Click here to switch to the map view.

The map label for this gene is pyrH [H]

Identifier: 197119127

GI number: 197119127

Start: 3183715

End: 3184437

Strand: Reverse

Name: pyrH [H]

Synonym: Gbem_2754

Alternate gene names: 197119127

Gene position: 3184437-3183715 (Counterclockwise)

Preceding gene: 197119128

Following gene: 197119126

Centisome position: 69.0

GC content: 62.66

Gene sequence:

>723_bases
ATGGGAGAACCTCATTATAAAAGAGTACTTCTGAAACTCTCCGGCGAGGCCCTTGGGGGCGAGCAGGGGTATGGCATCGA
CCCGAACACCATCACCGCTATCGCCCGCGAGGTGAAGCAGGTGGTAGAACTCGGGGTCGAGCTTTCGCTGGTGATCGGCG
GCGGCAACATCTTCCGCGGCCTCGCGGCCTCCTCCAAGGGGATGGACCGCGCCAGCGCCGACTACATGGGGATGCTGGCC
ACCATGATCAACTCCCTGGCCATGCAGGACGCGCTGGAGAAGGTCGGTGTAGACACCCGCGTGCAGTCCGCCATCGCCAT
GGCCGAAGTGGCCGAGCCTTACATCCGCAGGCGTGCCGTCAGGCATCTGGAAAAGGGAAGGGTGGTCATCTTCGGCGCCG
GCACCGGCAACCCCTACTTCACCACCGATACCGCAGCAAGCCTCAGGGCGATGGAGATCGGCGCCGACGTGATCCTCAAG
GGGACCAAGGTCGACGGCGTCTACTCCGCAGACCCGGCCAAGGACAAGACCGCCACCAAGTACGGGACGCTCAGCTACCT
CGAGGTGCTGAGAAAGGGGCTCCAGGTAATGGACGCCACCGCGATCTCGCTTTGCATGGACAACAGCCTCCCGATCATCG
TCTTCGACGTGACCACCGACGGCAACGTCGTCCGGGTGGTCAACGGTGAACCGATCGGTACCCTCGTCAAGGAAGGAGAA
TAG

Upstream 100 bases:

>100_bases
GTCCGTTTTTCCCCGCTGATCAAGGGAGCCGGCCCTCCGACTCCCCAATCCGATCCAACAGCAGTTTTTTTCCCGCAACA
AAGAAGGTAAGGTGACAACG

Downstream 100 bases:

>100_bases
CATGGTCAAGGATGTCATCTCCAGCATGAACGTCCATATGGACAAATCCATAGAATCGCTCAGGAAAGAGTACCAGAAGG
TGCGCACCGGCCGTGCCAGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MGEPHYKRVLLKLSGEALGGEQGYGIDPNTITAIAREVKQVVELGVELSLVIGGGNIFRGLAASSKGMDRASADYMGMLA
TMINSLAMQDALEKVGVDTRVQSAIAMAEVAEPYIRRRAVRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILK
GTKVDGVYSADPAKDKTATKYGTLSYLEVLRKGLQVMDATAISLCMDNSLPIIVFDVTTDGNVVRVVNGEPIGTLVKEGE

Sequences:

>Translated_240_residues
MGEPHYKRVLLKLSGEALGGEQGYGIDPNTITAIAREVKQVVELGVELSLVIGGGNIFRGLAASSKGMDRASADYMGMLA
TMINSLAMQDALEKVGVDTRVQSAIAMAEVAEPYIRRRAVRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILK
GTKVDGVYSADPAKDKTATKYGTLSYLEVLRKGLQVMDATAISLCMDNSLPIIVFDVTTDGNVVRVVNGEPIGTLVKEGE
>Mature_239_residues
GEPHYKRVLLKLSGEALGGEQGYGIDPNTITAIAREVKQVVELGVELSLVIGGGNIFRGLAASSKGMDRASADYMGMLAT
MINSLAMQDALEKVGVDTRVQSAIAMAEVAEPYIRRRAVRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKG
TKVDGVYSADPAKDKTATKYGTLSYLEVLRKGLQVMDATAISLCMDNSLPIIVFDVTTDGNVVRVVNGEPIGTLVKEGE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=54.6610169491525, Blast_Score=257, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25498; Mature: 25367

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEPHYKRVLLKLSGEALGGEQGYGIDPNTITAIAREVKQVVELGVELSLVIGGGNIFRG
CCCHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
LAASSKGMDRASADYMGMLATMINSLAMQDALEKVGVDTRVQSAIAMAEVAEPYIRRRAV
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKGTKVDGVYSADPAKDKTATK
HHHHCCCEEEEECCCCCCEEECCHHHHHHHEEECCEEEEECCCCCCEECCCCCCCCCHHH
YGTLSYLEVLRKGLQVMDATAISLCMDNSLPIIVFDVTTDGNVVRVVNGEPIGTLVKEGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCHHCCCCC
>Mature Secondary Structure 
GEPHYKRVLLKLSGEALGGEQGYGIDPNTITAIAREVKQVVELGVELSLVIGGGNIFRG
CCHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
LAASSKGMDRASADYMGMLATMINSLAMQDALEKVGVDTRVQSAIAMAEVAEPYIRRRAV
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKGTKVDGVYSADPAKDKTATK
HHHHCCCEEEEECCCCCCEEECCHHHHHHHEEECCEEEEECCCCCCEECCCCCCCCCHHH
YGTLSYLEVLRKGLQVMDATAISLCMDNSLPIIVFDVTTDGNVVRVVNGEPIGTLVKEGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA