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The map label for this gene is mip [H]

Identifier: 197118446

GI number: 197118446

Start: 2378792

End: 2379472

Strand: Direct

Name: mip [H]

Synonym: Gbem_2064

Alternate gene names: 197118446

Gene position: 2378792-2379472 (Clockwise)

Preceding gene: 197118445

Following gene: 197118447

Centisome position: 51.54

GC content: 61.82

Gene sequence:

>681_bases
ATGCGATGCTTCCTCATTTTAGTTGCGGTATTGCTCGCGTCGGCTACGGCCCACGCGGCCGAAGCTCTCTCCACCCCGAA
GGAGCGGACCAGCTACGCCATAGGCGTGAACCTCATCGGCAACCTGAAGCAGCAGGAGGTCGATGTCGACCTGGAACTGG
TGGTGAAGGGGATGCGCGACGCCCTTGCCGGCGGAAAGCTCCTCATGTCCGACGAGGAACTGCGTAAGTACATAAGCTTC
TACCAGCACGACGTGCGCCGGAAAACGGCGAAGAGCAGGGGGGAAGCGGCACAGGAAAACAAGAAGGCAGGAGTGGAGTT
CCTTTCCGCCAACAAGAAGGAAAAGGGGGTCGTCGCCCTCCCGAGCGGCCTGCAGTACCGGGTGCTCAAGGAAGGGACCG
GCAAGCGCCCAGCCGACGCCGACAGCGTGACTTTCCATTACCGCACCGCTTCGATCACCGGCACCGAGTACGAAAGCTCC
TATCGCATAGGGGAGCCAGCCAGGCGCCGGGTAGGGGACGGGGTGCTACCGGGGTTGTCGGAGGCGCTCAAGCTGATGCC
GGCCGGGTCCAAGTGGCAGCTCTTCCTGCCGCCGCAGTTAGCCTACGGCAACAAGGGAAACGGCAAGGTCGGCCCCAACG
AAACCATCGTCTTTGAAATAGAGCTTCTCGCGGTCAACTGA

Upstream 100 bases:

>100_bases
CCGTCGTCACCGGGCTCAGGAACCCCAACGGCATCACCACCGACGGCGTCACGCTCTACGTCGCCGATGCGCACGACAAC
ACCGTGATCAGGGTGCACTG

Downstream 100 bases:

>100_bases
TAGCGGGAAGCGACCATCTGAAATTACCCGCAGGAGGATGCAATGAAAAAAATGATGTCAGCCATAGCGGCCCTGGCCGT
GACCATGTCGCTTGCGGCGG

Product: FKBP-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MRCFLILVAVLLASATAHAAEALSTPKERTSYAIGVNLIGNLKQQEVDVDLELVVKGMRDALAGGKLLMSDEELRKYISF
YQHDVRRKTAKSRGEAAQENKKAGVEFLSANKKEKGVVALPSGLQYRVLKEGTGKRPADADSVTFHYRTASITGTEYESS
YRIGEPARRRVGDGVLPGLSEALKLMPAGSKWQLFLPPQLAYGNKGNGKVGPNETIVFEIELLAVN

Sequences:

>Translated_226_residues
MRCFLILVAVLLASATAHAAEALSTPKERTSYAIGVNLIGNLKQQEVDVDLELVVKGMRDALAGGKLLMSDEELRKYISF
YQHDVRRKTAKSRGEAAQENKKAGVEFLSANKKEKGVVALPSGLQYRVLKEGTGKRPADADSVTFHYRTASITGTEYESS
YRIGEPARRRVGDGVLPGLSEALKLMPAGSKWQLFLPPQLAYGNKGNGKVGPNETIVFEIELLAVN
>Mature_226_residues
MRCFLILVAVLLASATAHAAEALSTPKERTSYAIGVNLIGNLKQQEVDVDLELVVKGMRDALAGGKLLMSDEELRKYISF
YQHDVRRKTAKSRGEAAQENKKAGVEFLSANKKEKGVVALPSGLQYRVLKEGTGKRPADADSVTFHYRTASITGTEYESS
YRIGEPARRRVGDGVLPGLSEALKLMPAGSKWQLFLPPQLAYGNKGNGKVGPNETIVFEIELLAVN

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=205, Percent_Identity=37.5609756097561, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=35.5450236966825, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24621; Mature: 24621

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCFLILVAVLLASATAHAAEALSTPKERTSYAIGVNLIGNLKQQEVDVDLELVVKGMRD
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEHHHCCCCHHHCCCHHHHHHHHHHH
ALAGGKLLMSDEELRKYISFYQHDVRRKTAKSRGEAAQENKKAGVEFLSANKKEKGVVAL
HHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEC
PSGLQYRVLKEGTGKRPADADSVTFHYRTASITGTEYESSYRIGEPARRRVGDGVLPGLS
CCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCHH
EALKLMPAGSKWQLFLPPQLAYGNKGNGKVGPNETIVFEIELLAVN
HHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure
MRCFLILVAVLLASATAHAAEALSTPKERTSYAIGVNLIGNLKQQEVDVDLELVVKGMRD
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEHHHCCCCHHHCCCHHHHHHHHHHH
ALAGGKLLMSDEELRKYISFYQHDVRRKTAKSRGEAAQENKKAGVEFLSANKKEKGVVAL
HHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEC
PSGLQYRVLKEGTGKRPADADSVTFHYRTASITGTEYESSYRIGEPARRRVGDGVLPGLS
CCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCHH
EALKLMPAGSKWQLFLPPQLAYGNKGNGKVGPNETIVFEIELLAVN
HHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA