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The map label for this gene is atoC [H]

Identifier: 197118541

GI number: 197118541

Start: 2514145

End: 2515494

Strand: Reverse

Name: atoC [H]

Synonym: Gbem_2160

Alternate gene names: 197118541

Gene position: 2515494-2514145 (Counterclockwise)

Preceding gene: 197118542

Following gene: 197118540

Centisome position: 54.51

GC content: 63.11

Gene sequence:

>1350_bases
ATGAAAGGAAACATTCTGGTGGTCGAGGATGACGGCACCTTCCGCGCTTTTCTGGAGACAGTGCTGCAGGACGACGGGCA
CCAGGTAAAGACCGCCGCCGATGGCGAAAATGCGCTTCGTCTGCTGAAGCAGGGAAGCTACGACGTGGTGGTCTCCGACC
TGAAGCTCCCCGGCAAAAGCGGCCTCGACCTCTTTCGTGAGACGCGCAACGATCCAGCCGCGCCGCAGTTCATCTTCCTG
ACCGCCTACGGGAAGGTCGGAGAAGCCGTCGCCGCCATCAAGGAAGGGGCGGTCGACTTCCTCACCAAGCCGCTGCAGGA
TCCGGATGTGCTGCTCCGCCTGGTGCGGCACGTCATCGAGGAACAGCTCCGGGAGCGCGACTATCTCTCCCTCAAGCAGT
GCGAGGTAGCCGGGCTGCCGCCGGAGGATCTCATCTTCGCCGGCCAAGCCATGGCCCCCGTGCGCAAGCTGGTACACGAC
GTGGCAGGCACCATGGCGAACGTCCTCGTCTTCGGCGAGAGCGGAACGGGAAAGGAATTGGTCGCAAGGACCATTCATCA
GCTGAGTTCCCGCCGGGAGGCCGGCTTCGTCGCGCTAAACTGCGCCGCCATCCCGGAAACCCTTCTGGAAAGCGAGCTTT
TCGGGCACGAGAAGGGGGCTTTCACCGGTGCGGTGCAGGCGAGGCAGGGGAAATTCGAACTGGCCCGGGGCGGAACCATC
CTGCTGGACGAGATCGGGGAGATGCCGCTTGCCCTGCAGGCCAAGCTCCTGCGGGTGATCCAGGAGCGCGTCTTCGAGAG
GGTGGGAGGGACCAAAGAGATCAAGGCCGACGTCCGGCTGATCGCGGCGACCAACCGTAACCTGCGCGAGGAGGTCAGGG
AGCGCCGCTTCCGCGAGGACCTTTACTACCGCCTCAACGTATTCCCGGTGCAGCTCCCTCCATTGCGGGAAAGGGGCGAT
GCGGTGCCGGTTTTGAGCAGATACTTCATGCAACGCTTCAGTAGTCAGACTGGCAAAACCTTGAAAGGGATCGACGCCGA
CGCCCTCGCCGCCCTGGAAAGGTACCGCTGGCCCGGCAACATCAGGGAGCTGCAAAACGTAATGGAGCGGGCCGTCATCC
TCTCCAGGGAAAAGGTGGGGCTATCCGCCCTCCCGGAGGAAATGCTGCGCACGCCCGAGCCGGATGCCCTCGATAGCCGC
GAGAGGCTGAAGTCGGCGGAGAGGGAGATCATCGCAGAGGCGATCAAGAAGCATCACGGCAACCGGCGCCTGGCTGCCGA
GGAACTCGGGGTATCGCGGCGGACCCTGCAGTACAAGCTCAAGGATTACGGCTTTCTTGACGAAAGCTGA

Upstream 100 bases:

>100_bases
TCGAAGAGCACGGCGGAACCATCGGGTTGGAGAGCAGGATAGGGGAGGGGACCACGGTGACCCTCGCCTTGCCTTTGCTC
CCCGCGGACAAGGAGCAGAC

Downstream 100 bases:

>100_bases
CCGGTGCAAATCCGCGTCGCCCGAGTGCAAAGGATTGCACCATTTCCCCCTTGGCGCGAGCGCCCTTTGCTGTTGGTCTC
CTGCTAAATCAGCCACTTGC

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKGNILVVEDDGTFRAFLETVLQDDGHQVKTAADGENALRLLKQGSYDVVVSDLKLPGKSGLDLFRETRNDPAAPQFIFL
TAYGKVGEAVAAIKEGAVDFLTKPLQDPDVLLRLVRHVIEEQLRERDYLSLKQCEVAGLPPEDLIFAGQAMAPVRKLVHD
VAGTMANVLVFGESGTGKELVARTIHQLSSRREAGFVALNCAAIPETLLESELFGHEKGAFTGAVQARQGKFELARGGTI
LLDEIGEMPLALQAKLLRVIQERVFERVGGTKEIKADVRLIAATNRNLREEVRERRFREDLYYRLNVFPVQLPPLRERGD
AVPVLSRYFMQRFSSQTGKTLKGIDADALAALERYRWPGNIRELQNVMERAVILSREKVGLSALPEEMLRTPEPDALDSR
ERLKSAEREIIAEAIKKHHGNRRLAAEELGVSRRTLQYKLKDYGFLDES

Sequences:

>Translated_449_residues
MKGNILVVEDDGTFRAFLETVLQDDGHQVKTAADGENALRLLKQGSYDVVVSDLKLPGKSGLDLFRETRNDPAAPQFIFL
TAYGKVGEAVAAIKEGAVDFLTKPLQDPDVLLRLVRHVIEEQLRERDYLSLKQCEVAGLPPEDLIFAGQAMAPVRKLVHD
VAGTMANVLVFGESGTGKELVARTIHQLSSRREAGFVALNCAAIPETLLESELFGHEKGAFTGAVQARQGKFELARGGTI
LLDEIGEMPLALQAKLLRVIQERVFERVGGTKEIKADVRLIAATNRNLREEVRERRFREDLYYRLNVFPVQLPPLRERGD
AVPVLSRYFMQRFSSQTGKTLKGIDADALAALERYRWPGNIRELQNVMERAVILSREKVGLSALPEEMLRTPEPDALDSR
ERLKSAEREIIAEAIKKHHGNRRLAAEELGVSRRTLQYKLKDYGFLDES
>Mature_449_residues
MKGNILVVEDDGTFRAFLETVLQDDGHQVKTAADGENALRLLKQGSYDVVVSDLKLPGKSGLDLFRETRNDPAAPQFIFL
TAYGKVGEAVAAIKEGAVDFLTKPLQDPDVLLRLVRHVIEEQLRERDYLSLKQCEVAGLPPEDLIFAGQAMAPVRKLVHD
VAGTMANVLVFGESGTGKELVARTIHQLSSRREAGFVALNCAAIPETLLESELFGHEKGAFTGAVQARQGKFELARGGTI
LLDEIGEMPLALQAKLLRVIQERVFERVGGTKEIKADVRLIAATNRNLREEVRERRFREDLYYRLNVFPVQLPPLRERGD
AVPVLSRYFMQRFSSQTGKTLKGIDADALAALERYRWPGNIRELQNVMERAVILSREKVGLSALPEEMLRTPEPDALDSR
ERLKSAEREIIAEAIKKHHGNRRLAAEELGVSRRTLQYKLKDYGFLDES

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=43.9024390243902, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=43.0493273542601, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI1790299, Length=474, Percent_Identity=39.4514767932489, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI87082117, Length=347, Percent_Identity=44.0922190201729, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI1789087, Length=311, Percent_Identity=48.8745980707396, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788905, Length=460, Percent_Identity=38.4782608695652, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=43.9628482972136, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI87082152, Length=334, Percent_Identity=45.2095808383234, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1786524, Length=325, Percent_Identity=42.4615384615385, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=40.6832298136646, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1787583, Length=306, Percent_Identity=40.1960784313725, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI87081858, Length=306, Percent_Identity=34.3137254901961, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789828, Length=234, Percent_Identity=38.034188034188, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789809, Length=121, Percent_Identity=38.0165289256198, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787375, Length=110, Percent_Identity=35.4545454545455, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790863, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786911, Length=102, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50219; Mature: 50219

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGNILVVEDDGTFRAFLETVLQDDGHQVKTAADGENALRLLKQGSYDVVVSDLKLPGKS
CCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCC
GLDLFRETRNDPAAPQFIFLTAYGKVGEAVAAIKEGAVDFLTKPLQDPDVLLRLVRHVIE
CHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EQLRERDYLSLKQCEVAGLPPEDLIFAGQAMAPVRKLVHDVAGTMANVLVFGESGTGKEL
HHHHHCCCCCHHHHHCCCCCHHHHEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
VARTIHQLSSRREAGFVALNCAAIPETLLESELFGHEKGAFTGAVQARQGKFELARGGTI
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCEE
LLDEIGEMPLALQAKLLRVIQERVFERVGGTKEIKADVRLIAATNRNLREEVRERRFRED
EEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHCEEEEECCCCHHHHHHHHHHHHHH
LYYRLNVFPVQLPPLRERGDAVPVLSRYFMQRFSSQTGKTLKGIDADALAALERYRWPGN
HHEEEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCC
IRELQNVMERAVILSREKVGLSALPEEMLRTPEPDALDSRERLKSAEREIIAEAIKKHHG
HHHHHHHHHHHHHHHHHHCCHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NRRLAAEELGVSRRTLQYKLKDYGFLDES
CCCHHHHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKGNILVVEDDGTFRAFLETVLQDDGHQVKTAADGENALRLLKQGSYDVVVSDLKLPGKS
CCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCC
GLDLFRETRNDPAAPQFIFLTAYGKVGEAVAAIKEGAVDFLTKPLQDPDVLLRLVRHVIE
CHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EQLRERDYLSLKQCEVAGLPPEDLIFAGQAMAPVRKLVHDVAGTMANVLVFGESGTGKEL
HHHHHCCCCCHHHHHCCCCCHHHHEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
VARTIHQLSSRREAGFVALNCAAIPETLLESELFGHEKGAFTGAVQARQGKFELARGGTI
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCEE
LLDEIGEMPLALQAKLLRVIQERVFERVGGTKEIKADVRLIAATNRNLREEVRERRFRED
EEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHCEEEEECCCCHHHHHHHHHHHHHH
LYYRLNVFPVQLPPLRERGDAVPVLSRYFMQRFSSQTGKTLKGIDADALAALERYRWPGN
HHEEEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCC
IRELQNVMERAVILSREKVGLSALPEEMLRTPEPDALDSRERLKSAEREIIAEAIKKHHG
HHHHHHHHHHHHHHHHHHCCHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NRRLAAEELGVSRRTLQYKLKDYGFLDES
CCCHHHHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]