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The map label for this gene is htpX-2 [H]

Identifier: 197118318

GI number: 197118318

Start: 2237108

End: 2237962

Strand: Direct

Name: htpX-2 [H]

Synonym: Gbem_1935

Alternate gene names: 197118318

Gene position: 2237108-2237962 (Clockwise)

Preceding gene: 197118317

Following gene: 197118319

Centisome position: 48.47

GC content: 64.21

Gene sequence:

>855_bases
ATGCAAAGACTCAAGACAACCTTCCTACTGGCTCTACTCACCGTTCTCATGGTCACCATGGGAAGCGCGCTGGGCGGCAG
AACCGGCATGGTGACCGCCTTCGTCCTGGCGCTCGGCATGAACTTCTTCTCCTACTGGTTCTCCGACAAGATCGTCCTAA
AAATGTACGGCGCCCAGGAGATCGAGGAGCACGACAACCCCATGTTCTACAACATGGTGCGCCACCTGGCCGCCCGCGCC
GGGCTTCCTATGCCTAAGGTCTACATCATCCCCTCGGACAGCCCCAACGCCTTCGCCACCGGGCGAAACCCCGAGCATGC
CGCGGTCGCGGCAACTGAAGGGATCCTGCGCATCCTCTCTCCCGAAGAGCTAGAAGGGGTGATGGCGCACGAGTTGGCCC
ACGTGCAAAACCGCGACATCCTGGTCGGCACCATCGCGGCCACCTTCGCCGGCGCCATATCCATGATCGGCAACATGCTC
CAGTGGGGCGCCATGTTCGGGGCAGGGCGGGGCGACGACGAAGAGGGTGGCGGTATCGGCGGCCTGGTCGGGTCTCTCGC
CATGGCCATCATCGCGCCCATCGCCGCCATGCTGATTCAGATGGCCGTTTCCCGCTCGCGCGAGTACCTGGCAGATGCCT
CTGGCGCCCAGATCTGCGGCCGCCCCCTGGCGCTGGCCTCTGCACTCAGGAAACTACACCTGGCGTCGCAGGCGCTTCCG
ATGCAGGAGGCGCGGCCCGCCACCGCCCACATGTTCATCGTCAACCCGCTTACAGGCGGCGGCATCGCATCGCTTTTTTC
GACCCATCCCCCCATGGAGGAGCGGATCGCGCGGCTGGAGCAGATGGCGAGATAG

Upstream 100 bases:

>100_bases
TTATCCAGGCATTAACGTGTCGCGGGTAAAGGTTTTTTTATTTGCCCGGTGACAAAACGGTCCCAACAGCGGACTTACTA
CAATCGTCGAGGTAAATACT

Downstream 100 bases:

>100_bases
TAGTTTCGTTCAGGCGTTAAACCCTTCCCCCCTCCCGACCTCCCCCCGCTGGGGGGAGGGGCCAATCAAAGTTGAGGTGC
GGCAAGGTATCAGGTCAATC

Product: membrane-bound zinc-dependent protease HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MQRLKTTFLLALLTVLMVTMGSALGGRTGMVTAFVLALGMNFFSYWFSDKIVLKMYGAQEIEEHDNPMFYNMVRHLAARA
GLPMPKVYIIPSDSPNAFATGRNPEHAAVAATEGILRILSPEELEGVMAHELAHVQNRDILVGTIAATFAGAISMIGNML
QWGAMFGAGRGDDEEGGGIGGLVGSLAMAIIAPIAAMLIQMAVSRSREYLADASGAQICGRPLALASALRKLHLASQALP
MQEARPATAHMFIVNPLTGGGIASLFSTHPPMEERIARLEQMAR

Sequences:

>Translated_284_residues
MQRLKTTFLLALLTVLMVTMGSALGGRTGMVTAFVLALGMNFFSYWFSDKIVLKMYGAQEIEEHDNPMFYNMVRHLAARA
GLPMPKVYIIPSDSPNAFATGRNPEHAAVAATEGILRILSPEELEGVMAHELAHVQNRDILVGTIAATFAGAISMIGNML
QWGAMFGAGRGDDEEGGGIGGLVGSLAMAIIAPIAAMLIQMAVSRSREYLADASGAQICGRPLALASALRKLHLASQALP
MQEARPATAHMFIVNPLTGGGIASLFSTHPPMEERIARLEQMAR
>Mature_284_residues
MQRLKTTFLLALLTVLMVTMGSALGGRTGMVTAFVLALGMNFFSYWFSDKIVLKMYGAQEIEEHDNPMFYNMVRHLAARA
GLPMPKVYIIPSDSPNAFATGRNPEHAAVAATEGILRILSPEELEGVMAHELAHVQNRDILVGTIAATFAGAISMIGNML
QWGAMFGAGRGDDEEGGGIGGLVGSLAMAIIAPIAAMLIQMAVSRSREYLADASGAQICGRPLALASALRKLHLASQALP
MQEARPATAHMFIVNPLTGGGIASLFSTHPPMEERIARLEQMAR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=259, Percent_Identity=33.5907335907336, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 30336; Mature: 30336

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLKTTFLLALLTVLMVTMGSALGGRTGMVTAFVLALGMNFFSYWFSDKIVLKMYGAQE
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHH
IEEHDNPMFYNMVRHLAARAGLPMPKVYIIPSDSPNAFATGRNPEHAAVAATEGILRILS
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHCC
PEELEGVMAHELAHVQNRDILVGTIAATFAGAISMIGNMLQWGAMFGAGRGDDEEGGGIG
HHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
GLVGSLAMAIIAPIAAMLIQMAVSRSREYLADASGAQICGRPLALASALRKLHLASQALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHCCC
MQEARPATAHMFIVNPLTGGGIASLFSTHPPMEERIARLEQMAR
HHHCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQRLKTTFLLALLTVLMVTMGSALGGRTGMVTAFVLALGMNFFSYWFSDKIVLKMYGAQE
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHH
IEEHDNPMFYNMVRHLAARAGLPMPKVYIIPSDSPNAFATGRNPEHAAVAATEGILRILS
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHCC
PEELEGVMAHELAHVQNRDILVGTIAATFAGAISMIGNMLQWGAMFGAGRGDDEEGGGIG
HHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
GLVGSLAMAIIAPIAAMLIQMAVSRSREYLADASGAQICGRPLALASALRKLHLASQALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHCCC
MQEARPATAHMFIVNPLTGGGIASLFSTHPPMEERIARLEQMAR
HHHCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA