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The map label for this gene is serA [H]

Identifier: 197118344

GI number: 197118344

Start: 2264474

End: 2266072

Strand: Direct

Name: serA [H]

Synonym: Gbem_1961

Alternate gene names: 197118344

Gene position: 2264474-2266072 (Clockwise)

Preceding gene: 197118343

Following gene: 197118349

Centisome position: 49.07

GC content: 60.66

Gene sequence:

>1599_bases
ATGAAGATTATCGTAACCGATGAAGTGGCTCAGGAAGGACTGGCACTTTTGCAGCGCGACCCGCGCGTGCAGATGGACAT
CAAGCTGGGACTGAAGAAGGAAGAGCTTTACTCGATCATTGGTGATTACGACGTTATCATCACCAGAAGCGGCACCACCG
TGGACAAGCCCCTGCTTGACGCAGCGACCAACCTGAAAATGGTGGCGCGCGCCGGCGTCGGCGTCGACAACGTGGATGTC
GACTATGCCTCCGCCAAGGGCGTCATCGTCGTCAATGCACCTTTCGGCAACACCAACAGCGCGGCGGAACACGCCATGGC
GCTGCTGCTTTCCTTCTGCCGCAATATCACCAAGGCTAACTCGTCCCTCAAAGGTGGCGCCTGGAAGCGTGCCCCCTTCA
CCGGCTACGAACTTAAAGGGCGCACCGCCGGCGTCATCGGTCTGGGCAAGGTAGGGGGAAGGGTGGCTACCCGCCTCAAG
GCCTTCGAGTGCGAAGTGCTCGCCTGCGACCCGTACATCGCAGAGAAAAGGGCGCACGACCTCGGCGTCAAGCTGGTTTC
GCTGGATGAAATCGTCCGCGTCTGCGACATCATCACCGTCCACACCCCGCTCACCGCGGAGACCAGCAACATGATCGGCA
AGAAAGAGCTCGCCGCCATGAAGGAAGGGGTCATCGTCATCAACGCGGCGCGCGGCGGCATCATCAACGAGGAGGCGATG
CTGGAGGCGCTCGATTCCGGCAAGGTAACCGGCGCAGCCTTCGACGTCTGGAGCCAGGAGCCCCCCGACACCGATACCCT
GAAAAAGCTGATCGGGCACGAGAAGATGGTGGTCACGCCGCACCTGGGCGCCAACACCTTCGAAGCGCAGGTGAACGTGG
CGGTGGACGTCTCCCGTGAGATCATCCACTACCTGGACGAGCAGCCGCTGGAGAACGCCATCAACATCCCGAGGTTCGAC
GCAGCCCTCATGGGGCAGATGCGTCCTTACCTGAACCTGATGAACGTCCTGTCCGATTTCGTCATCCAGTTGGTGGACAC
CAACCTGAACAAGATCACCTTCACCTATACCGGCAACCTCGCCCAGTACGACTGCACGCCGATCACCGTCCTTGGTCTCG
CGTCGCTTCTGAACCGCAGGGTCGAGCAGGACGTGAACATGGTCAACGCGCAGCTTGTCGCGGACAACATGGGGATCGTC
GTGGAAGAGGTGAAGTCCAACCAGGCCGAGGCCTTCTCCAACATGATCACCATCGCCATCGAGGGCCCCGGCGAAAAGAG
GCTCATCAGCGGTACCTTGTTCGAAGGGATTCCGCGCATCGTCAAGCTGCGCGACTACCAGATGGACTTCCGCCCCGAAG
AGCACATGCTGCTCATGGCTTACGGCGACCGTCCGGGCATCATCGGCAAGATCGGCACCATCCTGGGCACCCATGAGATC
AACATCGCCTCGATGAACCTGGGGCGTCGCGAGAAGAAAGGGGAGGCGATGGTCATCCTCTCCCTCGATTCCGCCGTGAC
CCCGGAAGTCGTGGAAGAGGTGCGAGGCGCCACCGATGCGACCTTCGTCAAACCGCTCTACCTGGTGACCGCGAAGTAG

Upstream 100 bases:

>100_bases
AATCCTCTCCCGACCCTTTCCACAAGGCAGGGGGAGTTTGTACCTGATAACGTAGAACCTTGAAGCATGAGCGGTTTTAA
CCCAAACCAAAGGAGTGGCA

Downstream 100 bases:

>100_bases
GAAGGAAACCACAGGCAAAAGGAAAAGGCCCCGGCGAAAGCTCGGGGCCTTTTTTTTAACCTGAAAGCGTAAGGCGGAAC
ACAGAGGGCACAGGGGAAAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MKIIVTDEVAQEGLALLQRDPRVQMDIKLGLKKEELYSIIGDYDVIITRSGTTVDKPLLDAATNLKMVARAGVGVDNVDV
DYASAKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKANSSLKGGAWKRAPFTGYELKGRTAGVIGLGKVGGRVATRLK
AFECEVLACDPYIAEKRAHDLGVKLVSLDEIVRVCDIITVHTPLTAETSNMIGKKELAAMKEGVIVINAARGGIINEEAM
LEALDSGKVTGAAFDVWSQEPPDTDTLKKLIGHEKMVVTPHLGANTFEAQVNVAVDVSREIIHYLDEQPLENAINIPRFD
AALMGQMRPYLNLMNVLSDFVIQLVDTNLNKITFTYTGNLAQYDCTPITVLGLASLLNRRVEQDVNMVNAQLVADNMGIV
VEEVKSNQAEAFSNMITIAIEGPGEKRLISGTLFEGIPRIVKLRDYQMDFRPEEHMLLMAYGDRPGIIGKIGTILGTHEI
NIASMNLGRREKKGEAMVILSLDSAVTPEVVEEVRGATDATFVKPLYLVTAK

Sequences:

>Translated_532_residues
MKIIVTDEVAQEGLALLQRDPRVQMDIKLGLKKEELYSIIGDYDVIITRSGTTVDKPLLDAATNLKMVARAGVGVDNVDV
DYASAKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKANSSLKGGAWKRAPFTGYELKGRTAGVIGLGKVGGRVATRLK
AFECEVLACDPYIAEKRAHDLGVKLVSLDEIVRVCDIITVHTPLTAETSNMIGKKELAAMKEGVIVINAARGGIINEEAM
LEALDSGKVTGAAFDVWSQEPPDTDTLKKLIGHEKMVVTPHLGANTFEAQVNVAVDVSREIIHYLDEQPLENAINIPRFD
AALMGQMRPYLNLMNVLSDFVIQLVDTNLNKITFTYTGNLAQYDCTPITVLGLASLLNRRVEQDVNMVNAQLVADNMGIV
VEEVKSNQAEAFSNMITIAIEGPGEKRLISGTLFEGIPRIVKLRDYQMDFRPEEHMLLMAYGDRPGIIGKIGTILGTHEI
NIASMNLGRREKKGEAMVILSLDSAVTPEVVEEVRGATDATFVKPLYLVTAK
>Mature_532_residues
MKIIVTDEVAQEGLALLQRDPRVQMDIKLGLKKEELYSIIGDYDVIITRSGTTVDKPLLDAATNLKMVARAGVGVDNVDV
DYASAKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKANSSLKGGAWKRAPFTGYELKGRTAGVIGLGKVGGRVATRLK
AFECEVLACDPYIAEKRAHDLGVKLVSLDEIVRVCDIITVHTPLTAETSNMIGKKELAAMKEGVIVINAARGGIINEEAM
LEALDSGKVTGAAFDVWSQEPPDTDTLKKLIGHEKMVVTPHLGANTFEAQVNVAVDVSREIIHYLDEQPLENAINIPRFD
AALMGQMRPYLNLMNVLSDFVIQLVDTNLNKITFTYTGNLAQYDCTPITVLGLASLLNRRVEQDVNMVNAQLVADNMGIV
VEEVKSNQAEAFSNMITIAIEGPGEKRLISGTLFEGIPRIVKLRDYQMDFRPEEHMLLMAYGDRPGIIGKIGTILGTHEI
NIASMNLGRREKKGEAMVILSLDSAVTPEVVEEVRGATDATFVKPLYLVTAK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=463, Percent_Identity=34.341252699784, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=30.8641975308642, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI61743967, Length=281, Percent_Identity=29.1814946619217, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI4557497, Length=281, Percent_Identity=29.1814946619217, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=28.7272727272727, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=28.7272727272727, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=29.277566539924, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789279, Length=367, Percent_Identity=31.0626702997275, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87082289, Length=270, Percent_Identity=28.5185185185185, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787645, Length=241, Percent_Identity=31.1203319502075, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788660, Length=257, Percent_Identity=32.6848249027237, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081824, Length=240, Percent_Identity=27.5, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=43.0921052631579, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=29.3877551020408, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=328, Percent_Identity=31.0975609756098, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=30.4878048780488, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=31.7829457364341, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=322, Percent_Identity=27.3291925465839, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=27.7486910994764, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=148, Percent_Identity=31.7567567567568, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=45.0331125827815, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=32.6923076923077, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646446, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646448, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646452, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646450, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=24.6875, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=24.6875, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=24.6875, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=24.6875, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=24.6875, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472511, Length=267, Percent_Identity=28.4644194756554, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=26.2658227848101, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=23.0496453900709, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57862; Mature: 57862

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVTDEVAQEGLALLQRDPRVQMDIKLGLKKEELYSIIGDYDVIITRSGTTVDKPLLD
CEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCEEEEEECCCCCCCHHHHH
AATNLKMVARAGVGVDNVDVDYASAKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKAN
HHCCHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
SSLKGGAWKRAPFTGYELKGRTAGVIGLGKVGGRVATRLKAFECEVLACDPYIAEKRAHD
CCCCCCCCCCCCCCCEEECCCEECEEEECCCCHHHHHHHHHEEEEEEEECCHHHHHHHHH
LGVKLVSLDEIVRVCDIITVHTPLTAETSNMIGKKELAAMKEGVIVINAARGGIINEEAM
HCEEEECHHHHHHHHHHEEECCCCCCCHHHHCCHHHHHHHHCCEEEEEECCCCCCCHHHH
LEALDSGKVTGAAFDVWSQEPPDTDTLKKLIGHEKMVVTPHLGANTFEAQVNVAVDVSRE
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEEEHHHH
IIHYLDEQPLENAINIPRFDAALMGQMRPYLNLMNVLSDFVIQLVDTNLNKITFTYTGNL
HHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCE
AQYDCTPITVLGLASLLNRRVEQDVNMVNAQLVADNMGIVVEEVKSNQAEAFSNMITIAI
EEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEHHHCCHHHHHCCEEEEEE
EGPGEKRLISGTLFEGIPRIVKLRDYQMDFRPEEHMLLMAYGDRPGIIGKIGTILGTHEI
ECCCCCEEEECHHHHCCHHHEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHEECCEE
NIASMNLGRREKKGEAMVILSLDSAVTPEVVEEVRGATDATFVKPLYLVTAK
EEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCEECEEEEEECC
>Mature Secondary Structure
MKIIVTDEVAQEGLALLQRDPRVQMDIKLGLKKEELYSIIGDYDVIITRSGTTVDKPLLD
CEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCEEEEEECCCCCCCHHHHH
AATNLKMVARAGVGVDNVDVDYASAKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKAN
HHCCHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
SSLKGGAWKRAPFTGYELKGRTAGVIGLGKVGGRVATRLKAFECEVLACDPYIAEKRAHD
CCCCCCCCCCCCCCCEEECCCEECEEEECCCCHHHHHHHHHEEEEEEEECCHHHHHHHHH
LGVKLVSLDEIVRVCDIITVHTPLTAETSNMIGKKELAAMKEGVIVINAARGGIINEEAM
HCEEEECHHHHHHHHHHEEECCCCCCCHHHHCCHHHHHHHHCCEEEEEECCCCCCCHHHH
LEALDSGKVTGAAFDVWSQEPPDTDTLKKLIGHEKMVVTPHLGANTFEAQVNVAVDVSRE
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEEEHHHH
IIHYLDEQPLENAINIPRFDAALMGQMRPYLNLMNVLSDFVIQLVDTNLNKITFTYTGNL
HHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCE
AQYDCTPITVLGLASLLNRRVEQDVNMVNAQLVADNMGIVVEEVKSNQAEAFSNMITIAI
EEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEHHHCCHHHHHCCEEEEEE
EGPGEKRLISGTLFEGIPRIVKLRDYQMDFRPEEHMLLMAYGDRPGIIGKIGTILGTHEI
ECCCCCEEEECHHHHCCHHHEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHEECCEE
NIASMNLGRREKKGEAMVILSLDSAVTPEVVEEVRGATDATFVKPLYLVTAK
EEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCEECEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]