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The map label for this gene is wzc [H]

Identifier: 197117992

GI number: 197117992

Start: 1862811

End: 1863998

Strand: Direct

Name: wzc [H]

Synonym: Gbem_1605

Alternate gene names: 197117992

Gene position: 1862811-1863998 (Clockwise)

Preceding gene: 197117991

Following gene: 197117993

Centisome position: 40.36

GC content: 52.86

Gene sequence:

>1188_bases
ATGACAGAGAACCAGAATCAGGCTGACATTGATGTAGAGGAACAGATTAATCTGCTCGAACTTTTACAGATTATCGCGAA
ACGAAAGATGTTTATCATCAAGATGTGCACATTCGCGGTCGTCGCATCTGTTGCTTACAGCTTCACTCTCCCCAATATCT
ATTCCGCAACTGCCAAGGTGTTGCCGCCACAGAAAGAAACGGCCGGCGGGCTTTCTGCAATGTTGGGACAGGTCGGTGGC
ATAGCTGGTCTCGCACCGGGTGGCCTTGGTTCTGGTACCGAACTCTACCTTGGCCTTCTGAGAAGTAGATCTGTGGCGGA
CGAGGTTGTGCGGCGTCTTGACCTTACTGCATATTATAAAACCAAGGATGCCGAATTGGCTAGGAGAGGCCTAGAAGCGA
CCGTGCGTATGCAGACCGGCAAGGACGGTATCATTAACATCACGGCCGATGATAAGGATCCGAAGATGGCGGCTCGCGTC
GCAAACATGTATGTTGAGGAGCTTGGCAGGACTTCGGTGAGGCTTAACCTATCCAAGGCAGGCTCTGAAAGAGCATTTCT
CGAAAAACGGCTGGAATTGGTAAAGGGAGAACTGAAGAAGGCTGAAGATGAAATCAAAGCATTCTCCCAGCAAAACAGCA
TAGTACAGGTTGACTCGCAGGCCAAGGCAAGCATCGAAGGGATAGCACGGCTAAAGGCTGAACTGGCGACTAAGGAAGTT
CAGTTGGCAGCACTGCGCTCCAGGCAGACAGACGAGAGCCCAGAGGTGCGCTCACTCCTGGCGGGGATCAAGCGCCTGCA
GGCCGAGATGGATAGGATGTCAGGTCCCGGTCTAGGTGGCGAGGGTATTCCGGCGATAGGCAATGTTCCTAGGCTGGGGC
TCGAGTATGCCCGGAAGATGCGTGAGCTCAAGATACAGGAATCTGTCTTTGAGCAACTCACCAAGCAATATGAGATGGCC
AAGCTCAGCGAGGCGAAGGATTCTTCAGCGTTCCAGGTGCTCGACACGGCTGTAGCCCCCTCTGTAAAAAGTAAGCCAAG
ACGCTCCGCCATTGTCATCACCGCTACCATGGTGGCGGTGGCCGCCTCTCTGGTGCTGATATTCTTGCAAGAGCACCTGG
AAAAGATGAGTGAGGCGGATAGAAAGATCTTGGCCGATATCAAAGGGCGCCTCCTCTCTTTGAGGTAA

Upstream 100 bases:

>100_bases
TCCTTTAGTTGTGTCGCGTCCGGGAGCGGGCATCGCAGATTTACCACCTTACTAACTGGATTTCGCGCTTTCCGGCGCAG
GAGCAACTCGAAGGAAGCCC

Downstream 100 bases:

>100_bases
CAGATTTGACGTCAATGACCTGATATGTCGCTGTGCAGGCTATGGATCGTCTTGCTACGATAGGTGTTGCCTTATGAACT
CACATTCCCAAAATGCTGAC

Product: polysaccharide chain length determinant domain-containing protein

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTENQNQADIDVEEQINLLELLQIIAKRKMFIIKMCTFAVVASVAYSFTLPNIYSATAKVLPPQKETAGGLSAMLGQVGG
IAGLAPGGLGSGTELYLGLLRSRSVADEVVRRLDLTAYYKTKDAELARRGLEATVRMQTGKDGIINITADDKDPKMAARV
ANMYVEELGRTSVRLNLSKAGSERAFLEKRLELVKGELKKAEDEIKAFSQQNSIVQVDSQAKASIEGIARLKAELATKEV
QLAALRSRQTDESPEVRSLLAGIKRLQAEMDRMSGPGLGGEGIPAIGNVPRLGLEYARKMRELKIQESVFEQLTKQYEMA
KLSEAKDSSAFQVLDTAVAPSVKSKPRRSAIVITATMVAVAASLVLIFLQEHLEKMSEADRKILADIKGRLLSLR

Sequences:

>Translated_395_residues
MTENQNQADIDVEEQINLLELLQIIAKRKMFIIKMCTFAVVASVAYSFTLPNIYSATAKVLPPQKETAGGLSAMLGQVGG
IAGLAPGGLGSGTELYLGLLRSRSVADEVVRRLDLTAYYKTKDAELARRGLEATVRMQTGKDGIINITADDKDPKMAARV
ANMYVEELGRTSVRLNLSKAGSERAFLEKRLELVKGELKKAEDEIKAFSQQNSIVQVDSQAKASIEGIARLKAELATKEV
QLAALRSRQTDESPEVRSLLAGIKRLQAEMDRMSGPGLGGEGIPAIGNVPRLGLEYARKMRELKIQESVFEQLTKQYEMA
KLSEAKDSSAFQVLDTAVAPSVKSKPRRSAIVITATMVAVAASLVLIFLQEHLEKMSEADRKILADIKGRLLSLR
>Mature_394_residues
TENQNQADIDVEEQINLLELLQIIAKRKMFIIKMCTFAVVASVAYSFTLPNIYSATAKVLPPQKETAGGLSAMLGQVGGI
AGLAPGGLGSGTELYLGLLRSRSVADEVVRRLDLTAYYKTKDAELARRGLEATVRMQTGKDGIINITADDKDPKMAARVA
NMYVEELGRTSVRLNLSKAGSERAFLEKRLELVKGELKKAEDEIKAFSQQNSIVQVDSQAKASIEGIARLKAELATKEVQ
LAALRSRQTDESPEVRSLLAGIKRLQAEMDRMSGPGLGGEGIPAIGNVPRLGLEYARKMRELKIQESVFEQLTKQYEMAK
LSEAKDSSAFQVLDTAVAPSVKSKPRRSAIVITATMVAVAASLVLIFLQEHLEKMSEADRKILADIKGRLLSLR

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=237, Percent_Identity=23.2067510548523, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 43107; Mature: 42975

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENQNQADIDVEEQINLLELLQIIAKRKMFIIKMCTFAVVASVAYSFTLPNIYSATAKV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
LPPQKETAGGLSAMLGQVGGIAGLAPGGLGSGTELYLGLLRSRSVADEVVRRLDLTAYYK
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
TKDAELARRGLEATVRMQTGKDGIINITADDKDPKMAARVANMYVEELGRTSVRLNLSKA
CCHHHHHHCCCHHEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHC
GSERAFLEKRLELVKGELKKAEDEIKAFSQQNSIVQVDSQAKASIEGIARLKAELATKEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
QLAALRSRQTDESPEVRSLLAGIKRLQAEMDRMSGPGLGGEGIPAIGNVPRLGLEYARKM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RELKIQESVFEQLTKQYEMAKLSEAKDSSAFQVLDTAVAPSVKSKPRRSAIVITATMVAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHH
AASLVLIFLQEHLEKMSEADRKILADIKGRLLSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TENQNQADIDVEEQINLLELLQIIAKRKMFIIKMCTFAVVASVAYSFTLPNIYSATAKV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
LPPQKETAGGLSAMLGQVGGIAGLAPGGLGSGTELYLGLLRSRSVADEVVRRLDLTAYYK
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
TKDAELARRGLEATVRMQTGKDGIINITADDKDPKMAARVANMYVEELGRTSVRLNLSKA
CCHHHHHHCCCHHEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHC
GSERAFLEKRLELVKGELKKAEDEIKAFSQQNSIVQVDSQAKASIEGIARLKAELATKEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
QLAALRSRQTDESPEVRSLLAGIKRLQAEMDRMSGPGLGGEGIPAIGNVPRLGLEYARKM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RELKIQESVFEQLTKQYEMAKLSEAKDSSAFQVLDTAVAPSVKSKPRRSAIVITATMVAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHH
AASLVLIFLQEHLEKMSEADRKILADIKGRLLSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]