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The map label for this gene is trpE [H]

Identifier: 197118792

GI number: 197118792

Start: 2796704

End: 2798179

Strand: Reverse

Name: trpE [H]

Synonym: Gbem_2413

Alternate gene names: 197118792

Gene position: 2798179-2796704 (Counterclockwise)

Preceding gene: 197118794

Following gene: 197118791

Centisome position: 60.63

GC content: 61.79

Gene sequence:

>1476_bases
ATGTACTATCCCGATTTTGCCTCGTTCCAAACCCTTTCCACCAAAGGCAACCTCATCCCGGTCTACAGGGAAATCCTGGC
CGACCTGGATACGCCGGTCAGCGCCTTCAAGAAGATCGACGACGGCCGCTACGGCTTTCTCCTGGAGAGTATCGAGGGGG
GCGAGAAATGGGGACGCTACACCTTCCTCGGTTCTTCGCCGGCGGTCGTGATCCGCGGCAAGGACAATTGGGTGGAGATC
GTGGAAGGGGGGGAGGTGCGGCGCGTCGAGGTGTCGGATCCCCTCAACTACATCCGCGACTACATGGCCCGCTATCAGCC
GGTGGAGGTCCCTGGCATCCCGCGCTTCTTCGGCGGCGCGGTCGGTTATCTGGGGTACGATGCGGTCAGGCACTTTGAGA
CGCTTCCTGACAGCAATCCGAGCGACATCAACACCTACGACGCCAACTTCATCATCACCGACACCATCCTCATCTTCGAT
AGCCTGAGCCAAAAGATCAAGGTGGTATCCAACGCCCATGTCGACGGCGGTACCTCGCTTCAGGCCGCCTACGACGACGC
CATAGCGAAGATCGAGGGGCTCATCGCCCGCCTGAAGGCGCCGCTTCCCCCGAATGAGAAGAAGCCTTTTAACGGGAAGG
TGGAGTTCAGCTCCAACGTGAAACCGGAGGAGTTCGAGGCTGCGGTCACCCGCGCCAAGGAATACGTCAGAAACGGCGAC
ATCATCCAGGTGGTACTCTCCCAGCGATTTTCCGGCGACCTCACCGTCGAACCGTTCGACATCTACCGCGCGCTCCGCAC
CCTGAACCCGTCCCCGTATATGTTCTTCCTCCGCCTGGACGAGACCCTGGTCGTGGGCGCTTCCCCCGAGGTGATGGTGC
GTAAGGAAGGGGAGATGGTGGAACTAAGGCCCATCGCCGGCACCCGTCCCCGCGGCGCGACCACCGCGGCCGACGAGGAA
CTGGCGCGGGACCTCCTCGACGACCCCAAGGAGCGCGCCGAACACGTCATGCTGGTCGACCTGGGAAGAAATGACCTGGG
GCGCGTCTGCAAGATCGGTAGCGTCAAGGTCACCGAGCTCATGATAATCGAACGCTATTCCCACGTGATGCACATCGTCT
CCAACGTGCAGGGGGAACTCTCCCCGGGGCAGGATGCCTTCGATGTCGTGCGTGCGACCTTCCCCGCGGGGACCCTCTCC
GGAGCCCCTAAGGTGCGGGCGATGGAGATCATCGACGAGCTGGAAGGAGTGCGGCGCGAGGTGTATGGCGGCGCCGTCGG
CTACTTCTCCTTTTCCGGCAACATGGACATGGCTATCGCCATCAGGACCTTGGTCATAAAGGACGGCAAGGTGCATCTGC
AGGCCGGCGCCGGCATCGTCGCCGATTCCGACCCCGCAGCCGAGTACGTCGAGACCGTCAACAAGGCGAAAGCCGTGGTC
AAGGCCATCGAGATGGCGGAAAAGGGACTGGATTAG

Upstream 100 bases:

>100_bases
CACTCCCCTGGCGAATATGTTAATAAAGTCGGGCTTAAATTCTTTCCCGGCAGGGAGATACGTCCCGTTCCTTCCTCCTT
GCCCACCCCCAAGGAGCCCC

Downstream 100 bases:

>100_bases
AAAAAAGGGGGACAGGCTACTTTTTCGAAAGATAAAGTAGCCTGTCCCCCTTTGGCTTTTAGGACTCGTCTATAACTCGT
ATAGCCCTGTTTTTCTTGTT

Product: anthranilate synthase protein I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MYYPDFASFQTLSTKGNLIPVYREILADLDTPVSAFKKIDDGRYGFLLESIEGGEKWGRYTFLGSSPAVVIRGKDNWVEI
VEGGEVRRVEVSDPLNYIRDYMARYQPVEVPGIPRFFGGAVGYLGYDAVRHFETLPDSNPSDINTYDANFIITDTILIFD
SLSQKIKVVSNAHVDGGTSLQAAYDDAIAKIEGLIARLKAPLPPNEKKPFNGKVEFSSNVKPEEFEAAVTRAKEYVRNGD
IIQVVLSQRFSGDLTVEPFDIYRALRTLNPSPYMFFLRLDETLVVGASPEVMVRKEGEMVELRPIAGTRPRGATTAADEE
LARDLLDDPKERAEHVMLVDLGRNDLGRVCKIGSVKVTELMIIERYSHVMHIVSNVQGELSPGQDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEGVRREVYGGAVGYFSFSGNMDMAIAIRTLVIKDGKVHLQAGAGIVADSDPAAEYVETVNKAKAVV
KAIEMAEKGLD

Sequences:

>Translated_491_residues
MYYPDFASFQTLSTKGNLIPVYREILADLDTPVSAFKKIDDGRYGFLLESIEGGEKWGRYTFLGSSPAVVIRGKDNWVEI
VEGGEVRRVEVSDPLNYIRDYMARYQPVEVPGIPRFFGGAVGYLGYDAVRHFETLPDSNPSDINTYDANFIITDTILIFD
SLSQKIKVVSNAHVDGGTSLQAAYDDAIAKIEGLIARLKAPLPPNEKKPFNGKVEFSSNVKPEEFEAAVTRAKEYVRNGD
IIQVVLSQRFSGDLTVEPFDIYRALRTLNPSPYMFFLRLDETLVVGASPEVMVRKEGEMVELRPIAGTRPRGATTAADEE
LARDLLDDPKERAEHVMLVDLGRNDLGRVCKIGSVKVTELMIIERYSHVMHIVSNVQGELSPGQDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEGVRREVYGGAVGYFSFSGNMDMAIAIRTLVIKDGKVHLQAGAGIVADSDPAAEYVETVNKAKAVV
KAIEMAEKGLD
>Mature_491_residues
MYYPDFASFQTLSTKGNLIPVYREILADLDTPVSAFKKIDDGRYGFLLESIEGGEKWGRYTFLGSSPAVVIRGKDNWVEI
VEGGEVRRVEVSDPLNYIRDYMARYQPVEVPGIPRFFGGAVGYLGYDAVRHFETLPDSNPSDINTYDANFIITDTILIFD
SLSQKIKVVSNAHVDGGTSLQAAYDDAIAKIEGLIARLKAPLPPNEKKPFNGKVEFSSNVKPEEFEAAVTRAKEYVRNGD
IIQVVLSQRFSGDLTVEPFDIYRALRTLNPSPYMFFLRLDETLVVGASPEVMVRKEGEMVELRPIAGTRPRGATTAADEE
LARDLLDDPKERAEHVMLVDLGRNDLGRVCKIGSVKVTELMIIERYSHVMHIVSNVQGELSPGQDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEGVRREVYGGAVGYFSFSGNMDMAIAIRTLVIKDGKVHLQAGAGIVADSDPAAEYVETVNKAKAVV
KAIEMAEKGLD

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=472, Percent_Identity=34.5338983050847, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1787518, Length=386, Percent_Identity=40.9326424870466, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1786809, Length=256, Percent_Identity=30.859375, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082077, Length=225, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=503, Percent_Identity=42.544731610338, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=26.302729528536, Blast_Score=123, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54102; Mature: 54102

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYPDFASFQTLSTKGNLIPVYREILADLDTPVSAFKKIDDGRYGFLLESIEGGEKWGRY
CCCCCCCCCEEECCCCCEEHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCE
TFLGSSPAVVIRGKDNWVEIVEGGEVRRVEVSDPLNYIRDYMARYQPVEVPGIPRFFGGA
EEECCCCEEEEECCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHCCH
VGYLGYDAVRHFETLPDSNPSDINTYDANFIITDTILIFDSLSQKIKVVSNAHVDGGTSL
HHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCC
QAAYDDAIAKIEGLIARLKAPLPPNEKKPFNGKVEFSSNVKPEEFEAAVTRAKEYVRNGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
IIQVVLSQRFSGDLTVEPFDIYRALRTLNPSPYMFFLRLDETLVVGASPEVMVRKEGEMV
EEEEEHHHCCCCCCEECHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEECCCCEE
ELRPIAGTRPRGATTAADEELARDLLDDPKERAEHVMLVDLGRNDLGRVCKIGSVKVTEL
EEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHCCCCEEHHHH
MIIERYSHVMHIVSNVQGELSPGQDAFDVVRATFPAGTLSGAPKVRAMEIIDELEGVRRE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGNMDMAIAIRTLVIKDGKVHLQAGAGIVADSDPAAEYVETVNKAKAVV
HHCCEEEEEEECCCCCEEEEEEEEEEECCEEEEEECCCEEECCCHHHHHHHHHHHHHHHH
KAIEMAEKGLD
HHHHHHHHCCC
>Mature Secondary Structure
MYYPDFASFQTLSTKGNLIPVYREILADLDTPVSAFKKIDDGRYGFLLESIEGGEKWGRY
CCCCCCCCCEEECCCCCEEHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCE
TFLGSSPAVVIRGKDNWVEIVEGGEVRRVEVSDPLNYIRDYMARYQPVEVPGIPRFFGGA
EEECCCCEEEEECCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHCCH
VGYLGYDAVRHFETLPDSNPSDINTYDANFIITDTILIFDSLSQKIKVVSNAHVDGGTSL
HHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCC
QAAYDDAIAKIEGLIARLKAPLPPNEKKPFNGKVEFSSNVKPEEFEAAVTRAKEYVRNGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
IIQVVLSQRFSGDLTVEPFDIYRALRTLNPSPYMFFLRLDETLVVGASPEVMVRKEGEMV
EEEEEHHHCCCCCCEECHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEECCCCEE
ELRPIAGTRPRGATTAADEELARDLLDDPKERAEHVMLVDLGRNDLGRVCKIGSVKVTEL
EEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHCCCCEEHHHH
MIIERYSHVMHIVSNVQGELSPGQDAFDVVRATFPAGTLSGAPKVRAMEIIDELEGVRRE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGNMDMAIAIRTLVIKDGKVHLQAGAGIVADSDPAAEYVETVNKAKAVV
HHCCEEEEEEECCCCCEEEEEEEEEEECCEEEEEECCCEEECCCHHHHHHHHHHHHHHHH
KAIEMAEKGLD
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]