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The map label for this gene is atoC [H]

Identifier: 197117921

GI number: 197117921

Start: 1779159

End: 1780529

Strand: Direct

Name: atoC [H]

Synonym: Gbem_1534

Alternate gene names: 197117921

Gene position: 1779159-1780529 (Clockwise)

Preceding gene: 197117920

Following gene: 197117922

Centisome position: 38.55

GC content: 63.97

Gene sequence:

>1371_bases
GTGACCGAGAAGAAGAAAATACTGGTGGTGGACGACGAGGAAAACCTGCGCCACATGCTCCAGGTCATGCTGAAAAAGCA
GGGATACCAGGTGGAGCAGGCGGCGAACGGCGAGCAGGCCATGGAGAAGGCGCGACAGGGGAGCTACGCCTTCATCCTCT
GCGACATCCGCATGCCGGTCCTGGACGGCAGGGCTTTCCTGGCCGCCTGCACCACTGCGGGGATAAACAGCACCGTGATC
ATGATGTCCGCCTACGGCACGCTTGAGGATGCCGTGGGCTGCATGAAGCTCGGCGCCTACGACTACATCTCCAAGCCTTT
CAACAGCGACGAGATCTCGCTGGTGCTGAAGAAAGCGGAGGAGCGCGAAAGGCTGAAGGATGAAAACCGGAGGCTGCGCG
AGGAGGTGGTGCGCCGCCGTCCCTTGGGCGACATCATCAGCAGAAGCGAACGCATGGCCGAGATCGGGCGGCTGGTGTTG
AAGCTCTCCGAGCACAAGACTTCGGTGCTCATCCTGGGGGAGTCGGGGACCGGCAAGGAACTCGTCGCCCGGGCGCTGCA
CTACTGCGGGGTGCGCCGGGCTGGCCCCTTTGTGGCGGTCAACTGCGGCGCCATCCCCGAATCGCTGCTGGAAAGCGAAC
TCTTCGGGCACGTGAAGGGCGCCTTCACCGACGCGAGCCAAGACAAGACGGGGCTCTTTGAGGAAGCCGACGGCGGCACT
CTGTTCCTCGACGAGATCTCCGAGCTCTCCTTGCCGCTTCAGGTAAAGCTTTTGCGCGTGCTGCAGGAGGAGGAGATCCG
CCGGGTCGGTGCTGCAACCTCCCAGGCCGTTAACGTCCGCGTTGTTTCGGCCACCTCGCGCGACCTGGCACAGGAGGTGG
CGGCAGGAAGGTTCCGCGAGGACCTCTACTTCAGGCTCAACGTCTTTCCCATCTCGCTGCCGGCCCTGCGGGACAGGATC
GAGGACGTCCCCCTCCTGGTGGATCACTTCCTGGAAAAGCATGGTGAGAGGATGGGGATAACCGGCGTGCGCCCGAGCCC
CGAGACGCTGCAGGCCCTGGTGCGCTACCGCTGGCCGGGGAACGTGAGGGAACTGGAGAACTGCATCGAACGCGGGCTGG
TGCTGTGCGAAGCGGGTGCCCTTGGGCTGTCGTGCCTGCCGGAGAGTGTGCGCCGCGGGGTGGGGATCGAGAGAAGGGCG
ACCGACATCCCCGAGTCGCTGTCGATAAAAAAGGGGGGGGAGGCCCTGGAGCGCGCGCTTATCGTGCGCGCCCTGGAACA
GACCGCAGGCAACAGGACTCGCGCCGCTAAGCTCCTGGAAATAAGCCACCGGGCGCTTTTGTACAAGCTGAAGGAGTACG
AGCTGGGGTGA

Upstream 100 bases:

>100_bases
TTCAGGCTGACGCTGCCGGCGGGAGGCAGTGGCTAGGGGCTGGGGCCGCAAGGTCAGACAGGTCAGACAGGTCAGACAGG
CTGGGCGTTTAGGAGAAAGT

Downstream 100 bases:

>100_bases
TCGATGCCACGCCGCGCCGACCGGGCTCACGCGAAAGAGAAGGCACTTTTTGCATACCTCTTGCTTTTGCTATGAAAAAA
TTGCATAGTTTTCGCCGGGA

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTEKKKILVVDDEENLRHMLQVMLKKQGYQVEQAANGEQAMEKARQGSYAFILCDIRMPVLDGRAFLAACTTAGINSTVI
MMSAYGTLEDAVGCMKLGAYDYISKPFNSDEISLVLKKAEERERLKDENRRLREEVVRRRPLGDIISRSERMAEIGRLVL
KLSEHKTSVLILGESGTGKELVARALHYCGVRRAGPFVAVNCGAIPESLLESELFGHVKGAFTDASQDKTGLFEEADGGT
LFLDEISELSLPLQVKLLRVLQEEEIRRVGAATSQAVNVRVVSATSRDLAQEVAAGRFREDLYFRLNVFPISLPALRDRI
EDVPLLVDHFLEKHGERMGITGVRPSPETLQALVRYRWPGNVRELENCIERGLVLCEAGALGLSCLPESVRRGVGIERRA
TDIPESLSIKKGGEALERALIVRALEQTAGNRTRAAKLLEISHRALLYKLKEYELG

Sequences:

>Translated_456_residues
MTEKKKILVVDDEENLRHMLQVMLKKQGYQVEQAANGEQAMEKARQGSYAFILCDIRMPVLDGRAFLAACTTAGINSTVI
MMSAYGTLEDAVGCMKLGAYDYISKPFNSDEISLVLKKAEERERLKDENRRLREEVVRRRPLGDIISRSERMAEIGRLVL
KLSEHKTSVLILGESGTGKELVARALHYCGVRRAGPFVAVNCGAIPESLLESELFGHVKGAFTDASQDKTGLFEEADGGT
LFLDEISELSLPLQVKLLRVLQEEEIRRVGAATSQAVNVRVVSATSRDLAQEVAAGRFREDLYFRLNVFPISLPALRDRI
EDVPLLVDHFLEKHGERMGITGVRPSPETLQALVRYRWPGNVRELENCIERGLVLCEAGALGLSCLPESVRRGVGIERRA
TDIPESLSIKKGGEALERALIVRALEQTAGNRTRAAKLLEISHRALLYKLKEYELG
>Mature_455_residues
TEKKKILVVDDEENLRHMLQVMLKKQGYQVEQAANGEQAMEKARQGSYAFILCDIRMPVLDGRAFLAACTTAGINSTVIM
MSAYGTLEDAVGCMKLGAYDYISKPFNSDEISLVLKKAEERERLKDENRRLREEVVRRRPLGDIISRSERMAEIGRLVLK
LSEHKTSVLILGESGTGKELVARALHYCGVRRAGPFVAVNCGAIPESLLESELFGHVKGAFTDASQDKTGLFEEADGGTL
FLDEISELSLPLQVKLLRVLQEEEIRRVGAATSQAVNVRVVSATSRDLAQEVAAGRFREDLYFRLNVFPISLPALRDRIE
DVPLLVDHFLEKHGERMGITGVRPSPETLQALVRYRWPGNVRELENCIERGLVLCEAGALGLSCLPESVRRGVGIERRAT
DIPESLSIKKGGEALERALIVRALEQTAGNRTRAAKLLEISHRALLYKLKEYELG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=44.1758241758242, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=43.5267857142857, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=39.0086206896552, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=38.6516853932584, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87082117, Length=262, Percent_Identity=52.6717557251908, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=45.1923076923077, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=45.8083832335329, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082152, Length=303, Percent_Identity=45.8745874587459, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1786524, Length=339, Percent_Identity=40.7079646017699, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=36.9085173501577, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=36.875, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1789828, Length=284, Percent_Identity=34.5070422535211, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI87081858, Length=307, Percent_Identity=32.8990228013029, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789809, Length=112, Percent_Identity=36.6071428571429, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786784, Length=107, Percent_Identity=32.7102803738318, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787375, Length=165, Percent_Identity=24.8484848484848, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082012, Length=107, Percent_Identity=30.8411214953271, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50728; Mature: 50597

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKKILVVDDEENLRHMLQVMLKKQGYQVEQAANGEQAMEKARQGSYAFILCDIRMPV
CCCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCEEEEEEEEECCC
LDGRAFLAACTTAGINSTVIMMSAYGTLEDAVGCMKLGAYDYISKPFNSDEISLVLKKAE
CCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
ERERLKDENRRLREEVVRRRPLGDIISRSERMAEIGRLVLKLSEHKTSVLILGESGTGKE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
LVARALHYCGVRRAGPFVAVNCGAIPESLLESELFGHVKGAFTDASQDKTGLFEEADGGT
HHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
LFLDEISELSLPLQVKLLRVLQEEEIRRVGAATSQAVNVRVVSATSRDLAQEVAAGRFRE
EECCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
DLYFRLNVFPISLPALRDRIEDVPLLVDHFLEKHGERMGITGVRPSPETLQALVRYRWPG
CEEEEEEEEEEECHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHCCCC
NVRELENCIERGLVLCEAGALGLSCLPESVRRGVGIERRATDIPESLSIKKGGEALERAL
CHHHHHHHHHHCEEEEECCCCCHHHCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
IVRALEQTAGNRTRAAKLLEISHRALLYKLKEYELG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEKKKILVVDDEENLRHMLQVMLKKQGYQVEQAANGEQAMEKARQGSYAFILCDIRMPV
CCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCEEEEEEEEECCC
LDGRAFLAACTTAGINSTVIMMSAYGTLEDAVGCMKLGAYDYISKPFNSDEISLVLKKAE
CCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
ERERLKDENRRLREEVVRRRPLGDIISRSERMAEIGRLVLKLSEHKTSVLILGESGTGKE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
LVARALHYCGVRRAGPFVAVNCGAIPESLLESELFGHVKGAFTDASQDKTGLFEEADGGT
HHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
LFLDEISELSLPLQVKLLRVLQEEEIRRVGAATSQAVNVRVVSATSRDLAQEVAAGRFRE
EECCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
DLYFRLNVFPISLPALRDRIEDVPLLVDHFLEKHGERMGITGVRPSPETLQALVRYRWPG
CEEEEEEEEEEECHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHCCCC
NVRELENCIERGLVLCEAGALGLSCLPESVRRGVGIERRATDIPESLSIKKGGEALERAL
CHHHHHHHHHHCEEEEECCCCCHHHCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
IVRALEQTAGNRTRAAKLLEISHRALLYKLKEYELG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]