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The map label for this gene is rtcA [H]

Identifier: 197119192

GI number: 197119192

Start: 3244983

End: 3246035

Strand: Reverse

Name: rtcA [H]

Synonym: Gbem_2819

Alternate gene names: 197119192

Gene position: 3246035-3244983 (Counterclockwise)

Preceding gene: 197119193

Following gene: 197119182

Centisome position: 70.33

GC content: 66.57

Gene sequence:

>1053_bases
ATGATAGAGATCGACGGCAGCGTCGGTGAGGGGGGAGGGCAAGTGCTGCGCAGCGCGCTCAGCCTCTCCTGCCTCACCGG
CCAAGGCTTCAGGATCCACAACATCCGCAAGAACAGGTCCAAGCCCGGCCTGATGCGCCAGCACCTGATGGCGGTGCAGG
CCGCGGCCCGCATCTCTTCCGCGGAGCTGGCCGGAGACCGGGTCGGCTCCGCAGAGATCAGCTTCGTCCCCCGGGCAGTC
CGGGGGGGCGACTACAGTTTCGACATCGGCACCGCGGGCTCTGTTTCCCTGGTGCTGCAGACCGTCATCCCCGCGCTCTT
GTCCGCAGACAGGAAAAGCAGCGTCACCGTCACCGGCGGCACCCACGTCCCGTTCAGTCCCTGCTGGAACTACCTATCCG
AAATCTTCTGGCCTGCCGTCTCCCGCCTGGGAGTCAGAGGCAACCTCGACCTGGAGGCGTACGGCTTCTACCCGAAGGGG
GGTGGGAGGATACGCTGCCGCCTTCAGCCGCAGGGAACCCCGTCCTCCCTCACCCTCACCGAGCGCGGGCGCCTTTTGCG
GATCACCGGCTTTTCTGCAGTCGGAAACCTCCCCCTCTCCATAGCGCAAAGGGAGCGCAGCTCGGCGCTCCACCTTTTGC
GGCAAGAACTGGGAGAGGAGGTCCCCATCGACCTGGAAGTGCGGGAGGTGCGGGTCTACGGGCAGGGGACCTTCATCTTC
ATCAAGGCCCACTACGAGCGCGCGGAGGCGGGGTTCACCTCCTTGGGCGCGCGCGGCAAACCAGCGGAGCTGGTGGGGGA
GGAGGTGGCGCGCGAGCTCCTGGAGCACCATGCTACCGGGATGCCGGTGGACCCGCATCTTGCCGACCAACTGGTGCTCT
ACCTTGCCCGGGCGCAGGAGGGGTCGCGGTTCGCGACCTCGCGCATCACCTCGCATCTCGAAACCAACCTCCTGGTGGCG
GGGTATTTCCTGGAATTGAAAACGGAACTTGGAGGCGCGGAGGGCGCGCCGGGAGAGGTGCGGATCGTGCCGGCAGGAAA
CCGCGCCCGATAG

Upstream 100 bases:

>100_bases
GGGTAGACGTGGCCGAACTCTACGACCTCGCGGAGTACCGCCCCAAGGTGCGCCACGTACTCGGCAAACCGATGTTCCTG
TACTAATCCCAGACAAACAT

Downstream 100 bases:

>100_bases
GGAGGCATGAGGTGAAGCGCTGGATGGAAGTAAAGAAGGCGGCCCGTGTGGGGGCCGCCTTCGTCGTTTCGGTTGCTGCG
GCGGGTCTGGTCCTAAGAAT

Product: RNA 3'-phosphate cyclase, class II

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIEIDGSVGEGGGQVLRSALSLSCLTGQGFRIHNIRKNRSKPGLMRQHLMAVQAAARISSAELAGDRVGSAEISFVPRAV
RGGDYSFDIGTAGSVSLVLQTVIPALLSADRKSSVTVTGGTHVPFSPCWNYLSEIFWPAVSRLGVRGNLDLEAYGFYPKG
GGRIRCRLQPQGTPSSLTLTERGRLLRITGFSAVGNLPLSIAQRERSSALHLLRQELGEEVPIDLEVREVRVYGQGTFIF
IKAHYERAEAGFTSLGARGKPAELVGEEVARELLEHHATGMPVDPHLADQLVLYLARAQEGSRFATSRITSHLETNLLVA
GYFLELKTELGGAEGAPGEVRIVPAGNRAR

Sequences:

>Translated_350_residues
MIEIDGSVGEGGGQVLRSALSLSCLTGQGFRIHNIRKNRSKPGLMRQHLMAVQAAARISSAELAGDRVGSAEISFVPRAV
RGGDYSFDIGTAGSVSLVLQTVIPALLSADRKSSVTVTGGTHVPFSPCWNYLSEIFWPAVSRLGVRGNLDLEAYGFYPKG
GGRIRCRLQPQGTPSSLTLTERGRLLRITGFSAVGNLPLSIAQRERSSALHLLRQELGEEVPIDLEVREVRVYGQGTFIF
IKAHYERAEAGFTSLGARGKPAELVGEEVARELLEHHATGMPVDPHLADQLVLYLARAQEGSRFATSRITSHLETNLLVA
GYFLELKTELGGAEGAPGEVRIVPAGNRAR
>Mature_350_residues
MIEIDGSVGEGGGQVLRSALSLSCLTGQGFRIHNIRKNRSKPGLMRQHLMAVQAAARISSAELAGDRVGSAEISFVPRAV
RGGDYSFDIGTAGSVSLVLQTVIPALLSADRKSSVTVTGGTHVPFSPCWNYLSEIFWPAVSRLGVRGNLDLEAYGFYPKG
GGRIRCRLQPQGTPSSLTLTERGRLLRITGFSAVGNLPLSIAQRERSSALHLLRQELGEEVPIDLEVREVRVYGQGTFIF
IKAHYERAEAGFTSLGARGKPAELVGEEVARELLEHHATGMPVDPHLADQLVLYLARAQEGSRFATSRITSHLETNLLVA
GYFLELKTELGGAEGAPGEVRIVPAGNRAR

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=322, Percent_Identity=37.2670807453416, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI195927044, Length=335, Percent_Identity=35.8208955223881, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI48994937, Length=338, Percent_Identity=39.0532544378698, Blast_Score=218, Evalue=5e-58,
Organism=Drosophila melanogaster, GI18543269, Length=342, Percent_Identity=33.9181286549708, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 37692; Mature: 37692

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIDGSVGEGGGQVLRSALSLSCLTGQGFRIHNIRKNRSKPGLMRQHLMAVQAAARISS
CEEECCCCCCCHHHHHHHHHHHEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
AELAGDRVGSAEISFVPRAVRGGDYSFDIGTAGSVSLVLQTVIPALLSADRKSSVTVTGG
HHHCCCCCCCCEEEECCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECC
THVPFSPCWNYLSEIFWPAVSRLGVRGNLDLEAYGFYPKGGGRIRCRLQPQGTPSSLTLT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEE
ERGRLLRITGFSAVGNLPLSIAQRERSSALHLLRQELGEEVPIDLEVREVRVYGQGTFIF
CCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCEEEE
IKAHYERAEAGFTSLGARGKPAELVGEEVARELLEHHATGMPVDPHLADQLVLYLARAQE
EEEECCHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
GSRFATSRITSHLETNLLVAGYFLELKTELGGAEGAPGEVRIVPAGNRAR
CCHHHHHHHHHHHHCCEEEEEHEEEEEHHCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MIEIDGSVGEGGGQVLRSALSLSCLTGQGFRIHNIRKNRSKPGLMRQHLMAVQAAARISS
CEEECCCCCCCHHHHHHHHHHHEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
AELAGDRVGSAEISFVPRAVRGGDYSFDIGTAGSVSLVLQTVIPALLSADRKSSVTVTGG
HHHCCCCCCCCEEEECCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECC
THVPFSPCWNYLSEIFWPAVSRLGVRGNLDLEAYGFYPKGGGRIRCRLQPQGTPSSLTLT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEE
ERGRLLRITGFSAVGNLPLSIAQRERSSALHLLRQELGEEVPIDLEVREVRVYGQGTFIF
CCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCEEEE
IKAHYERAEAGFTSLGARGKPAELVGEEVARELLEHHATGMPVDPHLADQLVLYLARAQE
EEEECCHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
GSRFATSRITSHLETNLLVAGYFLELKTELGGAEGAPGEVRIVPAGNRAR
CCHHHHHHHHHHHHCCEEEEEHEEEEEHHCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]