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The map label for this gene is yddQ [H]

Identifier: 197118854

GI number: 197118854

Start: 2869942

End: 2870523

Strand: Direct

Name: yddQ [H]

Synonym: Gbem_2477

Alternate gene names: 197118854

Gene position: 2869942-2870523 (Clockwise)

Preceding gene: 197118853

Following gene: 197118855

Centisome position: 62.19

GC content: 61.17

Gene sequence:

>582_bases
ATGAGCCAGGCAACGATGGAGAGCGAAGCAGAGAACGCAACTTGCCTGATCCTGGTCGACCTGCAAAACGATTACTTCCC
AGGCGGCAGCATGGAACTCGTAGGGATGGTGGAAGCCACCGCCAACGCGAAGCTCCTACTGGAGCAGGCGAGAAAGAGCG
GGACCCCGGTCATCCATATCCAGCACATCGCCGCGCGCCCGGGTGCGACCTTCTTCGTGCCCGGCACCGACGGCGCCGAG
ATCAACCCGGTGGCGGAGCCTGTGGCCGGCGAATCGATCGTGGTCAAGAACTTCCCCAACAGCTTCCGCGGTACTTCGCT
TCTTGAGCTGCTCGCGGCCCGGCAGGTGAAGGACCTGGTGATCTGCGGGGCGATGAGCCACATGTGCATAGACGCGACGA
CCAGGGCGGCGTTCGATTTGGGCTTTAACTGCACCGTCGTCGCAGACGCCTGCGCTACCAGGGACCTGCAGTTCCAGGGA
CGGACGGTCAAGGCTGCCGATGTGCACGCCTCCTTTATGGCTGCGCTTGCGATCCCTTATGCCAAGATAGTCACCACAAA
GGAGATGGTGCATCAAATCTAA

Upstream 100 bases:

>100_bases
TCAACTACTTCGATCCGGCGCAAAGACGCGAACGGTACCAGAAGCAGTTTCCCGAAGACTGCAAGAAGGCGTTCGCGCTC
GGCGCGCGGCTGGTGCAACC

Downstream 100 bases:

>100_bases
TTGACTTCCCGGCGTTAAGGAGTGTATTAGAACTGGTTCTGAAACCTGTCCTAAGCCAAGACAGGGCAATCTATGAGCAA
AGACAGAGCCGCCTGTTTCA

Product: nicotinamidase-like cysteine hydrolase

Products: Nicotinate; pyrazinoic acid; NH3 [C]

Alternate protein names: NA

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSQATMESEAENATCLILVDLQNDYFPGGSMELVGMVEATANAKLLLEQARKSGTPVIHIQHIAARPGATFFVPGTDGAE
INPVAEPVAGESIVVKNFPNSFRGTSLLELLAARQVKDLVICGAMSHMCIDATTRAAFDLGFNCTVVADACATRDLQFQG
RTVKAADVHASFMAALAIPYAKIVTTKEMVHQI

Sequences:

>Translated_193_residues
MSQATMESEAENATCLILVDLQNDYFPGGSMELVGMVEATANAKLLLEQARKSGTPVIHIQHIAARPGATFFVPGTDGAE
INPVAEPVAGESIVVKNFPNSFRGTSLLELLAARQVKDLVICGAMSHMCIDATTRAAFDLGFNCTVVADACATRDLQFQG
RTVKAADVHASFMAALAIPYAKIVTTKEMVHQI
>Mature_192_residues
SQATMESEAENATCLILVDLQNDYFPGGSMELVGMVEATANAKLLLEQARKSGTPVIHIQHIAARPGATFFVPGTDGAEI
NPVAEPVAGESIVVKNFPNSFRGTSLLELLAARQVKDLVICGAMSHMCIDATTRAAFDLGFNCTVVADACATRDLQFQGR
TVKAADVHASFMAALAIPYAKIVTTKEMVHQI

Specific function: NAD biosynthesis; nicotinamide to NaMN; first step. [C]

COG id: COG1335

COG function: function code Q; Amidases related to nicotinamidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismatase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000868 [H]

Pfam domain/function: PF00857 Isochorismatase [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 20540; Mature: 20409

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQATMESEAENATCLILVDLQNDYFPGGSMELVGMVEATANAKLLLEQARKSGTPVIHI
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEE
QHIAARPGATFFVPGTDGAEINPVAEPVAGESIVVKNFPNSFRGTSLLELLAARQVKDLV
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ICGAMSHMCIDATTRAAFDLGFNCTVVADACATRDLQFQGRTVKAADVHASFMAALAIPY
HHCCHHHHEEHHHHHHHEECCCCEEEEECCCCCCCEEECCCEEEEHHHHHHHHHHHHCCH
AKIVTTKEMVHQI
HHHHHHHHHHHCC
>Mature Secondary Structure 
SQATMESEAENATCLILVDLQNDYFPGGSMELVGMVEATANAKLLLEQARKSGTPVIHI
CCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEE
QHIAARPGATFFVPGTDGAEINPVAEPVAGESIVVKNFPNSFRGTSLLELLAARQVKDLV
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ICGAMSHMCIDATTRAAFDLGFNCTVVADACATRDLQFQGRTVKAADVHASFMAALAIPY
HHCCHHHHEEHHHHHHHEECCCCEEEEECCCCCCCEEECCCEEEEHHHHHHHHHHHHCCH
AKIVTTKEMVHQI
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Nicotinamide; pyrazinamide; H2O [C]

Specific reaction: Nicotinamide + H2O = Nicotinate + NH3 pyrazinamide + H2O = pyrazinoic acid + NH3 [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]