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The map label for this gene is cysS

Identifier: 197120161

GI number: 197120161

Start: 4339462

End: 4340904

Strand: Direct

Name: cysS

Synonym: Gbem_3800

Alternate gene names: 197120161

Gene position: 4339462-4340904 (Clockwise)

Preceding gene: 197120160

Following gene: 197120164

Centisome position: 94.03

GC content: 61.4

Gene sequence:

>1443_bases
ATGCCCCTACGCGTCTACAACACCCTTACCGGCAGCAAGGAAGAATTCGTACCGATCAACCCCGGCAAGGTCGGCATGTA
CGTCTGCGGCGTAACGGTCTACGACCACTGCCATATCGGTCACGCCCGCGCCAACGTGGTGTTCGACATGATCTACCGCC
ACCTCCGCTCCAAGGGGCTAGAGGTCACCTACGTCAGGAACTACACGGACATCGACGACAAGATCATCAACCGCGCCAAC
CGCGACGGCGTCCCCTATAACGAGATCTCCGAGCGCTTCATCAAGGAATTCGACAACGACATGGCGCGGCTCATGCTGCA
GCTCCCCACCTTCCAGCCCAAGGCGACGGAACACATCCCCGAGATCATCGCACTGGTGCAGACGCTGATCGACAAGGGGT
TCGCCTACCAGTCCGGCTCCGACGTCTTCTACCGCGTGGACCGCTTCGAGGGATACCTGAAGCTTTCCAAGCGGAACCTC
GAAGACATGCAGGCGGGCGCCCGCATAGACGTGGACGAAAGGAAGGAACACCCCATGGACTTCGCCCTCTGGAAAGGGGC
GAAGCCTGGCGAGCCGTACTGGGAATCCCCCTGGGGCCAGGGAAGGCCGGGGTGGCACATCGAGTGCTCCGCAATGAGCA
CCAAGTTCCTGGGCGAGACCCTCGACATCCACGGCGGCGGTAAGGACCTGATCTTCCCGCACCACGAGAACGAAATCGCG
CAGTCGGAGGCGGCGTCCGGGAAACCCTTCGTCAAGTACTGGCTGCACAATGGCTTCGTCAACATCAACTCGGAGAAGAT
GTCCAAGTCCCTAGGGAACTTCTTCACCATCAAGGAGATCCTGGAGAGCTACGACGCGGAGGTGCTCCGCTTCTTCCTCC
TTTCGGCCCACTACCGCTCGCCGATCGACTTCTCGGACCAGAACCTGAAAGAAGCCGAGCTCGGGCTAGAGCGGATCTAC
AAGGCGCTGGCCGGCATATACGAGCGGCTGGCAAGCGGGGCGAACACCCCCGCGGGCGCGGATAACGCCGAGTTCGTCGA
GAAGGTCGCCGGGTTTGCAGGGCGCTTCGGCGACGCCATGGACGACGACTTCAACACCGCGCTGGCTCTGGGGCATCTCT
TCGACCTGGTGCGCGTAATCAACAGGGAGCTTCCCACCGCATCGACCGGGCTCCTAGAACAGGCCAAGGCCGAGGTGGCC
AAGATGGCCGCCGTGCTCGGGATCTGCGACTCCGTTCCCGCCGCGTTCCTGCAGCGCATGAAGGATCGCAAGACCTCCGA
CATTGAGATGTCGGCAGAGGAGATAGAGGCGCTGATAGCCGAGCGCGCCGAGGCGAGGAAGGCGAAGAACTTCAAGCGGG
GGGACGAGATCAGAGACCTGCTCCTGGAAAAGAACATCGTCCTTTTGGACAGCGCGCAGGGTACTACCTGGAAGGTGAAG
TAA

Upstream 100 bases:

>100_bases
GGCCGCAGGCCGGGTGAGGGAGAGGCCGCAGGCAAAAATTCGGCTGCAACAGATAACATCGGTCGCATGACCTTCAACAC
TTTGGAAAAGAGGAACTGAT

Downstream 100 bases:

>100_bases
ACGGCTTTCCTTTCGAATGCAGGTATAAAAAAAGGCCGCTTAACGCGGCCGTTTTTTATTGGGTTGGTGTTGCAAGGCGG
CCTTAGGCCGCCTTCTGGCT

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MPLRVYNTLTGSKEEFVPINPGKVGMYVCGVTVYDHCHIGHARANVVFDMIYRHLRSKGLEVTYVRNYTDIDDKIINRAN
RDGVPYNEISERFIKEFDNDMARLMLQLPTFQPKATEHIPEIIALVQTLIDKGFAYQSGSDVFYRVDRFEGYLKLSKRNL
EDMQAGARIDVDERKEHPMDFALWKGAKPGEPYWESPWGQGRPGWHIECSAMSTKFLGETLDIHGGGKDLIFPHHENEIA
QSEAASGKPFVKYWLHNGFVNINSEKMSKSLGNFFTIKEILESYDAEVLRFFLLSAHYRSPIDFSDQNLKEAELGLERIY
KALAGIYERLASGANTPAGADNAEFVEKVAGFAGRFGDAMDDDFNTALALGHLFDLVRVINRELPTASTGLLEQAKAEVA
KMAAVLGICDSVPAAFLQRMKDRKTSDIEMSAEEIEALIAERAEARKAKNFKRGDEIRDLLLEKNIVLLDSAQGTTWKVK

Sequences:

>Translated_480_residues
MPLRVYNTLTGSKEEFVPINPGKVGMYVCGVTVYDHCHIGHARANVVFDMIYRHLRSKGLEVTYVRNYTDIDDKIINRAN
RDGVPYNEISERFIKEFDNDMARLMLQLPTFQPKATEHIPEIIALVQTLIDKGFAYQSGSDVFYRVDRFEGYLKLSKRNL
EDMQAGARIDVDERKEHPMDFALWKGAKPGEPYWESPWGQGRPGWHIECSAMSTKFLGETLDIHGGGKDLIFPHHENEIA
QSEAASGKPFVKYWLHNGFVNINSEKMSKSLGNFFTIKEILESYDAEVLRFFLLSAHYRSPIDFSDQNLKEAELGLERIY
KALAGIYERLASGANTPAGADNAEFVEKVAGFAGRFGDAMDDDFNTALALGHLFDLVRVINRELPTASTGLLEQAKAEVA
KMAAVLGICDSVPAAFLQRMKDRKTSDIEMSAEEIEALIAERAEARKAKNFKRGDEIRDLLLEKNIVLLDSAQGTTWKVK
>Mature_479_residues
PLRVYNTLTGSKEEFVPINPGKVGMYVCGVTVYDHCHIGHARANVVFDMIYRHLRSKGLEVTYVRNYTDIDDKIINRANR
DGVPYNEISERFIKEFDNDMARLMLQLPTFQPKATEHIPEIIALVQTLIDKGFAYQSGSDVFYRVDRFEGYLKLSKRNLE
DMQAGARIDVDERKEHPMDFALWKGAKPGEPYWESPWGQGRPGWHIECSAMSTKFLGETLDIHGGGKDLIFPHHENEIAQ
SEAASGKPFVKYWLHNGFVNINSEKMSKSLGNFFTIKEILESYDAEVLRFFLLSAHYRSPIDFSDQNLKEAELGLERIYK
ALAGIYERLASGANTPAGADNAEFVEKVAGFAGRFGDAMDDDFNTALALGHLFDLVRVINRELPTASTGLLEQAKAEVAK
MAAVLGICDSVPAAFLQRMKDRKTSDIEMSAEEIEALIAERAEARKAKNFKRGDEIRDLLLEKNIVLLDSAQGTTWKVK

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=392, Percent_Identity=40.0510204081633, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI303304987, Length=245, Percent_Identity=40.4081632653061, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI21269877, Length=245, Percent_Identity=40.4081632653061, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI62240992, Length=245, Percent_Identity=40.4081632653061, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI10835051, Length=245, Percent_Identity=40.4081632653061, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1786737, Length=479, Percent_Identity=50.7306889352818, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17509795, Length=260, Percent_Identity=42.3076923076923, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17509797, Length=260, Percent_Identity=42.3076923076923, Blast_Score=187, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6324082, Length=337, Percent_Identity=35.6083086053413, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19922218, Length=503, Percent_Identity=33.7972166998012, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI19922364, Length=245, Percent_Identity=40.8163265306122, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_GEOBB (B5EEK6)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002140588.1
- ProteinModelPortal:   B5EEK6
- SMR:   B5EEK6
- GeneID:   6780664
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_3800
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- ProtClustDB:   PRK00260
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 54132; Mature: 54001

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 269-269

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRVYNTLTGSKEEFVPINPGKVGMYVCGVTVYDHCHIGHARANVVFDMIYRHLRSKGL
CCEEEEECCCCCCCCEEECCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
EVTYVRNYTDIDDKIINRANRDGVPYNEISERFIKEFDNDMARLMLQLPTFQPKATEHIP
EEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
EIIALVQTLIDKGFAYQSGSDVFYRVDRFEGYLKLSKRNLEDMQAGARIDVDERKEHPMD
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHCCCCC
FALWKGAKPGEPYWESPWGQGRPGWHIECSAMSTKFLGETLDIHGGGKDLIFPHHENEIA
EEHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCEEECCCCCCEECCCCCCHHH
QSEAASGKPFVKYWLHNGFVNINSEKMSKSLGNFFTIKEILESYDAEVLRFFLLSAHYRS
HHHCCCCCHHHHHHHHCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIDFSDQNLKEAELGLERIYKALAGIYERLASGANTPAGADNAEFVEKVAGFAGRFGDAM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
DDDFNTALALGHLFDLVRVINRELPTASTGLLEQAKAEVAKMAAVLGICDSVPAAFLQRM
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDRKTSDIEMSAEEIEALIAERAEARKAKNFKRGDEIRDLLLEKNIVLLDSAQGTTWKVK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCCEEECC
>Mature Secondary Structure 
PLRVYNTLTGSKEEFVPINPGKVGMYVCGVTVYDHCHIGHARANVVFDMIYRHLRSKGL
CEEEEECCCCCCCCEEECCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
EVTYVRNYTDIDDKIINRANRDGVPYNEISERFIKEFDNDMARLMLQLPTFQPKATEHIP
EEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
EIIALVQTLIDKGFAYQSGSDVFYRVDRFEGYLKLSKRNLEDMQAGARIDVDERKEHPMD
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHCCCCC
FALWKGAKPGEPYWESPWGQGRPGWHIECSAMSTKFLGETLDIHGGGKDLIFPHHENEIA
EEHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCEEECCCCCCEECCCCCCHHH
QSEAASGKPFVKYWLHNGFVNINSEKMSKSLGNFFTIKEILESYDAEVLRFFLLSAHYRS
HHHCCCCCHHHHHHHHCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIDFSDQNLKEAELGLERIYKALAGIYERLASGANTPAGADNAEFVEKVAGFAGRFGDAM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
DDDFNTALALGHLFDLVRVINRELPTASTGLLEQAKAEVAKMAAVLGICDSVPAAFLQRM
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDRKTSDIEMSAEEIEALIAERAEARKAKNFKRGDEIRDLLLEKNIVLLDSAQGTTWKVK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA