGGIENMLVETMGEHGK
PFFPLVATLALFILVSNLIGLVPGFFPPTANINTTAACAVVVFVTTHIVGVKHHGAGYIKHFLGPIAWLAPMMFFIEVIG
HLSRVISLTLRLFGNMNGHELVLIIFFGLAPFIVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEHAH

Sequences:

>Translated_229_residues
MVHPYLFLNFFRELLHPLGFSEAGADAVVYTWLIMIGLVVLSIAATKRLQAVPSGLQNFMEVIVGGIENMLVETMGEHGK
PFFPLVATLALFILVSNLIGLVPGFFPPTANINTTAACAVVVFVTTHIVGVKHHGAGYIKHFLGPIAWLAPMMFFIEVIG
HLSRVISLTLRLFGNMNGHELVLIIFFGLAPFIVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEHAH
>Mature_229_residues
MVHPYLFLNFFRELLHPLGFSEAGADAVVYTWLIMIGLVVLSIAATKRLQAVPSGLQNFMEVIVGGIENMLVETMGEHGK
PFFPLVATLALFILVSNLIGLVPGFFPPTANINTTAACAVVVFVTTHIVGVKHHGAGYIKHFLGPIAWLAPMMFFIEVIG
HLSRVISLTLRLFGNMNGHELVLIIFFGLAPFIVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEHAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=208, Percent_Identity=29.8076923076923, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6226527, Length=183, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_GEOBB (B5EFG8)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002140719.1
- ProteinModelPortal:   B5EFG8
- GeneID:   6780795
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_3931
- HOGENOM:   HBG734175
- OMA:   LHGQVFL
- ProtClustDB:   CLSK924394
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 25116; Mature: 25116

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfaace9c)-; HASH(0xfe1cda4)-; HASH(0xf368f20)-; HASH(0x10fcdbac)-; HASH(0xef1adb0)-; HASH(0xfc2f5e8)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHPYLFLNFFRELLHPLGFSEAGADAVVYTWLIMIGLVVLSIAATKRLQAVPSGLQNFM
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVIVGGIENMLVETMGEHGKPFFPLVATLALFILVSNLIGLVPGFFPPTANINTTAACAV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
VVFVTTHIVGVKHHGAGYIKHFLGPIAWLAPMMFFIEVIGHLSRVISLTLRLFGNMNGHE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LVLIIFFGLAPFIVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEHAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MVHPYLFLNFFRELLHPLGFSEAGADAVVYTWLIMIGLVVLSIAATKRLQAVPSGLQNFM
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVIVGGIENMLVETMGEHGKPFFPLVATLALFILVSNLIGLVPGFFPPTANINTTAACAV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
VVFVTTHIVGVKHHGAGYIKHFLGPIAWLAPMMFFIEVIGHLSRVISLTLRLFGNMNGHE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LVLIIFFGLAPFIVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEHAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA