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The map label for this gene is rnr [H]

Identifier: 197118978

GI number: 197118978

Start: 3012876

End: 3015089

Strand: Reverse

Name: rnr [H]

Synonym: Gbem_2601

Alternate gene names: 197118978

Gene position: 3015089-3012876 (Counterclockwise)

Preceding gene: 197118981

Following gene: 197118977

Centisome position: 65.33

GC content: 64.95

Gene sequence:

>2214_bases
ATGCGCAAGGGTAAGGACGCGGTCATGAGGCTTTTGGCCAAGGGGGAACCGATCCCGTACCGGCAGATGCTGAAGGCTCT
CAATATATCCCGACGCGACCGGGATCAGTTGGACCAGCAACTGGACTTCCTGGTCGAGTCCGGGGAGATCGTCAAGATGC
CGGGGCGCATCTACGCGCTGGCCGGCTCCGGCGACAGCGTGCGCGGCAAGCTCTCGGTCCACCGCGACGGCTACGGCTTC
GTCATGCCTGAAGAGGGAGGGGAGGATCTTTTCGTTCCCGCGCGCTATCTCACCGAGTACATGAACGGCGACATAGTGGA
GGCCCAGGTGGTCTCGACGCGCCGCGACGGGAAGCGGGAGGGGAGGGTGACCGCCCTGGTGCAGCGGGGCGTCACAGAGA
TCGTCGGGCGCTTCGAGGCGATCGGCAAGGGGGGGAGGGTGATCCCCGACGACCCGAAACTGGGGCGGGACCTCTTCGTC
ACCCCGGGTGCCGCCGGCGGCGCGGCCAAGGCCAGGGACGGGCAGATCGTGCTGGCGCAGATCACCGCCTACCCCGCGGG
CGCGCGTCCGCTGGAGGGAAGGATAACGGAGGTGCTGGGCGAGGCCAACGACCCCGAGGTCGAGGCGCTTACCGTGATCA
AGAAGTACGAGCTCCCCCACGTCTTCGACGAGAAGGTGTTGGAGGAGGCGCAGAAGCAGCCCCAGCAGGTGACCGAAGAG
GCCGTGGCCGGCCGCACCGACCTGCGCGAAAGGCTCACCGTCACCATCGACGGCGAGACGGCGCGCGACTTCGACGACGC
GGTTTCGGTCGCCCGGGAAGGTGACAAGATCCGGCTCTGGGTCTCCATAGCGGACGTCTCCCACTACGTCGTCGAGGGCT
CAAGGCTCGACACCGAGGCGTACCTGAGGGGGACCTCGGTCTATTTCCCCGACCGCTGCATCCCCATGCTTCCGGAAGAG
CTATCCAACGGGATCTGCTCGCTGAATCCGCAGGTGGACCGCCTCACCATGACCGCGGAGATGCTCTTCGACGCCGCCGG
CGAGCGGGTCGACGCCCGCTTCTACACGAGCGTCATCAAGAGCGCCGCGCGCCTTACCTACACGACGGTGAAGCGGATAC
TGGTGGACCGAGATCTGGAGGCGGTCGAGCAGAACGCCCATCTTGTTGAAGATCTCAAGGTCATGGAGGATCTTTCGCTG
CGCCTGAACGCGGTGCGCCGCACCAGGGGGAGCATCGACTTCGACCTCCCCGAGCCCCAGATCATCCTCGACCTGCAGGG
GGAGACGACCGCCATCGTAAGGGCCGAGAGAAACCTCGCCCACCGCATCATCGAGGAGTTCATGCTCGCTGCAAACGAAG
CGGTGGCTGGGTTCCTGGAGAACACGCCGGTCCCGTCCCTGTACCGGGTGCACGAGAACCCGGACCCGCTGAAGTTGAAG
GATCTCGCCGAGTTCGTCTTCGGCTTCGGCTATATCCTGAAGCTGCAGGACGAAAAGGTGAACCCGCTGGAGCTGCAGAG
GCTCCTGGCCGAGGTGGAGGGAAAACCGGAGGAGCGCCTGATCAACGAGGTGCTTTTACGCTGCATGAAGCAGGCGCGCT
ACAGCGCCGAGAACCTCGGGCACTACGGCCTTGCGGCGGGAAGTTACACCCACTTCACCTCGCCCATCCGCCGCTACCCC
GACCTCGTGGTGCACCGCATCCTGAAGAGGGTGCTGTCGCAGAAGATGAAGCAGGTGGACAAGGACCGGCTTGAGGCGAG
GCTCCCCGAGACCGCGGCGCATACCTCCAAGAGGGAGCGGGTCGCCATGGAGGCGGAGCGGGAGATGGTGGACCTCAAAA
AGATGCAGTTCATGCGGGACAAGATCGGCGAGGAGTACGACGGCTACATCACCGGCGTCGCCCCCTTTGGGCTCTTCGTC
GAGCTGGTGGACCTTTTCGTGGAGGGGATGGTCCCGGTTGCCACGCTCCCCATGGACTACTACGTGCACCTGGAGAAGAG
CCACGCCCTCGTGGGGGAGAGGACCCGCGCCATGTACCGCATCGCGGACAAGATCAGGGTCAAGGTGTCCGCCGTCAACG
AGGCGCGCAAGCAGGTGGAGTTCTCGCTGGTGGGGACCCTGGAAAAACGCCCCATCGAGCCGATCCAGGATGTCAGGAAC
AGCTATGACCGGATACCGGTCAAGGGTAAGCGCCCCAAGCCCCGGCGGCGCTGA

Upstream 100 bases:

>100_bases
CCGACCGTGCCCGTTCCCGCTTCTTGACTTTCATCGGACGCTTCTGCATTATCCACAACTATGATTTTTTACATATGCTT
TTTTCCCGAAGGGGGTTTTC

Downstream 100 bases:

>100_bases
AAGCTGTTGCGCTCGCTTTAGCCGCTGTGCTATAAAATTTGTTTGGGCTCGGCGCGGCTTTAATTAGGAGATATAGGGTA
TATGGTTCAAGAAAAAGTTC

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MRKGKDAVMRLLAKGEPIPYRQMLKALNISRRDRDQLDQQLDFLVESGEIVKMPGRIYALAGSGDSVRGKLSVHRDGYGF
VMPEEGGEDLFVPARYLTEYMNGDIVEAQVVSTRRDGKREGRVTALVQRGVTEIVGRFEAIGKGGRVIPDDPKLGRDLFV
TPGAAGGAAKARDGQIVLAQITAYPAGARPLEGRITEVLGEANDPEVEALTVIKKYELPHVFDEKVLEEAQKQPQQVTEE
AVAGRTDLRERLTVTIDGETARDFDDAVSVAREGDKIRLWVSIADVSHYVVEGSRLDTEAYLRGTSVYFPDRCIPMLPEE
LSNGICSLNPQVDRLTMTAEMLFDAAGERVDARFYTSVIKSAARLTYTTVKRILVDRDLEAVEQNAHLVEDLKVMEDLSL
RLNAVRRTRGSIDFDLPEPQIILDLQGETTAIVRAERNLAHRIIEEFMLAANEAVAGFLENTPVPSLYRVHENPDPLKLK
DLAEFVFGFGYILKLQDEKVNPLELQRLLAEVEGKPEERLINEVLLRCMKQARYSAENLGHYGLAAGSYTHFTSPIRRYP
DLVVHRILKRVLSQKMKQVDKDRLEARLPETAAHTSKRERVAMEAEREMVDLKKMQFMRDKIGEEYDGYITGVAPFGLFV
ELVDLFVEGMVPVATLPMDYYVHLEKSHALVGERTRAMYRIADKIRVKVSAVNEARKQVEFSLVGTLEKRPIEPIQDVRN
SYDRIPVKGKRPKPRRR

Sequences:

>Translated_737_residues
MRKGKDAVMRLLAKGEPIPYRQMLKALNISRRDRDQLDQQLDFLVESGEIVKMPGRIYALAGSGDSVRGKLSVHRDGYGF
VMPEEGGEDLFVPARYLTEYMNGDIVEAQVVSTRRDGKREGRVTALVQRGVTEIVGRFEAIGKGGRVIPDDPKLGRDLFV
TPGAAGGAAKARDGQIVLAQITAYPAGARPLEGRITEVLGEANDPEVEALTVIKKYELPHVFDEKVLEEAQKQPQQVTEE
AVAGRTDLRERLTVTIDGETARDFDDAVSVAREGDKIRLWVSIADVSHYVVEGSRLDTEAYLRGTSVYFPDRCIPMLPEE
LSNGICSLNPQVDRLTMTAEMLFDAAGERVDARFYTSVIKSAARLTYTTVKRILVDRDLEAVEQNAHLVEDLKVMEDLSL
RLNAVRRTRGSIDFDLPEPQIILDLQGETTAIVRAERNLAHRIIEEFMLAANEAVAGFLENTPVPSLYRVHENPDPLKLK
DLAEFVFGFGYILKLQDEKVNPLELQRLLAEVEGKPEERLINEVLLRCMKQARYSAENLGHYGLAAGSYTHFTSPIRRYP
DLVVHRILKRVLSQKMKQVDKDRLEARLPETAAHTSKRERVAMEAEREMVDLKKMQFMRDKIGEEYDGYITGVAPFGLFV
ELVDLFVEGMVPVATLPMDYYVHLEKSHALVGERTRAMYRIADKIRVKVSAVNEARKQVEFSLVGTLEKRPIEPIQDVRN
SYDRIPVKGKRPKPRRR
>Mature_737_residues
MRKGKDAVMRLLAKGEPIPYRQMLKALNISRRDRDQLDQQLDFLVESGEIVKMPGRIYALAGSGDSVRGKLSVHRDGYGF
VMPEEGGEDLFVPARYLTEYMNGDIVEAQVVSTRRDGKREGRVTALVQRGVTEIVGRFEAIGKGGRVIPDDPKLGRDLFV
TPGAAGGAAKARDGQIVLAQITAYPAGARPLEGRITEVLGEANDPEVEALTVIKKYELPHVFDEKVLEEAQKQPQQVTEE
AVAGRTDLRERLTVTIDGETARDFDDAVSVAREGDKIRLWVSIADVSHYVVEGSRLDTEAYLRGTSVYFPDRCIPMLPEE
LSNGICSLNPQVDRLTMTAEMLFDAAGERVDARFYTSVIKSAARLTYTTVKRILVDRDLEAVEQNAHLVEDLKVMEDLSL
RLNAVRRTRGSIDFDLPEPQIILDLQGETTAIVRAERNLAHRIIEEFMLAANEAVAGFLENTPVPSLYRVHENPDPLKLK
DLAEFVFGFGYILKLQDEKVNPLELQRLLAEVEGKPEERLINEVLLRCMKQARYSAENLGHYGLAAGSYTHFTSPIRRYP
DLVVHRILKRVLSQKMKQVDKDRLEARLPETAAHTSKRERVAMEAEREMVDLKKMQFMRDKIGEEYDGYITGVAPFGLFV
ELVDLFVEGMVPVATLPMDYYVHLEKSHALVGERTRAMYRIADKIRVKVSAVNEARKQVEFSLVGTLEKRPIEPIQDVRN
SYDRIPVKGKRPKPRRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=610, Percent_Identity=27.8688524590164, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI190014623, Length=610, Percent_Identity=27.8688524590164, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI219521928, Length=548, Percent_Identity=27.7372262773723, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI19115966, Length=545, Percent_Identity=27.5229357798165, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI134288890, Length=408, Percent_Identity=31.3725490196078, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI156105695, Length=446, Percent_Identity=27.3542600896861, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI156105693, Length=446, Percent_Identity=27.3542600896861, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI87082383, Length=680, Percent_Identity=39.5588235294118, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1787542, Length=636, Percent_Identity=28.1446540880503, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=502, Percent_Identity=30.8764940239044, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17553506, Length=521, Percent_Identity=28.2149712092131, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324552, Length=566, Percent_Identity=29.8586572438163, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320499, Length=509, Percent_Identity=22.7897838899804, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24649634, Length=553, Percent_Identity=29.8372513562387, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19922976, Length=380, Percent_Identity=30.2631578947368, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24654597, Length=380, Percent_Identity=30.2631578947368, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24654592, Length=380, Percent_Identity=30.2631578947368, Blast_Score=168, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 83093; Mature: 83093

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGKDAVMRLLAKGEPIPYRQMLKALNISRRDRDQLDQQLDFLVESGEIVKMPGRIYAL
CCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEEEE
AGSGDSVRGKLSVHRDGYGFVMPEEGGEDLFVPARYLTEYMNGDIVEAQVVSTRRDGKRE
ECCCCCCEEEEEEEECCCEEEECCCCCCCCEECHHHHHHHHCCCEEEHHHHHHHCCCCCC
GRVTALVQRGVTEIVGRFEAIGKGGRVIPDDPKLGRDLFVTPGAAGGAAKARDGQIVLAQ
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEE
ITAYPAGARPLEGRITEVLGEANDPEVEALTVIKKYELPHVFDEKVLEEAQKQPQQVTEE
EECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHH
AVAGRTDLRERLTVTIDGETARDFDDAVSVAREGDKIRLWVSIADVSHYVVEGSRLDTEA
HHCCHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECHHHHHCCCCCCCHHH
YLRGTSVYFPDRCIPMLPEELSNGICSLNPQVDRLTMTAEMLFDAAGERVDARFYTSVIK
HHCCCCEECCCCCCCCCCHHHCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SAARLTYTTVKRILVDRDLEAVEQNAHLVEDLKVMEDLSLRLNAVRRTRGSIDFDLPEPQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
IILDLQGETTAIVRAERNLAHRIIEEFMLAANEAVAGFLENTPVPSLYRVHENPDPLKLK
EEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHH
DLAEFVFGFGYILKLQDEKVNPLELQRLLAEVEGKPEERLINEVLLRCMKQARYSAENLG
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHCC
HYGLAAGSYTHFTSPIRRYPDLVVHRILKRVLSQKMKQVDKDRLEARLPETAAHTSKRER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VAMEAEREMVDLKKMQFMRDKIGEEYDGYITGVAPFGLFVELVDLFVEGMVPVATLPMDY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEECCCEE
YVHLEKSHALVGERTRAMYRIADKIRVKVSAVNEARKQVEFSLVGTLEKRPIEPIQDVRN
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHH
SYDRIPVKGKRPKPRRR
HHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKGKDAVMRLLAKGEPIPYRQMLKALNISRRDRDQLDQQLDFLVESGEIVKMPGRIYAL
CCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEEEE
AGSGDSVRGKLSVHRDGYGFVMPEEGGEDLFVPARYLTEYMNGDIVEAQVVSTRRDGKRE
ECCCCCCEEEEEEEECCCEEEECCCCCCCCEECHHHHHHHHCCCEEEHHHHHHHCCCCCC
GRVTALVQRGVTEIVGRFEAIGKGGRVIPDDPKLGRDLFVTPGAAGGAAKARDGQIVLAQ
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEE
ITAYPAGARPLEGRITEVLGEANDPEVEALTVIKKYELPHVFDEKVLEEAQKQPQQVTEE
EECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHH
AVAGRTDLRERLTVTIDGETARDFDDAVSVAREGDKIRLWVSIADVSHYVVEGSRLDTEA
HHCCHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECHHHHHCCCCCCCHHH
YLRGTSVYFPDRCIPMLPEELSNGICSLNPQVDRLTMTAEMLFDAAGERVDARFYTSVIK
HHCCCCEECCCCCCCCCCHHHCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SAARLTYTTVKRILVDRDLEAVEQNAHLVEDLKVMEDLSLRLNAVRRTRGSIDFDLPEPQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
IILDLQGETTAIVRAERNLAHRIIEEFMLAANEAVAGFLENTPVPSLYRVHENPDPLKLK
EEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHH
DLAEFVFGFGYILKLQDEKVNPLELQRLLAEVEGKPEERLINEVLLRCMKQARYSAENLG
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHCC
HYGLAAGSYTHFTSPIRRYPDLVVHRILKRVLSQKMKQVDKDRLEARLPETAAHTSKRER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VAMEAEREMVDLKKMQFMRDKIGEEYDGYITGVAPFGLFVELVDLFVEGMVPVATLPMDY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEECCCEE
YVHLEKSHALVGERTRAMYRIADKIRVKVSAVNEARKQVEFSLVGTLEKRPIEPIQDVRN
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHH
SYDRIPVKGKRPKPRRR
HHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]