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The map label for this gene is mutS-2 [H]

Identifier: 197119171

GI number: 197119171

Start: 3225722

End: 3228073

Strand: Direct

Name: mutS-2 [H]

Synonym: Gbem_2798

Alternate gene names: 197119171

Gene position: 3225722-3228073 (Clockwise)

Preceding gene: 197119170

Following gene: 197119172

Centisome position: 69.89

GC content: 64.12

Gene sequence:

>2352_bases
ATGATCAGCACCGATACACTCAAGCGGCTGGAGTTCGACAAGATCCTCGACACGGTCGCTTCTTATGCACACTGCGACGC
CTCTCACTTTGGGGCGCTGTCCATAACACCCCTTTCGGCACGTGACGAGATCGAACTCCGCCTGGGGCTCGTCGATGAGG
TGCGCAAGCTCACCCGGTTCGGCATCAGCCTCAAGCTCTCGGAGTTCGAGGACATCACCCCCCAGGTCAGAGCGGTCCGC
CCGACCGGCGCGGTGATCTCGCCGCTTGAGTTGCAGCGCTTCATCCCGACGCTGCGCGTAATGAGCGCCATCTCCGCACA
GCTCGGTTTCCGCACCGACGTGCCGCTCCTCACCTCGCAAGCGGGCTCCATCACCGGATTCCCGGACCTCTTGAATCCAC
TGGAACACACGGTGAACGAGGAAGGTGAGATCCTCGACACCGCTTCCAGGCTCCTGGCCGACATCCGCGGCCGCAAGAAG
GGGTTCACCGCCCGCATCAAGAAAAGGCTGGAGGAGATCGTCCGGGAGCGGCATACCGCCATCTTCCTGCAGGACGACTT
CATCACCCAGAGGTCCGGGCGCTGGGTCATCCCGGTGCGCATGGACTCGAAGGGGATGGTCCCGGGCGTCGTGCACGACG
TCTCCAACTCGGGCGAGACAGCCTTCATGGAGCCCTTGGAGATCATCGGGCTCGCCAACGAGCTGGAGAACCTGGTCGCC
GACGAGAGGGCCGAGGAGATCAGGATCGTCAGGCAGATCTGCAACTGGATCAGGGAGGACGCGGAACAGATCCTGGAGCA
GTTCGAGGCTCTGGTGCGCCTGGACATCCTCAACTGCATCGCCACCCTGAGCGACAAGCTCAGGAGCGAGACGCCGGTCA
TCTCGCCTACCCCCGCCATACTGCTCAAGTCGGCACGCCACCCTATCCTCACCCTGATGGGTAAGGAGGTGGTCCCCCTC
GACCTGGAGCTCGCCGCCGACAACCGGGTCATGGTGGTCACCGGCCCCAACACCGGCGGCAAGACCATCGCCATCAAGAG
CGCGGGTCTCCTCTGCGTCATGGCCCTTTGCGGCATGCCGGTCCCGGCGCTTCCCGGCACTGTGCTCCCCTTGGTGGAAA
GCATCCTGGTCGACATCGGGGACGAACAGTCCATAGAGGAAAGCCTCTCCACCTTCTCCGCCCACATCTTCAAGATCTCC
AGCATCATCGAGGAGGCAGGACAAGGCGCGCTGGTGCTTCTGGACGAACTGGGGACCGGCACCGAGCCGGGCCAGGGCGC
GGCCATCGCCTGCGCGGTCCTCAAGGAGCTGCAGAACAAGGGGGCGCTGGTGGTCGCCACCACGCACCTCACCGAGATCA
TCGGCTTCGTGCAGCGCGAGGAGGGGATGGTGAACGCCGCCATGGCCTTCGACCGCGATAAGCTGGCGCCGCTCTACCGG
CTCGTGGTCGGCGAACCGGGAGAATCGCACGCTCTCGAAATAGCCAGCCGCTACGGCCTGCCCGATCGCGTGGTGCGCTT
CGCCCGGGGGATGCTCGGGACCATGGAGGCCGACTTCCATTCCCTTTTGCGCGACCTCAAGGGAAAGCGGGCTCAACTGG
AGCGCGCCCTGGCGGATATGGCAGAAAGAGAGGAAAAGGTGGCCTTCGCCGAGCGGAACCTGGTGGACCGCAGGGATGAG
GCGGCCCAGTTGGTAAAGGACGCCAAGGAAAAGGGGTTATTGGAAGCGCAGCAGATTATCTGGAAGGCAAAGCGCGAGGT
GGCGACCCTTCTGGACGAGGCCAAGCGCGAGAAGACCAAGACGCGGGAGGCGAAGGAAAAGCTCGACCAGGCAGCGAACG
AGTTGGAGCAGGCGCTGGAAGAGTTGCACCCCGAGGAGAACGTGGACCCGGAGAAGGTGTCGGTGGGGGACGTACTTTTC
GTCAAGCCGCTCAACTGCGACGCCACCATCCTCGCCATCGATACGCGCTCCGGCAAGGCGCGGGTCCGTGCCGGGAGCAT
GGAAATGGAGGTGCAGGTCAATTCGTTGCTAAAGCCCAAGGGCAAAGAGCCGAAGAAGGTACAGAAGCGGCGCGAAAAGC
AGCAGGCCCAAGAGCAGGAGCGCGCCGAGCCGGCCTCCACCATCAACCTTCTCGGGATGCGCGTGGAGGAGGCGGTCGGC
GTTTTAGAACCGTTCCTGAACCACGCCGCGCTGGACCGGATCCCGGAAGTGCACATCGTGCACGGCAAGGGAACCGGCGC
CCTGATGAAGGGGGTGCGGAGCTACTTGGCCGACCACCCGCTGGTTGCCTCCTTCCGCACCGGCGAGCGCTACGAAGGGG
GCGATGGGGTGACGGTGGTGACCCTGCGCTGA

Upstream 100 bases:

>100_bases
GCACGAGAGGCGGGGATGGTCGATCCGTTTCCTGGAGCGGCTCTTCAGCCCCGTCGCCTGGTTTTTGTAAAACCTTCTAC
TACCCTCCGGAGTTAATTTA

Downstream 100 bases:

>100_bases
CGATGGACGGTAAGACCTTTATGCACTAACGACCTCGGAGGTCATGATGATCATCTCCACGATAGCGGCCTTGTCTGACA
ACAGGGTGATAGGCGCAGAC

Product: DNA mismatch repair ATPase MutS-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MISTDTLKRLEFDKILDTVASYAHCDASHFGALSITPLSARDEIELRLGLVDEVRKLTRFGISLKLSEFEDITPQVRAVR
PTGAVISPLELQRFIPTLRVMSAISAQLGFRTDVPLLTSQAGSITGFPDLLNPLEHTVNEEGEILDTASRLLADIRGRKK
GFTARIKKRLEEIVRERHTAIFLQDDFITQRSGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
DERAEEIRIVRQICNWIREDAEQILEQFEALVRLDILNCIATLSDKLRSETPVISPTPAILLKSARHPILTLMGKEVVPL
DLELAADNRVMVVTGPNTGGKTIAIKSAGLLCVMALCGMPVPALPGTVLPLVESILVDIGDEQSIEESLSTFSAHIFKIS
SIIEEAGQGALVLLDELGTGTEPGQGAAIACAVLKELQNKGALVVATTHLTEIIGFVQREEGMVNAAMAFDRDKLAPLYR
LVVGEPGESHALEIASRYGLPDRVVRFARGMLGTMEADFHSLLRDLKGKRAQLERALADMAEREEKVAFAERNLVDRRDE
AAQLVKDAKEKGLLEAQQIIWKAKREVATLLDEAKREKTKTREAKEKLDQAANELEQALEELHPEENVDPEKVSVGDVLF
VKPLNCDATILAIDTRSGKARVRAGSMEMEVQVNSLLKPKGKEPKKVQKRREKQQAQEQERAEPASTINLLGMRVEEAVG
VLEPFLNHAALDRIPEVHIVHGKGTGALMKGVRSYLADHPLVASFRTGERYEGGDGVTVVTLR

Sequences:

>Translated_783_residues
MISTDTLKRLEFDKILDTVASYAHCDASHFGALSITPLSARDEIELRLGLVDEVRKLTRFGISLKLSEFEDITPQVRAVR
PTGAVISPLELQRFIPTLRVMSAISAQLGFRTDVPLLTSQAGSITGFPDLLNPLEHTVNEEGEILDTASRLLADIRGRKK
GFTARIKKRLEEIVRERHTAIFLQDDFITQRSGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
DERAEEIRIVRQICNWIREDAEQILEQFEALVRLDILNCIATLSDKLRSETPVISPTPAILLKSARHPILTLMGKEVVPL
DLELAADNRVMVVTGPNTGGKTIAIKSAGLLCVMALCGMPVPALPGTVLPLVESILVDIGDEQSIEESLSTFSAHIFKIS
SIIEEAGQGALVLLDELGTGTEPGQGAAIACAVLKELQNKGALVVATTHLTEIIGFVQREEGMVNAAMAFDRDKLAPLYR
LVVGEPGESHALEIASRYGLPDRVVRFARGMLGTMEADFHSLLRDLKGKRAQLERALADMAEREEKVAFAERNLVDRRDE
AAQLVKDAKEKGLLEAQQIIWKAKREVATLLDEAKREKTKTREAKEKLDQAANELEQALEELHPEENVDPEKVSVGDVLF
VKPLNCDATILAIDTRSGKARVRAGSMEMEVQVNSLLKPKGKEPKKVQKRREKQQAQEQERAEPASTINLLGMRVEEAVG
VLEPFLNHAALDRIPEVHIVHGKGTGALMKGVRSYLADHPLVASFRTGERYEGGDGVTVVTLR
>Mature_783_residues
MISTDTLKRLEFDKILDTVASYAHCDASHFGALSITPLSARDEIELRLGLVDEVRKLTRFGISLKLSEFEDITPQVRAVR
PTGAVISPLELQRFIPTLRVMSAISAQLGFRTDVPLLTSQAGSITGFPDLLNPLEHTVNEEGEILDTASRLLADIRGRKK
GFTARIKKRLEEIVRERHTAIFLQDDFITQRSGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
DERAEEIRIVRQICNWIREDAEQILEQFEALVRLDILNCIATLSDKLRSETPVISPTPAILLKSARHPILTLMGKEVVPL
DLELAADNRVMVVTGPNTGGKTIAIKSAGLLCVMALCGMPVPALPGTVLPLVESILVDIGDEQSIEESLSTFSAHIFKIS
SIIEEAGQGALVLLDELGTGTEPGQGAAIACAVLKELQNKGALVVATTHLTEIIGFVQREEGMVNAAMAFDRDKLAPLYR
LVVGEPGESHALEIASRYGLPDRVVRFARGMLGTMEADFHSLLRDLKGKRAQLERALADMAEREEKVAFAERNLVDRRDE
AAQLVKDAKEKGLLEAQQIIWKAKREVATLLDEAKREKTKTREAKEKLDQAANELEQALEELHPEENVDPEKVSVGDVLF
VKPLNCDATILAIDTRSGKARVRAGSMEMEVQVNSLLKPKGKEPKKVQKRREKQQAQEQERAEPASTINLLGMRVEEAVG
VLEPFLNHAALDRIPEVHIVHGKGTGALMKGVRSYLADHPLVASFRTGERYEGGDGVTVVTLR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=471, Percent_Identity=27.1762208067941, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI26638666, Length=285, Percent_Identity=30.1754385964912, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI4505253, Length=285, Percent_Identity=30.1754385964912, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI26638664, Length=286, Percent_Identity=30.0699300699301, Blast_Score=106, Evalue=1e-22,
Organism=Homo sapiens, GI4504191, Length=307, Percent_Identity=27.3615635179153, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4557761, Length=274, Percent_Identity=27.7372262773723, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI262231786, Length=224, Percent_Identity=31.25, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI36949366, Length=429, Percent_Identity=24.9417249417249, Blast_Score=85, Evalue=3e-16,
Organism=Escherichia coli, GI1789089, Length=278, Percent_Identity=27.6978417266187, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17534743, Length=361, Percent_Identity=24.9307479224377, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508445, Length=386, Percent_Identity=25.9067357512953, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17508447, Length=230, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=268, Percent_Identity=24.6268656716418, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324482, Length=389, Percent_Identity=24.1645244215938, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=184, Percent_Identity=32.6086956521739, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=321, Percent_Identity=24.9221183800623, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321109, Length=198, Percent_Identity=29.2929292929293, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=241, Percent_Identity=25.7261410788382, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24584320, Length=252, Percent_Identity=29.3650793650794, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24664545, Length=298, Percent_Identity=27.5167785234899, Blast_Score=100, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86161; Mature: 86161

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTDTLKRLEFDKILDTVASYAHCDASHFGALSITPLSARDEIELRLGLVDEVRKLTRF
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCCCCCHHEEECHHHHHHHHHHH
GISLKLSEFEDITPQVRAVRPTGAVISPLELQRFIPTLRVMSAISAQLGFRTDVPLLTSQ
CCEEEECHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
AGSITGFPDLLNPLEHTVNEEGEILDTASRLLADIRGRKKGFTARIKKRLEEIVRERHTA
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCE
IFLQDDFITQRSGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
DERAEEIRIVRQICNWIREDAEQILEQFEALVRLDILNCIATLSDKLRSETPVISPTPAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LLKSARHPILTLMGKEVVPLDLELAADNRVMVVTGPNTGGKTIAIKSAGLLCVMALCGMP
HHHCCCCCHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEECCHHHHHHHHHCCC
VPALPGTVLPLVESILVDIGDEQSIEESLSTFSAHIFKISSIIEEAGQGALVLLDELGTG
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
TEPGQGAAIACAVLKELQNKGALVVATTHLTEIIGFVQREEGMVNAAMAFDRDKLAPLYR
CCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHH
LVVGEPGESHALEIASRYGLPDRVVRFARGMLGTMEADFHSLLRDLKGKRAQLERALADM
HHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AEREEKVAFAERNLVDRRDEAAQLVKDAKEKGLLEAQQIIWKAKREVATLLDEAKREKTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TREAKEKLDQAANELEQALEELHPEENVDPEKVSVGDVLFVKPLNCDATILAIDTRSGKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEECCCCCC
RVRAGSMEMEVQVNSLLKPKGKEPKKVQKRREKQQAQEQERAEPASTINLLGMRVEEAVG
EEEECCEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VLEPFLNHAALDRIPEVHIVHGKGTGALMKGVRSYLADHPLVASFRTGERYEGGDGVTVV
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEE
TLR
EEC
>Mature Secondary Structure
MISTDTLKRLEFDKILDTVASYAHCDASHFGALSITPLSARDEIELRLGLVDEVRKLTRF
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCCCCCHHEEECHHHHHHHHHHH
GISLKLSEFEDITPQVRAVRPTGAVISPLELQRFIPTLRVMSAISAQLGFRTDVPLLTSQ
CCEEEECHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
AGSITGFPDLLNPLEHTVNEEGEILDTASRLLADIRGRKKGFTARIKKRLEEIVRERHTA
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCE
IFLQDDFITQRSGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
DERAEEIRIVRQICNWIREDAEQILEQFEALVRLDILNCIATLSDKLRSETPVISPTPAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LLKSARHPILTLMGKEVVPLDLELAADNRVMVVTGPNTGGKTIAIKSAGLLCVMALCGMP
HHHCCCCCHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEECCHHHHHHHHHCCC
VPALPGTVLPLVESILVDIGDEQSIEESLSTFSAHIFKISSIIEEAGQGALVLLDELGTG
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
TEPGQGAAIACAVLKELQNKGALVVATTHLTEIIGFVQREEGMVNAAMAFDRDKLAPLYR
CCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHH
LVVGEPGESHALEIASRYGLPDRVVRFARGMLGTMEADFHSLLRDLKGKRAQLERALADM
HHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AEREEKVAFAERNLVDRRDEAAQLVKDAKEKGLLEAQQIIWKAKREVATLLDEAKREKTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TREAKEKLDQAANELEQALEELHPEENVDPEKVSVGDVLFVKPLNCDATILAIDTRSGKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEECCCCCC
RVRAGSMEMEVQVNSLLKPKGKEPKKVQKRREKQQAQEQERAEPASTINLLGMRVEEAVG
EEEECCEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VLEPFLNHAALDRIPEVHIVHGKGTGALMKGVRSYLADHPLVASFRTGERYEGGDGVTVV
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEE
TLR
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]