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The map label for this gene is gltA-1 [H]

Identifier: 197118039

GI number: 197118039

Start: 1919042

End: 1920367

Strand: Direct

Name: gltA-1 [H]

Synonym: Gbem_1652

Alternate gene names: 197118039

Gene position: 1919042-1920367 (Clockwise)

Preceding gene: 197118038

Following gene: 308535256

Centisome position: 41.58

GC content: 61.24

Gene sequence:

>1326_bases
ATGACGCAATTAAAAGAGAAATTGTTTGAGAAGATCCAAGCCCACCGTCCCCGTATCACCCGCCTGACCAAAGAGTTCGG
CTCGGTGATCATCGACAAGGTGGACATCGGTCAGTGCATCGGCGGCGCCCGCGACATCCGTTCGCTCGTTACCGACATCT
CCTACCTCGACCCGCAGGAAGGGATCCGTTTCCGCGGCAAGACCATCCCCGAGACCTTCGAAGCGCTGCCGAAAGCGGCC
GGCTCCGAGTACCCGACCGTCGAGTCTTTCTGGTACTTCCTTTTGACCGGCGAAGTTCCGACCGCGGCTCAGGTCTCTGC
TGTCGAGGCTGAGTTCAAGACCCGTCAGGTCGTACCCGAGTACGTTTACACTGCAGTCCGCGCGCTCCCGAAAGAGAGCC
ACCCGATGGTCATGCTCTCCGTCGGCATCATGGCTATGCAGAAGGACTCCAAGTTCGCCGCATTCTACAGCGGCGGCAAG
TTCAACAAGATGGACGCCTGGGAGTCCGTTTACGAGGACGCAAGCGACATCGTCGCCCGTATCCCGGTACTGGCCGCATT
CATCTACAACCTCAAATACCGCGGCGACAAGCAGATCGCCATCGATCCGAAGCTCGACATGGGCGCAAACTTCGCCCACA
TGATCGGCCAGAGCGAGCAGTACAAGGACGTGGCAAGGATGTACTTCATCCTGCACTCCGACCATGAGTCCGGCAACGTC
TCGGCTCACACCACCCACCTGGTGCACTCCGCTCTCTCCGACCCCTACTACGCATACTCCGCAGGCCTCAACGGCCTGGC
AGGCCCGCTGCACGGCCTTGCCAACCAGGAAGTGCTCGGCTGGATCATGGAGTTCCAGAAGAAGCTCAACGGCGCAGAGC
CGACCAAAGAGAACGTCACCAAGGCTCTGTGGGATACCCTCAACGCCGGCCAGGTCGTTCCGGGCTACGGCCACGCGGTT
CTCAGGAAAACCGACCCGCGCTACACCGCTCAGCGCGAGTTCTGCCTCAAGACCCCGGGCCTCAAGGACGATCAGCTGTT
CAAGCTGGTCGCCATGATCTTCGAGACCGCACCGGGCGTCCTCACCGAGCACGGCAAGACCAAGAACCCCTGGCCGAACG
TCGACGCGCAGTCCGGCGTCATCCAGTGGTACTACGGCCTCAAGGAGTGGGACTTCTACACCGTTCTCTTCGGCGTAGGG
CGCGCCCTGGGCTGCATGGCGAACATCACCTGGGACCGCGGCCTCGGCTACGCCATCGAGCGTCCGAAGTCCGTCACCAC
CGACATGCTCGAGAAGTGGGCTGCCGAGGGCGGCAGGAAGATGTAA

Upstream 100 bases:

>100_bases
GCCGAGGTCTATTTCGACGGGCACGCTGTCAGCGGGCGATTCGATCGTTTTAATTCATCCAGTGTGTACCTCAACCCCAA
CAGAAAAGGAGATCTGGCAC

Downstream 100 bases:

>100_bases
GCAAGAAGCTGCAGAAACAAGAAAGGGGGCGCTCATGGCGTCCCCTTTTTTTATGCCCTATTGGTAAATAACGGCGATGC
CCCTCTTTGCGGGAAAGGCG

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTQLKEKLFEKIQAHRPRITRLTKEFGSVIIDKVDIGQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFEALPKAA
GSEYPTVESFWYFLLTGEVPTAAQVSAVEAEFKTRQVVPEYVYTAVRALPKESHPMVMLSVGIMAMQKDSKFAAFYSGGK
FNKMDAWESVYEDASDIVARIPVLAAFIYNLKYRGDKQIAIDPKLDMGANFAHMIGQSEQYKDVARMYFILHSDHESGNV
SAHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLGWIMEFQKKLNGAEPTKENVTKALWDTLNAGQVVPGYGHAV
LRKTDPRYTAQREFCLKTPGLKDDQLFKLVAMIFETAPGVLTEHGKTKNPWPNVDAQSGVIQWYYGLKEWDFYTVLFGVG
RALGCMANITWDRGLGYAIERPKSVTTDMLEKWAAEGGRKM

Sequences:

>Translated_441_residues
MTQLKEKLFEKIQAHRPRITRLTKEFGSVIIDKVDIGQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFEALPKAA
GSEYPTVESFWYFLLTGEVPTAAQVSAVEAEFKTRQVVPEYVYTAVRALPKESHPMVMLSVGIMAMQKDSKFAAFYSGGK
FNKMDAWESVYEDASDIVARIPVLAAFIYNLKYRGDKQIAIDPKLDMGANFAHMIGQSEQYKDVARMYFILHSDHESGNV
SAHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLGWIMEFQKKLNGAEPTKENVTKALWDTLNAGQVVPGYGHAV
LRKTDPRYTAQREFCLKTPGLKDDQLFKLVAMIFETAPGVLTEHGKTKNPWPNVDAQSGVIQWYYGLKEWDFYTVLFGVG
RALGCMANITWDRGLGYAIERPKSVTTDMLEKWAAEGGRKM
>Mature_440_residues
TQLKEKLFEKIQAHRPRITRLTKEFGSVIIDKVDIGQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFEALPKAAG
SEYPTVESFWYFLLTGEVPTAAQVSAVEAEFKTRQVVPEYVYTAVRALPKESHPMVMLSVGIMAMQKDSKFAAFYSGGKF
NKMDAWESVYEDASDIVARIPVLAAFIYNLKYRGDKQIAIDPKLDMGANFAHMIGQSEQYKDVARMYFILHSDHESGNVS
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLGWIMEFQKKLNGAEPTKENVTKALWDTLNAGQVVPGYGHAVL
RKTDPRYTAQREFCLKTPGLKDDQLFKLVAMIFETAPGVLTEHGKTKNPWPNVDAQSGVIQWYYGLKEWDFYTVLFGVGR
ALGCMANITWDRGLGYAIERPKSVTTDMLEKWAAEGGRKM

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=434, Percent_Identity=49.0783410138249, Blast_Score=435, Evalue=1e-122,
Organism=Escherichia coli, GI1786939, Length=397, Percent_Identity=29.7229219143577, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786527, Length=344, Percent_Identity=24.4186046511628, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555174, Length=435, Percent_Identity=49.6551724137931, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6324328, Length=426, Percent_Identity=53.0516431924883, Blast_Score=460, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319850, Length=426, Percent_Identity=50.7042253521127, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6325257, Length=449, Percent_Identity=40.5345211581292, Blast_Score=340, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24640126, Length=431, Percent_Identity=51.7401392111369, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640124, Length=431, Percent_Identity=51.7401392111369, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21356863, Length=437, Percent_Identity=42.1052631578947, Blast_Score=347, Evalue=8e-96,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49332; Mature: 49201

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLKEKLFEKIQAHRPRITRLTKEFGSVIIDKVDIGQCIGGARDIRSLVTDISYLDPQE
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCHHH
GIRFRGKTIPETFEALPKAAGSEYPTVESFWYFLLTGEVPTAAQVSAVEAEFKTRQVVPE
CCEECCCCCHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
YVYTAVRALPKESHPMVMLSVGIMAMQKDSKFAAFYSGGKFNKMDAWESVYEDASDIVAR
HHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
IPVLAAFIYNLKYRGDKQIAIDPKLDMGANFAHMIGQSEQYKDVARMYFILHSDHESGNV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHEECCCCCCCC
SAHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLGWIMEFQKKLNGAEPTKENVT
CHHHHHHHHHHHCCCCEEHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHH
KALWDTLNAGQVVPGYGHAVLRKTDPRYTAQREFCLKTPGLKDDQLFKLVAMIFETAPGV
HHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
LTEHGKTKNPWPNVDAQSGVIQWYYGLKEWDFYTVLFGVGRALGCMANITWDRGLGYAIE
HHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
RPKSVTTDMLEKWAAEGGRKM
CCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TQLKEKLFEKIQAHRPRITRLTKEFGSVIIDKVDIGQCIGGARDIRSLVTDISYLDPQE
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCHHH
GIRFRGKTIPETFEALPKAAGSEYPTVESFWYFLLTGEVPTAAQVSAVEAEFKTRQVVPE
CCEECCCCCHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
YVYTAVRALPKESHPMVMLSVGIMAMQKDSKFAAFYSGGKFNKMDAWESVYEDASDIVAR
HHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
IPVLAAFIYNLKYRGDKQIAIDPKLDMGANFAHMIGQSEQYKDVARMYFILHSDHESGNV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHEECCCCCCCC
SAHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLGWIMEFQKKLNGAEPTKENVT
CHHHHHHHHHHHCCCCEEHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHH
KALWDTLNAGQVVPGYGHAVLRKTDPRYTAQREFCLKTPGLKDDQLFKLVAMIFETAPGV
HHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
LTEHGKTKNPWPNVDAQSGVIQWYYGLKEWDFYTVLFGVGRALGCMANITWDRGLGYAIE
HHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
RPKSVTTDMLEKWAAEGGRKM
CCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]