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The map label for this gene is yegE [H]

Identifier: 197118534

GI number: 197118534

Start: 2505098

End: 2507035

Strand: Reverse

Name: yegE [H]

Synonym: Gbem_2153

Alternate gene names: 197118534

Gene position: 2507035-2505098 (Counterclockwise)

Preceding gene: 197118537

Following gene: 197118533

Centisome position: 54.32

GC content: 58.77

Gene sequence:

>1938_bases
ATGAAGCGGGGTGACGGCGCGGCCATGCCCATGGACGCAGACAAATTGGCAGCAATGGTGGAATCGTCTGGCGACGCGAT
TGTCGGAATGAACTTGGACGGTACCATCAGCAGCTGGAACCCCGCTGCGACCAGGCTCTATGGGTATTCCGCAAAGGAAG
CTGTAGGCTGCGATATTTCCGTACTGGAATCTTTGGAGCGCCCCGGCGAGATCGCGGCGGAGCTGCAAGAGGTGCAAAAG
GAGAAGCGATCCCGGCACTATGACCGCTACCGCCGGCGCAAAGACGGCAGCCAGGTTTTCGTCTCACTGACGCTCTCCCC
GATACTGGACAGGCAAAATACGCTGATCGGCCTGTCCTCCATCGGCCGCGATGCGGAGGAACTGGTACAGAAACGTACCA
AGGAACTGATGCAGGCCATCCGGGCACTGCAAGTTGAGATCTCCGAGCGGAGCAGGGCAGAGGAGGCGCTTACCCAGAGC
GAGGAGATGCTCCGCTTCGCGGCATTGGCGGCGGATATCGGCATATGGCACTACGATCTGCTGACAGGGGACCTGGTCTG
GAGCGACAGGTGCAAGGAGTTGTTCGGCTATCCTCACGACTTTCAGATGACCTACGAAGCTTTCCTCGACGCCGTAGCGG
AGGAGGACCGGCAGAGGGTAGACCAAGCGGTTCAGAGGGCTTTGCAGGACAAGTCCGAATATGCAGTAGAGCTGAGGGTG
ATATTGCAAGACGGACAGGTGCGGTGGGTGATGAGCAAAGGGCACGCCTTCTACGATAGCCAGGGGAAACCGCTGCGGAT
GGCAGGCATAGCCTTGGACATCACCCAGACGAAAAAAACGGAAGCGGCGTTATTGCGAGCGAAGGAGGAATGGGAAAGCA
CTTTCAACAGCGTCCCCGATCTCATCGCCATACTAGACGAAAAGTGCCGCATCGTCCGGGTCAACGAGGCCATGGCGCAG
CGGGTCCATATCAGCGCCGACGGGTGTGTCGGGCTTTTTTGCTACCAGGTTCTTCACGGGGAGAATGCGCCGCCTCATTT
CTGCCCCCACGGCCAGAGCTTGATGGACAATATGCAGCACATTGTCGAGGTCTACGATCCCCACCTGTCCGGGACCTTTC
TGGTCAGCACCACGCCCCTTGTTGCGGCGGACGGCAAATCTATCGGAACGGTTCATGTTGCCAGGGACATAACGGAGCGC
AAGAGGGCGGAAGAGGAGATCGCCCGGCTGAACGCCGACCTGGGGGCGCACCTAGCCGAACTGGAGGAGAGAAACCAGGA
ACTGGATGCCTTCAACCGGATGATATCCCACGACCTGCGGCAGCCCTTGAACATCATGTCCCTTGCCGGCCAGCACATCG
AGATGCTATGCAGCAGCGACACCCCCGAGTGCCGGCAAAGCGTGCAGACCCTCGAACAGTCGGTATTGCGCATGAACACA
ATGATCGAGACGCTGCTTTCCTTCTCGCGTTCGACCCATGGGAATTTGATGCGAGAGGATTTCGACATCAGCGAGATGGT
ACAGGTGATACTCGCGGAATTTTATCTGGCCGAGCCGCCGCGCAGGATAACCACAGTGATAGCGGAAGAGACAAAGGTCA
ATGCCGACCCCCGGCTGTTGAGGACTGCGCTGGAAAACCTCCTGGGCAACGCCTGGAAATATACCGGTGGCCGTGAAGAG
GGATACATCGAGTTCGGTGTGAGGGGAGGGGGGGCAAAACCGGTCTACTTCATCAAGGACAACGGGATGGGGTTCGACAT
GGCCGATGCGGATAAGCTCTTCGTCCCCTTCCAGCGGCTGGCCGGGGCCGATGCGTTCAAAGGTTCGGGCATCGGCCTTG
CGACCGTGGAAAAGATCATCAAGCGGCACGGCGGAAGAATCTGGGCAGAGGGCGAGCCGGACAAGGGAGCCACCTTCTAC
TTCACGCTGGAAAGTTGA

Upstream 100 bases:

>100_bases
TAAAGTGTTATAATTCGCACTTGTCTTTCAGGGGGATACCCCCTATAACACTTGCTGGCGCGGTACTGCAAGAAAACCGG
CGCGCACGGGAGGCAAAGAC

Downstream 100 bases:

>100_bases
ATCGCTTCGCCTACCCGCCACCGAGTTCGCCAGGATGAACAGCGCCGCTACCGCGGATACTTCCCTGACCTTCCCCCAAT
TGAGCAGCAGGAGCAACGGG

Product: PAS/PAC domain-containing sensor histidine kinase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MKRGDGAAMPMDADKLAAMVESSGDAIVGMNLDGTISSWNPAATRLYGYSAKEAVGCDISVLESLERPGEIAAELQEVQK
EKRSRHYDRYRRRKDGSQVFVSLTLSPILDRQNTLIGLSSIGRDAEELVQKRTKELMQAIRALQVEISERSRAEEALTQS
EEMLRFAALAADIGIWHYDLLTGDLVWSDRCKELFGYPHDFQMTYEAFLDAVAEEDRQRVDQAVQRALQDKSEYAVELRV
ILQDGQVRWVMSKGHAFYDSQGKPLRMAGIALDITQTKKTEAALLRAKEEWESTFNSVPDLIAILDEKCRIVRVNEAMAQ
RVHISADGCVGLFCYQVLHGENAPPHFCPHGQSLMDNMQHIVEVYDPHLSGTFLVSTTPLVAADGKSIGTVHVARDITER
KRAEEEIARLNADLGAHLAELEERNQELDAFNRMISHDLRQPLNIMSLAGQHIEMLCSSDTPECRQSVQTLEQSVLRMNT
MIETLLSFSRSTHGNLMREDFDISEMVQVILAEFYLAEPPRRITTVIAEETKVNADPRLLRTALENLLGNAWKYTGGREE
GYIEFGVRGGGAKPVYFIKDNGMGFDMADADKLFVPFQRLAGADAFKGSGIGLATVEKIIKRHGGRIWAEGEPDKGATFY
FTLES

Sequences:

>Translated_645_residues
MKRGDGAAMPMDADKLAAMVESSGDAIVGMNLDGTISSWNPAATRLYGYSAKEAVGCDISVLESLERPGEIAAELQEVQK
EKRSRHYDRYRRRKDGSQVFVSLTLSPILDRQNTLIGLSSIGRDAEELVQKRTKELMQAIRALQVEISERSRAEEALTQS
EEMLRFAALAADIGIWHYDLLTGDLVWSDRCKELFGYPHDFQMTYEAFLDAVAEEDRQRVDQAVQRALQDKSEYAVELRV
ILQDGQVRWVMSKGHAFYDSQGKPLRMAGIALDITQTKKTEAALLRAKEEWESTFNSVPDLIAILDEKCRIVRVNEAMAQ
RVHISADGCVGLFCYQVLHGENAPPHFCPHGQSLMDNMQHIVEVYDPHLSGTFLVSTTPLVAADGKSIGTVHVARDITER
KRAEEEIARLNADLGAHLAELEERNQELDAFNRMISHDLRQPLNIMSLAGQHIEMLCSSDTPECRQSVQTLEQSVLRMNT
MIETLLSFSRSTHGNLMREDFDISEMVQVILAEFYLAEPPRRITTVIAEETKVNADPRLLRTALENLLGNAWKYTGGREE
GYIEFGVRGGGAKPVYFIKDNGMGFDMADADKLFVPFQRLAGADAFKGSGIGLATVEKIIKRHGGRIWAEGEPDKGATFY
FTLES
>Mature_645_residues
MKRGDGAAMPMDADKLAAMVESSGDAIVGMNLDGTISSWNPAATRLYGYSAKEAVGCDISVLESLERPGEIAAELQEVQK
EKRSRHYDRYRRRKDGSQVFVSLTLSPILDRQNTLIGLSSIGRDAEELVQKRTKELMQAIRALQVEISERSRAEEALTQS
EEMLRFAALAADIGIWHYDLLTGDLVWSDRCKELFGYPHDFQMTYEAFLDAVAEEDRQRVDQAVQRALQDKSEYAVELRV
ILQDGQVRWVMSKGHAFYDSQGKPLRMAGIALDITQTKKTEAALLRAKEEWESTFNSVPDLIAILDEKCRIVRVNEAMAQ
RVHISADGCVGLFCYQVLHGENAPPHFCPHGQSLMDNMQHIVEVYDPHLSGTFLVSTTPLVAADGKSIGTVHVARDITER
KRAEEEIARLNADLGAHLAELEERNQELDAFNRMISHDLRQPLNIMSLAGQHIEMLCSSDTPECRQSVQTLEQSVLRMNT
MIETLLSFSRSTHGNLMREDFDISEMVQVILAEFYLAEPPRRITTVIAEETKVNADPRLLRTALENLLGNAWKYTGGREE
GYIEFGVRGGGAKPVYFIKDNGMGFDMADADKLFVPFQRLAGADAFKGSGIGLATVEKIIKRHGGRIWAEGEPDKGATFY
FTLES

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=421, Percent_Identity=25.41567695962, Blast_Score=122, Evalue=9e-29,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=33.0396475770925, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=474, Percent_Identity=24.4725738396624, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789149, Length=270, Percent_Identity=28.5185185185185, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=26.3736263736264, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=27.1186440677966, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=28.3842794759825, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=248, Percent_Identity=28.2258064516129, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=28.5106382978723, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=27.5193798449612, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=27.0642201834862, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 72157; Mature: 72157

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGDGAAMPMDADKLAAMVESSGDAIVGMNLDGTISSWNPAATRLYGYSAKEAVGCDIS
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHEECCCCCHHCCCCHH
VLESLERPGEIAAELQEVQKEKRSRHYDRYRRRKDGSQVFVSLTLSPILDRQNTLIGLSS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCEEEHHH
IGRDAEELVQKRTKELMQAIRALQVEISERSRAEEALTQSEEMLRFAALAADIGIWHYDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGDLVWSDRCKELFGYPHDFQMTYEAFLDAVAEEDRQRVDQAVQRALQDKSEYAVELRV
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEE
ILQDGQVRWVMSKGHAFYDSQGKPLRMAGIALDITQTKKTEAALLRAKEEWESTFNSVPD
EEECCCEEEEEECCCEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LIAILDEKCRIVRVNEAMAQRVHISADGCVGLFCYQVLHGENAPPHFCPHGQSLMDNMQH
HHHHHHCCCEEEEECHHHHHHEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
IVEVYDPHLSGTFLVSTTPLVAADGKSIGTVHVARDITERKRAEEEIARLNADLGAHLAE
HHHHHCCCCCCEEEEECCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEERNQELDAFNRMISHDLRQPLNIMSLAGQHIEMLCSSDTPECRQSVQTLEQSVLRMNT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MIETLLSFSRSTHGNLMREDFDISEMVQVILAEFYLAEPPRRITTVIAEETKVNADPRLL
HHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHH
RTALENLLGNAWKYTGGREEGYIEFGVRGGGAKPVYFIKDNGMGFDMADADKLFVPFQRL
HHHHHHHHCCCEECCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
AGADAFKGSGIGLATVEKIIKRHGGRIWAEGEPDKGATFYFTLES
CCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECC
>Mature Secondary Structure
MKRGDGAAMPMDADKLAAMVESSGDAIVGMNLDGTISSWNPAATRLYGYSAKEAVGCDIS
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHEECCCCCHHCCCCHH
VLESLERPGEIAAELQEVQKEKRSRHYDRYRRRKDGSQVFVSLTLSPILDRQNTLIGLSS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCEEEHHH
IGRDAEELVQKRTKELMQAIRALQVEISERSRAEEALTQSEEMLRFAALAADIGIWHYDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGDLVWSDRCKELFGYPHDFQMTYEAFLDAVAEEDRQRVDQAVQRALQDKSEYAVELRV
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEE
ILQDGQVRWVMSKGHAFYDSQGKPLRMAGIALDITQTKKTEAALLRAKEEWESTFNSVPD
EEECCCEEEEEECCCEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LIAILDEKCRIVRVNEAMAQRVHISADGCVGLFCYQVLHGENAPPHFCPHGQSLMDNMQH
HHHHHHCCCEEEEECHHHHHHEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
IVEVYDPHLSGTFLVSTTPLVAADGKSIGTVHVARDITERKRAEEEIARLNADLGAHLAE
HHHHHCCCCCCEEEEECCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEERNQELDAFNRMISHDLRQPLNIMSLAGQHIEMLCSSDTPECRQSVQTLEQSVLRMNT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MIETLLSFSRSTHGNLMREDFDISEMVQVILAEFYLAEPPRRITTVIAEETKVNADPRLL
HHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHH
RTALENLLGNAWKYTGGREEGYIEFGVRGGGAKPVYFIKDNGMGFDMADADKLFVPFQRL
HHHHHHHHCCCEECCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
AGADAFKGSGIGLATVEKIIKRHGGRIWAEGEPDKGATFYFTLES
CCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]