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The map label for this gene is cls-1 [H]

Identifier: 197119170

GI number: 197119170

Start: 3224504

End: 3225691

Strand: Direct

Name: cls-1 [H]

Synonym: Gbem_2797

Alternate gene names: 197119170

Gene position: 3224504-3225691 (Clockwise)

Preceding gene: 197119169

Following gene: 197119171

Centisome position: 69.87

GC content: 62.21

Gene sequence:

>1188_bases
ATGATCAGGATGCGGCGTAAAAGAAAGCAGTTGCTGTTCCAGACCAAGAAGTTCTTCGACTTCTTCAGGAGGAACACGGA
GGCTGTTTCCTTTGCGGGCAACCGCGCCACGCTGTTTCGTTACGGCTCCGACTTTTTTCCCGCCCTTTTCGATGCGATCC
CAAAAGCCACCACCAGCATCTGCCTTGAGTTCTACACGGTCGCAGACGACGAGACCGGGCGCCTGATGGCGGACGCACTC
ATGGCCGCTGCCGCCCGCGGGGTCCGGGTTTACCTCCTGTACGACTACATCGGATGTTTCGACACACCCGCCGCCTTCTT
CAAGAGGCTCTCCAAAGGGGGGGTGTGCTGCCGTGCCTTCAATCCTCCTCCGTTTCGCAAAGGAATCGCCTGGTTCGACA
AGAGGGACCACAGAAAGCTCGCGGTCATGGACGGCTGGCGCGTCTTCACCGGCGGCATGAACATCGCCAACGTCTACTCC
GGTCTCGGGAAGAAGCGGACCAAGTGGCGCGACGTCGGCCTCAAGATCGAGGGCGAAGTCGGGCTGGAACTTTTGAGGCT
GTTCCAGGAGACCTGGACCGGCGAATGCGGCACTCCCCCCATCGGCTGCGATCCCGGCCCCCCGCCGGATATCGTCGGGG
ACGCGAACGTCATGGTCATCAACGGCGGCCCCCACCACGAACGGAGCTTCATCAGGAGCGCCTTCCGACTCGCCATAGCC
GGCGCCTCGGAGAGCGTCACCATAGCCAGTCCCTACTTCGTCCCCGGCCCCCGTGTGATCCGCTCGCTTTTGCGGGCGGC
GGGGCGCGGCGTGAGGGTGCGGCTCCTTTTGCCGCACAAAAGCGACGTCCCCCTGGTGCGCCTGGTCAGCAGAACCTATT
ACGCGCAACTGTTGCGAAACGGGATCGAGATTTGCGAGATGAACAGCGCGGTCCTGCACGCGAAGGTGCTGCTCATCGAC
GGCAACTGGACCATGGTCGGCTCCGCCAACATGGACCTCAGGAGTTTCCACCGCAACTACGAGTTGAACGTGGTCGTGGA
TAGCCAGATCTTCGGCGCGCAGGTGGAGCAGATGCTGGAATTCGACCTGGCTGGCGCCCGCCGCATCGTCCTGCACGAGC
ACGAGAGGCGGGGATGGTCGATCCGTTTCCTGGAGCGGCTCTTCAGCCCCGTCGCCTGGTTTTTGTAA

Upstream 100 bases:

>100_bases
GCCGACCGACTCCTTCAGTCCGCAGTACCTGAAGCGCGGAAGTAATGCCATGACGTTATTTCCGCGCTTCTTCGCTTAAA
GAAAGGCAGGCTCGCTAAAG

Downstream 100 bases:

>100_bases
AACCTTCTACTACCCTCCGGAGTTAATTTAATGATCAGCACCGATACACTCAAGCGGCTGGAGTTCGACAAGATCCTCGA
CACGGTCGCTTCTTATGCAC

Product: cardiolipin synthase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIRMRRKRKQLLFQTKKFFDFFRRNTEAVSFAGNRATLFRYGSDFFPALFDAIPKATTSICLEFYTVADDETGRLMADAL
MAAAARGVRVYLLYDYIGCFDTPAAFFKRLSKGGVCCRAFNPPPFRKGIAWFDKRDHRKLAVMDGWRVFTGGMNIANVYS
GLGKKRTKWRDVGLKIEGEVGLELLRLFQETWTGECGTPPIGCDPGPPPDIVGDANVMVINGGPHHERSFIRSAFRLAIA
GASESVTIASPYFVPGPRVIRSLLRAAGRGVRVRLLLPHKSDVPLVRLVSRTYYAQLLRNGIEICEMNSAVLHAKVLLID
GNWTMVGSANMDLRSFHRNYELNVVVDSQIFGAQVEQMLEFDLAGARRIVLHEHERRGWSIRFLERLFSPVAWFL

Sequences:

>Translated_395_residues
MIRMRRKRKQLLFQTKKFFDFFRRNTEAVSFAGNRATLFRYGSDFFPALFDAIPKATTSICLEFYTVADDETGRLMADAL
MAAAARGVRVYLLYDYIGCFDTPAAFFKRLSKGGVCCRAFNPPPFRKGIAWFDKRDHRKLAVMDGWRVFTGGMNIANVYS
GLGKKRTKWRDVGLKIEGEVGLELLRLFQETWTGECGTPPIGCDPGPPPDIVGDANVMVINGGPHHERSFIRSAFRLAIA
GASESVTIASPYFVPGPRVIRSLLRAAGRGVRVRLLLPHKSDVPLVRLVSRTYYAQLLRNGIEICEMNSAVLHAKVLLID
GNWTMVGSANMDLRSFHRNYELNVVVDSQIFGAQVEQMLEFDLAGARRIVLHEHERRGWSIRFLERLFSPVAWFL
>Mature_395_residues
MIRMRRKRKQLLFQTKKFFDFFRRNTEAVSFAGNRATLFRYGSDFFPALFDAIPKATTSICLEFYTVADDETGRLMADAL
MAAAARGVRVYLLYDYIGCFDTPAAFFKRLSKGGVCCRAFNPPPFRKGIAWFDKRDHRKLAVMDGWRVFTGGMNIANVYS
GLGKKRTKWRDVGLKIEGEVGLELLRLFQETWTGECGTPPIGCDPGPPPDIVGDANVMVINGGPHHERSFIRSAFRLAIA
GASESVTIASPYFVPGPRVIRSLLRAAGRGVRVRLLLPHKSDVPLVRLVSRTYYAQLLRNGIEICEMNSAVLHAKVLLID
GNWTMVGSANMDLRSFHRNYELNVVVDSQIFGAQVEQMLEFDLAGARRIVLHEHERRGWSIRFLERLFSPVAWFL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=382, Percent_Identity=28.2722513089005, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787007, Length=334, Percent_Identity=31.437125748503, Blast_Score=155, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 44666; Mature: 44666

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRMRRKRKQLLFQTKKFFDFFRRNTEAVSFAGNRATLFRYGSDFFPALFDAIPKATTSI
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHH
CLEFYTVADDETGRLMADALMAAAARGVRVYLLYDYIGCFDTPAAFFKRLSKGGVCCRAF
HHHHEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCHHHHHHHHHCCCEEEECC
NPPPFRKGIAWFDKRDHRKLAVMDGWRVFTGGMNIANVYSGLGKKRTKWRDVGLKIEGEV
CCCCCHHCCHHCCCCCCCEEEEECCCEEEECCCCHHHHHHHCCCCCCHHHHCCEEEECHH
GLELLRLFQETWTGECGTPPIGCDPGPPPDIVGDANVMVINGGPHHERSFIRSAFRLAIA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEE
GASESVTIASPYFVPGPRVIRSLLRAAGRGVRVRLLLPHKSDVPLVRLVSRTYYAQLLRN
CCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GIEICEMNSAVLHAKVLLIDGNWTMVGSANMDLRSFHRNYELNVVVDSQIFGAQVEQMLE
CHHEEECCCEEEEEEEEEEECCEEEEECCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHH
FDLAGARRIVLHEHERRGWSIRFLERLFSPVAWFL
HHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRMRRKRKQLLFQTKKFFDFFRRNTEAVSFAGNRATLFRYGSDFFPALFDAIPKATTSI
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHH
CLEFYTVADDETGRLMADALMAAAARGVRVYLLYDYIGCFDTPAAFFKRLSKGGVCCRAF
HHHHEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCHHHHHHHHHCCCEEEECC
NPPPFRKGIAWFDKRDHRKLAVMDGWRVFTGGMNIANVYSGLGKKRTKWRDVGLKIEGEV
CCCCCHHCCHHCCCCCCCEEEEECCCEEEECCCCHHHHHHHCCCCCCHHHHCCEEEECHH
GLELLRLFQETWTGECGTPPIGCDPGPPPDIVGDANVMVINGGPHHERSFIRSAFRLAIA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEE
GASESVTIASPYFVPGPRVIRSLLRAAGRGVRVRLLLPHKSDVPLVRLVSRTYYAQLLRN
CCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GIEICEMNSAVLHAKVLLIDGNWTMVGSANMDLRSFHRNYELNVVVDSQIFGAQVEQMLE
CHHEEECCCEEEEEEEEEEECCEEEEECCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHH
FDLAGARRIVLHEHERRGWSIRFLERLFSPVAWFL
HHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA