Click here to switch to the map view.

The map label for this gene is galE [C]

Identifier: 197118069

GI number: 197118069

Start: 1947289

End: 1948410

Strand: Direct

Name: galE [C]

Synonym: Gbem_1683

Alternate gene names: 197118069

Gene position: 1947289-1948410 (Clockwise)

Preceding gene: 197118058

Following gene: 197118070

Centisome position: 42.19

GC content: 66.04

Gene sequence:

>1122_bases
ATGGCAGGGAGCGTTCTAATCACGGGTGGAGCCGGATTCATTGGATCTCACCTGGCAGATGAGCTTCTTCGTCACGGTTA
CCGCGTCCGCGTTTTGGACAGCCTGGTGCTGCAGGTGCATGGACCGGACGGGAGGCGACCCGGCTATCTGGATCCGGAGG
TCGAGCTGATCAAGGGGGACGTGCGGGACGCGGCCGCCGTGCAGAGGGCGCTTGCCGGGACCGAGGCGGTCTTTCACCTG
GCCTCCATGGTGGGCGTCGGCCAGAGCATGTACGAGATCGAGCAGTACACCTCCGTCAACAACTGCGGGACTGCGGTGCT
CCTGGAGGCGATGGCCCACGCCAAGGGGCATCGCAAGCTGATCGTCGCCTCAAGCATGAGCATCTACGGCGAGGGGCGCT
ACCTGGACGCCGACGGGCTTTGCTACGACGACGTCCGGCGTCCCTTGGAGCAGTTGCAGCGGGGGCGCTGGGAGCCGTTC
AACCGCAGGAGCGAGCCGCTGCGCCCGGTGGCAACCCCTGAGGACAAGTCGCCGTCGCTCGCCTCGGTCTACGCCCTATC
CAAGTACGACCAGGAGCGGATGGCGCTCATCGTCGGGGAATGTTACCGCATCCCGGTGATCGCCCTGCGCTTTTTCAACG
TCTACGGCACCAGGCAGGCGCTCTCCAACCCCTACACCGGGGTGCTCGCCATCTTCGCCTCCAGGCTCATGAACGGCAAC
CCGCCGCGCATCTACGAGGACGGGCTGCAGCAGAGGGACTTCGTCAGCGTGCACGACGTGGTGACGGCCTGCCGGCTCGC
GCTCCAGGTGGACCAGCAGCAGGCGCAGTTCTTCAACATCGGCAGCGGCGCCAACGTCAGCGTCCTCGAGGTGCTGCAGC
GCTTCCGCCGGGTGCTCAACTGCGACGGGATCGAGCCGGAGATCACCGGCAACTACCGGGCCGGCGACATCAGGCACTGC
TTCGCGGACATAAGCTCCGCCCGCTCCGTCCTGGGATACGCCCCGAGGATCTCCTTCGACGATGGGCTTGCCGAACTGGC
CGGCTGGCTGGAAGGGGAGGTCGCCATAGACCGTGTCTCCGAGGCGCATGCCGAACTCACCCAGCGGGGGTTGACGCTAT
GA

Upstream 100 bases:

>100_bases
TCACACTGCTAGTATTGGCTTCTATTAATTTAAAACGATTAACTTGGTGCTAATTAGATAAATGGCCTGCAGCATATCCC
GTCAAGCCAAGGAGGGCCTT

Downstream 100 bases:

>100_bases
AAAGGGCGACCAGTGAAGCGGTACCGGAGCACTTCGGCATAGTGGAGTGGTTCCGGCCGGGCGAGCGGGAACGGGTGGAA
CGGGTCCTTTCCGACATGAA

Product: NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MAGSVLITGGAGFIGSHLADELLRHGYRVRVLDSLVLQVHGPDGRRPGYLDPEVELIKGDVRDAAAVQRALAGTEAVFHL
ASMVGVGQSMYEIEQYTSVNNCGTAVLLEAMAHAKGHRKLIVASSMSIYGEGRYLDADGLCYDDVRRPLEQLQRGRWEPF
NRRSEPLRPVATPEDKSPSLASVYALSKYDQERMALIVGECYRIPVIALRFFNVYGTRQALSNPYTGVLAIFASRLMNGN
PPRIYEDGLQQRDFVSVHDVVTACRLALQVDQQQAQFFNIGSGANVSVLEVLQRFRRVLNCDGIEPEITGNYRAGDIRHC
FADISSARSVLGYAPRISFDDGLAELAGWLEGEVAIDRVSEAHAELTQRGLTL

Sequences:

>Translated_373_residues
MAGSVLITGGAGFIGSHLADELLRHGYRVRVLDSLVLQVHGPDGRRPGYLDPEVELIKGDVRDAAAVQRALAGTEAVFHL
ASMVGVGQSMYEIEQYTSVNNCGTAVLLEAMAHAKGHRKLIVASSMSIYGEGRYLDADGLCYDDVRRPLEQLQRGRWEPF
NRRSEPLRPVATPEDKSPSLASVYALSKYDQERMALIVGECYRIPVIALRFFNVYGTRQALSNPYTGVLAIFASRLMNGN
PPRIYEDGLQQRDFVSVHDVVTACRLALQVDQQQAQFFNIGSGANVSVLEVLQRFRRVLNCDGIEPEITGNYRAGDIRHC
FADISSARSVLGYAPRISFDDGLAELAGWLEGEVAIDRVSEAHAELTQRGLTL
>Mature_372_residues
AGSVLITGGAGFIGSHLADELLRHGYRVRVLDSLVLQVHGPDGRRPGYLDPEVELIKGDVRDAAAVQRALAGTEAVFHLA
SMVGVGQSMYEIEQYTSVNNCGTAVLLEAMAHAKGHRKLIVASSMSIYGEGRYLDADGLCYDDVRRPLEQLQRGRWEPFN
RRSEPLRPVATPEDKSPSLASVYALSKYDQERMALIVGECYRIPVIALRFFNVYGTRQALSNPYTGVLAIFASRLMNGNP
PRIYEDGLQQRDFVSVHDVVTACRLALQVDQQQAQFFNIGSGANVSVLEVLQRFRRVLNCDGIEPEITGNYRAGDIRHCF
ADISSARSVLGYAPRISFDDGLAELAGWLEGEVAIDRVSEAHAELTQRGLTL

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=375, Percent_Identity=29.0666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI56118217, Length=375, Percent_Identity=29.0666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI189083684, Length=375, Percent_Identity=29.0666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7657641, Length=364, Percent_Identity=26.6483516483516, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI42516563, Length=354, Percent_Identity=25.9887005649718, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI239745448, Length=143, Percent_Identity=33.5664335664336, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI310132178, Length=143, Percent_Identity=32.8671328671329, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI310113012, Length=143, Percent_Identity=32.8671328671329, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786974, Length=366, Percent_Identity=26.775956284153, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982035, Length=371, Percent_Identity=26.1455525606469, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=373, Percent_Identity=25.7372654155496, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19923002, Length=374, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 41056; Mature: 40925

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSVLITGGAGFIGSHLADELLRHGYRVRVLDSLVLQVHGPDGRRPGYLDPEVELIKGD
CCCCEEEECCCHHHHHHHHHHHHHCCCEEEEHHHHHHEEECCCCCCCCCCCCCHHHHHCC
VRDAAAVQRALAGTEAVFHLASMVGVGQSMYEIEQYTSVNNCGTAVLLEAMAHAKGHRKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEE
IVASSMSIYGEGRYLDADGLCYDDVRRPLEQLQRGRWEPFNRRSEPLRPVATPEDKSPSL
EEEECCEEECCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
ASVYALSKYDQERMALIVGECYRIPVIALRFFNVYGTRQALSNPYTGVLAIFASRLMNGN
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
PPRIYEDGLQQRDFVSVHDVVTACRLALQVDQQQAQFFNIGSGANVSVLEVLQRFRRVLN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHC
CDGIEPEITGNYRAGDIRHCFADISSARSVLGYAPRISFDDGLAELAGWLEGEVAIDRVS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHH
EAHAELTQRGLTL
HHHHHHHHCCCCC
>Mature Secondary Structure 
AGSVLITGGAGFIGSHLADELLRHGYRVRVLDSLVLQVHGPDGRRPGYLDPEVELIKGD
CCCEEEECCCHHHHHHHHHHHHHCCCEEEEHHHHHHEEECCCCCCCCCCCCCHHHHHCC
VRDAAAVQRALAGTEAVFHLASMVGVGQSMYEIEQYTSVNNCGTAVLLEAMAHAKGHRKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEE
IVASSMSIYGEGRYLDADGLCYDDVRRPLEQLQRGRWEPFNRRSEPLRPVATPEDKSPSL
EEEECCEEECCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
ASVYALSKYDQERMALIVGECYRIPVIALRFFNVYGTRQALSNPYTGVLAIFASRLMNGN
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
PPRIYEDGLQQRDFVSVHDVVTACRLALQVDQQQAQFFNIGSGANVSVLEVLQRFRRVLN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHC
CDGIEPEITGNYRAGDIRHCFADISSARSVLGYAPRISFDDGLAELAGWLEGEVAIDRVS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHH
EAHAELTQRGLTL
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]