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The map label for this gene is gmhA

Identifier: 197118884

GI number: 197118884

Start: 2907179

End: 2907757

Strand: Reverse

Name: gmhA

Synonym: Gbem_2507

Alternate gene names: 197118884

Gene position: 2907757-2907179 (Counterclockwise)

Preceding gene: 197118885

Following gene: 197118883

Centisome position: 63.0

GC content: 62.18

Gene sequence:

>579_bases
ATGCTTGTAGAGATAAAGGCCCAGCTTAAGGCCCATTGCGAAGTCATGACGGCGCTTCAGGGGGAGTTGTCCCCCGCAAT
AGAGAGCGCCGTTTCGCTTGTGGTAGACGCCTATAAGGCGGGGAACAAGCTCCTGGTTATGGGAAACGGCGGGTCTGCCG
CCGACGCCCAGCATTTCGTGGCAGAGATGGTCGGCCGCTTCAAGCTGGAGCGGCGCGCGCTTCCCGCCATCGCGCTTCAC
ACCGACACCTCCATCCTTACCGCCATCGGCAACGACTACGGCTTTGACCGGATCTTCTCCCGTCAGGTCGAGGCTCACGC
CGCGGCGGGCGACGTCGTGGTGGGGATCTCCACCTCCGGCAACTCCCCCAACGTCCAGCTTGCCCTGGAACTCGCCCGCG
AGAAAGGGTGCCGCACCATAGCGCTCCTCGGCAAAGACGGGGGGAGCATCAAGTCGGTGGCCGAACTCCCCCTCATCGTT
CCCAGCAACGACACCCCCCGCATCCAGGAAGGGCACATAACCATCATCCACATCATCTGCGACCTGGTAGAGCGGGAGCT
TTTCGTGAAGGGCAAATAG

Upstream 100 bases:

>100_bases
CGGTACCTGTCCTTCTCCGAGCTTTGCGAGAGGATCAAGGCCCGCTACCAGTAGTCGCGGTCTCGCTGAGGCTTGTATAT
CCAATGCAGGAGGGTAGTGG

Downstream 100 bases:

>100_bases
GGCGCGGGGGAACCATGGCGAAGCACAGGGCGGTTTTTCTCGACCGCGACGGGACCATCAACGTCGAGGTGCAGTATCTG
AGCAAGGTGGAGGAGTTTGA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MLVEIKAQLKAHCEVMTALQGELSPAIESAVSLVVDAYKAGNKLLVMGNGGSAADAQHFVAEMVGRFKLERRALPAIALH
TDTSILTAIGNDYGFDRIFSRQVEAHAAAGDVVVGISTSGNSPNVQLALELAREKGCRTIALLGKDGGSIKSVAELPLIV
PSNDTPRIQEGHITIIHIICDLVERELFVKGK

Sequences:

>Translated_192_residues
MLVEIKAQLKAHCEVMTALQGELSPAIESAVSLVVDAYKAGNKLLVMGNGGSAADAQHFVAEMVGRFKLERRALPAIALH
TDTSILTAIGNDYGFDRIFSRQVEAHAAAGDVVVGISTSGNSPNVQLALELAREKGCRTIALLGKDGGSIKSVAELPLIV
PSNDTPRIQEGHITIIHIICDLVERELFVKGK
>Mature_192_residues
MLVEIKAQLKAHCEVMTALQGELSPAIESAVSLVVDAYKAGNKLLVMGNGGSAADAQHFVAEMVGRFKLERRALPAIALH
TDTSILTAIGNDYGFDRIFSRQVEAHAAAGDVVVGISTSGNSPNVQLALELAREKGCRTIALLGKDGGSIKSVAELPLIV
PSNDTPRIQEGHITIIHIICDLVERELFVKGK

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=163, Percent_Identity=50.3067484662577, Blast_Score=157, Evalue=3e-40,
Organism=Escherichia coli, GI1789539, Length=191, Percent_Identity=41.3612565445026, Blast_Score=143, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_GEOBB (B5EGN2)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002139311.1
- ProteinModelPortal:   B5EGN2
- SMR:   B5EGN2
- GeneID:   6782504
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_2507
- HOGENOM:   HBG671955
- OMA:   QEMHILI
- ProtClustDB:   PRK13937
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20393; Mature: 20393

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51464 SIS

Important sites: BINDING 62-62 BINDING 122-122 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVEIKAQLKAHCEVMTALQGELSPAIESAVSLVVDAYKAGNKLLVMGNGGSAADAQHFV
CEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
AEMVGRFKLERRALPAIALHTDTSILTAIGNDYGFDRIFSRQVEAHAAAGDVVVGISTSG
HHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
NSPNVQLALELAREKGCRTIALLGKDGGSIKSVAELPLIVPSNDTPRIQEGHITIIHIIC
CCCCEEEEEEEHHHCCCEEEEEEECCCCCCHHHHHCEEEECCCCCCCEECCCEEHHHHHH
DLVERELFVKGK
HHHHHHHEECCC
>Mature Secondary Structure
MLVEIKAQLKAHCEVMTALQGELSPAIESAVSLVVDAYKAGNKLLVMGNGGSAADAQHFV
CEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
AEMVGRFKLERRALPAIALHTDTSILTAIGNDYGFDRIFSRQVEAHAAAGDVVVGISTSG
HHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
NSPNVQLALELAREKGCRTIALLGKDGGSIKSVAELPLIVPSNDTPRIQEGHITIIHIIC
CCCCEEEEEEEHHHCCCEEEEEEECCCCCCHHHHHCEEEECCCCCCCEECCCEEHHHHHH
DLVERELFVKGK
HHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA