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The map label for this gene is bioA [H]

Identifier: 197118433

GI number: 197118433

Start: 2364679

End: 2366040

Strand: Reverse

Name: bioA [H]

Synonym: Gbem_2051

Alternate gene names: 197118433

Gene position: 2366040-2364679 (Counterclockwise)

Preceding gene: 197118434

Following gene: 197118432

Centisome position: 51.27

GC content: 62.7

Gene sequence:

>1362_bases
GTGGTTGAACTGGATACGGAAACGCTGAGACGCTACGACAGCGAATACCTCTGGCACCCCTTTACCCAGATGAGCGAGTG
GGAAGGCGCCGAGAACATCATCATCACCAGGGGCGAAGGCTCGTACATCATAGATACGGACGGCAACCGCTACCTTGACG
GGGTGGGCGCGATCTGGACCAACGTGCACGGACACTGCCGCGCCGAGATTAACGAGGCGGTGAAACAGCAGGTGGACCGG
CTGGAGCACTCGACGCTCCTCGGGCTCTCTAACGACCGCGCTGCACACCTGGCCAAACGCCTGATCGATATCGCCCCGCC
GGGACTGGCCAAGGTCTTCTACTCTGACAACGGCTCGACCGCGGTCGAGATCGGCGTCAAGATGGCGTTCCAGTACCAGC
AGCAGACCGGGAACAAGCAAAAAACCAAGTTCATCCGCTTCGACAACGCCTACCACGGCGACACGGTGGGCTCGATGAGC
GTGGGCGGCATCGCCATCTACCACGAGGTTTACGCGCCGCTTCTCTTCCCTACCATCATGGCACCCTCCCCTTACTGCTA
CCGCTGCACTCTTTCCCCGGAAGGCGACTGCAACAGTTGCGGCCTGCTCTGCCTGAAGGAACTGGAGCGGCTCATGGAAC
AGCACGCCCACGAACTGGCGGGGCTCGTCATCGAGCCGTCGGTGCAGGGCGCGGGCGGGATGATCGTGCAGCCCCCCGGT
TTCGTCAAGGGGGTGAGGGAGCTCTGCGACCGCTTCGACGTGCTGATGATCGCGGACGAAGTGGCGGTCGGTTTCGGCAG
GACCGGCGCCATGTTCGCCTGCGGCAAGGAAGGGGTCACCCCCGACATCATGGCCCTTTCCAAGGGGATCTCCGCCGGCT
ACCTCCCCCTTGCCGCGACGCTCACCACGAAGAAGATCTACGACGCCTTCTGGGGTGACTACGCGGAACTGAAGACCTTC
TTCCACGGGCACACCTTCACCGGCAACCCCATCGCCTGCGCCGCGGCTCTGGCGAGCCTCGATCTTTTCGAAAAGGAGCG
CCTGCTCGAGTCGCTCCCCCCCAAGATCGCCTACCTGAACCAGCGGCTGCATGGGCTTCTCGAACTCCCGCACGTTGGAG
ACGTGAGGCAGGAGGGGATGATCGGCGGCATCGAGCTCGTGGTCGACAAGGATACGAGAAAGCCCTATCACTGGGAGGAG
CGTGTCGGCGTCAGGGTATGCCTGGAGGCGAGAAAGCGCGGCCTGTTCCTGCGGCCGCTGGGAAACATCATCGTTATCTT
CCCGCCTCTTTCCATCTCCATGGACGAGCTTGCCCTCCTGATGGACGGCATCGAGGCGTCCATCACCGCAGTCACCGGCT
GA

Upstream 100 bases:

>100_bases
GCGGGAGCTGTTCGATTAACAGCAATTGACAATTGACGATTGATAATTGACAACGAAAAACCCTGAACACAGCAGGGACT
GACGTTGAGGAGATTTGAAC

Downstream 100 bases:

>100_bases
TAGCAGCTTCATCCGGGCAGTGCCTCTACGGGTCAGAAAGCTCTAGCTTCCTGGCCCGTATTGCATTAGAATGACTGACT
TTGCGGCGAGAAGCTCCCCT

Product: lysine--8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MVELDTETLRRYDSEYLWHPFTQMSEWEGAENIIITRGEGSYIIDTDGNRYLDGVGAIWTNVHGHCRAEINEAVKQQVDR
LEHSTLLGLSNDRAAHLAKRLIDIAPPGLAKVFYSDNGSTAVEIGVKMAFQYQQQTGNKQKTKFIRFDNAYHGDTVGSMS
VGGIAIYHEVYAPLLFPTIMAPSPYCYRCTLSPEGDCNSCGLLCLKELERLMEQHAHELAGLVIEPSVQGAGGMIVQPPG
FVKGVRELCDRFDVLMIADEVAVGFGRTGAMFACGKEGVTPDIMALSKGISAGYLPLAATLTTKKIYDAFWGDYAELKTF
FHGHTFTGNPIACAAALASLDLFEKERLLESLPPKIAYLNQRLHGLLELPHVGDVRQEGMIGGIELVVDKDTRKPYHWEE
RVGVRVCLEARKRGLFLRPLGNIIVIFPPLSISMDELALLMDGIEASITAVTG

Sequences:

>Translated_453_residues
MVELDTETLRRYDSEYLWHPFTQMSEWEGAENIIITRGEGSYIIDTDGNRYLDGVGAIWTNVHGHCRAEINEAVKQQVDR
LEHSTLLGLSNDRAAHLAKRLIDIAPPGLAKVFYSDNGSTAVEIGVKMAFQYQQQTGNKQKTKFIRFDNAYHGDTVGSMS
VGGIAIYHEVYAPLLFPTIMAPSPYCYRCTLSPEGDCNSCGLLCLKELERLMEQHAHELAGLVIEPSVQGAGGMIVQPPG
FVKGVRELCDRFDVLMIADEVAVGFGRTGAMFACGKEGVTPDIMALSKGISAGYLPLAATLTTKKIYDAFWGDYAELKTF
FHGHTFTGNPIACAAALASLDLFEKERLLESLPPKIAYLNQRLHGLLELPHVGDVRQEGMIGGIELVVDKDTRKPYHWEE
RVGVRVCLEARKRGLFLRPLGNIIVIFPPLSISMDELALLMDGIEASITAVTG
>Mature_453_residues
MVELDTETLRRYDSEYLWHPFTQMSEWEGAENIIITRGEGSYIIDTDGNRYLDGVGAIWTNVHGHCRAEINEAVKQQVDR
LEHSTLLGLSNDRAAHLAKRLIDIAPPGLAKVFYSDNGSTAVEIGVKMAFQYQQQTGNKQKTKFIRFDNAYHGDTVGSMS
VGGIAIYHEVYAPLLFPTIMAPSPYCYRCTLSPEGDCNSCGLLCLKELERLMEQHAHELAGLVIEPSVQGAGGMIVQPPG
FVKGVRELCDRFDVLMIADEVAVGFGRTGAMFACGKEGVTPDIMALSKGISAGYLPLAATLTTKKIYDAFWGDYAELKTF
FHGHTFTGNPIACAAALASLDLFEKERLLESLPPKIAYLNQRLHGLLELPHVGDVRQEGMIGGIELVVDKDTRKPYHWEE
RVGVRVCLEARKRGLFLRPLGNIIVIFPPLSISMDELALLMDGIEASITAVTG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=426, Percent_Identity=30.5164319248826, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI13994255, Length=386, Percent_Identity=30.3108808290155, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI37574042, Length=433, Percent_Identity=27.7136258660508, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226442705, Length=432, Percent_Identity=27.7777777777778, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI24119277, Length=434, Percent_Identity=27.8801843317972, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI284507298, Length=340, Percent_Identity=31.7647058823529, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=27.7078085642317, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI188536080, Length=447, Percent_Identity=22.1476510067114, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38679950, Length=447, Percent_Identity=22.1476510067114, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38679946, Length=447, Percent_Identity=22.1476510067114, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786991, Length=438, Percent_Identity=35.1598173515982, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI145693181, Length=437, Percent_Identity=30.4347826086957, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1788044, Length=422, Percent_Identity=29.8578199052133, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789759, Length=355, Percent_Identity=32.6760563380282, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789016, Length=424, Percent_Identity=32.311320754717, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787560, Length=413, Percent_Identity=30.7506053268765, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=28.9855072463768, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=442, Percent_Identity=28.5067873303167, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144271, Length=428, Percent_Identity=27.1028037383178, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=442, Percent_Identity=26.2443438914027, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=246, Percent_Identity=31.7073170731707, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=312, Percent_Identity=26.6025641025641, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=461, Percent_Identity=29.2841648590022, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6324432, Length=440, Percent_Identity=26.8181818181818, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323470, Length=446, Percent_Identity=26.2331838565022, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=30.9576837416481, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=30.3571428571429, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21357415, Length=428, Percent_Identity=28.5046728971963, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=29.5454545454545, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281366494, Length=284, Percent_Identity=27.112676056338, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667139, Length=284, Percent_Identity=27.112676056338, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667143, Length=284, Percent_Identity=27.112676056338, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49925; Mature: 49925

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELDTETLRRYDSEYLWHPFTQMSEWEGAENIIITRGEGSYIIDTDGNRYLDGVGAIWT
CCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEECCCCCEEEECCCCEEECCHHHHHH
NVHGHCRAEINEAVKQQVDRLEHSTLLGLSNDRAAHLAKRLIDIAPPGLAKVFYSDNGST
CCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCE
AVEIGVKMAFQYQQQTGNKQKTKFIRFDNAYHGDTVGSMSVGGIAIYHEVYAPLLFPTIM
EEEEHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
APSPYCYRCTLSPEGDCNSCGLLCLKELERLMEQHAHELAGLVIEPSVQGAGGMIVQPPG
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCEEECCCH
FVKGVRELCDRFDVLMIADEVAVGFGRTGAMFACGKEGVTPDIMALSKGISAGYLPLAAT
HHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHH
LTTKKIYDAFWGDYAELKTFFHGHTFTGNPIACAAALASLDLFEKERLLESLPPKIAYLN
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
QRLHGLLELPHVGDVRQEGMIGGIELVVDKDTRKPYHWEERVGVRVCLEARKRGLFLRPL
HHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEC
GNIIVIFPPLSISMDELALLMDGIEASITAVTG
CCEEEEECCCCCCHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MVELDTETLRRYDSEYLWHPFTQMSEWEGAENIIITRGEGSYIIDTDGNRYLDGVGAIWT
CCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEECCCCCEEEECCCCEEECCHHHHHH
NVHGHCRAEINEAVKQQVDRLEHSTLLGLSNDRAAHLAKRLIDIAPPGLAKVFYSDNGST
CCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCE
AVEIGVKMAFQYQQQTGNKQKTKFIRFDNAYHGDTVGSMSVGGIAIYHEVYAPLLFPTIM
EEEEHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
APSPYCYRCTLSPEGDCNSCGLLCLKELERLMEQHAHELAGLVIEPSVQGAGGMIVQPPG
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCEEECCCH
FVKGVRELCDRFDVLMIADEVAVGFGRTGAMFACGKEGVTPDIMALSKGISAGYLPLAAT
HHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHH
LTTKKIYDAFWGDYAELKTFFHGHTFTGNPIACAAALASLDLFEKERLLESLPPKIAYLN
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
QRLHGLLELPHVGDVRQEGMIGGIELVVDKDTRKPYHWEERVGVRVCLEARKRGLFLRPL
HHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEC
GNIIVIFPPLSISMDELALLMDGIEASITAVTG
CCEEEEECCCCCCHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]