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The map label for this gene is fadE [H]

Identifier: 197118510

GI number: 197118510

Start: 2474568

End: 2476346

Strand: Direct

Name: fadE [H]

Synonym: Gbem_2128

Alternate gene names: 197118510

Gene position: 2474568-2476346 (Clockwise)

Preceding gene: 197118509

Following gene: 197118511

Centisome position: 53.62

GC content: 62.56

Gene sequence:

>1779_bases
ATGACTGCGAGGGTATTCAAAGGCGGGGAGTTTCTGATCGCTGAAACCGGAAAGGACGAGCTGTTCACCCCGGAGGATTT
CACCGACGAGCAGAAGCAGATAGGGCAGACCACCGAGCAGTTCGTGGCGAACGAGGTGCTTCCGGTGCGGGAAGAGATCG
AGCACCAGCAGTTCGAGCATGTGGTGCACCTGATGAAGAGATGCGGCGAACTCGGGCTTTTGATGATCGACGTCCCCGAG
GAGTACGGTGGGCTGGAACTGGACAAGGCGACCAGCATGCTCGCGGCGGAGAACATCTCCGGTTCGGGCTCCTTTTCCGT
CGCCTACTCGGCCCACACCGGCATCGGTACGCTCCCGCTGGTCTACTACGGCACCGAGGAGCAAAAAAAGAAGTACCTCG
AAAAACTGGTTACCGGCGAATGGATCGCGGCCTACTGCCTTACCGAGCCCGATTCCGGTAGCGACGCCCTGGGAGCCAAG
GCGACGGCGACCCTCTCCGCCGACGGCAGCCACTACCTTTTGAACGGCACCAAGCAGTTCACCACCAACGGCTCCATCGC
GAGCCTCTACACCATTTTCGCCAAGGTGGACAAGGAGCATTTCACCGCCTTCCTGGTCGAGCGCGGCTTCGAAGGGGTGA
GCGTCGGGCCCGAGGAGAAGAAGATGGGGATCAAGGGCTCCTCCACGACCCAGGTGATCCTCGACAACGCCAAGGTGCCG
GTGCAAAACGTCCTGGGCGAGATCGGCAAGGGGCACAAGATCGCTTTCAACGTGCTCAACGTAGGGCGCTTCAAGCTCGG
GGCCGCGGTCACCGGGGCAGCCAAGGGAGCGCTTGCCGACGGCATCAAGTACGCGAACCTGAGAAAGCAGTTCGGGCGCA
CCATAGGCTCCTTCGGCGCCATCAAGGAGAAGATCGCCGACATGACGTCCGCGGTCTTCGCTGCCGAATCGATGGTCTAC
CGACTGGCCGGGCTCATAGACCAGCGTCTTGCCACCATCCCCCGCGACACCCCCAACTACTACGACGTCTACCAGCGCGC
CATCGAGGAGTACGCCATGGAGTGCGCCGTCGCCAAGGTCTTCTGCAGCGAGGTGCTCGCTTTCGTGGCGGACGAAGTGG
TGCAGATCCACGGCGGCTACGGCTTCGTGCAGGAGTACCCCGCCGAGCGCTACTACCGCGACGAGCGCATCAACCGGATC
TTCGAAGGGACCAACGAGATCAACCGTCTGCTCGTCCCGGGGACGCTTTTGGCCCGCGCCATGAAGGGCGAGATCCCGCT
GCAGCAGGAAGCGCTCAAGGCCTTCGAGTCGCTGATGACCCCCTCCTTCGAGGAGTTGGACGACAGCGTCCCATTCGCCG
CCGAGAAGGCGCTCTTGGCCGGGCTGAAACAGGCGTTTCTGGTCCTGGCGGGAAGCGCGGCGCAAAAGTTCCAGGCCGCC
GTCAAGGAAGAGCAGGAGGTGCTGTTAGCCGTGGCGGACGTGGTGATCAACATCTTCGCCATCGAAAGTGCCGTGCTGCG
GGGCGAGAAGATGCTCCCGTCGCTTAGCCCCGCCCGCAGGGACGCGGTGCAGGCGGCTGTTAAGACCTTCACCTTCAACG
CCGGCGAGAACTGCGCCGCTGCGGCCCGCAAGGCTGCCTATTACATCGAAGAAGGCGACGCGCTGGCCCTGATGCTGAGC
GGCATCCGGCGCTTCACCAAATACGACGCCACAGGTCTGCTGCAGCAAAAGCGCAAGCTTGCCGATGCCGCGCTGGAAGC
TGAGCGGTACCTTTTCTAG

Upstream 100 bases:

>100_bases
TCCCCTCGCCCTCTGGGGGGGGCGGGGGTGAGGGAAGGGGTGTGCGGGGGTGAGGGTTTCCCGCTCCGACTGAAATGACA
TTACAAGACAGAGGTGCTTT

Downstream 100 bases:

>100_bases
GCGTTATTTCCCTGCTGCCGCAATCTCTCCTTCATAGTCCCCCGTGCGACAATACCCTCGTTCCCAAGGCTCACCTTGGG
AACGAGATCGAGTTCCGCCT

Product: very-long-chain acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MTARVFKGGEFLIAETGKDELFTPEDFTDEQKQIGQTTEQFVANEVLPVREEIEHQQFEHVVHLMKRCGELGLLMIDVPE
EYGGLELDKATSMLAAENISGSGSFSVAYSAHTGIGTLPLVYYGTEEQKKKYLEKLVTGEWIAAYCLTEPDSGSDALGAK
ATATLSADGSHYLLNGTKQFTTNGSIASLYTIFAKVDKEHFTAFLVERGFEGVSVGPEEKKMGIKGSSTTQVILDNAKVP
VQNVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKGALADGIKYANLRKQFGRTIGSFGAIKEKIADMTSAVFAAESMVY
RLAGLIDQRLATIPRDTPNYYDVYQRAIEEYAMECAVAKVFCSEVLAFVADEVVQIHGGYGFVQEYPAERYYRDERINRI
FEGTNEINRLLVPGTLLARAMKGEIPLQQEALKAFESLMTPSFEELDDSVPFAAEKALLAGLKQAFLVLAGSAAQKFQAA
VKEEQEVLLAVADVVINIFAIESAVLRGEKMLPSLSPARRDAVQAAVKTFTFNAGENCAAAARKAAYYIEEGDALALMLS
GIRRFTKYDATGLLQQKRKLADAALEAERYLF

Sequences:

>Translated_592_residues
MTARVFKGGEFLIAETGKDELFTPEDFTDEQKQIGQTTEQFVANEVLPVREEIEHQQFEHVVHLMKRCGELGLLMIDVPE
EYGGLELDKATSMLAAENISGSGSFSVAYSAHTGIGTLPLVYYGTEEQKKKYLEKLVTGEWIAAYCLTEPDSGSDALGAK
ATATLSADGSHYLLNGTKQFTTNGSIASLYTIFAKVDKEHFTAFLVERGFEGVSVGPEEKKMGIKGSSTTQVILDNAKVP
VQNVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKGALADGIKYANLRKQFGRTIGSFGAIKEKIADMTSAVFAAESMVY
RLAGLIDQRLATIPRDTPNYYDVYQRAIEEYAMECAVAKVFCSEVLAFVADEVVQIHGGYGFVQEYPAERYYRDERINRI
FEGTNEINRLLVPGTLLARAMKGEIPLQQEALKAFESLMTPSFEELDDSVPFAAEKALLAGLKQAFLVLAGSAAQKFQAA
VKEEQEVLLAVADVVINIFAIESAVLRGEKMLPSLSPARRDAVQAAVKTFTFNAGENCAAAARKAAYYIEEGDALALMLS
GIRRFTKYDATGLLQQKRKLADAALEAERYLF
>Mature_591_residues
TARVFKGGEFLIAETGKDELFTPEDFTDEQKQIGQTTEQFVANEVLPVREEIEHQQFEHVVHLMKRCGELGLLMIDVPEE
YGGLELDKATSMLAAENISGSGSFSVAYSAHTGIGTLPLVYYGTEEQKKKYLEKLVTGEWIAAYCLTEPDSGSDALGAKA
TATLSADGSHYLLNGTKQFTTNGSIASLYTIFAKVDKEHFTAFLVERGFEGVSVGPEEKKMGIKGSSTTQVILDNAKVPV
QNVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKGALADGIKYANLRKQFGRTIGSFGAIKEKIADMTSAVFAAESMVYR
LAGLIDQRLATIPRDTPNYYDVYQRAIEEYAMECAVAKVFCSEVLAFVADEVVQIHGGYGFVQEYPAERYYRDERINRIF
EGTNEINRLLVPGTLLARAMKGEIPLQQEALKAFESLMTPSFEELDDSVPFAAEKALLAGLKQAFLVLAGSAAQKFQAAV
KEEQEVLLAVADVVINIFAIESAVLRGEKMLPSLSPARRDAVQAAVKTFTFNAGENCAAAARKAAYYIEEGDALALMLSG
IRRFTKYDATGLLQQKRKLADAALEAERYLF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=612, Percent_Identity=35.2941176470588, Blast_Score=319, Evalue=5e-87,
Organism=Homo sapiens, GI4557235, Length=407, Percent_Identity=39.8034398034398, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI76496475, Length=407, Percent_Identity=39.8034398034398, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI4557233, Length=402, Percent_Identity=34.5771144278607, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=32.994923857868, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI226958414, Length=377, Percent_Identity=33.42175066313, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI187960098, Length=395, Percent_Identity=34.1772151898734, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4557231, Length=395, Percent_Identity=34.1772151898734, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI7656849, Length=420, Percent_Identity=29.5238095238095, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4501859, Length=406, Percent_Identity=30.7881773399015, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4501857, Length=392, Percent_Identity=28.5714285714286, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI4503943, Length=413, Percent_Identity=28.3292978208232, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI7669494, Length=318, Percent_Identity=30.188679245283, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI38505218, Length=306, Percent_Identity=23.8562091503268, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87081958, Length=350, Percent_Identity=31.4285714285714, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786223, Length=360, Percent_Identity=26.9444444444444, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI87081702, Length=360, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=405, Percent_Identity=39.5061728395062, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71985192, Length=353, Percent_Identity=37.9603399433428, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17506239, Length=390, Percent_Identity=35.8974358974359, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=34.1902313624679, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=400, Percent_Identity=31.5, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17570075, Length=429, Percent_Identity=31.2354312354312, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=400, Percent_Identity=31, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=30.25, Blast_Score=188, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17533517, Length=389, Percent_Identity=29.5629820051414, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71990804, Length=307, Percent_Identity=32.5732899022801, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=40.2542372881356, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=292, Percent_Identity=31.1643835616438, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=417, Percent_Identity=24.9400479616307, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=25.3405994550409, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=29.0983606557377, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17505929, Length=385, Percent_Identity=24.1558441558442, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=379, Percent_Identity=27.4406332453826, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=281, Percent_Identity=25.2669039145907, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363737, Length=354, Percent_Identity=40.9604519774011, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI21356377, Length=398, Percent_Identity=35.929648241206, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24646207, Length=424, Percent_Identity=33.7264150943396, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24660351, Length=395, Percent_Identity=33.6708860759494, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24666513, Length=388, Percent_Identity=33.5051546391753, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI21355753, Length=393, Percent_Identity=32.3155216284987, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19920834, Length=409, Percent_Identity=25.1833740831296, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652780, Length=333, Percent_Identity=24.9249249249249, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 64602; Mature: 64471

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARVFKGGEFLIAETGKDELFTPEDFTDEQKQIGQTTEQFVANEVLPVREEIEHQQFEH
CCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VVHLMKRCGELGLLMIDVPEEYGGLELDKATSMLAAENISGSGSFSVAYSAHTGIGTLPL
HHHHHHHCCCCCEEEEECCHHHCCEEHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCE
VYYGTEEQKKKYLEKLVTGEWIAAYCLTEPDSGSDALGAKATATLSADGSHYLLNGTKQF
EEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECCCEEE
TTNGSIASLYTIFAKVDKEHFTAFLVERGFEGVSVGPEEKKMGIKGSSTTQVILDNAKVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCC
VQNVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKGALADGIKYANLRKQFGRTIGSFGA
HHHHHHHHCCCCEEEEEEECCCCHHHCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
IKEKIADMTSAVFAAESMVYRLAGLIDQRLATIPRDTPNYYDVYQRAIEEYAMECAVAKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FCSEVLAFVADEVVQIHGGYGFVQEYPAERYYRDERINRIFEGTNEINRLLVPGTLLARA
HHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCHHHHHHEECCHHHHHHH
MKGEIPLQQEALKAFESLMTPSFEELDDSVPFAAEKALLAGLKQAFLVLAGSAAQKFQAA
HCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VKEEQEVLLAVADVVINIFAIESAVLRGEKMLPSLSPARRDAVQAAVKTFTFNAGENCAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
AARKAAYYIEEGDALALMLSGIRRFTKYDATGLLQQKRKLADAALEAERYLF
HHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TARVFKGGEFLIAETGKDELFTPEDFTDEQKQIGQTTEQFVANEVLPVREEIEHQQFEH
CCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VVHLMKRCGELGLLMIDVPEEYGGLELDKATSMLAAENISGSGSFSVAYSAHTGIGTLPL
HHHHHHHCCCCCEEEEECCHHHCCEEHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCE
VYYGTEEQKKKYLEKLVTGEWIAAYCLTEPDSGSDALGAKATATLSADGSHYLLNGTKQF
EEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECCCEEE
TTNGSIASLYTIFAKVDKEHFTAFLVERGFEGVSVGPEEKKMGIKGSSTTQVILDNAKVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCC
VQNVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKGALADGIKYANLRKQFGRTIGSFGA
HHHHHHHHCCCCEEEEEEECCCCHHHCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
IKEKIADMTSAVFAAESMVYRLAGLIDQRLATIPRDTPNYYDVYQRAIEEYAMECAVAKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FCSEVLAFVADEVVQIHGGYGFVQEYPAERYYRDERINRIFEGTNEINRLLVPGTLLARA
HHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCHHHHHHEECCHHHHHHH
MKGEIPLQQEALKAFESLMTPSFEELDDSVPFAAEKALLAGLKQAFLVLAGSAAQKFQAA
HCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VKEEQEVLLAVADVVINIFAIESAVLRGEKMLPSLSPARRDAVQAAVKTFTFNAGENCAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
AARKAAYYIEEGDALALMLSGIRRFTKYDATGLLQQKRKLADAALEAERYLF
HHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]