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The map label for this gene is pyrG [H]

Identifier: 197117987

GI number: 197117987

Start: 1854340

End: 1855941

Strand: Direct

Name: pyrG [H]

Synonym: Gbem_1600

Alternate gene names: 197117987

Gene position: 1854340-1855941 (Clockwise)

Preceding gene: 308535252

Following gene: 197117988

Centisome position: 40.18

GC content: 61.74

Gene sequence:

>1602_bases
GTGAAGACAAAATTCATCTTTGTTACCGGCGGCGTTGTCTCCTCGATCGGCAAGGGACTCGCCGCCGCTTCTTTGGGCGC
TCTTCTTGAGGCTAGGGGGCTTCGGGTCACCATCCAGAAGCTGGATCCGTACATAAACGTCGATCCCGGGACCATGTCCC
CCTTCCAGCACGGCGAGGTCTTCGTCACCGACGACGGCGCCGAGACCGACCTCGACCTCGGGCACTACGAGCGCTACACC
TCCGGCAAGCTCTCCAAAAAGAGCAACTTCACCACCGGCCAGGTCTACTTCTCGGTCATCGAGAAGGAGCGCCGCGGCGA
CTACCTGGGCGGGACCGTGCAGGTCATCCCGCACATCACCGACCAGATCAAGCTGAACATCCTGGAAAACGCCAAGGGCT
CCGACATCGCCATCGTCGAGATCGGCGGCACCGTGGGCGACATCGAGTCGCTCCCTTTCCTTGAGGCGATCCGCCAGTTA
AAGAGCGACCGCGGCCCCGGCAACGTCCTCTACCTGCACGTGACGCTGGTACCCTACATCAAGACGGCCGGCGAATTGAA
GACCAAGCCGACCCAGCACTCGGTGAAGGAGCTGCGCGAGATCGGCATCCAGCCCGATATCCTCCTTTGCCGCTGCGAGC
AGGACGTCCCGCAGGACATGAAGGCGAAGATCGCGCTTTTCTGCAACGTGGAAGAGAAGGCGGTCATCACCTCCCAGGAC
GCCGAGCACATCTACGCGGTGCCGATGGCGCTGAACCATCAGGGGCTCGACGACCAGGTGGTGGAAAAACTCAACATCTG
GACCAAGGCTCCGGACCTCTCCCACTGGCAGCAGGTGGTGTCCAAGCTCACCAATCCCGGCTCCGGCGAGGTGCGCATAG
CGGTGGTCGGCAAGTACGTCGACCTCAAGGAGTCCTACAAGTCGCTCTCCGAGGCGCTCACCCACGGCGGCATCGCCAAC
GACTGCCGCGTCAAGCTGGTCTACCTCGATTCCGAGAAGATAGAGGAGGACGGGGGCGAGAAGGCGCTGGCCGACGTCGA
TGGCATCCTGGTCCCGGGCGGTTTTGGCGAGCGCGGCACCGAAGGGAAGATCAAGGCGATCGAATACGCCCGCGTCAACA
AGGTCCCCTTCTTCGGGATCTGCCTCGGCATGCAGATGGCAGCCGTCGAGTACGCCCGCAACGTCTGCCGGCTTCCCGAA
GCGTTCTCCAGCGAATTCAAGCCGGACTGCGAGAGCCCGGTGATCCACCTGATGGAAGAGCAAAAGGGAGTGGAGAACAA
AGGGGGGACCATGAGGCTCGGCGCCTATCCCTGTTCCCTCACCAAGGGGACCTTCGCCCAGAAGGCCTACGGCGCCACCG
AGATCTCCGAACGCCACCGCCACCGTTACGAGTTCAACAACCTTTTCCGCAGTTGCCTTGAGGAGAAGGGGATGGTCATC
TCGGGGGTCTACAAAGAGGGGAACCTGGTGGAAATCATCGAACTTCCCGACCATCCGTGGTTCTTGGGGTGCCAGTTCCA
CCCCGAGTTCAAGTCCAAGCCGTTGAACCCGCACCCGCTCTTCAAGGCCTTCATCGGGGCCACCAAGGCGAAGAGAGGCT
AA

Upstream 100 bases:

>100_bases
CTTCAGGTTCACGTCACGCTGCCGCTGGAGTTTTCAGTAGTTTTCGTTGAACGTTGAACCTTGAACGTTGAACTGTTTCT
ACGTTTCGGAGGTTTTTTAA

Downstream 100 bases:

>100_bases
CCCAGGGTCACGCAAAGCCGCAACCTGAAGCGACCCGTGTCACGCAAAGCCGCAAAGACGCAAAGAAAGGCAAAAGCAAA
AACGTTTAACAGGGATAAAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTIQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYT
SGKLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDQIKLNILENAKGSDIAIVEIGGTVGDIESLPFLEAIRQL
KSDRGPGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILLCRCEQDVPQDMKAKIALFCNVEEKAVITSQD
AEHIYAVPMALNHQGLDDQVVEKLNIWTKAPDLSHWQQVVSKLTNPGSGEVRIAVVGKYVDLKESYKSLSEALTHGGIAN
DCRVKLVYLDSEKIEEDGGEKALADVDGILVPGGFGERGTEGKIKAIEYARVNKVPFFGICLGMQMAAVEYARNVCRLPE
AFSSEFKPDCESPVIHLMEEQKGVENKGGTMRLGAYPCSLTKGTFAQKAYGATEISERHRHRYEFNNLFRSCLEEKGMVI
SGVYKEGNLVEIIELPDHPWFLGCQFHPEFKSKPLNPHPLFKAFIGATKAKRG

Sequences:

>Translated_533_residues
MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTIQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYT
SGKLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDQIKLNILENAKGSDIAIVEIGGTVGDIESLPFLEAIRQL
KSDRGPGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILLCRCEQDVPQDMKAKIALFCNVEEKAVITSQD
AEHIYAVPMALNHQGLDDQVVEKLNIWTKAPDLSHWQQVVSKLTNPGSGEVRIAVVGKYVDLKESYKSLSEALTHGGIAN
DCRVKLVYLDSEKIEEDGGEKALADVDGILVPGGFGERGTEGKIKAIEYARVNKVPFFGICLGMQMAAVEYARNVCRLPE
AFSSEFKPDCESPVIHLMEEQKGVENKGGTMRLGAYPCSLTKGTFAQKAYGATEISERHRHRYEFNNLFRSCLEEKGMVI
SGVYKEGNLVEIIELPDHPWFLGCQFHPEFKSKPLNPHPLFKAFIGATKAKRG
>Mature_533_residues
MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTIQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYT
SGKLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDQIKLNILENAKGSDIAIVEIGGTVGDIESLPFLEAIRQL
KSDRGPGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILLCRCEQDVPQDMKAKIALFCNVEEKAVITSQD
AEHIYAVPMALNHQGLDDQVVEKLNIWTKAPDLSHWQQVVSKLTNPGSGEVRIAVVGKYVDLKESYKSLSEALTHGGIAN
DCRVKLVYLDSEKIEEDGGEKALADVDGILVPGGFGERGTEGKIKAIEYARVNKVPFFGICLGMQMAAVEYARNVCRLPE
AFSSEFKPDCESPVIHLMEEQKGVENKGGTMRLGAYPCSLTKGTFAQKAYGATEISERHRHRYEFNNLFRSCLEEKGMVI
SGVYKEGNLVEIIELPDHPWFLGCQFHPEFKSKPLNPHPLFKAFIGATKAKRG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=45.1905626134301, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI28559085, Length=549, Percent_Identity=44.4444444444444, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI28559083, Length=549, Percent_Identity=44.4444444444444, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI221316689, Length=549, Percent_Identity=44.4444444444444, Blast_Score=458, Evalue=1e-129,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=57.1694599627561, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI25148299, Length=608, Percent_Identity=37.5, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322563, Length=564, Percent_Identity=42.0212765957447, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319432, Length=565, Percent_Identity=41.5929203539823, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24664469, Length=549, Percent_Identity=44.2622950819672, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21357815, Length=494, Percent_Identity=42.5101214574899, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 58757; Mature: 58757

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTIQKLDPYINVDPGTMSPFQHGEV
CCEEEEEEECHHHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERYTSGKLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DQIKLNILENAKGSDIAIVEIGGTVGDIESLPFLEAIRQLKSDRGPGNVLYLHVTLVPYI
CEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEHHH
KTAGELKTKPTQHSVKELREIGIQPDILLCRCEQDVPQDMKAKIALFCNVEEKAVITSQD
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEECCC
AEHIYAVPMALNHQGLDDQVVEKLNIWTKAPDLSHWQQVVSKLTNPGSGEVRIAVVGKYV
CCEEEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCH
DLKESYKSLSEALTHGGIANDCRVKLVYLDSEKIEEDGGEKALADVDGILVPGGFGERGT
HHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCEEHHCCCCEEECCCCCCCCC
EGKIKAIEYARVNKVPFFGICLGMQMAAVEYARNVCRLPEAFSSEFKPDCESPVIHLMEE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHH
QKGVENKGGTMRLGAYPCSLTKGTFAQKAYGATEISERHRHRYEFNNLFRSCLEEKGMVI
HCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
SGVYKEGNLVEIIELPDHPWFLGCQFHPEFKSKPLNPHPLFKAFIGATKAKRG
EEEECCCCEEEEEECCCCCEEEEEEECCHHCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTIQKLDPYINVDPGTMSPFQHGEV
CCEEEEEEECHHHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERYTSGKLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DQIKLNILENAKGSDIAIVEIGGTVGDIESLPFLEAIRQLKSDRGPGNVLYLHVTLVPYI
CEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEHHH
KTAGELKTKPTQHSVKELREIGIQPDILLCRCEQDVPQDMKAKIALFCNVEEKAVITSQD
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEECCC
AEHIYAVPMALNHQGLDDQVVEKLNIWTKAPDLSHWQQVVSKLTNPGSGEVRIAVVGKYV
CCEEEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCH
DLKESYKSLSEALTHGGIANDCRVKLVYLDSEKIEEDGGEKALADVDGILVPGGFGERGT
HHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCEEHHCCCCEEECCCCCCCCC
EGKIKAIEYARVNKVPFFGICLGMQMAAVEYARNVCRLPEAFSSEFKPDCESPVIHLMEE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHH
QKGVENKGGTMRLGAYPCSLTKGTFAQKAYGATEISERHRHRYEFNNLFRSCLEEKGMVI
HCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
SGVYKEGNLVEIIELPDHPWFLGCQFHPEFKSKPLNPHPLFKAFIGATKAKRG
EEEECCCCEEEEEECCCCCEEEEEEECCHHCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA