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The map label for this gene is trpF

Identifier: 197118343

GI number: 197118343

Start: 2263749

End: 2264369

Strand: Direct

Name: trpF

Synonym: Gbem_1960

Alternate gene names: 197118343

Gene position: 2263749-2264369 (Clockwise)

Preceding gene: 197118342

Following gene: 197118344

Centisome position: 49.05

GC content: 64.09

Gene sequence:

>621_bases
ATGACAAAGGTGAAGATCTGTGGCATAACAACGCTTGAGGATGCTCTCATGGCAGTCGAGGCCGGGGCCGACGCCCTTGG
GTTCGTCTTCTTCGAGAAGTCGCCGCGCTATATCGGGCCTGAAGCGGCCGCCCGGATCATCCGGGAGCTTCCCCCCTTCG
TCCAGGTGGTGGGGCTCTTCGTCAACGCCGAACTCGATTTCGTCAACCGTACCGCAGACACCTGCGGCCTCGATCTGGTC
CAGCTGCACGGCGAGGAGAGCCCGGCATACTGCGGGCTTGTGCGCCGGAGGGTGATGAAGGCGTTCCGGGTGCGCGGCGC
CGAGAGCCTTGCCGCACTTGCCGACTACAAGGTTTCGGCCTATCTGCTCGACGCCTACTCCCCGGCTTCACACGGCGGGA
CCGGCGAGCGCTTCGACTGGGATCACGCCGTAGCCGCCAAAGGGCAGGGTAGGATAGTCCTGGCAGGGGGGCTCGATCCC
GACAACGTCGCCCAGGCGGTGGCAAAGGTCGCCCCCTATGCGGTCGACGTCTCCAGCGGCGTGGAGCTTTCCCCCGGCCG
CAAGGACCCCGAGAAAGTCAGGCGTCTCATTGCCGAAGCCAAGAAGATCGCCTTAATTTAA

Upstream 100 bases:

>100_bases
TGCTGGAAAGGATGTTTCTTCCGGCCGAAATGAAGGCTCCGCTCGGGCGATATTCCCCGGTGGTAGGTGGGAAATTGTAC
AATTTTAAGGGTATACGCCG

Downstream 100 bases:

>100_bases
GTCGAATCCTCTCCCGACCCTTTCCACAAGGCAGGGGGAGTTTGTACCTGATAACGTAGAACCTTGAAGCATGAGCGGTT
TTAACCCAAACCAAAGGAGT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTKVKICGITTLEDALMAVEAGADALGFVFFEKSPRYIGPEAAARIIRELPPFVQVVGLFVNAELDFVNRTADTCGLDLV
QLHGEESPAYCGLVRRRVMKAFRVRGAESLAALADYKVSAYLLDAYSPASHGGTGERFDWDHAVAAKGQGRIVLAGGLDP
DNVAQAVAKVAPYAVDVSSGVELSPGRKDPEKVRRLIAEAKKIALI

Sequences:

>Translated_206_residues
MTKVKICGITTLEDALMAVEAGADALGFVFFEKSPRYIGPEAAARIIRELPPFVQVVGLFVNAELDFVNRTADTCGLDLV
QLHGEESPAYCGLVRRRVMKAFRVRGAESLAALADYKVSAYLLDAYSPASHGGTGERFDWDHAVAAKGQGRIVLAGGLDP
DNVAQAVAKVAPYAVDVSSGVELSPGRKDPEKVRRLIAEAKKIALI
>Mature_205_residues
TKVKICGITTLEDALMAVEAGADALGFVFFEKSPRYIGPEAAARIIRELPPFVQVVGLFVNAELDFVNRTADTCGLDLVQ
LHGEESPAYCGLVRRRVMKAFRVRGAESLAALADYKVSAYLLDAYSPASHGGTGERFDWDHAVAAKGQGRIVLAGGLDPD
NVAQAVAKVAPYAVDVSSGVELSPGRKDPEKVRRLIAEAKKIALI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=191, Percent_Identity=36.1256544502618, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320210, Length=220, Percent_Identity=31.8181818181818, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_GEOBB (B5EBV0)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002138770.1
- ProteinModelPortal:   B5EBV0
- SMR:   B5EBV0
- GeneID:   6781950
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_1960
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22043; Mature: 21911

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVKICGITTLEDALMAVEAGADALGFVFFEKSPRYIGPEAAARIIRELPPFVQVVGLF
CCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHH
VNAELDFVNRTADTCGLDLVQLHGEESPAYCGLVRRRVMKAFRVRGAESLAALADYKVSA
HCCCHHHHHCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEE
YLLDAYSPASHGGTGERFDWDHAVAAKGQGRIVLAGGLDPDNVAQAVAKVAPYAVDVSSG
EEEECCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCC
VELSPGRKDPEKVRRLIAEAKKIALI
CEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKVKICGITTLEDALMAVEAGADALGFVFFEKSPRYIGPEAAARIIRELPPFVQVVGLF
CEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHH
VNAELDFVNRTADTCGLDLVQLHGEESPAYCGLVRRRVMKAFRVRGAESLAALADYKVSA
HCCCHHHHHCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEE
YLLDAYSPASHGGTGERFDWDHAVAAKGQGRIVLAGGLDPDNVAQAVAKVAPYAVDVSSG
EEEECCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCC
VELSPGRKDPEKVRRLIAEAKKIALI
CEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA