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The map label for this gene is adhB [H]

Identifier: 197120238

GI number: 197120238

Start: 4415175

End: 4416335

Strand: Direct

Name: adhB [H]

Synonym: Gbem_3877

Alternate gene names: 197120238

Gene position: 4415175-4416335 (Clockwise)

Preceding gene: 197120236

Following gene: 197120239

Centisome position: 95.67

GC content: 65.72

Gene sequence:

>1161_bases
ATGGCGGAAGGTCTCGAACTGAGGAAATTTCTGGCCCCCGAGTTTATTTGCGGCGCCGGAGCGCGGCAACTGGCCGGCAG
ATACGCCAAGAACCTCGGCGGGCGCAAGATACTGGTGGTGTCGGACCCCGGGGTGGTCGAGGCGGGGTGGACCAAGGACG
TGACCGACAGCCTGGAGGCCGCCGGTCTTTCCTATGTCCTCTTCACCGCCATCACCCCGAACCCCAAGGTCGAAGAGGTC
ATGGCCGGGGTGGCGCTCTACCAGGCGGAGCGCTGCGACCTGCTGGTCGCGGTCGGCGGGGGGAGCCCCATCGACTGCGC
CAAGGGGATCGGCATAGTCAGCACCAACAAGAGGCACATCCTCGATTTCGAAGGGGTGGACATGGTGACCTCCCCCATGC
CCCCCTTGATCTGCATCCCCACCACCGGGGGAACCTCCGCCGACGTCTCCCAGTTCGCCATCATCAGCAACCCCATGGAG
AGGGTCAAGATCGCCATCATCAGCAAGTCGGTCGTCCCCGACATCGCCCTCATCGACCCCGTCACCCTCACCACCATGGA
TCCCTACCTGACCGCCTGCACCGGGCTAGACGCCATGACCCACGCCATCGAGGCCTTCGTTTCCACGGCCCGCTCCAACA
TGACCGACCTGCACGCCCTGGAGGCGCTGCGCCTGCTCTCGGCCAGCCTCGTCCCCAGCATACGCAATCCCGAGGACCTG
AACCTGCGCGGCGACGTCATGATGGGGAGCCTGCAGGCCGGGCTCGCCTTCTCCAACGCCATCCTCGGTGCCACCCACGC
CATGGCGCATAGTCTAGGGGGCGCGCTCGACCTGGCGCACGGGGAGTGCAACGCCATCCTGCTGGACCACGTCATAGAGT
TCAACTTCGCCGCGTCGCCGGAGCGGTTCGAGCGCATAGCCCAGGTCATGGGGCTCGACCTGCGGGGCCTGGGGGATCAG
GAGAGTAAAAAGGCACTCTTGCGGCATGTCAGGGAGCTGAAGGCCCAAGCGGGGGTGGCCCGGACCCTGGCCGAGGTAGG
GGTGGGGGTGAGCGACCTCTCCCTGTTCAGCGAGCATGCCCTCAAAGACCCCTGCATGGCGACGAACCCGCGCCGCCCCT
CCAAGAGGGACATCGAGGTCGTGTATGAAGAAAGCCTCTGA

Upstream 100 bases:

>100_bases
TAATGCCTGTGAAATATTGTTATAGTGGTCGGCGAGTTGGAAGCAGACAGTGGCGCTTTTGTCGACAAACGATGAACAAC
GGAGCAGGGGAGACGGGAGC

Downstream 100 bases:

>100_bases
CCCGCCCCAACCCGACCCCCAGGACGCCCTGGCTGCGCTGCAGCAAAAGCTCGCAGGTCTTGGGGAATCCTCGATGCGCA
AGAGCTACTACCCCGAGCTG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MAEGLELRKFLAPEFICGAGARQLAGRYAKNLGGRKILVVSDPGVVEAGWTKDVTDSLEAAGLSYVLFTAITPNPKVEEV
MAGVALYQAERCDLLVAVGGGSPIDCAKGIGIVSTNKRHILDFEGVDMVTSPMPPLICIPTTGGTSADVSQFAIISNPME
RVKIAIISKSVVPDIALIDPVTLTTMDPYLTACTGLDAMTHAIEAFVSTARSNMTDLHALEALRLLSASLVPSIRNPEDL
NLRGDVMMGSLQAGLAFSNAILGATHAMAHSLGGALDLAHGECNAILLDHVIEFNFAASPERFERIAQVMGLDLRGLGDQ
ESKKALLRHVRELKAQAGVARTLAEVGVGVSDLSLFSEHALKDPCMATNPRRPSKRDIEVVYEESL

Sequences:

>Translated_386_residues
MAEGLELRKFLAPEFICGAGARQLAGRYAKNLGGRKILVVSDPGVVEAGWTKDVTDSLEAAGLSYVLFTAITPNPKVEEV
MAGVALYQAERCDLLVAVGGGSPIDCAKGIGIVSTNKRHILDFEGVDMVTSPMPPLICIPTTGGTSADVSQFAIISNPME
RVKIAIISKSVVPDIALIDPVTLTTMDPYLTACTGLDAMTHAIEAFVSTARSNMTDLHALEALRLLSASLVPSIRNPEDL
NLRGDVMMGSLQAGLAFSNAILGATHAMAHSLGGALDLAHGECNAILLDHVIEFNFAASPERFERIAQVMGLDLRGLGDQ
ESKKALLRHVRELKAQAGVARTLAEVGVGVSDLSLFSEHALKDPCMATNPRRPSKRDIEVVYEESL
>Mature_385_residues
AEGLELRKFLAPEFICGAGARQLAGRYAKNLGGRKILVVSDPGVVEAGWTKDVTDSLEAAGLSYVLFTAITPNPKVEEVM
AGVALYQAERCDLLVAVGGGSPIDCAKGIGIVSTNKRHILDFEGVDMVTSPMPPLICIPTTGGTSADVSQFAIISNPMER
VKIAIISKSVVPDIALIDPVTLTTMDPYLTACTGLDAMTHAIEAFVSTARSNMTDLHALEALRLLSASLVPSIRNPEDLN
LRGDVMMGSLQAGLAFSNAILGATHAMAHSLGGALDLAHGECNAILLDHVIEFNFAASPERFERIAQVMGLDLRGLGDQE
SKKALLRHVRELKAQAGVARTLAEVGVGVSDLSLFSEHALKDPCMATNPRRPSKRDIEVVYEESL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=408, Percent_Identity=25.9803921568627, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=36.5079365079365, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI1789163, Length=359, Percent_Identity=34.8189415041783, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082107, Length=370, Percent_Identity=34.0540540540541, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787493, Length=375, Percent_Identity=31.4666666666667, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789386, Length=345, Percent_Identity=27.2463768115942, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=420, Percent_Identity=26.1904761904762, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=36.968085106383, Blast_Score=259, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24657991, Length=408, Percent_Identity=25.9803921568627, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40997; Mature: 40866

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGLELRKFLAPEFICGAGARQLAGRYAKNLGGRKILVVSDPGVVEAGWTKDVTDSLEA
CCCCHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHH
AGLSYVLFTAITPNPKVEEVMAGVALYQAERCDLLVAVGGGSPIDCAKGIGIVSTNKRHI
CCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEECCCCEE
LDFEGVDMVTSPMPPLICIPTTGGTSADVSQFAIISNPMERVKIAIISKSVVPDIALIDP
EEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHEEEEEEHHHCCCEEEECC
VTLTTMDPYLTACTGLDAMTHAIEAFVSTARSNMTDLHALEALRLLSASLVPSIRNPEDL
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLRGDVMMGSLQAGLAFSNAILGATHAMAHSLGGALDLAHGECNAILLDHVIEFNFAASP
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCCH
ERFERIAQVMGLDLRGLGDQESKKALLRHVRELKAQAGVARTLAEVGVGVSDLSLFSEHA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LKDPCMATNPRRPSKRDIEVVYEESL
HCCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
AEGLELRKFLAPEFICGAGARQLAGRYAKNLGGRKILVVSDPGVVEAGWTKDVTDSLEA
CCCHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHH
AGLSYVLFTAITPNPKVEEVMAGVALYQAERCDLLVAVGGGSPIDCAKGIGIVSTNKRHI
CCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEECCCCEE
LDFEGVDMVTSPMPPLICIPTTGGTSADVSQFAIISNPMERVKIAIISKSVVPDIALIDP
EEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHEEEEEEHHHCCCEEEECC
VTLTTMDPYLTACTGLDAMTHAIEAFVSTARSNMTDLHALEALRLLSASLVPSIRNPEDL
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLRGDVMMGSLQAGLAFSNAILGATHAMAHSLGGALDLAHGECNAILLDHVIEFNFAASP
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCCH
ERFERIAQVMGLDLRGLGDQESKKALLRHVRELKAQAGVARTLAEVGVGVSDLSLFSEHA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LKDPCMATNPRRPSKRDIEVVYEESL
HCCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]